4Y32A

Crystal structure of c-terminal modified tau peptide-hybrid 109b with 14-3-3sigma
Total Genus 102
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
236
structure length
235
Chain Sequence
GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Stabilizer-Guided Inhibition of Protein-Protein Interactions.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords 14-3-3 protein sigma
total genus 102
structure length 235
sequence length 236
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4y32A00
4DAUA 2NPMA 1YZ5A 5EWZA 4DATA 3UX0A 5D3FA 2O8PA 5LU1A 3O8IA 3P1OA 4DHOA 2V7DA 3IQUA 5LX2A 3P1QA 3UZDA 1O9EA 4N7YA 2BTPA 4DHUA 4F7RA 3P1SA 4IEAA 4FJ3A 4E2EA 4Y3BA 1IB1A 5BY9A 4FL5A 4DHTA 5BTVA 3SMOA 3T0LA 5LU2A 4N84A 5D2DA 3NKXA 3SMMA 4DHSA 4O46A 1O9DA 1QJBA 5LVZA 5EXAA 3MHRA 3LW1A 1YWTA 3UBWA 3IQJA 5LHOA 2C1JA 1O9FA 3IQVA 5J31A 1A37A 4J6SA 5D3EA 4GNTA 4DX0A 3M51A 4IHLA 2O98A 3CU8A 5F74A 2C23A 4ZDRA 4HKCA 5HF3A 4DNKA 3AXYC 4Y32A 3RDHA 1QJAA 2BQ0A 5IQPA 4Y5IA 3E6YA 3SMKA 4DHQA 3UALA 2B05A 4FR3A 3SMLA 2BR9A 4QLIA 1A38A 2C63A 3P1RA 3M50A 3SPRA 1A4OA 2WH0A 4WRQA 3U9XA 4DHNA 4DHPA 3SMNA 2C74A 1O9CA 3P1PA 3T0MA 4JDDA 2O02A 2C1NA 4JC3A 3EFZA 4BG6A 3P1NA 4N7GA 4DHMA 4ZQ0A 3SP5A 4DHRA
chains in the Genus database with same CATH superfamily
4DAUA 2NPMA 1YZ5A 4QX0A 1I5PA 5EWZA 4DATA 3UX0A 5D3FA 3X0UA 2O8PA 5LU1A 4ARYA 3O8IA 3P1OA 4DHOA 2V7DA 3CQCA 1W99A 3IQUA 5LX2A 3P1QA 3UZDA 1O9EA 4N7YA 4W8JA 2BTPA 4DHUA 4F7RA 3P1SA 4IEAA 4FJ3A 4E2EA 2C9KA 1S2XA 4Y3BA 4ARXA 1IB1A 5BY9A 4FL5A 4DHTA 4D8MA 4QX1A 3SMOA 5BTVA 3I4RA 1CIYA 3T0LA 5LU2A 4QX2A 4N84A 5D2DA 3NKXA 3SMMA 1URJA 4DHSA 4O46A 1O9DA 1QJBA 5LVZA 5EXAA 3MHRA 3LW1A 1YWTA 3UBWA 3IQJA 5LHOA 2C1JA 1O9FA 3IQVA 5J31A 3EB7A 1A37A 3ZHEB 4J6SA 5D3EA 4GNTA 4MOAA 4DX0A 3M51A 4IHLA 1JI6A 2O98A 3CU8A 5F74A 2C23A 4ZDRA 4HKCA 5HF3A 4DNKA 3AXYC 4Y32A 3RDHA 1QJAA 2BQ0A 5IQPA 4Y5IA 3E6YA 3SMKA 4DHQA 3UALA 2B05A 4FR3A 3SMLA 2BR9A 4QLIA 1A38A 4QX3A 2C63A 3P1RA 3M50A 3SPRA 1A4OA 2WH0A 4WRQA 3U9XA 4DHNA 4DHPA 3SMNA 2C74A 1O9CA 3P1PA 3T0MA 4JDDA 2O02A 3CQGA 1DLCA 2C1NA 4JC3A 3EFZA 4BG6A 3P1NA 4N7GA 4DHMA 4ZQ0A 3SP5A 4DHRA
chains in the Genus database with same CATH topology
4DAUA 2NPMA 1YZ5A 5EWZA 4DATA 3UX0A 5D3FA 2O8PA 5LU1A 3O8IA 3P1OA 4DHOA 2V7DA 3IQUA 5LX2A 3P1QA 3UZDA 1O9EA 4N7YA 2BTPA 4DHUA 4F7RA 3P1SA 4IEAA 4FJ3A 4E2EA 4Y3BA 1IB1A 5BY9A 4FL5A 4DHTA 5BTVA 3SMOA 3T0LA 5LU2A 4N84A 5D2DA 3NKXA 3SMMA 4DHSA 4O46A 1O9DA 1QJBA 5LVZA 5EXAA 3MHRA 3LW1A 1YWTA 3UBWA 3IQJA 5LHOA 2C1JA 1O9FA 3IQVA 5J31A 1A37A 4J6SA 5D3EA 4GNTA 4DX0A 3M51A 4IHLA 2O98A 3CU8A 5F74A 2C23A 4ZDRA 4HKCA 5HF3A 4DNKA 3AXYC 4Y32A 3RDHA 1QJAA 2BQ0A 5IQPA 4Y5IA 3E6YA 3SMKA 4DHQA 3UALA 2B05A 4FR3A 3SMLA 2BR9A 4QLIA 1A38A 2C63A 3P1RA 3M50A 3SPRA 1A4OA 2WH0A 4WRQA 3U9XA 4DHNA 4DHPA 3SMNA 2C74A 1O9CA 3P1PA 3T0MA 4JDDA 2O02A 2C1NA 4JC3A 3EFZA 4BG6A 3P1NA 4N7GA 4DHMA 4ZQ0A 3SP5A 4DHRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DAU A;  2NPM A;  1YZ5 A;  5EWZ A;  4DAT A;  3UX0 A;  5D3F A;  2O8P A;  5LU1 A;  3O8I A;  3P1O A;  4DHO A;  2V7D A;  3IQU A;  5LX2 A;  3P1Q A;  3UZD A;  1O9E A;  4N7Y A;  2BTP A;  4DHU A;  4F7R A;  3P1S A;  4IEA A;  4FJ3 A;  4E2E A;  4Y3B A;  1IB1 A;  5BY9 A;  4FL5 A;  4DHT A;  5BTV A;  3SMO A;  3T0L A;  5LU2 A;  4N84 A;  5D2D A;  3NKX A;  3SMM A;  4DHS A;  4O46 A;  1O9D A;  1QJB A;  5LVZ A;  5EXA A;  3MHR A;  3LW1 A;  1YWT A;  3UBW A;  3IQJ A;  5LHO A;  2C1J A;  1O9F A;  3IQV A;  5J31 A;  1A37 A;  4J6S A;  5D3E A;  4GNT A;  4DX0 A;  3M51 A;  4IHL A;  2O98 A;  3CU8 A;  5F74 A;  2C23 A;  4ZDR A;  4HKC A;  5HF3 A;  4DNK A;  3AXY C;  4Y32 A;  3RDH A;  1QJA A;  2BQ0 A;  5IQP A;  4Y5I A;  3E6Y A;  3SMK A;  4DHQ A;  3UAL A;  2B05 A;  4FR3 A;  3SML A;  2BR9 A;  4QLI A;  1A38 A;  2C63 A;  3P1R A;  3M50 A;  3SPR A;  1A4O A;  2WH0 A;  4WRQ A;  3U9X A;  4DHN A;  4DHP A;  3SMN A;  2C74 A;  1O9C A;  3P1P A;  3T0M A;  4JDD A;  2O02 A;  2C1N A;  4JC3 A;  3EFZ A;  4BG6 A;  3P1N A;  4N7G A;  4DHM A;  4ZQ0 A;  3SP5 A;  4DHR A; 
#chains in the Genus database with same CATH topology
 4DAU A;  2NPM A;  1YZ5 A;  4QX0 A;  1I5P A;  5EWZ A;  4DAT A;  3UX0 A;  5D3F A;  3X0U A;  2O8P A;  5LU1 A;  4ARY A;  3O8I A;  3P1O A;  4DHO A;  2V7D A;  3CQC A;  1W99 A;  3IQU A;  5LX2 A;  3P1Q A;  3UZD A;  1O9E A;  4N7Y A;  4W8J A;  2BTP A;  4DHU A;  4F7R A;  3P1S A;  4IEA A;  4FJ3 A;  4E2E A;  2C9K A;  1S2X A;  4Y3B A;  4ARX A;  1IB1 A;  5BY9 A;  4FL5 A;  4DHT A;  4D8M A;  4QX1 A;  3SMO A;  5BTV A;  3I4R A;  1CIY A;  3T0L A;  5LU2 A;  4QX2 A;  4N84 A;  5D2D A;  3NKX A;  3SMM A;  1URJ A;  4DHS A;  4O46 A;  1O9D A;  1QJB A;  5LVZ A;  5EXA A;  3MHR A;  3LW1 A;  1YWT A;  3UBW A;  3IQJ A;  5LHO A;  2C1J A;  1O9F A;  3IQV A;  5J31 A;  3EB7 A;  1A37 A;  3ZHE B;  4J6S A;  5D3E A;  4GNT A;  4MOA A;  4DX0 A;  3M51 A;  4IHL A;  1JI6 A;  2O98 A;  3CU8 A;  5F74 A;  2C23 A;  4ZDR A;  4HKC A;  5HF3 A;  4DNK A;  3AXY C;  4Y32 A;  3RDH A;  1QJA A;  2BQ0 A;  5IQP A;  4Y5I A;  3E6Y A;  3SMK A;  4DHQ A;  3UAL A;  2B05 A;  4FR3 A;  3SML A;  2BR9 A;  4QLI A;  1A38 A;  4QX3 A;  2C63 A;  3P1R A;  3M50 A;  3SPR A;  1A4O A;  2WH0 A;  4WRQ A;  3U9X A;  4DHN A;  4DHP A;  3SMN A;  2C74 A;  1O9C A;  3P1P A;  3T0M A;  4JDD A;  2O02 A;  3CQG A;  1DLC A;  2C1N A;  4JC3 A;  3EFZ A;  4BG6 A;  3P1N A;  4N7G A;  4DHM A;  4ZQ0 A;  3SP5 A;  4DHR A; 
#chains in the Genus database with same CATH homology
 4DAU A;  2NPM A;  1YZ5 A;  5EWZ A;  4DAT A;  3UX0 A;  5D3F A;  2O8P A;  5LU1 A;  3O8I A;  3P1O A;  4DHO A;  2V7D A;  3IQU A;  5LX2 A;  3P1Q A;  3UZD A;  1O9E A;  4N7Y A;  2BTP A;  4DHU A;  4F7R A;  3P1S A;  4IEA A;  4FJ3 A;  4E2E A;  4Y3B A;  1IB1 A;  5BY9 A;  4FL5 A;  4DHT A;  5BTV A;  3SMO A;  3T0L A;  5LU2 A;  4N84 A;  5D2D A;  3NKX A;  3SMM A;  4DHS A;  4O46 A;  1O9D A;  1QJB A;  5LVZ A;  5EXA A;  3MHR A;  3LW1 A;  1YWT A;  3UBW A;  3IQJ A;  5LHO A;  2C1J A;  1O9F A;  3IQV A;  5J31 A;  1A37 A;  4J6S A;  5D3E A;  4GNT A;  4DX0 A;  3M51 A;  4IHL A;  2O98 A;  3CU8 A;  5F74 A;  2C23 A;  4ZDR A;  4HKC A;  5HF3 A;  4DNK A;  3AXY C;  4Y32 A;  3RDH A;  1QJA A;  2BQ0 A;  5IQP A;  4Y5I A;  3E6Y A;  3SMK A;  4DHQ A;  3UAL A;  2B05 A;  4FR3 A;  3SML A;  2BR9 A;  4QLI A;  1A38 A;  2C63 A;  3P1R A;  3M50 A;  3SPR A;  1A4O A;  2WH0 A;  4WRQ A;  3U9X A;  4DHN A;  4DHP A;  3SMN A;  2C74 A;  1O9C A;  3P1P A;  3T0M A;  4JDD A;  2O02 A;  2C1N A;  4JC3 A;  3EFZ A;  4BG6 A;  3P1N A;  4N7G A;  4DHM A;  4ZQ0 A;  3SP5 A;  4DHR A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...