4YNMA

Ash1l wild-type set domain in complex with s-adenosyl methionine (sam)
Total Genus 49
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
215
structure length
215
Chain Sequence
AGSYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase ASH1L
publication title Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
pubmed doi rcsb
source organism Homo sapiens
total genus 49
structure length 215
sequence length 215
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2015-03-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF17907 AWS AWS domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4ynmA00
4NVQA 5T5GA 5CCMA 1PEGA 3HNAA 4LDGA 3K5KA 2QPWA 5TH7A 5EX3A 1ZKKA 5AYFA 3TG5A 5HQ8A 3F9ZA 5TEGA 5KJLA 5T0MA 3RJWA 1O9SA 3SW9A 1N3JA 3OOIA 5EX0A 3M56A 4IJ8A 3S8PA 4C1QA 3MO5A 4O30A 4QEOA 2W5YA 3OXLA 5F6KC 2BQZA 3M55A 5F59A 5JIYA 4J83A 4YPUA 3QWPA 3QWVA 4YNDA 3BO5A 5JHNA 1N6CA 3EP0A 3IHXA 5KJNA 4QENA 3S7JA 2IGQA 3CBPA 4MI0A 3RIBA 4FMUA 4J8OA 3OXFA 1MT6A 3RQ4A 3DALA 4YPAA 4I51A 3M57A 5CPRB 4AU7A 3S7FA 3M53A 3F9WA 5EG2A 1ML9A 3RU0A 5T0KA 4JLGA 3N71A 4RZ0A 3KMAA 3OS5A 4Z4PA 3M5AA 3QWWA 1MVHA 5TTFA 4NJ5A 4WUYA 3OPEA 5HI7A 5LSZA 2R3AA 5LSXA 3TG4A 3RAYA 3SWCA 3S7DA 5CCLA 4MI5A 4QEPA 5KJMA 5KJKA 4J7IA 3MO2A 5F6LA 3F9XA 5JINA 4IJDA 3DB5A 3PDNA 3MO0A 1N6AA 4E47A 3KMJA 3KMTA 4BUPA 4YPEA 1MUFA 1MVXA 3MEKA 2F69A 3CBMA 5ARGA 3VUZA 3OXGA 2W5ZA 4O6FA 5F5EA 1H3IA 3CBOA 4YNMA 4J7FA 5ARFA 3S7BA 3M58A 3VV0A 4YNPA 3M54A 3F9YA 4JDSA 1XQHA 3FPDA 2RFIA 2G46A 4H12A 3M59A 2O8JA 5JJ0A 2JV0A
chains in the Genus database with same CATH superfamily
4NVQA 5T5GA 5CCMA 1PEGA 3HNAA 4LDGA 3K5KA 2QPWA 5TH7A 5EX3A 1ZKKA 5AYFA 3TG5A 5HQ8A 3F9ZA 5TEGA 5KJLA 5T0MA 3RJWA 1O9SA 3SW9A 1N3JA 3OOIA 5EX0A 3M56A 4IJ8A 3S8PA 4C1QA 3MO5A 4O30A 4QEOA 2W5YA 3OXLA 5F6KC 2BQZA 3M55A 5F59A 5JIYA 4J83A 4YPUA 3QWPA 3QWVA 4YNDA 3BO5A 5JHNA 1N6CA 3EP0A 3IHXA 5KJNA 4QENA 3S7JA 2IGQA 3CBPA 4MI0A 3RIBA 4FMUA 4J8OA 3OXFA 1MT6A 3RQ4A 3DALA 4YPAA 4I51A 3M57A 5CPRB 4AU7A 3S7FA 3M53A 3F9WA 5EG2A 1ML9A 3RU0A 5T0KA 4JLGA 3N71A 4RZ0A 3KMAA 3OS5A 4Z4PA 3M5AA 3QWWA 1MVHA 5TTFA 4NJ5A 4WUYA 3OPEA 5HI7A 5LSZA 2R3AA 5LSXA 3TG4A 3RAYA 3SWCA 3S7DA 5CCLA 4MI5A 4QEPA 5KJMA 5KJKA 4J7IA 3MO2A 5F6LA 3F9XA 5JINA 4IJDA 3DB5A 3PDNA 3MO0A 1N6AA 4E47A 3KMJA 3KMTA 4BUPA 4YPEA 1MUFA 1MVXA 3MEKA 2F69A 3CBMA 5ARGA 3VUZA 3OXGA 2W5ZA 4O6FA 5F5EA 1H3IA 3CBOA 4YNMA 4J7FA 5ARFA 3S7BA 3M58A 3VV0A 4YNPA 3M54A 3F9YA 4JDSA 1XQHA 3FPDA 2RFIA 2G46A 4H12A 3M59A 2O8JA 5JJ0A 2JV0A
chains in the Genus database with same CATH topology
4NVQA 5T5GA 5CCMA 1PEGA 3HNAA 4LDGA 3K5KA 2QPWA 5TH7A 5EX3A 1ZKKA 5AYFA 3TG5A 5HQ8A 3F9ZA 5TEGA 5KJLA 5T0MA 3RJWA 1O9SA 3SW9A 1N3JA 3OOIA 5EX0A 3M56A 4IJ8A 3S8PA 4C1QA 3MO5A 4O30A 4QEOA 2W5YA 3OXLA 5F6KC 2BQZA 3M55A 5F59A 5JIYA 4J83A 4YPUA 3QWPA 3QWVA 4YNDA 3BO5A 5JHNA 1N6CA 3EP0A 3IHXA 5KJNA 4QENA 3S7JA 2IGQA 3CBPA 4MI0A 3RIBA 4FMUA 4J8OA 3OXFA 1MT6A 3RQ4A 3DALA 4YPAA 4I51A 3M57A 5CPRB 4AU7A 3S7FA 3M53A 3F9WA 5EG2A 1ML9A 3RU0A 5T0KA 4JLGA 3N71A 4RZ0A 3KMAA 3OS5A 4Z4PA 3M5AA 3QWWA 1MVHA 5TTFA 4NJ5A 4WUYA 3OPEA 5HI7A 5LSZA 2R3AA 5LSXA 3TG4A 3RAYA 3SWCA 3S7DA 5CCLA 4MI5A 4QEPA 5KJMA 5KJKA 4J7IA 3MO2A 5F6LA 3F9XA 5JINA 4IJDA 3DB5A 3PDNA 3MO0A 1N6AA 4E47A 3KMJA 3KMTA 4BUPA 4YPEA 1MUFA 1MVXA 3MEKA 2F69A 3CBMA 5ARGA 3VUZA 3OXGA 2W5ZA 4O6FA 5F5EA 1H3IA 3CBOA 4YNMA 4J7FA 5ARFA 3S7BA 3M58A 3VV0A 4YNPA 3M54A 3F9YA 4JDSA 1XQHA 3FPDA 2RFIA 2G46A 4H12A 3M59A 2O8JA 5JJ0A 2JV0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NVQ A;  5T5G A;  5CCM A;  1PEG A;  3HNA A;  4LDG A;  3K5K A;  2QPW A;  5TH7 A;  5EX3 A;  1ZKK A;  5AYF A;  3TG5 A;  5HQ8 A;  3F9Z A;  5TEG A;  5KJL A;  5T0M A;  3RJW A;  1O9S A;  3SW9 A;  1N3J A;  3OOI A;  5EX0 A;  3M56 A;  4IJ8 A;  3S8P A;  4C1Q A;  3MO5 A;  4O30 A;  4QEO A;  2W5Y A;  3OXL A;  5F6K C;  2BQZ A;  3M55 A;  5F59 A;  5JIY A;  4J83 A;  4YPU A;  3QWP A;  3QWV A;  4YND A;  3BO5 A;  5JHN A;  1N6C A;  3EP0 A;  3IHX A;  5KJN A;  4QEN A;  3S7J A;  2IGQ A;  3CBP A;  4MI0 A;  3RIB A;  4FMU A;  4J8O A;  3OXF A;  1MT6 A;  3RQ4 A;  3DAL A;  4YPA A;  4I51 A;  3M57 A;  5CPR B;  4AU7 A;  3S7F A;  3M53 A;  3F9W A;  5EG2 A;  1ML9 A;  3RU0 A;  5T0K A;  4JLG A;  3N71 A;  4RZ0 A;  3KMA A;  3OS5 A;  4Z4P A;  3M5A A;  3QWW A;  1MVH A;  5TTF A;  4NJ5 A;  4WUY A;  3OPE A;  5HI7 A;  5LSZ A;  2R3A A;  5LSX A;  3TG4 A;  3RAY A;  3SWC A;  3S7D A;  5CCL A;  4MI5 A;  4QEP A;  5KJM A;  5KJK A;  4J7I A;  3MO2 A;  5F6L A;  3F9X A;  5JIN A;  4IJD A;  3DB5 A;  3PDN A;  3MO0 A;  1N6A A;  4E47 A;  3KMJ A;  3KMT A;  4BUP A;  4YPE A;  1MUF A;  1MVX A;  3MEK A;  2F69 A;  3CBM A;  5ARG A;  3VUZ A;  3OXG A;  2W5Z A;  4O6F A;  5F5E A;  1H3I A;  3CBO A;  4YNM A;  4J7F A;  5ARF A;  3S7B A;  3M58 A;  3VV0 A;  4YNP A;  3M54 A;  3F9Y A;  4JDS A;  1XQH A;  3FPD A;  2RFI A;  2G46 A;  4H12 A;  3M59 A;  2O8J A;  5JJ0 A;  2JV0 A; 
#chains in the Genus database with same CATH topology
 4NVQ A;  5T5G A;  5CCM A;  1PEG A;  3HNA A;  4LDG A;  3K5K A;  2QPW A;  5TH7 A;  5EX3 A;  1ZKK A;  5AYF A;  3TG5 A;  5HQ8 A;  3F9Z A;  5TEG A;  5KJL A;  5T0M A;  3RJW A;  1O9S A;  3SW9 A;  1N3J A;  3OOI A;  5EX0 A;  3M56 A;  4IJ8 A;  3S8P A;  4C1Q A;  3MO5 A;  4O30 A;  4QEO A;  2W5Y A;  3OXL A;  5F6K C;  2BQZ A;  3M55 A;  5F59 A;  5JIY A;  4J83 A;  4YPU A;  3QWP A;  3QWV A;  4YND A;  3BO5 A;  5JHN A;  1N6C A;  3EP0 A;  3IHX A;  5KJN A;  4QEN A;  3S7J A;  2IGQ A;  3CBP A;  4MI0 A;  3RIB A;  4FMU A;  4J8O A;  3OXF A;  1MT6 A;  3RQ4 A;  3DAL A;  4YPA A;  4I51 A;  3M57 A;  5CPR B;  4AU7 A;  3S7F A;  3M53 A;  3F9W A;  5EG2 A;  1ML9 A;  3RU0 A;  5T0K A;  4JLG A;  3N71 A;  4RZ0 A;  3KMA A;  3OS5 A;  4Z4P A;  3M5A A;  3QWW A;  1MVH A;  5TTF A;  4NJ5 A;  4WUY A;  3OPE A;  5HI7 A;  5LSZ A;  2R3A A;  5LSX A;  3TG4 A;  3RAY A;  3SWC A;  3S7D A;  5CCL A;  4MI5 A;  4QEP A;  5KJM A;  5KJK A;  4J7I A;  3MO2 A;  5F6L A;  3F9X A;  5JIN A;  4IJD A;  3DB5 A;  3PDN A;  3MO0 A;  1N6A A;  4E47 A;  3KMJ A;  3KMT A;  4BUP A;  4YPE A;  1MUF A;  1MVX A;  3MEK A;  2F69 A;  3CBM A;  5ARG A;  3VUZ A;  3OXG A;  2W5Z A;  4O6F A;  5F5E A;  1H3I A;  3CBO A;  4YNM A;  4J7F A;  5ARF A;  3S7B A;  3M58 A;  3VV0 A;  4YNP A;  3M54 A;  3F9Y A;  4JDS A;  1XQH A;  3FPD A;  2RFI A;  2G46 A;  4H12 A;  3M59 A;  2O8J A;  5JJ0 A;  2JV0 A; 
#chains in the Genus database with same CATH homology
 4NVQ A;  5T5G A;  5CCM A;  1PEG A;  3HNA A;  4LDG A;  3K5K A;  2QPW A;  5TH7 A;  5EX3 A;  1ZKK A;  5AYF A;  3TG5 A;  5HQ8 A;  3F9Z A;  5TEG A;  5KJL A;  5T0M A;  3RJW A;  1O9S A;  3SW9 A;  1N3J A;  3OOI A;  5EX0 A;  3M56 A;  4IJ8 A;  3S8P A;  4C1Q A;  3MO5 A;  4O30 A;  4QEO A;  2W5Y A;  3OXL A;  5F6K C;  2BQZ A;  3M55 A;  5F59 A;  5JIY A;  4J83 A;  4YPU A;  3QWP A;  3QWV A;  4YND A;  3BO5 A;  5JHN A;  1N6C A;  3EP0 A;  3IHX A;  5KJN A;  4QEN A;  3S7J A;  2IGQ A;  3CBP A;  4MI0 A;  3RIB A;  4FMU A;  4J8O A;  3OXF A;  1MT6 A;  3RQ4 A;  3DAL A;  4YPA A;  4I51 A;  3M57 A;  5CPR B;  4AU7 A;  3S7F A;  3M53 A;  3F9W A;  5EG2 A;  1ML9 A;  3RU0 A;  5T0K A;  4JLG A;  3N71 A;  4RZ0 A;  3KMA A;  3OS5 A;  4Z4P A;  3M5A A;  3QWW A;  1MVH A;  5TTF A;  4NJ5 A;  4WUY A;  3OPE A;  5HI7 A;  5LSZ A;  2R3A A;  5LSX A;  3TG4 A;  3RAY A;  3SWC A;  3S7D A;  5CCL A;  4MI5 A;  4QEP A;  5KJM A;  5KJK A;  4J7I A;  3MO2 A;  5F6L A;  3F9X A;  5JIN A;  4IJD A;  3DB5 A;  3PDN A;  3MO0 A;  1N6A A;  4E47 A;  3KMJ A;  3KMT A;  4BUP A;  4YPE A;  1MUF A;  1MVX A;  3MEK A;  2F69 A;  3CBM A;  5ARG A;  3VUZ A;  3OXG A;  2W5Z A;  4O6F A;  5F5E A;  1H3I A;  3CBO A;  4YNM A;  4J7F A;  5ARF A;  3S7B A;  3M58 A;  3VV0 A;  4YNP A;  3M54 A;  3F9Y A;  4JDS A;  1XQH A;  3FPD A;  2RFI A;  2G46 A;  4H12 A;  3M59 A;  2O8J A;  5JJ0 A;  2JV0 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...