4YFNA

Escherichia coli rna polymerase in complex with squaramide compound 14 (n-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide)
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
235
structure length
235
Chain Sequence
MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords DNA-directed RNA polymerase subunit alpha
publication title X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
pubmed doi rcsb
source organism Escherichia coli o139:h28 (strain e24377a / etec)
molecule tags Transcription/transcription inhibitor
total genus 38
structure length 235
sequence length 235
chains with identical sequence B, G, H
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2015-02-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01000 RNA_pol_A_bac RNA polymerase Rpb3/RpoA insert domain
A PF01193 RNA_pol_L RNA polymerase Rpb3/Rpb11 dimerisation domain
A PF03118 RNA_pol_A_CTD Bacterial RNA polymerase, alpha chain C terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.120.12 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 DNA-directed RNA polymerase, insert domain 4yfnA02
3.30.1360.10 Alpha Beta 2-Layer Sandwich Gyrase A; domain 2 RNA polymerase, RBP11-like subunit 4yfnA01
3S1MC 5FLMK 3S14K 1TWHC 3HOZK 3S15C 5TMCA 3GTQC 3HOYC 1ZYRA 3H3VL 5IYDC 3I4NC 2YU9C 1TWGK 1I6VA 4C3IK 1R9TK 1K83C 4ZH4A 2VUMC 5D4DA 2NVQC 5C4XK 2JA7K 4KMUA 2R92K 2NVXC 1Y1VC 4Q5SA 3GTKK 2B63K 3HOUK 4G7HA 3GTMC 4BY1C 4BXXC 4OINA 3HKZL 4OIRA 5M5WK 3CQZC 2E2IC 1I6HC 5M5XK 4A3DK 3PO2C 4C2MK 3S1NC 3GTOK 4A3IC 4A3KC 5C4JK 3K7AK 3I4MC 3RZDC 1TWHK 4QJVA 4C3HC 3S1QC 4A3GC 5M3MK 2A68A 4A93K 2BE5A 3M3YC 1TWFK 3I4NK 5IYCC 2YU9K 1IW7A 4NOIA 2VUMK 2Y0SD 2JA8C 2PA8L 2JA5C 3GTLK 4A3CC 1TWAC 2A6EA 2WAQD 4KN7A 4LK0A 3S17C 1Y1VK 3PO3K 3M4OC 3GTMK 4BXXK 4BY1K 4LJZA 2A6HA 4G7ZA 2NVTK 4Y52C 3HOWC 2Y0SL 3GTJC 4A3FK 2E2IK 4X6AK 2O5IA 2WAQL 3S1NK 1SFOK 3S2HC 4A3IK 4A3KK 4AYBD 2O5JA 3RZDK 2PMZD 2E2HK 4BBSC 4A3JK 2E2JK 3GTGC 5IP7C 2WB1D 3FKIK 5IYCK 3M3YK 1BDFA 3H0GC 5C3EK 1SMYA 5TMFA 5C44C 1Y1WK 4MEXA 4AYBL 2JA5K 4LLGA 2JA8K 4A3CK 3S1MK 4BY7C 2PMZL 3S15K 3HOYK 3GTQK 4Y7NC 2WB1L 4BBRC 5IYBC 2NVYK 1YNJA 5IYDK 3GTJK 1I50C 1K83K 2NVQK 2R7ZC 2CW0A 3S16C 2NVXK 1TWCC 3S2HK 4YFXA 4C3JC 5IP9C 4A3MC 3S14C 5FLMC 4A3EC 3HOZC 4Q4ZA 4BBSK 2R93C 4OIQA 3CQZK 1I6HK 3PO2K 1R9TC 5C44K 3I4MK 2JA7C 4XLNA 4BY7K 2R92C 4C3HK 3S1QK 4A3GK 3GTPC 4MQ9A 2B63C 1I3QC 3HOUC 4XLPA 2JA6C 4BBRK 1YNNA 5IYBK 4YFNA 4G7OA 1WCMC 4OIPA 3RZOC 4QJVB 4A3BC 2R7ZK 2PPBA 3H3VD 5M3FK 4A3DC 4A3LC 1TWAK 4C2MC 5FJ8K 4C3JK 3S17K 3S1RC 5M5YK 5IP9K 4KN4A 3M4OK 3HOVC 4A3EK 3S2DC 4A93C 4Y52K 3HOWK 2R93K 4OIOA 4GZYA 1XPPA 1TWFC 3DXJA 3HKZD 4LK1A 4YG2A 3HOXC 3GTLC 2NVYC 3GTPK 4QIWD 4XSXA 4XSZA 3PO3C 1I3QK 5IP7K 2JA6K 3GTGK 4MEYA 1WCMK 3H0GK 3EQLA 1TWGC 3RZOK 4C3IC 4A3FC 4X6AC 4A3BK 2A69A 4A3LK 5C4XC 1SFOC 3S1RK 4QIWL 2PA8D 3GTKC 1HQMA 4JK1A 4Y7NK 3HOVK 3S2DK 1I50K 2E2HC 4A3JC 2E2JC 3FKIC 3S16K 1TWCK 5C3EC 1Y1WC 2NVTC 3GTOC 3HOXK 4YFKA 4A3MK 3WODA 5C4JC 3K7AC
chains in the Genus database with same CATH superfamily
5FLMK 3HOYC 1WOOA 4J3NA 3GTQA 4PABA 3T02A 2YU9A 4IO9S 2VUMA 5C4XK 4GTBA 2JA7K 2R92K 1Y1VA 4BLAA 3GTMC 4BY1C 4GT9A 4OINA 4G0WA 1AB4A 2E2IA 1I6HC 4KMHA 4P5BA 3HXAA 5C4JK 3S1QC 5IORA 1YCLA 5IYCC 5IOTA 4NOIA 3GTLK 2PA8L 3FOFA 3NUHA 1TWAA 3S17C 2V6TA 3MMLB 3GTMK 4BY1K 2A6HA 4G0UA 1WORA 4X6AK 3GEHA 3FOEA 1XXBA 4AYBD 2O5JA 3TTGA 3SZZA 2E2HK 3GTGA 2WB1D 5IYCK 5EGEA 3H0GC 4BY7C 3A8IA 2PMZL 1O28A 3S15K 1O24A 4C45A 3GTQK 4Y7NC 5IYBC 1YNJA 2JH3A 1I50A 3N0BA 1TWCC 4YFXA 1DCPA 1RU0A 5IP9C 3S14C 1ZVUA 2R93A 4KMDA 5EGHA 2GSNA 1USOA 1JVIA 4BY7K 4C3HK 3GTPA 4MQ9A 2B63C 3HOUC 5IYBK 1O2FB 1YNNA 2P8TA 1IQ0A 4A3BC 2PPBA 3H3VD 3GIRA 4A3LC 1TWAK 3OREA 3M4OK 5IP9K 3G4AA 3HOWK 4GZYA 5L46A 3HKZD 5CHPA 4YG2A 1G51A 2V6UA 2NVYA 1VRQC 1J6VA 3PO3C 4XSZA 3GTGK 1TWGC 4C3IC 4A3BK 4A3LK 3PIOS 1SFOA 1HQMA 4JK1A 1USMA 1I50K 4A3JC 3FKIA 4AH6A 2XCRB 4M1XA 5C3EC 2NVTC 4KMAA 2KXYA 2KWAA 3HOZK 3BP8C 4WJ4A 1ISEA 5TMCA 2ZJQS 5IYDC 1TWGK 4C3IK 1K83C 2NVQC 5JVOA 2NVXC 1IS1A 4LR2A 3GTMA 4G7HA 4BXXC 5HQHA 1O25A 1IE0A 4KDDA 3PO2C 3S1NC 4A3IC 4A3KC 4P9SA 1O26A 3I4MC 1ZXOA 2A68A 2RH6A 2L3UA 2Y0SD 2JA5C 3AD7C 1WQHA 1KQ4A 4BKWA 4KN7A 4BXXK 4LJZA 4G7ZA 1XXCA 4A3FK 5IOQA 4P5AA 3S1NK 1SFOK 1F93A 3S2HC 4A3IK 4A3KK 4WFNS 4RMFA 4KARA 3LYWA 2E2JK 3FKIK 5IP7C 2KQ1A 1JQWA 2GAGC 3H0GA 5TMFA 2GSUA 2JA5K 4AYBL 4LLGA 3BP3A 3HOYK 2WB1L 3LPXA 1B4AA 3S2HK 1TWCA 1UV7A 1EI6A 1WQFA 1I6HK 4KAWX 1R9TC 2FQOA 4XLNA 3S1QK 2B63A 2P5MA 1I3QC 1VGXA 1DD5A 3RZOC 3A8KA 4QJVB 3T01A 4A3DC 3S0XA 3S17K 4C2MC 1WIHA 4A93C 3AQOA 4OIOA 1TWFC 1ZBSA 1I3QK 4KASA 3H0GK 1TWGA 3RZOK 2PA8D 4Y7NK 2PHCB 3CF5S 4XCHA 2RGRA 1J6XA 2KPUA 1J6WA 4KB4A 1TWCK 1Y1WC 4ILDA 3WODA 3S1MC 1FEUA 4GFQA 1TWHC 4GTAA 5CJ9A 3S14K 5IOSA 1K83A 5D4DA 4KMUA 2NVXA 4Q5SA 4KM9A 2D6FC 2B63K 3HOUK 3Q3QA 1IBAA 5M5WK 3CQZC 5M5XK 4PAAA 2ZUFA 3L4KA 1XZPA 3RZDC 1TWHK 4QJVA 4A3GC 2XCOA 5M3MK 1ZQ1C 1IW7A 2JA5A 1B4BA 4G0VA 1WSRA 2WAQD 4LK0A 4LQYA 4FM9A 3PO3K 3GDZA 4Y52C 3OPFA 1VH2A 3GTJC 2XCQA 2Y0SL 3LAPA 3RZDK 2ZJRS 4BBSC 1WOPA 4A3JK 5C3EK 2NVTK 1SMYA 5C44C 3G4CA 5JFEA 5IYDK 1F9NA 1O29A 4O2DA 3GTJK 1K83K 2V6SA 2R7ZC 2NVQK 2CW0A 3S16C 2NVXK 4A3MC 4GTCA 1VLOA 4WJ3M 5FLMC 4A3EC 4Q4ZA 4BBSK 4OIQA 3PO2K 5C44K 4WCES 3I4MK 2JA7C 3VA7A 2R92C 1I3QA 2JA6C 1PJ5A 3DLLS 1WCMC 4OIPA 3TFHA 2R7ZK 5M3FK 3S1RC 3N0CA 5M5YK 4KN4A 1BJTA 3HOVC 4A3EK 1DCOA 1XPPA 3OEPA 1TWFA 4LK1A 4GTLA 3GTLC 4U67S 2FQTA 1J98A 4QIWD 4XSXA 5TJ3A 2JA6K 5IP7K 1F7VA 3AQPA 1WCMK 1O2BA 4X6AC 2A69A 1EK8A 3S1RK 3GTKC 3HOVK 4KC6A 1L0WA 1XZQB 1XZPB 2E2HC 1WOSA 3AD9C 3GTOC 3TFJA 1Y1WA 5C4JC 5JVHS 4YFKA 3K7AC 4WFAS 1PJ7A 1TWHA 1O2AA 3JSTA 3S15C 1DCHA 3GTQC 3T00A 1ZYRA 3H3VL 3SZYA 3I4NC 2YU9C 1R9TK 1I6VA 3PIPS 3ERED 4ZH4A 2VUMC 1HI9A 5DM7S 2CFAB 1Y1VC 4WILA 3GTKK 3QX3A 2Y3PA 3HKZL 4OIRA 3FHZA 3CQZA 2E2IC 3GSIA 4A3DK 4GTEA 4C2MK 3GTOK 1C0AA 4GTDA 3GEEA 3K7AK 4WFBS 4A93K 2W7VA 4C3HC 1O27A 2BE5A 3M3YC 1TWFK 3AD8C 3I4NK 2YU9K 2VUMK 2JA8C 2GSOA 3BUEA 4A3CC 1TWAC 2A6EA 1Y1VK 4WF9S 3M4OC 2ZFZA 1VJEA 3HOWC 4GTFA 3GTJA 2E2IK 3N3YA 2O5IA 2WAQL 4FZBA 3GEIA 2PMZD 3M3YK 3GTGC 1X31C 4BLBA 1BDFA 1Y1WK 2JA8K 4MEXA 1XZQA 4A3CK 3S1MK 3TFIA 1WSVA 2ZUEA 5DM6S 4BBRC 1I50C 5JVGS 3LAJA 1XXAA 3ADAC 2R7ZA 4IOAS 4C3JC 5E68A 4LOWA 3HOZC 2CFAA 1BS2A 2R93C 3CQZK 3L4JA 4IOCS 1WQGA 1YX2A 2JA7A 2R92A 4A3GK 3A8JA 1EQRA 3GTPC 2JA6A 4XLPA 4BBRK 1GE9A 2L5NA 4YFNA 4G7OA 1WCMA 2GAHC 1IL2A 5FJ8K 4C3JK 2ZJPS 5HL8A 4Y52K 3S2DC 3AH5A 2R93K 1BGWA 3DXJA 3IPJA 3V4GA 3GTLA 3HOXC 2NVYC 1EFWA 3GTPK 4MEYA 3EQLA 1R9TA 4KM8A 4A3FC 5C4XC 4KATA 4KB2A 1SFOC 4QIWL 3GTKA 1EH1A 1PJ6A 1F7UA 3S2DK 1INNA 3CAGA 2E2HA 2E2JC 4DDQA 3FKIC 1JOEA 5HL7S 3S16K 3GTOA 3HOXK 4A3MK 1V5VA 2NVYK 2EBBA
chains in the Genus database with same CATH topology
3S1MC 5FLMK 3S14K 1TWHC 3HOZK 3S15C 5TMCA 3GTQC 3HOYC 1ZYRA 3H3VL 5IYDC 3I4NC 2YU9C 1TWGK 1I6VA 4C3IK 1R9TK 1K83C 4ZH4A 2VUMC 5D4DA 2NVQC 5C4XK 2JA7K 4KMUA 2R92K 2NVXC 1Y1VC 4Q5SA 3GTKK 2B63K 3HOUK 4G7HA 3GTMC 4BY1C 4BXXC 4OINA 3HKZL 4OIRA 5M5WK 3CQZC 2E2IC 1I6HC 5M5XK 4A3DK 3PO2C 4C2MK 3S1NC 3GTOK 4A3IC 4A3KC 5C4JK 3K7AK 3I4MC 3RZDC 1TWHK 4QJVA 4C3HC 3S1QC 4A3GC 5M3MK 2A68A 4A93K 2BE5A 3M3YC 1TWFK 3I4NK 5IYCC 2YU9K 1IW7A 4NOIA 2VUMK 2Y0SD 2JA8C 2PA8L 2JA5C 3GTLK 4A3CC 1TWAC 2A6EA 2WAQD 4KN7A 4LK0A 3S17C 1Y1VK 3PO3K 3M4OC 3GTMK 4BXXK 4BY1K 4LJZA 2A6HA 4G7ZA 2NVTK 4Y52C 3HOWC 2Y0SL 3GTJC 4A3FK 2E2IK 4X6AK 2O5IA 2WAQL 3S1NK 1SFOK 3S2HC 4A3IK 4A3KK 4AYBD 2O5JA 3RZDK 2PMZD 2E2HK 4BBSC 4A3JK 2E2JK 3GTGC 5IP7C 2WB1D 3FKIK 5IYCK 3M3YK 1BDFA 3H0GC 5C3EK 1SMYA 5TMFA 5C44C 1Y1WK 4MEXA 4AYBL 2JA5K 4LLGA 2JA8K 4A3CK 3S1MK 4BY7C 2PMZL 3S15K 3HOYK 3GTQK 4Y7NC 2WB1L 4BBRC 5IYBC 2NVYK 1YNJA 5IYDK 3GTJK 1I50C 1K83K 2NVQK 2R7ZC 2CW0A 3S16C 2NVXK 1TWCC 3S2HK 4YFXA 4C3JC 5IP9C 4A3MC 3S14C 5FLMC 4A3EC 3HOZC 4Q4ZA 4BBSK 2R93C 4OIQA 3CQZK 1I6HK 3PO2K 1R9TC 5C44K 3I4MK 2JA7C 4XLNA 4BY7K 2R92C 4C3HK 3S1QK 4A3GK 3GTPC 4MQ9A 2B63C 1I3QC 3HOUC 4XLPA 2JA6C 4BBRK 1YNNA 5IYBK 4YFNA 4G7OA 1WCMC 4OIPA 3RZOC 4QJVB 4A3BC 2R7ZK 2PPBA 3H3VD 5M3FK 4A3DC 4A3LC 1TWAK 4C2MC 5FJ8K 4C3JK 3S17K 3S1RC 5M5YK 5IP9K 4KN4A 3M4OK 3HOVC 4A3EK 3S2DC 4A93C 4Y52K 3HOWK 2R93K 4OIOA 4GZYA 1XPPA 1TWFC 3DXJA 3HKZD 4LK1A 4YG2A 3HOXC 3GTLC 2NVYC 3GTPK 4QIWD 4XSXA 4XSZA 3PO3C 1I3QK 5IP7K 2JA6K 3GTGK 4MEYA 1WCMK 3H0GK 3EQLA 1TWGC 3RZOK 4C3IC 4A3FC 4X6AC 4A3BK 2A69A 4A3LK 5C4XC 1SFOC 3S1RK 4QIWL 2PA8D 3GTKC 1HQMA 4JK1A 4Y7NK 3HOVK 3S2DK 1I50K 2E2HC 4A3JC 2E2JC 3FKIC 3S16K 1TWCK 5C3EC 1Y1WC 2NVTC 3GTOC 3HOXK 4YFKA 4A3MK 3WODA 5C4JC 3K7AC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S1M C;  5FLM K;  3S14 K;  1TWH C;  3HOZ K;  3S15 C;  5TMC A;  3GTQ C;  3HOY C;  1ZYR A;  3H3V L;  5IYD C;  3I4N C;  2YU9 C;  1TWG K;  1I6V A;  4C3I K;  1R9T K;  1K83 C;  4ZH4 A;  2VUM C;  5D4D A;  2NVQ C;  5C4X K;  2JA7 K;  4KMU A;  2R92 K;  2NVX C;  1Y1V C;  4Q5S A;  3GTK K;  2B63 K;  3HOU K;  4G7H A;  3GTM C;  4BY1 C;  4BXX C;  4OIN A;  3HKZ L;  4OIR A;  5M5W K;  3CQZ C;  2E2I C;  1I6H C;  5M5X K;  4A3D K;  3PO2 C;  4C2M K;  3S1N C;  3GTO K;  4A3I C;  4A3K C;  5C4J K;  3K7A K;  3I4M C;  3RZD C;  1TWH K;  4QJV A;  4C3H C;  3S1Q C;  4A3G C;  5M3M K;  2A68 A;  4A93 K;  2BE5 A;  3M3Y C;  1TWF K;  3I4N K;  5IYC C;  2YU9 K;  1IW7 A;  4NOI A;  2VUM K;  2Y0S D;  2JA8 C;  2PA8 L;  2JA5 C;  3GTL K;  4A3C C;  1TWA C;  2A6E A;  2WAQ D;  4KN7 A;  4LK0 A;  3S17 C;  1Y1V K;  3PO3 K;  3M4O C;  3GTM K;  4BXX K;  4BY1 K;  4LJZ A;  2A6H A;  4G7Z A;  2NVT K;  4Y52 C;  3HOW C;  2Y0S L;  3GTJ C;  4A3F K;  2E2I K;  4X6A K;  2O5I A;  2WAQ L;  3S1N K;  1SFO K;  3S2H C;  4A3I K;  4A3K K;  4AYB D;  2O5J A;  3RZD K;  2PMZ D;  2E2H K;  4BBS C;  4A3J K;  2E2J K;  3GTG C;  5IP7 C;  2WB1 D;  3FKI K;  5IYC K;  3M3Y K;  1BDF A;  3H0G C;  5C3E K;  1SMY A;  5TMF A;  5C44 C;  1Y1W K;  4MEX A;  4AYB L;  2JA5 K;  4LLG A;  2JA8 K;  4A3C K;  3S1M K;  4BY7 C;  2PMZ L;  3S15 K;  3HOY K;  3GTQ K;  4Y7N C;  2WB1 L;  4BBR C;  5IYB C;  2NVY K;  1YNJ A;  5IYD K;  3GTJ K;  1I50 C;  1K83 K;  2NVQ K;  2R7Z C;  2CW0 A;  3S16 C;  2NVX K;  1TWC C;  3S2H K;  4YFX A;  4C3J C;  5IP9 C;  4A3M C;  3S14 C;  5FLM C;  4A3E C;  3HOZ C;  4Q4Z A;  4BBS K;  2R93 C;  4OIQ A;  3CQZ K;  1I6H K;  3PO2 K;  1R9T C;  5C44 K;  3I4M K;  2JA7 C;  4XLN A;  4BY7 K;  2R92 C;  4C3H K;  3S1Q K;  4A3G K;  3GTP C;  4MQ9 A;  2B63 C;  1I3Q C;  3HOU C;  4XLP A;  2JA6 C;  4BBR K;  1YNN A;  5IYB K;  4YFN A;  4G7O A;  1WCM C;  4OIP A;  3RZO C;  4QJV B;  4A3B C;  2R7Z K;  2PPB A;  3H3V D;  5M3F K;  4A3D C;  4A3L C;  1TWA K;  4C2M C;  5FJ8 K;  4C3J K;  3S17 K;  3S1R C;  5M5Y K;  5IP9 K;  4KN4 A;  3M4O K;  3HOV C;  4A3E K;  3S2D C;  4A93 C;  4Y52 K;  3HOW K;  2R93 K;  4OIO A;  4GZY A;  1XPP A;  1TWF C;  3DXJ A;  3HKZ D;  4LK1 A;  4YG2 A;  3HOX C;  3GTL C;  2NVY C;  3GTP K;  4QIW D;  4XSX A;  4XSZ A;  3PO3 C;  1I3Q K;  5IP7 K;  2JA6 K;  3GTG K;  4MEY A;  1WCM K;  3H0G K;  3EQL A;  1TWG C;  3RZO K;  4C3I C;  4A3F C;  4X6A C;  4A3B K;  2A69 A;  4A3L K;  5C4X C;  1SFO C;  3S1R K;  4QIW L;  2PA8 D;  3GTK C;  1HQM A;  4JK1 A;  4Y7N K;  3HOV K;  3S2D K;  1I50 K;  2E2H C;  4A3J C;  2E2J C;  3FKI C;  3S16 K;  1TWC K;  5C3E C;  1Y1W C;  2NVT C;  3GTO C;  3HOX K;  4YFK A;  4A3M K;  3WOD A;  5C4J C;  3K7A C; 
#chains in the Genus database with same CATH topology
 5FLM K;  3HOY C;  1WOO A;  4J3N A;  3GTQ A;  4PAB A;  3T02 A;  2YU9 A;  4IO9 S;  2VUM A;  5C4X K;  4GTB A;  2JA7 K;  2R92 K;  1Y1V A;  4BLA A;  3GTM C;  4BY1 C;  4GT9 A;  4OIN A;  4G0W A;  1AB4 A;  2E2I A;  1I6H C;  4KMH A;  4P5B A;  3HXA A;  5C4J K;  3S1Q C;  5IOR A;  1YCL A;  5IYC C;  5IOT A;  4NOI A;  3GTL K;  2PA8 L;  3FOF A;  3NUH A;  1TWA A;  3S17 C;  2V6T A;  3MML B;  3GTM K;  4BY1 K;  2A6H A;  4G0U A;  1WOR A;  4X6A K;  3GEH A;  3FOE A;  1XXB A;  4AYB D;  2O5J A;  3TTG A;  3SZZ A;  2E2H K;  3GTG A;  2WB1 D;  5IYC K;  5EGE A;  3H0G C;  4BY7 C;  3A8I A;  2PMZ L;  1O28 A;  3S15 K;  1O24 A;  4C45 A;  3GTQ K;  4Y7N C;  5IYB C;  1YNJ A;  2JH3 A;  1I50 A;  3N0B A;  1TWC C;  4YFX A;  1DCP A;  1RU0 A;  5IP9 C;  3S14 C;  1ZVU A;  2R93 A;  4KMD A;  5EGH A;  2GSN A;  1USO A;  1JVI A;  4BY7 K;  4C3H K;  3GTP A;  4MQ9 A;  2B63 C;  3HOU C;  5IYB K;  1O2F B;  1YNN A;  2P8T A;  1IQ0 A;  4A3B C;  2PPB A;  3H3V D;  3GIR A;  4A3L C;  1TWA K;  3ORE A;  3M4O K;  5IP9 K;  3G4A A;  3HOW K;  4GZY A;  5L46 A;  3HKZ D;  5CHP A;  4YG2 A;  1G51 A;  2V6U A;  2NVY A;  1VRQ C;  1J6V A;  3PO3 C;  4XSZ A;  3GTG K;  1TWG C;  4C3I C;  4A3B K;  4A3L K;  3PIO S;  1SFO A;  1HQM A;  4JK1 A;  1USM A;  1I50 K;  4A3J C;  3FKI A;  4AH6 A;  2XCR B;  4M1X A;  5C3E C;  2NVT C;  4KMA A;  2KXY A;  2KWA A;  3HOZ K;  3BP8 C;  4WJ4 A;  1ISE A;  5TMC A;  2ZJQ S;  5IYD C;  1TWG K;  4C3I K;  1K83 C;  2NVQ C;  5JVO A;  2NVX C;  1IS1 A;  4LR2 A;  3GTM A;  4G7H A;  4BXX C;  5HQH A;  1O25 A;  1IE0 A;  4KDD A;  3PO2 C;  3S1N C;  4A3I C;  4A3K C;  4P9S A;  1O26 A;  3I4M C;  1ZXO A;  2A68 A;  2RH6 A;  2L3U A;  2Y0S D;  2JA5 C;  3AD7 C;  1WQH A;  1KQ4 A;  4BKW A;  4KN7 A;  4BXX K;  4LJZ A;  4G7Z A;  1XXC A;  4A3F K;  5IOQ A;  4P5A A;  3S1N K;  1SFO K;  1F93 A;  3S2H C;  4A3I K;  4A3K K;  4WFN S;  4RMF A;  4KAR A;  3LYW A;  2E2J K;  3FKI K;  5IP7 C;  2KQ1 A;  1JQW A;  2GAG C;  3H0G A;  5TMF A;  2GSU A;  2JA5 K;  4AYB L;  4LLG A;  3BP3 A;  3HOY K;  2WB1 L;  3LPX A;  1B4A A;  3S2H K;  1TWC A;  1UV7 A;  1EI6 A;  1WQF A;  1I6H K;  4KAW X;  1R9T C;  2FQO A;  4XLN A;  3S1Q K;  2B63 A;  2P5M A;  1I3Q C;  1VGX A;  1DD5 A;  3RZO C;  3A8K A;  4QJV B;  3T01 A;  4A3D C;  3S0X A;  3S17 K;  4C2M C;  1WIH A;  4A93 C;  3AQO A;  4OIO A;  1TWF C;  1ZBS A;  1I3Q K;  4KAS A;  3H0G K;  1TWG A;  3RZO K;  2PA8 D;  4Y7N K;  2PHC B;  3CF5 S;  4XCH A;  2RGR A;  1J6X A;  2KPU A;  1J6W A;  4KB4 A;  1TWC K;  1Y1W C;  4ILD A;  3WOD A;  3S1M C;  1FEU A;  4GFQ A;  1TWH C;  4GTA A;  5CJ9 A;  3S14 K;  5IOS A;  1K83 A;  5D4D A;  4KMU A;  2NVX A;  4Q5S A;  4KM9 A;  2D6F C;  2B63 K;  3HOU K;  3Q3Q A;  1IBA A;  5M5W K;  3CQZ C;  5M5X K;  4PAA A;  2ZUF A;  3L4K A;  1XZP A;  3RZD C;  1TWH K;  4QJV A;  4A3G C;  2XCO A;  5M3M K;  1ZQ1 C;  1IW7 A;  2JA5 A;  1B4B A;  4G0V A;  1WSR A;  2WAQ D;  4LK0 A;  4LQY A;  4FM9 A;  3PO3 K;  3GDZ A;  4Y52 C;  3OPF A;  1VH2 A;  3GTJ C;  2XCQ A;  2Y0S L;  3LAP A;  3RZD K;  2ZJR S;  4BBS C;  1WOP A;  4A3J K;  5C3E K;  2NVT K;  1SMY A;  5C44 C;  3G4C A;  5JFE A;  5IYD K;  1F9N A;  1O29 A;  4O2D A;  3GTJ K;  1K83 K;  2V6S A;  2R7Z C;  2NVQ K;  2CW0 A;  3S16 C;  2NVX K;  4A3M C;  4GTC A;  1VLO A;  4WJ3 M;  5FLM C;  4A3E C;  4Q4Z A;  4BBS K;  4OIQ A;  3PO2 K;  5C44 K;  4WCE S;  3I4M K;  2JA7 C;  3VA7 A;  2R92 C;  1I3Q A;  2JA6 C;  1PJ5 A;  3DLL S;  1WCM C;  4OIP A;  3TFH A;  2R7Z K;  5M3F K;  3S1R C;  3N0C A;  5M5Y K;  4KN4 A;  1BJT A;  3HOV C;  4A3E K;  1DCO A;  1XPP A;  3OEP A;  1TWF A;  4LK1 A;  4GTL A;  3GTL C;  4U67 S;  2FQT A;  1J98 A;  4QIW D;  4XSX A;  5TJ3 A;  2JA6 K;  5IP7 K;  1F7V A;  3AQP A;  1WCM K;  1O2B A;  4X6A C;  2A69 A;  1EK8 A;  3S1R K;  3GTK C;  3HOV K;  4KC6 A;  1L0W A;  1XZQ B;  1XZP B;  2E2H C;  1WOS A;  3AD9 C;  3GTO C;  3TFJ A;  1Y1W A;  5C4J C;  5JVH S;  4YFK A;  3K7A C;  4WFA S;  1PJ7 A;  1TWH A;  1O2A A;  3JST A;  3S15 C;  1DCH A;  3GTQ C;  3T00 A;  1ZYR A;  3H3V L;  3SZY A;  3I4N C;  2YU9 C;  1R9T K;  1I6V A;  3PIP S;  3ERE D;  4ZH4 A;  2VUM C;  1HI9 A;  5DM7 S;  2CFA B;  1Y1V C;  4WIL A;  3GTK K;  3QX3 A;  2Y3P A;  3HKZ L;  4OIR A;  3FHZ A;  3CQZ A;  2E2I C;  3GSI A;  4A3D K;  4GTE A;  4C2M K;  3GTO K;  1C0A A;  4GTD A;  3GEE A;  3K7A K;  4WFB S;  4A93 K;  2W7V A;  4C3H C;  1O27 A;  2BE5 A;  3M3Y C;  1TWF K;  3AD8 C;  3I4N K;  2YU9 K;  2VUM K;  2JA8 C;  2GSO A;  3BUE A;  4A3C C;  1TWA C;  2A6E A;  1Y1V K;  4WF9 S;  3M4O C;  2ZFZ A;  1VJE A;  3HOW C;  4GTF A;  3GTJ A;  2E2I K;  3N3Y A;  2O5I A;  2WAQ L;  4FZB A;  3GEI A;  2PMZ D;  3M3Y K;  3GTG C;  1X31 C;  4BLB A;  1BDF A;  1Y1W K;  2JA8 K;  4MEX A;  1XZQ A;  4A3C K;  3S1M K;  3TFI A;  1WSV A;  2ZUE A;  5DM6 S;  4BBR C;  1I50 C;  5JVG S;  3LAJ A;  1XXA A;  3ADA C;  2R7Z A;  4IOA S;  4C3J C;  5E68 A;  4LOW A;  3HOZ C;  2CFA A;  1BS2 A;  2R93 C;  3CQZ K;  3L4J A;  4IOC S;  1WQG A;  1YX2 A;  2JA7 A;  2R92 A;  4A3G K;  3A8J A;  1EQR A;  3GTP C;  2JA6 A;  4XLP A;  4BBR K;  1GE9 A;  2L5N A;  4YFN A;  4G7O A;  1WCM A;  2GAH C;  1IL2 A;  5FJ8 K;  4C3J K;  2ZJP S;  5HL8 A;  4Y52 K;  3S2D C;  3AH5 A;  2R93 K;  1BGW A;  3DXJ A;  3IPJ A;  3V4G A;  3GTL A;  3HOX C;  2NVY C;  1EFW A;  3GTP K;  4MEY A;  3EQL A;  1R9T A;  4KM8 A;  4A3F C;  5C4X C;  4KAT A;  4KB2 A;  1SFO C;  4QIW L;  3GTK A;  1EH1 A;  1PJ6 A;  1F7U A;  3S2D K;  1INN A;  3CAG A;  2E2H A;  2E2J C;  4DDQ A;  3FKI C;  1JOE A;  5HL7 S;  3S16 K;  3GTO A;  3HOX K;  4A3M K;  1V5V A;  2NVY K;  2EBB A; 
#chains in the Genus database with same CATH homology
 3S1M C;  5FLM K;  3S14 K;  1TWH C;  3HOZ K;  3S15 C;  5TMC A;  3GTQ C;  3HOY C;  1ZYR A;  3H3V L;  5IYD C;  3I4N C;  2YU9 C;  1TWG K;  1I6V A;  4C3I K;  1R9T K;  1K83 C;  4ZH4 A;  2VUM C;  5D4D A;  2NVQ C;  5C4X K;  2JA7 K;  4KMU A;  2R92 K;  2NVX C;  1Y1V C;  4Q5S A;  3GTK K;  2B63 K;  3HOU K;  4G7H A;  3GTM C;  4BY1 C;  4BXX C;  4OIN A;  3HKZ L;  4OIR A;  5M5W K;  3CQZ C;  2E2I C;  1I6H C;  5M5X K;  4A3D K;  3PO2 C;  4C2M K;  3S1N C;  3GTO K;  4A3I C;  4A3K C;  5C4J K;  3K7A K;  3I4M C;  3RZD C;  1TWH K;  4QJV A;  4C3H C;  3S1Q C;  4A3G C;  5M3M K;  2A68 A;  4A93 K;  2BE5 A;  3M3Y C;  1TWF K;  3I4N K;  5IYC C;  2YU9 K;  1IW7 A;  4NOI A;  2VUM K;  2Y0S D;  2JA8 C;  2PA8 L;  2JA5 C;  3GTL K;  4A3C C;  1TWA C;  2A6E A;  2WAQ D;  4KN7 A;  4LK0 A;  3S17 C;  1Y1V K;  3PO3 K;  3M4O C;  3GTM K;  4BXX K;  4BY1 K;  4LJZ A;  2A6H A;  4G7Z A;  2NVT K;  4Y52 C;  3HOW C;  2Y0S L;  3GTJ C;  4A3F K;  2E2I K;  4X6A K;  2O5I A;  2WAQ L;  3S1N K;  1SFO K;  3S2H C;  4A3I K;  4A3K K;  4AYB D;  2O5J A;  3RZD K;  2PMZ D;  2E2H K;  4BBS C;  4A3J K;  2E2J K;  3GTG C;  5IP7 C;  2WB1 D;  3FKI K;  5IYC K;  3M3Y K;  1BDF A;  3H0G C;  5C3E K;  1SMY A;  5TMF A;  5C44 C;  1Y1W K;  4MEX A;  4AYB L;  2JA5 K;  4LLG A;  2JA8 K;  4A3C K;  3S1M K;  4BY7 C;  2PMZ L;  3S15 K;  3HOY K;  3GTQ K;  4Y7N C;  2WB1 L;  4BBR C;  5IYB C;  2NVY K;  1YNJ A;  5IYD K;  3GTJ K;  1I50 C;  1K83 K;  2NVQ K;  2R7Z C;  2CW0 A;  3S16 C;  2NVX K;  1TWC C;  3S2H K;  4YFX A;  4C3J C;  5IP9 C;  4A3M C;  3S14 C;  5FLM C;  4A3E C;  3HOZ C;  4Q4Z A;  4BBS K;  2R93 C;  4OIQ A;  3CQZ K;  1I6H K;  3PO2 K;  1R9T C;  5C44 K;  3I4M K;  2JA7 C;  4XLN A;  4BY7 K;  2R92 C;  4C3H K;  3S1Q K;  4A3G K;  3GTP C;  4MQ9 A;  2B63 C;  1I3Q C;  3HOU C;  4XLP A;  2JA6 C;  4BBR K;  1YNN A;  5IYB K;  4YFN A;  4G7O A;  1WCM C;  4OIP A;  3RZO C;  4QJV B;  4A3B C;  2R7Z K;  2PPB A;  3H3V D;  5M3F K;  4A3D C;  4A3L C;  1TWA K;  4C2M C;  5FJ8 K;  4C3J K;  3S17 K;  3S1R C;  5M5Y K;  5IP9 K;  4KN4 A;  3M4O K;  3HOV C;  4A3E K;  3S2D C;  4A93 C;  4Y52 K;  3HOW K;  2R93 K;  4OIO A;  4GZY A;  1XPP A;  1TWF C;  3DXJ A;  3HKZ D;  4LK1 A;  4YG2 A;  3HOX C;  3GTL C;  2NVY C;  3GTP K;  4QIW D;  4XSX A;  4XSZ A;  3PO3 C;  1I3Q K;  5IP7 K;  2JA6 K;  3GTG K;  4MEY A;  1WCM K;  3H0G K;  3EQL A;  1TWG C;  3RZO K;  4C3I C;  4A3F C;  4X6A C;  4A3B K;  2A69 A;  4A3L K;  5C4X C;  1SFO C;  3S1R K;  4QIW L;  2PA8 D;  3GTK C;  1HQM A;  4JK1 A;  4Y7N K;  3HOV K;  3S2D K;  1I50 K;  2E2H C;  4A3J C;  2E2J C;  3FKI C;  3S16 K;  1TWC K;  5C3E C;  1Y1W C;  2NVT C;  3GTO C;  3HOX K;  4YFK A;  4A3M K;  3WOD A;  5C4J C;  3K7A C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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