4YPAA

Ash1l set domain q2265a mutant in complex with s-adenosyl methionine (sam)
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
218
structure length
218
Chain Sequence
b'GAMAGSYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKAQLCKCGFEKCRGIIG'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase ASH1L
molecule tags Transferase
source organism Homo sapiens
publication title Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
pubmed doi rcsb
total genus 48
structure length 218
sequence length 218
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2015-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF17907 AWS AWS domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4ypaA00
3TG4A 5F5EA 3EP0A 3M57A 4JLGA 5TH7A 4YPUA 1ZKKA 1MVHA 3M59A 5CCMA 4WUYA 4J8OA 1N3JA 3CBMA 3SW9A 5TEGA 3TG5A 5LSZA 3SWCA 5KJNA 3OXLA 3RJWA 2R3AA 3MEKA 4MI5A 3DALA 5JIYA 1N6AA 3MO0A 3M54A 1H3IA 3F9WA 3CBOA 3OXGA 4O30A 2QPWA 5EX0A 4YPEA 5AYFA 1MT6A 3KMTA 4YNDA 3VV0A 3K5KA 2O8JA 5T0KA 3S7FA 4NVQA 4E47A 4YPAA 3RQ4A 5CPRB 4JDSA 2BQZA 5JINA 5KJKA 5F6LA 3F9XA 1PEGA 4QEOA 3IHXA 1O9SA 3OS5A 1MUFA 5ARGA 3CBPA 3M53A 4O6FA 3OOIA 3FPDA 3BO5A 2W5ZA 5LSXA 3S7DA 4FMUA 4J7IA 4AU7A 4C1QA 5F6KC 3M55A 3RIBA 4LDGA 5ARFA 3M56A 5T0MA 4IJDA 3F9ZA 4H12A 3QWVA 5F59A 1XQHA 3VUZA 2G46A 4J7FA 3N71A 4BUPA 2RFIA 3QWWA 2F69A 3S8PA 2W5YA 3RAYA 2JV0A 4RZ0A 1ML9A 5HI7A 3F9YA 5EX3A 3HNAA 4I51A 5KJMA 4QEPA 5EG2A 4NJ5A 3PDNA 3S7JA 3S7BA 3QWPA 2IGQA 3OXFA 5HQ8A 5KJLA 3KMJA 3DB5A 3OPEA 4QENA 5JHNA 3MO2A 4IJ8A 3KMAA 5TTFA 3M5AA 5CCLA 1N6CA 3RU0A 5JJ0A 4MI0A 5T5GA 1MVXA 3M58A 4J83A 4YNMA 4YNPA 3MO5A 4Z4PA
chains in the Genus database with same CATH superfamily
3TG4A 5F5EA 3EP0A 3M57A 4JLGA 5TH7A 4YPUA 1ZKKA 1MVHA 3M59A 5CCMA 4WUYA 4J8OA 1N3JA 3CBMA 3SW9A 5TEGA 3TG5A 5LSZA 3SWCA 5KJNA 3OXLA 3RJWA 2R3AA 3MEKA 4MI5A 3DALA 5JIYA 1N6AA 3MO0A 3M54A 1H3IA 3F9WA 3CBOA 3OXGA 4O30A 2QPWA 5EX0A 4YPEA 5AYFA 1MT6A 3KMTA 4YNDA 3VV0A 3K5KA 2O8JA 5T0KA 3S7FA 4NVQA 4E47A 4YPAA 3RQ4A 5CPRB 4JDSA 2BQZA 5JINA 5KJKA 5F6LA 3F9XA 1PEGA 4QEOA 3IHXA 1O9SA 3OS5A 1MUFA 5ARGA 3CBPA 3M53A 4O6FA 3OOIA 3FPDA 3BO5A 2W5ZA 5LSXA 3S7DA 4FMUA 4J7IA 4AU7A 4C1QA 5F6KC 3M55A 3RIBA 4LDGA 5ARFA 3M56A 5T0MA 4IJDA 3F9ZA 4H12A 3QWVA 5F59A 1XQHA 3VUZA 2G46A 4J7FA 3N71A 4BUPA 2RFIA 3QWWA 2F69A 3S8PA 2W5YA 3RAYA 2JV0A 4RZ0A 1ML9A 5HI7A 3F9YA 5EX3A 3HNAA 4I51A 5KJMA 4QEPA 5EG2A 4NJ5A 3PDNA 3S7JA 3S7BA 3QWPA 2IGQA 3OXFA 5HQ8A 5KJLA 3KMJA 3DB5A 3OPEA 4QENA 5JHNA 3MO2A 4IJ8A 3KMAA 5TTFA 3M5AA 5CCLA 1N6CA 3RU0A 5JJ0A 4MI0A 5T5GA 1MVXA 3M58A 4J83A 4YNMA 4YNPA 3MO5A 4Z4PA
chains in the Genus database with same CATH topology
3TG4A 5F5EA 3EP0A 3M57A 4JLGA 5TH7A 4YPUA 1ZKKA 1MVHA 3M59A 5CCMA 4WUYA 4J8OA 1N3JA 3CBMA 3SW9A 5TEGA 3TG5A 5LSZA 3SWCA 5KJNA 3OXLA 3RJWA 2R3AA 3MEKA 4MI5A 3DALA 5JIYA 1N6AA 3MO0A 3M54A 1H3IA 3F9WA 3CBOA 3OXGA 4O30A 2QPWA 5EX0A 4YPEA 5AYFA 1MT6A 3KMTA 4YNDA 3VV0A 3K5KA 2O8JA 5T0KA 3S7FA 4NVQA 4E47A 4YPAA 3RQ4A 5CPRB 4JDSA 2BQZA 5JINA 5KJKA 5F6LA 3F9XA 1PEGA 4QEOA 3IHXA 1O9SA 3OS5A 1MUFA 5ARGA 3CBPA 3M53A 4O6FA 3OOIA 3FPDA 3BO5A 2W5ZA 5LSXA 3S7DA 4FMUA 4J7IA 4AU7A 4C1QA 5F6KC 3M55A 3RIBA 4LDGA 5ARFA 3M56A 5T0MA 4IJDA 3F9ZA 4H12A 3QWVA 5F59A 1XQHA 3VUZA 2G46A 4J7FA 3N71A 4BUPA 2RFIA 3QWWA 2F69A 3S8PA 2W5YA 3RAYA 2JV0A 4RZ0A 1ML9A 5HI7A 3F9YA 5EX3A 3HNAA 4I51A 5KJMA 4QEPA 5EG2A 4NJ5A 3PDNA 3S7JA 3S7BA 3QWPA 2IGQA 3OXFA 5HQ8A 5KJLA 3KMJA 3DB5A 3OPEA 4QENA 5JHNA 3MO2A 4IJ8A 3KMAA 5TTFA 3M5AA 5CCLA 1N6CA 3RU0A 5JJ0A 4MI0A 5T5GA 1MVXA 3M58A 4J83A 4YNMA 4YNPA 3MO5A 4Z4PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TG4 A;  5F5E A;  3EP0 A;  3M57 A;  4JLG A;  5TH7 A;  4YPU A;  1ZKK A;  1MVH A;  3M59 A;  5CCM A;  4WUY A;  4J8O A;  1N3J A;  3CBM A;  3SW9 A;  5TEG A;  3TG5 A;  5LSZ A;  3SWC A;  5KJN A;  3OXL A;  3RJW A;  2R3A A;  3MEK A;  4MI5 A;  3DAL A;  5JIY A;  1N6A A;  3MO0 A;  3M54 A;  1H3I A;  3F9W A;  3CBO A;  3OXG A;  4O30 A;  2QPW A;  5EX0 A;  4YPE A;  5AYF A;  1MT6 A;  3KMT A;  4YND A;  3VV0 A;  3K5K A;  2O8J A;  5T0K A;  3S7F A;  4NVQ A;  4E47 A;  4YPA A;  3RQ4 A;  5CPR B;  4JDS A;  2BQZ A;  5JIN A;  5KJK A;  5F6L A;  3F9X A;  1PEG A;  4QEO A;  3IHX A;  1O9S A;  3OS5 A;  1MUF A;  5ARG A;  3CBP A;  3M53 A;  4O6F A;  3OOI A;  3FPD A;  3BO5 A;  2W5Z A;  5LSX A;  3S7D A;  4FMU A;  4J7I A;  4AU7 A;  4C1Q A;  5F6K C;  3M55 A;  3RIB A;  4LDG A;  5ARF A;  3M56 A;  5T0M A;  4IJD A;  3F9Z A;  4H12 A;  3QWV A;  5F59 A;  1XQH A;  3VUZ A;  2G46 A;  4J7F A;  3N71 A;  4BUP A;  2RFI A;  3QWW A;  2F69 A;  3S8P A;  2W5Y A;  3RAY A;  2JV0 A;  4RZ0 A;  1ML9 A;  5HI7 A;  3F9Y A;  5EX3 A;  3HNA A;  4I51 A;  5KJM A;  4QEP A;  5EG2 A;  4NJ5 A;  3PDN A;  3S7J A;  3S7B A;  3QWP A;  2IGQ A;  3OXF A;  5HQ8 A;  5KJL A;  3KMJ A;  3DB5 A;  3OPE A;  4QEN A;  5JHN A;  3MO2 A;  4IJ8 A;  3KMA A;  5TTF A;  3M5A A;  5CCL A;  1N6C A;  3RU0 A;  5JJ0 A;  4MI0 A;  5T5G A;  1MVX A;  3M58 A;  4J83 A;  4YNM A;  4YNP A;  3MO5 A;  4Z4P A; 
#chains in the Genus database with same CATH topology
 3TG4 A;  5F5E A;  3EP0 A;  3M57 A;  4JLG A;  5TH7 A;  4YPU A;  1ZKK A;  1MVH A;  3M59 A;  5CCM A;  4WUY A;  4J8O A;  1N3J A;  3CBM A;  3SW9 A;  5TEG A;  3TG5 A;  5LSZ A;  3SWC A;  5KJN A;  3OXL A;  3RJW A;  2R3A A;  3MEK A;  4MI5 A;  3DAL A;  5JIY A;  1N6A A;  3MO0 A;  3M54 A;  1H3I A;  3F9W A;  3CBO A;  3OXG A;  4O30 A;  2QPW A;  5EX0 A;  4YPE A;  5AYF A;  1MT6 A;  3KMT A;  4YND A;  3VV0 A;  3K5K A;  2O8J A;  5T0K A;  3S7F A;  4NVQ A;  4E47 A;  4YPA A;  3RQ4 A;  5CPR B;  4JDS A;  2BQZ A;  5JIN A;  5KJK A;  5F6L A;  3F9X A;  1PEG A;  4QEO A;  3IHX A;  1O9S A;  3OS5 A;  1MUF A;  5ARG A;  3CBP A;  3M53 A;  4O6F A;  3OOI A;  3FPD A;  3BO5 A;  2W5Z A;  5LSX A;  3S7D A;  4FMU A;  4J7I A;  4AU7 A;  4C1Q A;  5F6K C;  3M55 A;  3RIB A;  4LDG A;  5ARF A;  3M56 A;  5T0M A;  4IJD A;  3F9Z A;  4H12 A;  3QWV A;  5F59 A;  1XQH A;  3VUZ A;  2G46 A;  4J7F A;  3N71 A;  4BUP A;  2RFI A;  3QWW A;  2F69 A;  3S8P A;  2W5Y A;  3RAY A;  2JV0 A;  4RZ0 A;  1ML9 A;  5HI7 A;  3F9Y A;  5EX3 A;  3HNA A;  4I51 A;  5KJM A;  4QEP A;  5EG2 A;  4NJ5 A;  3PDN A;  3S7J A;  3S7B A;  3QWP A;  2IGQ A;  3OXF A;  5HQ8 A;  5KJL A;  3KMJ A;  3DB5 A;  3OPE A;  4QEN A;  5JHN A;  3MO2 A;  4IJ8 A;  3KMA A;  5TTF A;  3M5A A;  5CCL A;  1N6C A;  3RU0 A;  5JJ0 A;  4MI0 A;  5T5G A;  1MVX A;  3M58 A;  4J83 A;  4YNM A;  4YNP A;  3MO5 A;  4Z4P A; 
#chains in the Genus database with same CATH homology
 3TG4 A;  5F5E A;  3EP0 A;  3M57 A;  4JLG A;  5TH7 A;  4YPU A;  1ZKK A;  1MVH A;  3M59 A;  5CCM A;  4WUY A;  4J8O A;  1N3J A;  3CBM A;  3SW9 A;  5TEG A;  3TG5 A;  5LSZ A;  3SWC A;  5KJN A;  3OXL A;  3RJW A;  2R3A A;  3MEK A;  4MI5 A;  3DAL A;  5JIY A;  1N6A A;  3MO0 A;  3M54 A;  1H3I A;  3F9W A;  3CBO A;  3OXG A;  4O30 A;  2QPW A;  5EX0 A;  4YPE A;  5AYF A;  1MT6 A;  3KMT A;  4YND A;  3VV0 A;  3K5K A;  2O8J A;  5T0K A;  3S7F A;  4NVQ A;  4E47 A;  4YPA A;  3RQ4 A;  5CPR B;  4JDS A;  2BQZ A;  5JIN A;  5KJK A;  5F6L A;  3F9X A;  1PEG A;  4QEO A;  3IHX A;  1O9S A;  3OS5 A;  1MUF A;  5ARG A;  3CBP A;  3M53 A;  4O6F A;  3OOI A;  3FPD A;  3BO5 A;  2W5Z A;  5LSX A;  3S7D A;  4FMU A;  4J7I A;  4AU7 A;  4C1Q A;  5F6K C;  3M55 A;  3RIB A;  4LDG A;  5ARF A;  3M56 A;  5T0M A;  4IJD A;  3F9Z A;  4H12 A;  3QWV A;  5F59 A;  1XQH A;  3VUZ A;  2G46 A;  4J7F A;  3N71 A;  4BUP A;  2RFI A;  3QWW A;  2F69 A;  3S8P A;  2W5Y A;  3RAY A;  2JV0 A;  4RZ0 A;  1ML9 A;  5HI7 A;  3F9Y A;  5EX3 A;  3HNA A;  4I51 A;  5KJM A;  4QEP A;  5EG2 A;  4NJ5 A;  3PDN A;  3S7J A;  3S7B A;  3QWP A;  2IGQ A;  3OXF A;  5HQ8 A;  5KJL A;  3KMJ A;  3DB5 A;  3OPE A;  4QEN A;  5JHN A;  3MO2 A;  4IJ8 A;  3KMA A;  5TTF A;  3M5A A;  5CCL A;  1N6C A;  3RU0 A;  5JJ0 A;  4MI0 A;  5T5G A;  1MVX A;  3M58 A;  4J83 A;  4YNM A;  4YNP A;  3MO5 A;  4Z4P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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