4YPAA

Ash1l set domain q2265a mutant in complex with s-adenosyl methionine (sam)
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
218
structure length
218
Chain Sequence
GAMAGSYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKAQLCKCGFEKCRGIIG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase ASH1L
publication title Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 48
structure length 218
sequence length 218
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2015-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF17907 AWS AWS domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4ypaA00
3OXFA 5HQ8A 3QWPA 5KJNA 5ARFA 3KMAA 5EG2A 5TEGA 3BO5A 4E47A 2IGQA 3RIBA 5LSZA 4JLGA 3OPEA 3CBMA 5AYFA 1N3JA 5F6KC 5CCMA 2BQZA 1N6AA 1XQHA 5KJLA 4J7FA 2G46A 3F9WA 4RZ0A 3M54A 3HNAA 5CPRB 3KMTA 5T0MA 3TG5A 4QEPA 4Z4PA 3VV0A 2JV0A 3DB5A 4YPUA 5F59A 4AU7A 4JDSA 3RQ4A 3S7BA 2O8JA 3CBPA 4I51A 4LDGA 4QENA 4C1QA 1PEGA 3MEKA 5F6LA 3FPDA 1MVXA 4MI0A 1N6CA 3DALA 3F9YA 3S7DA 2F69A 5T0KA 4O6FA 4YNMA 3TG4A 1H3IA 4O30A 3VUZA 3QWWA 3KMJA 4J7IA 2QPWA 4NJ5A 4YNPA 4BUPA 1MUFA 3MO0A 3RU0A 5JIYA 1MT6A 3SW9A 5JHNA 1MVHA 3M55A 4J83A 1O9SA 4NVQA 3M56A 1ZKKA 2R3AA 4H12A 5TH7A 3MO5A 3M57A 3OXLA 4YPAA 3RAYA 3CBOA 3M5AA 3RJWA 5TTFA 5T5GA 3OOIA 3F9XA 3M59A 3S7JA 3MO2A 3M58A 4MI5A 3SWCA 3F9ZA 4J8OA 3EP0A 4QEOA 5CCLA 5KJKA 5EX0A 4YPEA 3K5KA 5EX3A 5ARGA 3S7FA 2RFIA 3S8PA 5JINA 1ML9A 4YNDA 4WUYA 3M53A 5HI7A 5JJ0A 2W5YA 5F5EA 3OS5A 5KJMA 3QWVA 3IHXA 3N71A 3OXGA 3PDNA 2W5ZA 4FMUA 4IJDA 5LSXA 4IJ8A
chains in the Genus database with same CATH superfamily
3OXFA 5HQ8A 3QWPA 5KJNA 5ARFA 3KMAA 5EG2A 5TEGA 3BO5A 4E47A 2IGQA 3RIBA 5LSZA 4JLGA 3OPEA 3CBMA 5AYFA 1N3JA 5F6KC 5CCMA 2BQZA 1N6AA 1XQHA 5KJLA 4J7FA 2G46A 3F9WA 4RZ0A 3M54A 3HNAA 5CPRB 3KMTA 5T0MA 3TG5A 4QEPA 4Z4PA 3VV0A 2JV0A 3DB5A 4YPUA 5F59A 4AU7A 4JDSA 3RQ4A 3S7BA 2O8JA 3CBPA 4I51A 4LDGA 4QENA 4C1QA 1PEGA 3MEKA 5F6LA 3FPDA 1MVXA 4MI0A 1N6CA 3DALA 3F9YA 3S7DA 2F69A 5T0KA 4O6FA 4YNMA 3TG4A 1H3IA 4O30A 3VUZA 3QWWA 3KMJA 4J7IA 2QPWA 4NJ5A 4YNPA 4BUPA 1MUFA 3MO0A 3RU0A 5JIYA 1MT6A 3SW9A 5JHNA 1MVHA 3M55A 4J83A 1O9SA 4NVQA 3M56A 1ZKKA 2R3AA 4H12A 5TH7A 3MO5A 3M57A 3OXLA 4YPAA 3RAYA 3CBOA 3M5AA 3RJWA 5TTFA 5T5GA 3OOIA 3F9XA 3M59A 3S7JA 3MO2A 3M58A 4MI5A 3SWCA 3F9ZA 4J8OA 3EP0A 4QEOA 5CCLA 5KJKA 5EX0A 4YPEA 3K5KA 5EX3A 5ARGA 3S7FA 2RFIA 3S8PA 5JINA 1ML9A 4YNDA 4WUYA 3M53A 5HI7A 5JJ0A 2W5YA 5F5EA 3OS5A 5KJMA 3QWVA 3IHXA 3N71A 3OXGA 3PDNA 2W5ZA 4FMUA 4IJDA 5LSXA 4IJ8A
chains in the Genus database with same CATH topology
3OXFA 5HQ8A 3QWPA 5KJNA 5ARFA 3KMAA 5EG2A 5TEGA 3BO5A 4E47A 2IGQA 3RIBA 5LSZA 4JLGA 3OPEA 3CBMA 5AYFA 1N3JA 5F6KC 5CCMA 2BQZA 1N6AA 1XQHA 5KJLA 4J7FA 2G46A 3F9WA 4RZ0A 3M54A 3HNAA 5CPRB 3KMTA 5T0MA 3TG5A 4QEPA 4Z4PA 3VV0A 2JV0A 3DB5A 4YPUA 5F59A 4AU7A 4JDSA 3RQ4A 3S7BA 2O8JA 3CBPA 4I51A 4LDGA 4QENA 4C1QA 1PEGA 3MEKA 5F6LA 3FPDA 1MVXA 4MI0A 1N6CA 3DALA 3F9YA 3S7DA 2F69A 5T0KA 4O6FA 4YNMA 3TG4A 1H3IA 4O30A 3VUZA 3QWWA 3KMJA 4J7IA 2QPWA 4NJ5A 4YNPA 4BUPA 1MUFA 3MO0A 3RU0A 5JIYA 1MT6A 3SW9A 5JHNA 1MVHA 3M55A 4J83A 1O9SA 4NVQA 3M56A 1ZKKA 2R3AA 4H12A 5TH7A 3MO5A 3M57A 3OXLA 4YPAA 3RAYA 3CBOA 3M5AA 3RJWA 5TTFA 5T5GA 3OOIA 3F9XA 3M59A 3S7JA 3MO2A 3M58A 4MI5A 3SWCA 3F9ZA 4J8OA 3EP0A 4QEOA 5CCLA 5KJKA 5EX0A 4YPEA 3K5KA 5EX3A 5ARGA 3S7FA 2RFIA 3S8PA 5JINA 1ML9A 4YNDA 4WUYA 3M53A 5HI7A 5JJ0A 2W5YA 5F5EA 3OS5A 5KJMA 3QWVA 3IHXA 3N71A 3OXGA 3PDNA 2W5ZA 4FMUA 4IJDA 5LSXA 4IJ8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OXF A;  5HQ8 A;  3QWP A;  5KJN A;  5ARF A;  3KMA A;  5EG2 A;  5TEG A;  3BO5 A;  4E47 A;  2IGQ A;  3RIB A;  5LSZ A;  4JLG A;  3OPE A;  3CBM A;  5AYF A;  1N3J A;  5F6K C;  5CCM A;  2BQZ A;  1N6A A;  1XQH A;  5KJL A;  4J7F A;  2G46 A;  3F9W A;  4RZ0 A;  3M54 A;  3HNA A;  5CPR B;  3KMT A;  5T0M A;  3TG5 A;  4QEP A;  4Z4P A;  3VV0 A;  2JV0 A;  3DB5 A;  4YPU A;  5F59 A;  4AU7 A;  4JDS A;  3RQ4 A;  3S7B A;  2O8J A;  3CBP A;  4I51 A;  4LDG A;  4QEN A;  4C1Q A;  1PEG A;  3MEK A;  5F6L A;  3FPD A;  1MVX A;  4MI0 A;  1N6C A;  3DAL A;  3F9Y A;  3S7D A;  2F69 A;  5T0K A;  4O6F A;  4YNM A;  3TG4 A;  1H3I A;  4O30 A;  3VUZ A;  3QWW A;  3KMJ A;  4J7I A;  2QPW A;  4NJ5 A;  4YNP A;  4BUP A;  1MUF A;  3MO0 A;  3RU0 A;  5JIY A;  1MT6 A;  3SW9 A;  5JHN A;  1MVH A;  3M55 A;  4J83 A;  1O9S A;  4NVQ A;  3M56 A;  1ZKK A;  2R3A A;  4H12 A;  5TH7 A;  3MO5 A;  3M57 A;  3OXL A;  4YPA A;  3RAY A;  3CBO A;  3M5A A;  3RJW A;  5TTF A;  5T5G A;  3OOI A;  3F9X A;  3M59 A;  3S7J A;  3MO2 A;  3M58 A;  4MI5 A;  3SWC A;  3F9Z A;  4J8O A;  3EP0 A;  4QEO A;  5CCL A;  5KJK A;  5EX0 A;  4YPE A;  3K5K A;  5EX3 A;  5ARG A;  3S7F A;  2RFI A;  3S8P A;  5JIN A;  1ML9 A;  4YND A;  4WUY A;  3M53 A;  5HI7 A;  5JJ0 A;  2W5Y A;  5F5E A;  3OS5 A;  5KJM A;  3QWV A;  3IHX A;  3N71 A;  3OXG A;  3PDN A;  2W5Z A;  4FMU A;  4IJD A;  5LSX A;  4IJ8 A; 
#chains in the Genus database with same CATH topology
 3OXF A;  5HQ8 A;  3QWP A;  5KJN A;  5ARF A;  3KMA A;  5EG2 A;  5TEG A;  3BO5 A;  4E47 A;  2IGQ A;  3RIB A;  5LSZ A;  4JLG A;  3OPE A;  3CBM A;  5AYF A;  1N3J A;  5F6K C;  5CCM A;  2BQZ A;  1N6A A;  1XQH A;  5KJL A;  4J7F A;  2G46 A;  3F9W A;  4RZ0 A;  3M54 A;  3HNA A;  5CPR B;  3KMT A;  5T0M A;  3TG5 A;  4QEP A;  4Z4P A;  3VV0 A;  2JV0 A;  3DB5 A;  4YPU A;  5F59 A;  4AU7 A;  4JDS A;  3RQ4 A;  3S7B A;  2O8J A;  3CBP A;  4I51 A;  4LDG A;  4QEN A;  4C1Q A;  1PEG A;  3MEK A;  5F6L A;  3FPD A;  1MVX A;  4MI0 A;  1N6C A;  3DAL A;  3F9Y A;  3S7D A;  2F69 A;  5T0K A;  4O6F A;  4YNM A;  3TG4 A;  1H3I A;  4O30 A;  3VUZ A;  3QWW A;  3KMJ A;  4J7I A;  2QPW A;  4NJ5 A;  4YNP A;  4BUP A;  1MUF A;  3MO0 A;  3RU0 A;  5JIY A;  1MT6 A;  3SW9 A;  5JHN A;  1MVH A;  3M55 A;  4J83 A;  1O9S A;  4NVQ A;  3M56 A;  1ZKK A;  2R3A A;  4H12 A;  5TH7 A;  3MO5 A;  3M57 A;  3OXL A;  4YPA A;  3RAY A;  3CBO A;  3M5A A;  3RJW A;  5TTF A;  5T5G A;  3OOI A;  3F9X A;  3M59 A;  3S7J A;  3MO2 A;  3M58 A;  4MI5 A;  3SWC A;  3F9Z A;  4J8O A;  3EP0 A;  4QEO A;  5CCL A;  5KJK A;  5EX0 A;  4YPE A;  3K5K A;  5EX3 A;  5ARG A;  3S7F A;  2RFI A;  3S8P A;  5JIN A;  1ML9 A;  4YND A;  4WUY A;  3M53 A;  5HI7 A;  5JJ0 A;  2W5Y A;  5F5E A;  3OS5 A;  5KJM A;  3QWV A;  3IHX A;  3N71 A;  3OXG A;  3PDN A;  2W5Z A;  4FMU A;  4IJD A;  5LSX A;  4IJ8 A; 
#chains in the Genus database with same CATH homology
 3OXF A;  5HQ8 A;  3QWP A;  5KJN A;  5ARF A;  3KMA A;  5EG2 A;  5TEG A;  3BO5 A;  4E47 A;  2IGQ A;  3RIB A;  5LSZ A;  4JLG A;  3OPE A;  3CBM A;  5AYF A;  1N3J A;  5F6K C;  5CCM A;  2BQZ A;  1N6A A;  1XQH A;  5KJL A;  4J7F A;  2G46 A;  3F9W A;  4RZ0 A;  3M54 A;  3HNA A;  5CPR B;  3KMT A;  5T0M A;  3TG5 A;  4QEP A;  4Z4P A;  3VV0 A;  2JV0 A;  3DB5 A;  4YPU A;  5F59 A;  4AU7 A;  4JDS A;  3RQ4 A;  3S7B A;  2O8J A;  3CBP A;  4I51 A;  4LDG A;  4QEN A;  4C1Q A;  1PEG A;  3MEK A;  5F6L A;  3FPD A;  1MVX A;  4MI0 A;  1N6C A;  3DAL A;  3F9Y A;  3S7D A;  2F69 A;  5T0K A;  4O6F A;  4YNM A;  3TG4 A;  1H3I A;  4O30 A;  3VUZ A;  3QWW A;  3KMJ A;  4J7I A;  2QPW A;  4NJ5 A;  4YNP A;  4BUP A;  1MUF A;  3MO0 A;  3RU0 A;  5JIY A;  1MT6 A;  3SW9 A;  5JHN A;  1MVH A;  3M55 A;  4J83 A;  1O9S A;  4NVQ A;  3M56 A;  1ZKK A;  2R3A A;  4H12 A;  5TH7 A;  3MO5 A;  3M57 A;  3OXL A;  4YPA A;  3RAY A;  3CBO A;  3M5A A;  3RJW A;  5TTF A;  5T5G A;  3OOI A;  3F9X A;  3M59 A;  3S7J A;  3MO2 A;  3M58 A;  4MI5 A;  3SWC A;  3F9Z A;  4J8O A;  3EP0 A;  4QEO A;  5CCL A;  5KJK A;  5EX0 A;  4YPE A;  3K5K A;  5EX3 A;  5ARG A;  3S7F A;  2RFI A;  3S8P A;  5JIN A;  1ML9 A;  4YND A;  4WUY A;  3M53 A;  5HI7 A;  5JJ0 A;  2W5Y A;  5F5E A;  3OS5 A;  5KJM A;  3QWV A;  3IHX A;  3N71 A;  3OXG A;  3PDN A;  2W5Z A;  4FMU A;  4IJD A;  5LSX A;  4IJ8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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