4YPAA

Ash1l set domain q2265a mutant in complex with s-adenosyl methionine (sam)
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
218
structure length
218
Chain Sequence
GAMAGSYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKAQLCKCGFEKCRGIIG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase ASH1L
total genus 48
structure length 218
sequence length 218
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2015-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF17907 AWS AWS domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4ypaA00
3CBPA 5ARFA 3OS5A 5CPRB 2RFIA 4LDGA 3DB5A 3M54A 5TEGA 3F9WA 3QWWA 4IJ8A 3F9YA 4MI5A 3M58A 5HQ8A 5F59A 4YNPA 5JIYA 5KJKA 3KMAA 4YPEA 2W5ZA 3FPDA 5KJMA 4JDSA 4I51A 5T5GA 5F6LA 4IJDA 1MVHA 4FMUA 3MO5A 5KJNA 4J83A 5LSXA 3F9XA 2R3AA 3RJWA 3M55A 5TH7A 3TG4A 1O9SA 3KMTA 3RAYA 3PDNA 4E47A 3HNAA 2W5YA 3TG5A 3QWVA 1H3IA 3S8PA 1XQHA 3VV0A 3MEKA 4H12A 1N6AA 1N3JA 4MI0A 3QWPA 1MVXA 2IGQA 3M56A 5CCMA 3M59A 3MO0A 3OXGA 3BO5A 5KJLA 5T0KA 3DALA 2F69A 5T0MA 3M5AA 5JHNA 5HI7A 4RZ0A 4NJ5A 3K5KA 3F9ZA 5JINA 2O8JA 3VUZA 3CBMA 4O30A 3S7JA 4AU7A 4NVQA 5TTFA 4WUYA 3MO2A 2BQZA 4YNMA 4O6FA 5EX3A 1ML9A 1ZKKA 3N71A 4YNDA 5JJ0A 1N6CA 3EP0A 3OPEA 4QEOA 4QEPA 5CCLA 3M57A 5F6KC 1MUFA 1PEGA 3OOIA 4JLGA 4J7FA 1MT6A 3IHXA 3OXLA 5LSZA 5F5EA 4Z4PA 4QENA 5EX0A 3RU0A 3CBOA 4BUPA 2QPWA 4C1QA 3OXFA 3SW9A 5AYFA 2JV0A 3S7BA 4YPAA 5ARGA 3KMJA 3RQ4A 3M53A 3RIBA 3S7FA 5EG2A 3S7DA 4J7IA 2G46A 3SWCA 4YPUA 4J8OA
chains in the Genus database with same CATH superfamily
3CBPA 5ARFA 3OS5A 5CPRB 2RFIA 4LDGA 3DB5A 3M54A 5TEGA 3F9WA 3QWWA 4IJ8A 3F9YA 4MI5A 3M58A 5HQ8A 5F59A 4YNPA 5JIYA 5KJKA 3KMAA 4YPEA 2W5ZA 3FPDA 5KJMA 4JDSA 4I51A 5T5GA 5F6LA 4IJDA 1MVHA 4FMUA 3MO5A 5KJNA 4J83A 5LSXA 3F9XA 2R3AA 3RJWA 3M55A 5TH7A 3TG4A 1O9SA 3KMTA 3RAYA 3PDNA 4E47A 3HNAA 2W5YA 3TG5A 3QWVA 1H3IA 3S8PA 1XQHA 3VV0A 3MEKA 4H12A 1N6AA 1N3JA 4MI0A 3QWPA 1MVXA 2IGQA 3M56A 5CCMA 3M59A 3MO0A 3OXGA 3BO5A 5KJLA 5T0KA 3DALA 2F69A 5T0MA 3M5AA 5JHNA 5HI7A 4RZ0A 4NJ5A 3K5KA 3F9ZA 5JINA 2O8JA 3VUZA 3CBMA 4O30A 3S7JA 4AU7A 4NVQA 5TTFA 4WUYA 3MO2A 2BQZA 4YNMA 4O6FA 5EX3A 1ML9A 1ZKKA 3N71A 4YNDA 5JJ0A 1N6CA 3EP0A 3OPEA 4QEOA 4QEPA 5CCLA 3M57A 5F6KC 1MUFA 1PEGA 3OOIA 4JLGA 4J7FA 1MT6A 3IHXA 3OXLA 5LSZA 5F5EA 4Z4PA 4QENA 5EX0A 3RU0A 3CBOA 4BUPA 2QPWA 4C1QA 3OXFA 3SW9A 5AYFA 2JV0A 3S7BA 4YPAA 5ARGA 3KMJA 3RQ4A 3M53A 3RIBA 3S7FA 5EG2A 3S7DA 4J7IA 2G46A 3SWCA 4YPUA 4J8OA
chains in the Genus database with same CATH topology
3CBPA 5ARFA 3OS5A 5CPRB 2RFIA 4LDGA 3DB5A 3M54A 5TEGA 3F9WA 3QWWA 4IJ8A 3F9YA 4MI5A 3M58A 5HQ8A 5F59A 4YNPA 5JIYA 5KJKA 3KMAA 4YPEA 2W5ZA 3FPDA 5KJMA 4JDSA 4I51A 5T5GA 5F6LA 4IJDA 1MVHA 4FMUA 3MO5A 5KJNA 4J83A 5LSXA 3F9XA 2R3AA 3RJWA 3M55A 5TH7A 3TG4A 1O9SA 3KMTA 3RAYA 3PDNA 4E47A 3HNAA 2W5YA 3TG5A 3QWVA 1H3IA 3S8PA 1XQHA 3VV0A 3MEKA 4H12A 1N6AA 1N3JA 4MI0A 3QWPA 1MVXA 2IGQA 3M56A 5CCMA 3M59A 3MO0A 3OXGA 3BO5A 5KJLA 5T0KA 3DALA 2F69A 5T0MA 3M5AA 5JHNA 5HI7A 4RZ0A 4NJ5A 3K5KA 3F9ZA 5JINA 2O8JA 3VUZA 3CBMA 4O30A 3S7JA 4AU7A 4NVQA 5TTFA 4WUYA 3MO2A 2BQZA 4YNMA 4O6FA 5EX3A 1ML9A 1ZKKA 3N71A 4YNDA 5JJ0A 1N6CA 3EP0A 3OPEA 4QEOA 4QEPA 5CCLA 3M57A 5F6KC 1MUFA 1PEGA 3OOIA 4JLGA 4J7FA 1MT6A 3IHXA 3OXLA 5LSZA 5F5EA 4Z4PA 4QENA 5EX0A 3RU0A 3CBOA 4BUPA 2QPWA 4C1QA 3OXFA 3SW9A 5AYFA 2JV0A 3S7BA 4YPAA 5ARGA 3KMJA 3RQ4A 3M53A 3RIBA 3S7FA 5EG2A 3S7DA 4J7IA 2G46A 3SWCA 4YPUA 4J8OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CBP A;  5ARF A;  3OS5 A;  5CPR B;  2RFI A;  4LDG A;  3DB5 A;  3M54 A;  5TEG A;  3F9W A;  3QWW A;  4IJ8 A;  3F9Y A;  4MI5 A;  3M58 A;  5HQ8 A;  5F59 A;  4YNP A;  5JIY A;  5KJK A;  3KMA A;  4YPE A;  2W5Z A;  3FPD A;  5KJM A;  4JDS A;  4I51 A;  5T5G A;  5F6L A;  4IJD A;  1MVH A;  4FMU A;  3MO5 A;  5KJN A;  4J83 A;  5LSX A;  3F9X A;  2R3A A;  3RJW A;  3M55 A;  5TH7 A;  3TG4 A;  1O9S A;  3KMT A;  3RAY A;  3PDN A;  4E47 A;  3HNA A;  2W5Y A;  3TG5 A;  3QWV A;  1H3I A;  3S8P A;  1XQH A;  3VV0 A;  3MEK A;  4H12 A;  1N6A A;  1N3J A;  4MI0 A;  3QWP A;  1MVX A;  2IGQ A;  3M56 A;  5CCM A;  3M59 A;  3MO0 A;  3OXG A;  3BO5 A;  5KJL A;  5T0K A;  3DAL A;  2F69 A;  5T0M A;  3M5A A;  5JHN A;  5HI7 A;  4RZ0 A;  4NJ5 A;  3K5K A;  3F9Z A;  5JIN A;  2O8J A;  3VUZ A;  3CBM A;  4O30 A;  3S7J A;  4AU7 A;  4NVQ A;  5TTF A;  4WUY A;  3MO2 A;  2BQZ A;  4YNM A;  4O6F A;  5EX3 A;  1ML9 A;  1ZKK A;  3N71 A;  4YND A;  5JJ0 A;  1N6C A;  3EP0 A;  3OPE A;  4QEO A;  4QEP A;  5CCL A;  3M57 A;  5F6K C;  1MUF A;  1PEG A;  3OOI A;  4JLG A;  4J7F A;  1MT6 A;  3IHX A;  3OXL A;  5LSZ A;  5F5E A;  4Z4P A;  4QEN A;  5EX0 A;  3RU0 A;  3CBO A;  4BUP A;  2QPW A;  4C1Q A;  3OXF A;  3SW9 A;  5AYF A;  2JV0 A;  3S7B A;  4YPA A;  5ARG A;  3KMJ A;  3RQ4 A;  3M53 A;  3RIB A;  3S7F A;  5EG2 A;  3S7D A;  4J7I A;  2G46 A;  3SWC A;  4YPU A;  4J8O A; 
#chains in the Genus database with same CATH topology
 3CBP A;  5ARF A;  3OS5 A;  5CPR B;  2RFI A;  4LDG A;  3DB5 A;  3M54 A;  5TEG A;  3F9W A;  3QWW A;  4IJ8 A;  3F9Y A;  4MI5 A;  3M58 A;  5HQ8 A;  5F59 A;  4YNP A;  5JIY A;  5KJK A;  3KMA A;  4YPE A;  2W5Z A;  3FPD A;  5KJM A;  4JDS A;  4I51 A;  5T5G A;  5F6L A;  4IJD A;  1MVH A;  4FMU A;  3MO5 A;  5KJN A;  4J83 A;  5LSX A;  3F9X A;  2R3A A;  3RJW A;  3M55 A;  5TH7 A;  3TG4 A;  1O9S A;  3KMT A;  3RAY A;  3PDN A;  4E47 A;  3HNA A;  2W5Y A;  3TG5 A;  3QWV A;  1H3I A;  3S8P A;  1XQH A;  3VV0 A;  3MEK A;  4H12 A;  1N6A A;  1N3J A;  4MI0 A;  3QWP A;  1MVX A;  2IGQ A;  3M56 A;  5CCM A;  3M59 A;  3MO0 A;  3OXG A;  3BO5 A;  5KJL A;  5T0K A;  3DAL A;  2F69 A;  5T0M A;  3M5A A;  5JHN A;  5HI7 A;  4RZ0 A;  4NJ5 A;  3K5K A;  3F9Z A;  5JIN A;  2O8J A;  3VUZ A;  3CBM A;  4O30 A;  3S7J A;  4AU7 A;  4NVQ A;  5TTF A;  4WUY A;  3MO2 A;  2BQZ A;  4YNM A;  4O6F A;  5EX3 A;  1ML9 A;  1ZKK A;  3N71 A;  4YND A;  5JJ0 A;  1N6C A;  3EP0 A;  3OPE A;  4QEO A;  4QEP A;  5CCL A;  3M57 A;  5F6K C;  1MUF A;  1PEG A;  3OOI A;  4JLG A;  4J7F A;  1MT6 A;  3IHX A;  3OXL A;  5LSZ A;  5F5E A;  4Z4P A;  4QEN A;  5EX0 A;  3RU0 A;  3CBO A;  4BUP A;  2QPW A;  4C1Q A;  3OXF A;  3SW9 A;  5AYF A;  2JV0 A;  3S7B A;  4YPA A;  5ARG A;  3KMJ A;  3RQ4 A;  3M53 A;  3RIB A;  3S7F A;  5EG2 A;  3S7D A;  4J7I A;  2G46 A;  3SWC A;  4YPU A;  4J8O A; 
#chains in the Genus database with same CATH homology
 3CBP A;  5ARF A;  3OS5 A;  5CPR B;  2RFI A;  4LDG A;  3DB5 A;  3M54 A;  5TEG A;  3F9W A;  3QWW A;  4IJ8 A;  3F9Y A;  4MI5 A;  3M58 A;  5HQ8 A;  5F59 A;  4YNP A;  5JIY A;  5KJK A;  3KMA A;  4YPE A;  2W5Z A;  3FPD A;  5KJM A;  4JDS A;  4I51 A;  5T5G A;  5F6L A;  4IJD A;  1MVH A;  4FMU A;  3MO5 A;  5KJN A;  4J83 A;  5LSX A;  3F9X A;  2R3A A;  3RJW A;  3M55 A;  5TH7 A;  3TG4 A;  1O9S A;  3KMT A;  3RAY A;  3PDN A;  4E47 A;  3HNA A;  2W5Y A;  3TG5 A;  3QWV A;  1H3I A;  3S8P A;  1XQH A;  3VV0 A;  3MEK A;  4H12 A;  1N6A A;  1N3J A;  4MI0 A;  3QWP A;  1MVX A;  2IGQ A;  3M56 A;  5CCM A;  3M59 A;  3MO0 A;  3OXG A;  3BO5 A;  5KJL A;  5T0K A;  3DAL A;  2F69 A;  5T0M A;  3M5A A;  5JHN A;  5HI7 A;  4RZ0 A;  4NJ5 A;  3K5K A;  3F9Z A;  5JIN A;  2O8J A;  3VUZ A;  3CBM A;  4O30 A;  3S7J A;  4AU7 A;  4NVQ A;  5TTF A;  4WUY A;  3MO2 A;  2BQZ A;  4YNM A;  4O6F A;  5EX3 A;  1ML9 A;  1ZKK A;  3N71 A;  4YND A;  5JJ0 A;  1N6C A;  3EP0 A;  3OPE A;  4QEO A;  4QEP A;  5CCL A;  3M57 A;  5F6K C;  1MUF A;  1PEG A;  3OOI A;  4JLG A;  4J7F A;  1MT6 A;  3IHX A;  3OXL A;  5LSZ A;  5F5E A;  4Z4P A;  4QEN A;  5EX0 A;  3RU0 A;  3CBO A;  4BUP A;  2QPW A;  4C1Q A;  3OXF A;  3SW9 A;  5AYF A;  2JV0 A;  3S7B A;  4YPA A;  5ARG A;  3KMJ A;  3RQ4 A;  3M53 A;  3RIB A;  3S7F A;  5EG2 A;  3S7D A;  4J7I A;  2G46 A;  3SWC A;  4YPU A;  4J8O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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