4YFNA

Escherichia coli rna polymerase in complex with squaramide compound 14 (n-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide)
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
235
structure length
235
Chain Sequence
MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords DNA-directed RNA polymerase subunit alpha
publication title X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
pubmed doi rcsb
source organism Escherichia coli o139:h28 (strain e24377a / etec)
molecule tags Transcription/transcription inhibitor
total genus 38
structure length 235
sequence length 235
chains with identical sequence B, G, H
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2015-02-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01000 RNA_pol_A_bac RNA polymerase Rpb3/RpoA insert domain
A PF01193 RNA_pol_L RNA polymerase Rpb3/Rpb11 dimerisation domain
A PF03118 RNA_pol_A_CTD Bacterial RNA polymerase, alpha chain C terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.120.12 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 DNA-directed RNA polymerase, insert domain 4yfnA02
3.30.1360.10 Alpha Beta 2-Layer Sandwich Gyrase A; domain 2 RNA polymerase, RBP11-like subunit 4yfnA01
1TWFC 4G7ZA 5IYCC 4XSZA 2R7ZK 4BBRK 4BY1K 1Y1WK 2A6EA 4A3MK 4A3JC 1BDFA 4XLPA 1SMYA 3HOWC 4X6AK 4A3CC 2O5IA 3GTMK 4BY1C 4A3GC 2NVXK 3GTKC 1I50K 4BXXC 2R7ZC 2JA5K 1TWHK 3WODA 4A3MC 5IP9K 3S14C 2CW0A 4C3JC 3S15C 3H3VL 3HOXK 3S1NC 3K7AC 1I3QK 1XPPA 5M5XK 1TWCC 4KN4A 4NOIA 1TWAK 5C4XK 2NVTK 2B63K 5M5YK 1ZYRA 2JA6C 4KN7A 5IP9C 4XLNA 3S2DC 4G7HA 3CQZK 4A3JK 3GTOC 4MEXA 3HOWK 4A3CK 3HKZD 3PO2C 1TWAC 4A3GK 1YNNA 3GTKK 3I4NC 2YU9C 4BXXK 3CQZC 5TMCA 3HOVC 3S1RC 3S14K 4KMUA 4C3JK 2JA7C 5M3MK 3S15K 4A3BC 5M3FK 3S16C 3K7AK 3GTPC 3S1NK 4AYBD 3M3YC 1TWCK 3RZOC 4YG2A 2PMZD 4OIQA 2WAQD 2R93C 2JA6K 4A3FC 1R9TC 3S2DK 1HQMA 4MQ9A 4LLGA 4G7OA 2R92C 5IYDC 3GTOK 4C2MC 4YFXA 3PO2K 3HKZL 2JA8C 3I4NK 2YU9K 4Y52C 2NVYC 3HOVK 3S1RK 5TMFA 1SFOK 3S17C 2JA7K 4A3BK 3S16K 3GTPK 2R93K 5IYBC 3M3YK 4Y7NC 2NVQC 4Q5SA 3RZOK 4LK0A 4AYBL 2PA8D 3S1QC 5FJ8K 3S1MC 3HOUC 2PMZL 1SFOC 3GTGC 2WAQL 4A3FK 1R9TK 3DXJA 2WB1D 4BY7K 1WCMC 3H0GC 4QIWD 5M5WK 2R92K 5IYDK 1TWGC 4C2MK 1Y1VC 5C3EC 5C4JC 3RZDC 3GTLC 4C3HK 2BE5A 1I6HC 3GTJC 2VUMC 2JA8K 5D4DA 5C44C 3GTQC 4A3EC 4MEYA 2A68A 4A93C 4Y52K 4JK1A 4BY7C 2NVYK 2E2JK 4QJVA 3S17K 4YFNA 4C3HC 4A3KC 3PO3C 2PPBA 3FKIC 4OIOA 5IYBK 4Y7NK 2NVQK 4YFKA 3S2HK 4C3IC 2E2HC 3S1QK 3S1MK 3HOUK 2Y0SD 2PA8L 2E2JC 3GTGK 3M4OC 1K83C 3HOZC 1WCMK 3H0GK 2WB1L 2E2IC 1TWGK 4QIWL 4A3LC 4BBSC 3I4MC 5FLMC 1Y1VK 5C3EK 5C4JK 3RZDK 3GTLK 4A3IC 3HOYC 3S2HC 4A3DC 3GTJK 4OIRA 1I6HK 5C44K 3GTQK 5IP7C 4A3EK 4LK1A 4A93K 4Q4ZA 4BBRC 1Y1WC 1YNJA 4X6AC 4OINA 4A3KK 4LJZA 4QJVB 3GTMC 3PO3K 3FKIK 1I6VA 2NVXC 4OIPA 1I50C 4C3IK 2E2HK 2JA5C 1TWHC 1TWFK 3M4OK 3EQLA 1K83K 2Y0SL 5IYCK 3HOZK 3H3VD 2O5JA 2E2IK 4ZH4A 4A3LK 4BBSK 3I4MK 3HOXC 5FLMK 2VUMK 4XSXA 1IW7A 1I3QC 2A69A 2A6HA 2NVTC 4GZYA 5C4XC 4A3IK 3HOYK 4A3DK 2B63C 5IP7K
chains in the Genus database with same CATH superfamily
1TWFC 1F7UA 5HL7S 1BDFA 3GTKA 3T02A 1EFWA 2O5IA 1VH2A 3GTMK 2NVXK 2GAGC 5IP9K 4BLBA 1WORA 1TWCA 4M1XA 3S1NC 3T00A 1XPPA 1XXBA 4NOIA 1TWAK 4RMFA 3LYWA 5C4XK 2B63K 5IP9C 1I3QA 4PAAA 3S2DC 1ZVUA 3LAPA 3HKZD 1TWAC 4WCES 4BXXK 1DCHA 5TMCA 3S1RC 3GTPA 4KASA 3FOEA 4KMUA 2JA7C 2R93A 1J6WA 1R9TA 3A8KA 4AYBD 3RZOC 3IPJA 4IOCS 2JA6K 2ZUFA 3CAGA 3TFHA 1YX2A 3GTOK 4C2MC 4O2DA 3PO2K 1X31C 2JA8C 5CHPA 2YU9K 2RH6A 4BLAA 3HOVK 1SFOK 3S17C 2EBBA 1PJ6A 3M3YK 4LK0A 3S1QC 2ZJRS 2VUMK 3HOUC 1SFOC 2WAQL 3HXAA 2WB1D 1WCMC 3GTLA 2R92K 5HQHA 5IYDK 1TWGC 1Y1VC 5C3EC 5C4JC 4C3HK 2KPUA 4P5BA 2VUMC 1WOPA 4LR2A 3FKIA 1WSVA 4C3HC 4GTBA 1O2FB 4Y7NK 3S1MK 2PA8L 2ZUEA 4QIWL 1WCMA 4A3IC 3L4KA 3GTJK 4OIRA 5C44K 3GTQK 5IP7C 4LK1A 3ADAC 1Y1WC 3N3YA 4X6AC 1I50A 2JA5A 2XCOA 3PO3K 5DM7S 1XXCA 4C3IK 4KATA 3M4OK 2Y0SL 4IO9S 4ZH4A 4A3LK 4BBSK 3HOXC 4XSXA 1IW7A 2NVTC 4A3DK 2V6SA 3GEIA 4P5AA 4G7ZA 4FM9A 3G4AA 2V6UA 1SMYA 4A3CC 2ZJPS 2GSUA 4KMHA 4A3GC 3GTKC 1J6XA 1TWHK 3WODA 5IOQA 3S14C 4C3JC 3S15C 1I3QK 3QX3A 5M5XK 1TWCC 4KN4A 4WFAS 4KAWX 1HI9A 5M5YK 1V5VA 3N0BA 1O24A 4XLNA 4G7HA 4MEXA 1IS1A 4KMAA 1INNA 3AQOA 3SZZA 1IE0A 3Q3QA 3NUHA 4A3BC 3S1NK 3GTPC 5JVGS 4WF9S 4ILDA 2R93C 2WAQD 3AD8C 1R9TC 3S2DK 4YFXA 2NVYA 1DCPA 2V6TA 5EGHA 4Y52C 2KQ1A 2L5NA 3S1RK 2JA7K 5JVHS 3GTGA 1XZQB 5IYBC 1EQRA 3H0GA 3RZOK 2PA8D 1UV7A 1JOEA 1XZQA 4BY7K 1GE9A 4QIWD 4C2MK 1XXAA 3RZDC 3GTLC 4G0UA 2JA8K 3DLLS 1BJTA 4A93C 4A3EC 4GTAA 4JK1A 4BY7C 2E2JK 3S17K 2E2HA 3FKIC 4OIOA 4YFKA 3FHZA 2E2IA 3S1QK 3HOUK 2Y0SD 2E2JC 1VRQC 1K83C 3V4GA 1WQFA 1WCMK 1TWGK 5FLMC 1Y1VK 5C3EK 5C4JK 2PHCB 4KB2A 4Q4ZA 4BBRC 3GTMA 2NVXA 1L0WA 1IL2A 1WOSA 4P9SA 5IOSA 4GT9A 1I50C 1ZQ1C 2JA5C 3VA7A 1WQGA 2D6FC 3EQLA 5IYCK 3MMLB 1VLOA 2O5JA 2W7VA 2B63A 1K83A 4FZBA 2A69A 3PIOS 4GZYA 3L4JA 4A3IK 2CFAB 4KARA 5IP7K 5IYCC 4XSZA 1Y1WK 4A3MK 4A3JC 3HOWC 2CFAA 4X6AK 2R7ZA 2Y3PA 1WSRA 4WJ3M 4G0WA 1ZXOA 4A3MC 3CF5S 4G0VA 2JA6A 3HOXK 3K7AC 1O2AA 2XCRB 2NVTK 3GTOA 1YCLA 1G51A 3BP8C 5EGEA 2YU9A 4A3CK 3CQZA 3JSTA 4A3GK 4DDQA 1YNNA 3GTKK 3I4NC 3G4CA 3TFJA 5L46A 1KQ4A 3S14K 1USMA 4C3JK 2JH3A 5M3MK 4AH6A 4KC6A 3ERED 3S15K 3S16C 3OPFA 3GEHA 1TWCK 5CJ9A 2R92A 4OIQA 1EH1A 3A8IA 2L3UA 4A3FC 1WQHA 1HQMA 4LLGA 4G7OA 5IORA 4WILA 1WIHA 3GDZA 3AH5A 2NVYC 5TMFA 2ZJQS 2P8TA 3GSIA 4A3BK 3GTPK 2NVQC 4Q5SA 3PIPS 2R93K 2PMZL 3GTGC 3AD7C 3FOFA 1R9TK 3DXJA 3H0GC 5M5WK 3GTJA 3GTQA 4WFBS 1O29A 1I6HC 5D4DA 2ZFZA 4Y52K 2KWAA 4MEYA 4KM8A 3AD9C 4C45A 4QJVA 4WJ4A 5E68A 4YFNA 4A3KC 2PPBA 5IYBK 1BS2A 2E2HC 5HL8A 3HOZC 4GTFA 2E2IC 1O2BA 4U67S 2XCQA 3I4MC 3T01A 3RZDK 3GTLK 3HOYC 4KM9A 4A93K 4A3EK 1YNJA 1IBAA 1IQ0A 1O26A 1TWHA 4OINA 4LJZA 3GTMC 3FKIK 1I6VA 2NVXC 1VGXA 4OIPA 5TJ3A 1K83K 1DCOA 1TWFA 5FLMK 2FQOA 3S0XA 5C4XC 4BY1K 1FEUA 2B63C 4LQYA 1O25A 2R7ZK 4BBRK 2A6EA 4GTDA 4XLPA 4KDDA 4BY1C 4WFNS 1I50K 4BXXC 2R7ZC 2JA5K 3SZYA 1B4AA 2CW0A 1F9NA 3GIRA 3H3VL 2RGRA 2GSOA 4BKWA 3A8JA 3OREA 5JVOA 1ZYRA 2JA6C 4KN7A 1USOA 3CQZK 1TWAA 1ZBSA 3TFIA 4A3JK 3GTOC 3HOWK 3PO2C 1WOOA 2YU9C 2JA7A 3CQZC 3HOVC 5M3FK 1DD5A 3K7AK 3M3YC 4YG2A 2PMZD 4GTCA 2P5MA 2GSNA 3BP3A 4MQ9A 2R92C 5IYDC 3TTGA 3LPXA 3N0CA 1O28A 3HKZL 3I4NK 5JFEA 1J6VA 1RU0A 1SFOA 3S16K 3LAJA 2KXYA 1O27A 4Y7NC 4AYBL 1TWGA 5FJ8K 3S1MC 1Y1VA 1VJEA 4A3FK 1C0AA 1J98A 4XCHA 2VUMA 3GEEA 1JQWA 5IOTA 2BE5A 3GTJC 1XZPB 5C44C 3GTQC 4GTLA 5DM6S 2A68A 2NVYK 1BGWA 1XZPA 2FQTA 1F7VA 1EK8A 3PO3C 2NVQK 3S2HK 4C3IC 3BUEA 1PJ5A 4LOWA 3GTGK 3M4OC 3H0GK 1PJ7A 2WB1L 4KB4A 1ISEA 4A3LC 4BBSC 1AB4A 3AQPA 4KMDA 1Y1WA 4A3DC 3S2HC 1I6HK 1F93A 4GFQA 4PABA 4A3KK 4QJVB 1EI6A 4J3NA 1JVIA 2E2HK 1TWHC 3OEPA 2GAHC 1TWFK 3HOZK 3H3VD 4IOAS 2E2IK 1B4BA 3I4MK 1I3QC 2A6HA 3HOYK 4GTEA
chains in the Genus database with same CATH topology
1TWFC 4G7ZA 5IYCC 4XSZA 2R7ZK 4BBRK 4BY1K 1Y1WK 2A6EA 4A3MK 4A3JC 1BDFA 4XLPA 1SMYA 3HOWC 4X6AK 4A3CC 2O5IA 3GTMK 4BY1C 4A3GC 2NVXK 3GTKC 1I50K 4BXXC 2R7ZC 2JA5K 1TWHK 3WODA 4A3MC 5IP9K 3S14C 2CW0A 4C3JC 3S15C 3H3VL 3HOXK 3S1NC 3K7AC 1I3QK 1XPPA 5M5XK 1TWCC 4KN4A 4NOIA 1TWAK 5C4XK 2NVTK 2B63K 5M5YK 1ZYRA 2JA6C 4KN7A 5IP9C 4XLNA 3S2DC 4G7HA 3CQZK 4A3JK 3GTOC 4MEXA 3HOWK 4A3CK 3HKZD 3PO2C 1TWAC 4A3GK 1YNNA 3GTKK 3I4NC 2YU9C 4BXXK 3CQZC 5TMCA 3HOVC 3S1RC 3S14K 4KMUA 4C3JK 2JA7C 5M3MK 3S15K 4A3BC 5M3FK 3S16C 3K7AK 3GTPC 3S1NK 4AYBD 3M3YC 1TWCK 3RZOC 4YG2A 2PMZD 4OIQA 2WAQD 2R93C 2JA6K 4A3FC 1R9TC 3S2DK 1HQMA 4MQ9A 4LLGA 4G7OA 2R92C 5IYDC 3GTOK 4C2MC 4YFXA 3PO2K 3HKZL 2JA8C 3I4NK 2YU9K 4Y52C 2NVYC 3HOVK 3S1RK 5TMFA 1SFOK 3S17C 2JA7K 4A3BK 3S16K 3GTPK 2R93K 5IYBC 3M3YK 4Y7NC 2NVQC 4Q5SA 3RZOK 4LK0A 4AYBL 2PA8D 3S1QC 5FJ8K 3S1MC 3HOUC 2PMZL 1SFOC 3GTGC 2WAQL 4A3FK 1R9TK 3DXJA 2WB1D 4BY7K 1WCMC 3H0GC 4QIWD 5M5WK 2R92K 5IYDK 1TWGC 4C2MK 1Y1VC 5C3EC 5C4JC 3RZDC 3GTLC 4C3HK 2BE5A 1I6HC 3GTJC 2VUMC 2JA8K 5D4DA 5C44C 3GTQC 4A3EC 4MEYA 2A68A 4A93C 4Y52K 4JK1A 4BY7C 2NVYK 2E2JK 4QJVA 3S17K 4YFNA 4C3HC 4A3KC 3PO3C 2PPBA 3FKIC 4OIOA 5IYBK 4Y7NK 2NVQK 4YFKA 3S2HK 4C3IC 2E2HC 3S1QK 3S1MK 3HOUK 2Y0SD 2PA8L 2E2JC 3GTGK 3M4OC 1K83C 3HOZC 1WCMK 3H0GK 2WB1L 2E2IC 1TWGK 4QIWL 4A3LC 4BBSC 3I4MC 5FLMC 1Y1VK 5C3EK 5C4JK 3RZDK 3GTLK 4A3IC 3HOYC 3S2HC 4A3DC 3GTJK 4OIRA 1I6HK 5C44K 3GTQK 5IP7C 4A3EK 4LK1A 4A93K 4Q4ZA 4BBRC 1Y1WC 1YNJA 4X6AC 4OINA 4A3KK 4LJZA 4QJVB 3GTMC 3PO3K 3FKIK 1I6VA 2NVXC 4OIPA 1I50C 4C3IK 2E2HK 2JA5C 1TWHC 1TWFK 3M4OK 3EQLA 1K83K 2Y0SL 5IYCK 3HOZK 3H3VD 2O5JA 2E2IK 4ZH4A 4A3LK 4BBSK 3I4MK 3HOXC 5FLMK 2VUMK 4XSXA 1IW7A 1I3QC 2A69A 2A6HA 2NVTC 4GZYA 5C4XC 4A3IK 3HOYK 4A3DK 2B63C 5IP7K
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TWF C;  4G7Z A;  5IYC C;  4XSZ A;  2R7Z K;  4BBR K;  4BY1 K;  1Y1W K;  2A6E A;  4A3M K;  4A3J C;  1BDF A;  4XLP A;  1SMY A;  3HOW C;  4X6A K;  4A3C C;  2O5I A;  3GTM K;  4BY1 C;  4A3G C;  2NVX K;  3GTK C;  1I50 K;  4BXX C;  2R7Z C;  2JA5 K;  1TWH K;  3WOD A;  4A3M C;  5IP9 K;  3S14 C;  2CW0 A;  4C3J C;  3S15 C;  3H3V L;  3HOX K;  3S1N C;  3K7A C;  1I3Q K;  1XPP A;  5M5X K;  1TWC C;  4KN4 A;  4NOI A;  1TWA K;  5C4X K;  2NVT K;  2B63 K;  5M5Y K;  1ZYR A;  2JA6 C;  4KN7 A;  5IP9 C;  4XLN A;  3S2D C;  4G7H A;  3CQZ K;  4A3J K;  3GTO C;  4MEX A;  3HOW K;  4A3C K;  3HKZ D;  3PO2 C;  1TWA C;  4A3G K;  1YNN A;  3GTK K;  3I4N C;  2YU9 C;  4BXX K;  3CQZ C;  5TMC A;  3HOV C;  3S1R C;  3S14 K;  4KMU A;  4C3J K;  2JA7 C;  5M3M K;  3S15 K;  4A3B C;  5M3F K;  3S16 C;  3K7A K;  3GTP C;  3S1N K;  4AYB D;  3M3Y C;  1TWC K;  3RZO C;  4YG2 A;  2PMZ D;  4OIQ A;  2WAQ D;  2R93 C;  2JA6 K;  4A3F C;  1R9T C;  3S2D K;  1HQM A;  4MQ9 A;  4LLG A;  4G7O A;  2R92 C;  5IYD C;  3GTO K;  4C2M C;  4YFX A;  3PO2 K;  3HKZ L;  2JA8 C;  3I4N K;  2YU9 K;  4Y52 C;  2NVY C;  3HOV K;  3S1R K;  5TMF A;  1SFO K;  3S17 C;  2JA7 K;  4A3B K;  3S16 K;  3GTP K;  2R93 K;  5IYB C;  3M3Y K;  4Y7N C;  2NVQ C;  4Q5S A;  3RZO K;  4LK0 A;  4AYB L;  2PA8 D;  3S1Q C;  5FJ8 K;  3S1M C;  3HOU C;  2PMZ L;  1SFO C;  3GTG C;  2WAQ L;  4A3F K;  1R9T K;  3DXJ A;  2WB1 D;  4BY7 K;  1WCM C;  3H0G C;  4QIW D;  5M5W K;  2R92 K;  5IYD K;  1TWG C;  4C2M K;  1Y1V C;  5C3E C;  5C4J C;  3RZD C;  3GTL C;  4C3H K;  2BE5 A;  1I6H C;  3GTJ C;  2VUM C;  2JA8 K;  5D4D A;  5C44 C;  3GTQ C;  4A3E C;  4MEY A;  2A68 A;  4A93 C;  4Y52 K;  4JK1 A;  4BY7 C;  2NVY K;  2E2J K;  4QJV A;  3S17 K;  4YFN A;  4C3H C;  4A3K C;  3PO3 C;  2PPB A;  3FKI C;  4OIO A;  5IYB K;  4Y7N K;  2NVQ K;  4YFK A;  3S2H K;  4C3I C;  2E2H C;  3S1Q K;  3S1M K;  3HOU K;  2Y0S D;  2PA8 L;  2E2J C;  3GTG K;  3M4O C;  1K83 C;  3HOZ C;  1WCM K;  3H0G K;  2WB1 L;  2E2I C;  1TWG K;  4QIW L;  4A3L C;  4BBS C;  3I4M C;  5FLM C;  1Y1V K;  5C3E K;  5C4J K;  3RZD K;  3GTL K;  4A3I C;  3HOY C;  3S2H C;  4A3D C;  3GTJ K;  4OIR A;  1I6H K;  5C44 K;  3GTQ K;  5IP7 C;  4A3E K;  4LK1 A;  4A93 K;  4Q4Z A;  4BBR C;  1Y1W C;  1YNJ A;  4X6A C;  4OIN A;  4A3K K;  4LJZ A;  4QJV B;  3GTM C;  3PO3 K;  3FKI K;  1I6V A;  2NVX C;  4OIP A;  1I50 C;  4C3I K;  2E2H K;  2JA5 C;  1TWH C;  1TWF K;  3M4O K;  3EQL A;  1K83 K;  2Y0S L;  5IYC K;  3HOZ K;  3H3V D;  2O5J A;  2E2I K;  4ZH4 A;  4A3L K;  4BBS K;  3I4M K;  3HOX C;  5FLM K;  2VUM K;  4XSX A;  1IW7 A;  1I3Q C;  2A69 A;  2A6H A;  2NVT C;  4GZY A;  5C4X C;  4A3I K;  3HOY K;  4A3D K;  2B63 C;  5IP7 K; 
#chains in the Genus database with same CATH topology
 1TWF C;  1F7U A;  5HL7 S;  1BDF A;  3GTK A;  3T02 A;  1EFW A;  2O5I A;  1VH2 A;  3GTM K;  2NVX K;  2GAG C;  5IP9 K;  4BLB A;  1WOR A;  1TWC A;  4M1X A;  3S1N C;  3T00 A;  1XPP A;  1XXB A;  4NOI A;  1TWA K;  4RMF A;  3LYW A;  5C4X K;  2B63 K;  5IP9 C;  1I3Q A;  4PAA A;  3S2D C;  1ZVU A;  3LAP A;  3HKZ D;  1TWA C;  4WCE S;  4BXX K;  1DCH A;  5TMC A;  3S1R C;  3GTP A;  4KAS A;  3FOE A;  4KMU A;  2JA7 C;  2R93 A;  1J6W A;  1R9T A;  3A8K A;  4AYB D;  3RZO C;  3IPJ A;  4IOC S;  2JA6 K;  2ZUF A;  3CAG A;  3TFH A;  1YX2 A;  3GTO K;  4C2M C;  4O2D A;  3PO2 K;  1X31 C;  2JA8 C;  5CHP A;  2YU9 K;  2RH6 A;  4BLA A;  3HOV K;  1SFO K;  3S17 C;  2EBB A;  1PJ6 A;  3M3Y K;  4LK0 A;  3S1Q C;  2ZJR S;  2VUM K;  3HOU C;  1SFO C;  2WAQ L;  3HXA A;  2WB1 D;  1WCM C;  3GTL A;  2R92 K;  5HQH A;  5IYD K;  1TWG C;  1Y1V C;  5C3E C;  5C4J C;  4C3H K;  2KPU A;  4P5B A;  2VUM C;  1WOP A;  4LR2 A;  3FKI A;  1WSV A;  4C3H C;  4GTB A;  1O2F B;  4Y7N K;  3S1M K;  2PA8 L;  2ZUE A;  4QIW L;  1WCM A;  4A3I C;  3L4K A;  3GTJ K;  4OIR A;  5C44 K;  3GTQ K;  5IP7 C;  4LK1 A;  3ADA C;  1Y1W C;  3N3Y A;  4X6A C;  1I50 A;  2JA5 A;  2XCO A;  3PO3 K;  5DM7 S;  1XXC A;  4C3I K;  4KAT A;  3M4O K;  2Y0S L;  4IO9 S;  4ZH4 A;  4A3L K;  4BBS K;  3HOX C;  4XSX A;  1IW7 A;  2NVT C;  4A3D K;  2V6S A;  3GEI A;  4P5A A;  4G7Z A;  4FM9 A;  3G4A A;  2V6U A;  1SMY A;  4A3C C;  2ZJP S;  2GSU A;  4KMH A;  4A3G C;  3GTK C;  1J6X A;  1TWH K;  3WOD A;  5IOQ A;  3S14 C;  4C3J C;  3S15 C;  1I3Q K;  3QX3 A;  5M5X K;  1TWC C;  4KN4 A;  4WFA S;  4KAW X;  1HI9 A;  5M5Y K;  1V5V A;  3N0B A;  1O24 A;  4XLN A;  4G7H A;  4MEX A;  1IS1 A;  4KMA A;  1INN A;  3AQO A;  3SZZ A;  1IE0 A;  3Q3Q A;  3NUH A;  4A3B C;  3S1N K;  3GTP C;  5JVG S;  4WF9 S;  4ILD A;  2R93 C;  2WAQ D;  3AD8 C;  1R9T C;  3S2D K;  4YFX A;  2NVY A;  1DCP A;  2V6T A;  5EGH A;  4Y52 C;  2KQ1 A;  2L5N A;  3S1R K;  2JA7 K;  5JVH S;  3GTG A;  1XZQ B;  5IYB C;  1EQR A;  3H0G A;  3RZO K;  2PA8 D;  1UV7 A;  1JOE A;  1XZQ A;  4BY7 K;  1GE9 A;  4QIW D;  4C2M K;  1XXA A;  3RZD C;  3GTL C;  4G0U A;  2JA8 K;  3DLL S;  1BJT A;  4A93 C;  4A3E C;  4GTA A;  4JK1 A;  4BY7 C;  2E2J K;  3S17 K;  2E2H A;  3FKI C;  4OIO A;  4YFK A;  3FHZ A;  2E2I A;  3S1Q K;  3HOU K;  2Y0S D;  2E2J C;  1VRQ C;  1K83 C;  3V4G A;  1WQF A;  1WCM K;  1TWG K;  5FLM C;  1Y1V K;  5C3E K;  5C4J K;  2PHC B;  4KB2 A;  4Q4Z A;  4BBR C;  3GTM A;  2NVX A;  1L0W A;  1IL2 A;  1WOS A;  4P9S A;  5IOS A;  4GT9 A;  1I50 C;  1ZQ1 C;  2JA5 C;  3VA7 A;  1WQG A;  2D6F C;  3EQL A;  5IYC K;  3MML B;  1VLO A;  2O5J A;  2W7V A;  2B63 A;  1K83 A;  4FZB A;  2A69 A;  3PIO S;  4GZY A;  3L4J A;  4A3I K;  2CFA B;  4KAR A;  5IP7 K;  5IYC C;  4XSZ A;  1Y1W K;  4A3M K;  4A3J C;  3HOW C;  2CFA A;  4X6A K;  2R7Z A;  2Y3P A;  1WSR A;  4WJ3 M;  4G0W A;  1ZXO A;  4A3M C;  3CF5 S;  4G0V A;  2JA6 A;  3HOX K;  3K7A C;  1O2A A;  2XCR B;  2NVT K;  3GTO A;  1YCL A;  1G51 A;  3BP8 C;  5EGE A;  2YU9 A;  4A3C K;  3CQZ A;  3JST A;  4A3G K;  4DDQ A;  1YNN A;  3GTK K;  3I4N C;  3G4C A;  3TFJ A;  5L46 A;  1KQ4 A;  3S14 K;  1USM A;  4C3J K;  2JH3 A;  5M3M K;  4AH6 A;  4KC6 A;  3ERE D;  3S15 K;  3S16 C;  3OPF A;  3GEH A;  1TWC K;  5CJ9 A;  2R92 A;  4OIQ A;  1EH1 A;  3A8I A;  2L3U A;  4A3F C;  1WQH A;  1HQM A;  4LLG A;  4G7O A;  5IOR A;  4WIL A;  1WIH A;  3GDZ A;  3AH5 A;  2NVY C;  5TMF A;  2ZJQ S;  2P8T A;  3GSI A;  4A3B K;  3GTP K;  2NVQ C;  4Q5S A;  3PIP S;  2R93 K;  2PMZ L;  3GTG C;  3AD7 C;  3FOF A;  1R9T K;  3DXJ A;  3H0G C;  5M5W K;  3GTJ A;  3GTQ A;  4WFB S;  1O29 A;  1I6H C;  5D4D A;  2ZFZ A;  4Y52 K;  2KWA A;  4MEY A;  4KM8 A;  3AD9 C;  4C45 A;  4QJV A;  4WJ4 A;  5E68 A;  4YFN A;  4A3K C;  2PPB A;  5IYB K;  1BS2 A;  2E2H C;  5HL8 A;  3HOZ C;  4GTF A;  2E2I C;  1O2B A;  4U67 S;  2XCQ A;  3I4M C;  3T01 A;  3RZD K;  3GTL K;  3HOY C;  4KM9 A;  4A93 K;  4A3E K;  1YNJ A;  1IBA A;  1IQ0 A;  1O26 A;  1TWH A;  4OIN A;  4LJZ A;  3GTM C;  3FKI K;  1I6V A;  2NVX C;  1VGX A;  4OIP A;  5TJ3 A;  1K83 K;  1DCO A;  1TWF A;  5FLM K;  2FQO A;  3S0X A;  5C4X C;  4BY1 K;  1FEU A;  2B63 C;  4LQY A;  1O25 A;  2R7Z K;  4BBR K;  2A6E A;  4GTD A;  4XLP A;  4KDD A;  4BY1 C;  4WFN S;  1I50 K;  4BXX C;  2R7Z C;  2JA5 K;  3SZY A;  1B4A A;  2CW0 A;  1F9N A;  3GIR A;  3H3V L;  2RGR A;  2GSO A;  4BKW A;  3A8J A;  3ORE A;  5JVO A;  1ZYR A;  2JA6 C;  4KN7 A;  1USO A;  3CQZ K;  1TWA A;  1ZBS A;  3TFI A;  4A3J K;  3GTO C;  3HOW K;  3PO2 C;  1WOO A;  2YU9 C;  2JA7 A;  3CQZ C;  3HOV C;  5M3F K;  1DD5 A;  3K7A K;  3M3Y C;  4YG2 A;  2PMZ D;  4GTC A;  2P5M A;  2GSN A;  3BP3 A;  4MQ9 A;  2R92 C;  5IYD C;  3TTG A;  3LPX A;  3N0C A;  1O28 A;  3HKZ L;  3I4N K;  5JFE A;  1J6V A;  1RU0 A;  1SFO A;  3S16 K;  3LAJ A;  2KXY A;  1O27 A;  4Y7N C;  4AYB L;  1TWG A;  5FJ8 K;  3S1M C;  1Y1V A;  1VJE A;  4A3F K;  1C0A A;  1J98 A;  4XCH A;  2VUM A;  3GEE A;  1JQW A;  5IOT A;  2BE5 A;  3GTJ C;  1XZP B;  5C44 C;  3GTQ C;  4GTL A;  5DM6 S;  2A68 A;  2NVY K;  1BGW A;  1XZP A;  2FQT A;  1F7V A;  1EK8 A;  3PO3 C;  2NVQ K;  3S2H K;  4C3I C;  3BUE A;  1PJ5 A;  4LOW A;  3GTG K;  3M4O C;  3H0G K;  1PJ7 A;  2WB1 L;  4KB4 A;  1ISE A;  4A3L C;  4BBS C;  1AB4 A;  3AQP A;  4KMD A;  1Y1W A;  4A3D C;  3S2H C;  1I6H K;  1F93 A;  4GFQ A;  4PAB A;  4A3K K;  4QJV B;  1EI6 A;  4J3N A;  1JVI A;  2E2H K;  1TWH C;  3OEP A;  2GAH C;  1TWF K;  3HOZ K;  3H3V D;  4IOA S;  2E2I K;  1B4B A;  3I4M K;  1I3Q C;  2A6H A;  3HOY K;  4GTE A; 
#chains in the Genus database with same CATH homology
 1TWF C;  4G7Z A;  5IYC C;  4XSZ A;  2R7Z K;  4BBR K;  4BY1 K;  1Y1W K;  2A6E A;  4A3M K;  4A3J C;  1BDF A;  4XLP A;  1SMY A;  3HOW C;  4X6A K;  4A3C C;  2O5I A;  3GTM K;  4BY1 C;  4A3G C;  2NVX K;  3GTK C;  1I50 K;  4BXX C;  2R7Z C;  2JA5 K;  1TWH K;  3WOD A;  4A3M C;  5IP9 K;  3S14 C;  2CW0 A;  4C3J C;  3S15 C;  3H3V L;  3HOX K;  3S1N C;  3K7A C;  1I3Q K;  1XPP A;  5M5X K;  1TWC C;  4KN4 A;  4NOI A;  1TWA K;  5C4X K;  2NVT K;  2B63 K;  5M5Y K;  1ZYR A;  2JA6 C;  4KN7 A;  5IP9 C;  4XLN A;  3S2D C;  4G7H A;  3CQZ K;  4A3J K;  3GTO C;  4MEX A;  3HOW K;  4A3C K;  3HKZ D;  3PO2 C;  1TWA C;  4A3G K;  1YNN A;  3GTK K;  3I4N C;  2YU9 C;  4BXX K;  3CQZ C;  5TMC A;  3HOV C;  3S1R C;  3S14 K;  4KMU A;  4C3J K;  2JA7 C;  5M3M K;  3S15 K;  4A3B C;  5M3F K;  3S16 C;  3K7A K;  3GTP C;  3S1N K;  4AYB D;  3M3Y C;  1TWC K;  3RZO C;  4YG2 A;  2PMZ D;  4OIQ A;  2WAQ D;  2R93 C;  2JA6 K;  4A3F C;  1R9T C;  3S2D K;  1HQM A;  4MQ9 A;  4LLG A;  4G7O A;  2R92 C;  5IYD C;  3GTO K;  4C2M C;  4YFX A;  3PO2 K;  3HKZ L;  2JA8 C;  3I4N K;  2YU9 K;  4Y52 C;  2NVY C;  3HOV K;  3S1R K;  5TMF A;  1SFO K;  3S17 C;  2JA7 K;  4A3B K;  3S16 K;  3GTP K;  2R93 K;  5IYB C;  3M3Y K;  4Y7N C;  2NVQ C;  4Q5S A;  3RZO K;  4LK0 A;  4AYB L;  2PA8 D;  3S1Q C;  5FJ8 K;  3S1M C;  3HOU C;  2PMZ L;  1SFO C;  3GTG C;  2WAQ L;  4A3F K;  1R9T K;  3DXJ A;  2WB1 D;  4BY7 K;  1WCM C;  3H0G C;  4QIW D;  5M5W K;  2R92 K;  5IYD K;  1TWG C;  4C2M K;  1Y1V C;  5C3E C;  5C4J C;  3RZD C;  3GTL C;  4C3H K;  2BE5 A;  1I6H C;  3GTJ C;  2VUM C;  2JA8 K;  5D4D A;  5C44 C;  3GTQ C;  4A3E C;  4MEY A;  2A68 A;  4A93 C;  4Y52 K;  4JK1 A;  4BY7 C;  2NVY K;  2E2J K;  4QJV A;  3S17 K;  4YFN A;  4C3H C;  4A3K C;  3PO3 C;  2PPB A;  3FKI C;  4OIO A;  5IYB K;  4Y7N K;  2NVQ K;  4YFK A;  3S2H K;  4C3I C;  2E2H C;  3S1Q K;  3S1M K;  3HOU K;  2Y0S D;  2PA8 L;  2E2J C;  3GTG K;  3M4O C;  1K83 C;  3HOZ C;  1WCM K;  3H0G K;  2WB1 L;  2E2I C;  1TWG K;  4QIW L;  4A3L C;  4BBS C;  3I4M C;  5FLM C;  1Y1V K;  5C3E K;  5C4J K;  3RZD K;  3GTL K;  4A3I C;  3HOY C;  3S2H C;  4A3D C;  3GTJ K;  4OIR A;  1I6H K;  5C44 K;  3GTQ K;  5IP7 C;  4A3E K;  4LK1 A;  4A93 K;  4Q4Z A;  4BBR C;  1Y1W C;  1YNJ A;  4X6A C;  4OIN A;  4A3K K;  4LJZ A;  4QJV B;  3GTM C;  3PO3 K;  3FKI K;  1I6V A;  2NVX C;  4OIP A;  1I50 C;  4C3I K;  2E2H K;  2JA5 C;  1TWH C;  1TWF K;  3M4O K;  3EQL A;  1K83 K;  2Y0S L;  5IYC K;  3HOZ K;  3H3V D;  2O5J A;  2E2I K;  4ZH4 A;  4A3L K;  4BBS K;  3I4M K;  3HOX C;  5FLM K;  2VUM K;  4XSX A;  1IW7 A;  1I3Q C;  2A69 A;  2A6H A;  2NVT C;  4GZY A;  5C4X C;  4A3I K;  3HOY K;  4A3D K;  2B63 C;  5IP7 K; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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