4YPAA

Ash1l set domain q2265a mutant in complex with s-adenosyl methionine (sam)
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
218
structure length
218
Chain Sequence
GAMAGSYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKAQLCKCGFEKCRGIIG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase ASH1L
publication title Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 48
structure length 218
sequence length 218
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2015-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF17907 AWS AWS domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4ypaA00
3M58A 4IJDA 3OXGA 4C1QA 3QWWA 1MVHA 5F5EA 1ZKKA 5HQ8A 2G46A 3M54A 4Z4PA 4H12A 1N3JA 3KMTA 3OXLA 4MI0A 3FPDA 4J8OA 4QEPA 3VV0A 3OOIA 4IJ8A 3SWCA 2O8JA 3RAYA 4QEOA 3F9ZA 5TTFA 3MO2A 1O9SA 3KMJA 4AU7A 5ARFA 2JV0A 4NJ5A 3MEKA 2BQZA 4I51A 3KMAA 5EX3A 3TG5A 1XQHA 5CCMA 5JIYA 1MUFA 2F69A 3CBPA 3OXFA 5F6KC 3PDNA 3MO0A 3CBMA 3CBOA 4WUYA 5EG2A 2IGQA 3SW9A 1MVXA 4MI5A 2R3AA 3RJWA 3HNAA 5T0KA 5ARGA 3F9YA 5F59A 3EP0A 4J83A 4YPEA 1PEGA 5T5GA 3M55A 3IHXA 5LSZA 3M5AA 3N71A 5KJLA 1N6CA 4O30A 3M53A 4YNMA 4QENA 3DALA 4YNPA 3RQ4A 1H3IA 5KJMA 3BO5A 4J7FA 5JJ0A 3RU0A 2W5YA 3M59A 3M56A 3OS5A 3TG4A 4O6FA 3M57A 1N6AA 5CCLA 3F9WA 5JHNA 4JLGA 4E47A 5EX0A 4FMUA 5JINA 3S7JA 5KJKA 2RFIA 4YPAA 4J7IA 3DB5A 3QWPA 4LDGA 4JDSA 5AYFA 3VUZA 5F6LA 4RZ0A 3S8PA 5KJNA 3S7DA 4BUPA 5TH7A 1ML9A 2W5ZA 3F9XA 4YNDA 5LSXA 5T0MA 3RIBA 3S7FA 3MO5A 2QPWA 4NVQA 3QWVA 5TEGA 4YPUA 3S7BA 3K5KA 5CPRB 5HI7A 1MT6A 3OPEA
chains in the Genus database with same CATH superfamily
3M58A 4IJDA 3OXGA 4C1QA 3QWWA 1MVHA 5F5EA 1ZKKA 5HQ8A 2G46A 3M54A 4Z4PA 4H12A 1N3JA 3KMTA 3OXLA 4MI0A 3FPDA 4J8OA 4QEPA 3VV0A 3OOIA 4IJ8A 3SWCA 2O8JA 3RAYA 4QEOA 3F9ZA 5TTFA 3MO2A 1O9SA 3KMJA 4AU7A 5ARFA 2JV0A 4NJ5A 3MEKA 2BQZA 4I51A 3KMAA 5EX3A 3TG5A 1XQHA 5CCMA 5JIYA 1MUFA 2F69A 3CBPA 3OXFA 5F6KC 3PDNA 3MO0A 3CBMA 3CBOA 4WUYA 5EG2A 2IGQA 3SW9A 1MVXA 4MI5A 2R3AA 3RJWA 3HNAA 5T0KA 5ARGA 3F9YA 5F59A 3EP0A 4J83A 4YPEA 1PEGA 5T5GA 3M55A 3IHXA 5LSZA 3M5AA 3N71A 5KJLA 1N6CA 4O30A 3M53A 4YNMA 4QENA 3DALA 4YNPA 3RQ4A 1H3IA 5KJMA 3BO5A 4J7FA 5JJ0A 3RU0A 2W5YA 3M59A 3M56A 3OS5A 3TG4A 4O6FA 3M57A 1N6AA 5CCLA 3F9WA 5JHNA 4JLGA 4E47A 5EX0A 4FMUA 5JINA 3S7JA 5KJKA 2RFIA 4YPAA 4J7IA 3DB5A 3QWPA 4LDGA 4JDSA 5AYFA 3VUZA 5F6LA 4RZ0A 3S8PA 5KJNA 3S7DA 4BUPA 5TH7A 1ML9A 2W5ZA 3F9XA 4YNDA 5LSXA 5T0MA 3RIBA 3S7FA 3MO5A 2QPWA 4NVQA 3QWVA 5TEGA 4YPUA 3S7BA 3K5KA 5CPRB 5HI7A 1MT6A 3OPEA
chains in the Genus database with same CATH topology
3M58A 4IJDA 3OXGA 4C1QA 3QWWA 1MVHA 5F5EA 1ZKKA 5HQ8A 2G46A 3M54A 4Z4PA 4H12A 1N3JA 3KMTA 3OXLA 4MI0A 3FPDA 4J8OA 4QEPA 3VV0A 3OOIA 4IJ8A 3SWCA 2O8JA 3RAYA 4QEOA 3F9ZA 5TTFA 3MO2A 1O9SA 3KMJA 4AU7A 5ARFA 2JV0A 4NJ5A 3MEKA 2BQZA 4I51A 3KMAA 5EX3A 3TG5A 1XQHA 5CCMA 5JIYA 1MUFA 2F69A 3CBPA 3OXFA 5F6KC 3PDNA 3MO0A 3CBMA 3CBOA 4WUYA 5EG2A 2IGQA 3SW9A 1MVXA 4MI5A 2R3AA 3RJWA 3HNAA 5T0KA 5ARGA 3F9YA 5F59A 3EP0A 4J83A 4YPEA 1PEGA 5T5GA 3M55A 3IHXA 5LSZA 3M5AA 3N71A 5KJLA 1N6CA 4O30A 3M53A 4YNMA 4QENA 3DALA 4YNPA 3RQ4A 1H3IA 5KJMA 3BO5A 4J7FA 5JJ0A 3RU0A 2W5YA 3M59A 3M56A 3OS5A 3TG4A 4O6FA 3M57A 1N6AA 5CCLA 3F9WA 5JHNA 4JLGA 4E47A 5EX0A 4FMUA 5JINA 3S7JA 5KJKA 2RFIA 4YPAA 4J7IA 3DB5A 3QWPA 4LDGA 4JDSA 5AYFA 3VUZA 5F6LA 4RZ0A 3S8PA 5KJNA 3S7DA 4BUPA 5TH7A 1ML9A 2W5ZA 3F9XA 4YNDA 5LSXA 5T0MA 3RIBA 3S7FA 3MO5A 2QPWA 4NVQA 3QWVA 5TEGA 4YPUA 3S7BA 3K5KA 5CPRB 5HI7A 1MT6A 3OPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M58 A;  4IJD A;  3OXG A;  4C1Q A;  3QWW A;  1MVH A;  5F5E A;  1ZKK A;  5HQ8 A;  2G46 A;  3M54 A;  4Z4P A;  4H12 A;  1N3J A;  3KMT A;  3OXL A;  4MI0 A;  3FPD A;  4J8O A;  4QEP A;  3VV0 A;  3OOI A;  4IJ8 A;  3SWC A;  2O8J A;  3RAY A;  4QEO A;  3F9Z A;  5TTF A;  3MO2 A;  1O9S A;  3KMJ A;  4AU7 A;  5ARF A;  2JV0 A;  4NJ5 A;  3MEK A;  2BQZ A;  4I51 A;  3KMA A;  5EX3 A;  3TG5 A;  1XQH A;  5CCM A;  5JIY A;  1MUF A;  2F69 A;  3CBP A;  3OXF A;  5F6K C;  3PDN A;  3MO0 A;  3CBM A;  3CBO A;  4WUY A;  5EG2 A;  2IGQ A;  3SW9 A;  1MVX A;  4MI5 A;  2R3A A;  3RJW A;  3HNA A;  5T0K A;  5ARG A;  3F9Y A;  5F59 A;  3EP0 A;  4J83 A;  4YPE A;  1PEG A;  5T5G A;  3M55 A;  3IHX A;  5LSZ A;  3M5A A;  3N71 A;  5KJL A;  1N6C A;  4O30 A;  3M53 A;  4YNM A;  4QEN A;  3DAL A;  4YNP A;  3RQ4 A;  1H3I A;  5KJM A;  3BO5 A;  4J7F A;  5JJ0 A;  3RU0 A;  2W5Y A;  3M59 A;  3M56 A;  3OS5 A;  3TG4 A;  4O6F A;  3M57 A;  1N6A A;  5CCL A;  3F9W A;  5JHN A;  4JLG A;  4E47 A;  5EX0 A;  4FMU A;  5JIN A;  3S7J A;  5KJK A;  2RFI A;  4YPA A;  4J7I A;  3DB5 A;  3QWP A;  4LDG A;  4JDS A;  5AYF A;  3VUZ A;  5F6L A;  4RZ0 A;  3S8P A;  5KJN A;  3S7D A;  4BUP A;  5TH7 A;  1ML9 A;  2W5Z A;  3F9X A;  4YND A;  5LSX A;  5T0M A;  3RIB A;  3S7F A;  3MO5 A;  2QPW A;  4NVQ A;  3QWV A;  5TEG A;  4YPU A;  3S7B A;  3K5K A;  5CPR B;  5HI7 A;  1MT6 A;  3OPE A; 
#chains in the Genus database with same CATH topology
 3M58 A;  4IJD A;  3OXG A;  4C1Q A;  3QWW A;  1MVH A;  5F5E A;  1ZKK A;  5HQ8 A;  2G46 A;  3M54 A;  4Z4P A;  4H12 A;  1N3J A;  3KMT A;  3OXL A;  4MI0 A;  3FPD A;  4J8O A;  4QEP A;  3VV0 A;  3OOI A;  4IJ8 A;  3SWC A;  2O8J A;  3RAY A;  4QEO A;  3F9Z A;  5TTF A;  3MO2 A;  1O9S A;  3KMJ A;  4AU7 A;  5ARF A;  2JV0 A;  4NJ5 A;  3MEK A;  2BQZ A;  4I51 A;  3KMA A;  5EX3 A;  3TG5 A;  1XQH A;  5CCM A;  5JIY A;  1MUF A;  2F69 A;  3CBP A;  3OXF A;  5F6K C;  3PDN A;  3MO0 A;  3CBM A;  3CBO A;  4WUY A;  5EG2 A;  2IGQ A;  3SW9 A;  1MVX A;  4MI5 A;  2R3A A;  3RJW A;  3HNA A;  5T0K A;  5ARG A;  3F9Y A;  5F59 A;  3EP0 A;  4J83 A;  4YPE A;  1PEG A;  5T5G A;  3M55 A;  3IHX A;  5LSZ A;  3M5A A;  3N71 A;  5KJL A;  1N6C A;  4O30 A;  3M53 A;  4YNM A;  4QEN A;  3DAL A;  4YNP A;  3RQ4 A;  1H3I A;  5KJM A;  3BO5 A;  4J7F A;  5JJ0 A;  3RU0 A;  2W5Y A;  3M59 A;  3M56 A;  3OS5 A;  3TG4 A;  4O6F A;  3M57 A;  1N6A A;  5CCL A;  3F9W A;  5JHN A;  4JLG A;  4E47 A;  5EX0 A;  4FMU A;  5JIN A;  3S7J A;  5KJK A;  2RFI A;  4YPA A;  4J7I A;  3DB5 A;  3QWP A;  4LDG A;  4JDS A;  5AYF A;  3VUZ A;  5F6L A;  4RZ0 A;  3S8P A;  5KJN A;  3S7D A;  4BUP A;  5TH7 A;  1ML9 A;  2W5Z A;  3F9X A;  4YND A;  5LSX A;  5T0M A;  3RIB A;  3S7F A;  3MO5 A;  2QPW A;  4NVQ A;  3QWV A;  5TEG A;  4YPU A;  3S7B A;  3K5K A;  5CPR B;  5HI7 A;  1MT6 A;  3OPE A; 
#chains in the Genus database with same CATH homology
 3M58 A;  4IJD A;  3OXG A;  4C1Q A;  3QWW A;  1MVH A;  5F5E A;  1ZKK A;  5HQ8 A;  2G46 A;  3M54 A;  4Z4P A;  4H12 A;  1N3J A;  3KMT A;  3OXL A;  4MI0 A;  3FPD A;  4J8O A;  4QEP A;  3VV0 A;  3OOI A;  4IJ8 A;  3SWC A;  2O8J A;  3RAY A;  4QEO A;  3F9Z A;  5TTF A;  3MO2 A;  1O9S A;  3KMJ A;  4AU7 A;  5ARF A;  2JV0 A;  4NJ5 A;  3MEK A;  2BQZ A;  4I51 A;  3KMA A;  5EX3 A;  3TG5 A;  1XQH A;  5CCM A;  5JIY A;  1MUF A;  2F69 A;  3CBP A;  3OXF A;  5F6K C;  3PDN A;  3MO0 A;  3CBM A;  3CBO A;  4WUY A;  5EG2 A;  2IGQ A;  3SW9 A;  1MVX A;  4MI5 A;  2R3A A;  3RJW A;  3HNA A;  5T0K A;  5ARG A;  3F9Y A;  5F59 A;  3EP0 A;  4J83 A;  4YPE A;  1PEG A;  5T5G A;  3M55 A;  3IHX A;  5LSZ A;  3M5A A;  3N71 A;  5KJL A;  1N6C A;  4O30 A;  3M53 A;  4YNM A;  4QEN A;  3DAL A;  4YNP A;  3RQ4 A;  1H3I A;  5KJM A;  3BO5 A;  4J7F A;  5JJ0 A;  3RU0 A;  2W5Y A;  3M59 A;  3M56 A;  3OS5 A;  3TG4 A;  4O6F A;  3M57 A;  1N6A A;  5CCL A;  3F9W A;  5JHN A;  4JLG A;  4E47 A;  5EX0 A;  4FMU A;  5JIN A;  3S7J A;  5KJK A;  2RFI A;  4YPA A;  4J7I A;  3DB5 A;  3QWP A;  4LDG A;  4JDS A;  5AYF A;  3VUZ A;  5F6L A;  4RZ0 A;  3S8P A;  5KJN A;  3S7D A;  4BUP A;  5TH7 A;  1ML9 A;  2W5Z A;  3F9X A;  4YND A;  5LSX A;  5T0M A;  3RIB A;  3S7F A;  3MO5 A;  2QPW A;  4NVQ A;  3QWV A;  5TEG A;  4YPU A;  3S7B A;  3K5K A;  5CPR B;  5HI7 A;  1MT6 A;  3OPE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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