4YSXC

Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with the specific inhibitor nn23
Total Genus 60
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
153
structure length
153
Chain Sequence
EKTPIQVWGWDYLMRQRALKRPIAPHLTIYKPQMTWMVSGLHRVTGCAMAGTLLIGGVGFSVLPLDFTTFVEFIRGLGIPWVILDTFKFIIAFPIAFHTLNGIRFIGFDMAKGTDIPSIYRGAYLVLGLAALISLAVVVYPRWERHKKATLPT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Succinate dehydrogenase flavoprotein
total genus 60
structure length 153
sequence length 153
chains with identical sequence G
ec nomenclature
pdb deposition date 2015-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01127 Sdh_cyt Succinate dehydrogenase/Fumarate reductase transmembrane subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunit 4ysxC00
5C2TC 3AEED 3SFEC 3AECD 3AE6D 2WU2D 3AE4D 2WS3C 1YQ3D 3CIRD 2B76D 4YXDD 3AEDC 4YT0C 2WP9D 3CIRC 3AE7C 3VR8D 1ZP0C 4YSXD 3AEGC 3P4SD 1L0VD 1ZOYC 5C3JD 3VR8C 5C2TD 4KX6D 4YSXC 3AE1C 3SFED 3VR9C 4KX6C 2WS3D 4YTPD 3AEDD 4YT0D 2FBWD 3P4RD 2BS4C 3AE7D 4YTMD 3AE3C 1ZP0D 2H89C 4YTPC 3P4QD 2FBWC 3AEGD 3ABVC 3P4RC 3AEAD 1ZOYD 2WDVC 4YTMC 3P4QC 3AE1D 3AEFC 3VR9D 3AEAC 3AE5D 3AE9D 1QLBC 1NEKC 2BS2C 3AEBC 3AE5C 1YQ4C 2WDQC 3AE9C 2H88C 3AE3D 2H89D 3AE8C 3P4PD 3ABVD 3AE2C 2WDVD 2WU5D 2BS3C 3P4PC 3AEFD 4YTNC 2WDRC 2WU5C 1NEKD 2ACZC 3AEBD 1NENC 2WQYD 3VRAC 1YQ4D 2WDQD 4YSZC 3SFDC 2H88D 2WQYC 3AE8D 3VRBC 3AE2D 3AEEC 3AECC 3AE6C 2WU2C 3AE4C 4YTND 1E7PC 4YSYD 1YQ3C 2WDRD 4YXDC 2B76C 1KFYD 1KF6D 4YSYC 2ACZD 1NEND 2WP9C 3VRAD 3P4SC 4YSZD 1KFYC 1KF6C 1L0VC 3SFDD 3VRBD 5C3JC
chains in the Genus database with same CATH superfamily
5C2TC 3AEED 3SFEC 3AECD 3AE6D 2WU2D 3AE4D 2WS3C 1YQ3D 3CIRD 2B76D 4YXDD 3AEDC 4YT0C 2WP9D 3CIRC 3AE7C 3VR8D 1ZP0C 4FJVA 4YSXD 4LDTA 3AEGC 3P4SD 1L0VD 1ZOYC 5C3JD 3VR8C 5C2TD 4KX6D 4YSXC 3AE1C 3SFED 3VR9C 4KX6C 2WS3D 4YTPD 3AEDD 4YT0D 2FBWD 3P4RD 2BS4C 3AE7D 4YTMD 3AE3C 1ZP0D 2H89C 4YTPC 3P4QD 2FBWC 3AEGD 3ABVC 3P4RC 3AEAD 4DDIA 1ZOYD 2WDVC 4YTMC 3P4QC 3AE1D 3AEFC 3VR9D 3AEAC 3AE5D 3AE9D 1QLBC 1NEKC 2BS2C 3AEBC 3AE5C 1YQ4C 3VONA 2WDQC 3AE9C 1TFFA 2ZFYA 2H88C 3AE3D 2H89D 3AE8C 3P4PD 3ABVD 3AE2C 2WDVD 2WU5D 2BS3C 3P4PC 3AEFD 4YTNC 4DHJA 2WDRC 2WU5C 4DHIB 1NEKD 2ACZC 3AEBD 1NENC 2WQYD 3VRAC 1YQ4D 2WDQD 4YSZC 3SFDC 2H88D 2WQYC 3AE8D 3VRBC 3AE2D 3AEEC 4DDGA 3AECC 3AE6C 2WU2C 3AE4C 4YTND 1E7PC 4YSYD 1YQ3C 2WDRD 4YXDC 2B76C 4DHZA 1KFYD 1KF6D 4YSYC 2ACZD 1NEND 2WP9C 3VRAD 3P4SC 4YSZD 1KFYC 1KF6C 1L0VC 3SFDD 4I6LA 3VRBD 5C3JC
chains in the Genus database with same CATH topology
5C2TC 3AEED 3SFEC 3AECD 3AE6D 2WU2D 3AE4D 2WS3C 1YQ3D 3CIRD 2B76D 4YXDD 3AEDC 4YT0C 2WP9D 3CIRC 3AE7C 3VR8D 1ZP0C 4YSXD 3AEGC 3P4SD 1L0VD 1ZOYC 5C3JD 3VR8C 5C2TD 4KX6D 4YSXC 3AE1C 3SFED 3VR9C 4KX6C 2WS3D 4YTPD 3AEDD 4YT0D 2FBWD 3P4RD 2BS4C 3AE7D 4YTMD 3AE3C 1ZP0D 2H89C 4YTPC 3P4QD 2FBWC 3AEGD 3ABVC 3P4RC 3AEAD 1ZOYD 2WDVC 4YTMC 3P4QC 3AE1D 3AEFC 3VR9D 3AEAC 3AE5D 3AE9D 1QLBC 1NEKC 2BS2C 3AEBC 3AE5C 1YQ4C 2WDQC 3AE9C 2H88C 3AE3D 2H89D 3AE8C 3P4PD 3ABVD 3AE2C 2WDVD 2WU5D 2BS3C 3P4PC 3AEFD 4YTNC 2WDRC 2WU5C 1NEKD 2ACZC 3AEBD 1NENC 2WQYD 3VRAC 1YQ4D 2WDQD 4YSZC 3SFDC 2H88D 2WQYC 3AE8D 3VRBC 3AE2D 3AEEC 3AECC 3AE6C 2WU2C 3AE4C 4YTND 1E7PC 4YSYD 1YQ3C 2WDRD 4YXDC 2B76C 1KFYD 1KF6D 4YSYC 2ACZD 1NEND 2WP9C 3VRAD 3P4SC 4YSZD 1KFYC 1KF6C 1L0VC 3SFDD 3VRBD 5C3JC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C2T C;  3AEE D;  3SFE C;  3AEC D;  3AE6 D;  2WU2 D;  3AE4 D;  2WS3 C;  1YQ3 D;  3CIR D;  2B76 D;  4YXD D;  3AED C;  4YT0 C;  2WP9 D;  3CIR C;  3AE7 C;  3VR8 D;  1ZP0 C;  4YSX D;  3AEG C;  3P4S D;  1L0V D;  1ZOY C;  5C3J D;  3VR8 C;  5C2T D;  4KX6 D;  4YSX C;  3AE1 C;  3SFE D;  3VR9 C;  4KX6 C;  2WS3 D;  4YTP D;  3AED D;  4YT0 D;  2FBW D;  3P4R D;  2BS4 C;  3AE7 D;  4YTM D;  3AE3 C;  1ZP0 D;  2H89 C;  4YTP C;  3P4Q D;  2FBW C;  3AEG D;  3ABV C;  3P4R C;  3AEA D;  1ZOY D;  2WDV C;  4YTM C;  3P4Q C;  3AE1 D;  3AEF C;  3VR9 D;  3AEA C;  3AE5 D;  3AE9 D;  1QLB C;  1NEK C;  2BS2 C;  3AEB C;  3AE5 C;  1YQ4 C;  2WDQ C;  3AE9 C;  2H88 C;  3AE3 D;  2H89 D;  3AE8 C;  3P4P D;  3ABV D;  3AE2 C;  2WDV D;  2WU5 D;  2BS3 C;  3P4P C;  3AEF D;  4YTN C;  2WDR C;  2WU5 C;  1NEK D;  2ACZ C;  3AEB D;  1NEN C;  2WQY D;  3VRA C;  1YQ4 D;  2WDQ D;  4YSZ C;  3SFD C;  2H88 D;  2WQY C;  3AE8 D;  3VRB C;  3AE2 D;  3AEE C;  3AEC C;  3AE6 C;  2WU2 C;  3AE4 C;  4YTN D;  1E7P C;  4YSY D;  1YQ3 C;  2WDR D;  4YXD C;  2B76 C;  1KFY D;  1KF6 D;  4YSY C;  2ACZ D;  1NEN D;  2WP9 C;  3VRA D;  3P4S C;  4YSZ D;  1KFY C;  1KF6 C;  1L0V C;  3SFD D;  3VRB D;  5C3J C; 
#chains in the Genus database with same CATH topology
 5C2T C;  3AEE D;  3SFE C;  3AEC D;  3AE6 D;  2WU2 D;  3AE4 D;  2WS3 C;  1YQ3 D;  3CIR D;  2B76 D;  4YXD D;  3AED C;  4YT0 C;  2WP9 D;  3CIR C;  3AE7 C;  3VR8 D;  1ZP0 C;  4FJV A;  4YSX D;  4LDT A;  3AEG C;  3P4S D;  1L0V D;  1ZOY C;  5C3J D;  3VR8 C;  5C2T D;  4KX6 D;  4YSX C;  3AE1 C;  3SFE D;  3VR9 C;  4KX6 C;  2WS3 D;  4YTP D;  3AED D;  4YT0 D;  2FBW D;  3P4R D;  2BS4 C;  3AE7 D;  4YTM D;  3AE3 C;  1ZP0 D;  2H89 C;  4YTP C;  3P4Q D;  2FBW C;  3AEG D;  3ABV C;  3P4R C;  3AEA D;  4DDI A;  1ZOY D;  2WDV C;  4YTM C;  3P4Q C;  3AE1 D;  3AEF C;  3VR9 D;  3AEA C;  3AE5 D;  3AE9 D;  1QLB C;  1NEK C;  2BS2 C;  3AEB C;  3AE5 C;  1YQ4 C;  3VON A;  2WDQ C;  3AE9 C;  1TFF A;  2ZFY A;  2H88 C;  3AE3 D;  2H89 D;  3AE8 C;  3P4P D;  3ABV D;  3AE2 C;  2WDV D;  2WU5 D;  2BS3 C;  3P4P C;  3AEF D;  4YTN C;  4DHJ A;  2WDR C;  2WU5 C;  4DHI B;  1NEK D;  2ACZ C;  3AEB D;  1NEN C;  2WQY D;  3VRA C;  1YQ4 D;  2WDQ D;  4YSZ C;  3SFD C;  2H88 D;  2WQY C;  3AE8 D;  3VRB C;  3AE2 D;  3AEE C;  4DDG A;  3AEC C;  3AE6 C;  2WU2 C;  3AE4 C;  4YTN D;  1E7P C;  4YSY D;  1YQ3 C;  2WDR D;  4YXD C;  2B76 C;  4DHZ A;  1KFY D;  1KF6 D;  4YSY C;  2ACZ D;  1NEN D;  2WP9 C;  3VRA D;  3P4S C;  4YSZ D;  1KFY C;  1KF6 C;  1L0V C;  3SFD D;  4I6L A;  3VRB D;  5C3J C; 
#chains in the Genus database with same CATH homology
 5C2T C;  3AEE D;  3SFE C;  3AEC D;  3AE6 D;  2WU2 D;  3AE4 D;  2WS3 C;  1YQ3 D;  3CIR D;  2B76 D;  4YXD D;  3AED C;  4YT0 C;  2WP9 D;  3CIR C;  3AE7 C;  3VR8 D;  1ZP0 C;  4YSX D;  3AEG C;  3P4S D;  1L0V D;  1ZOY C;  5C3J D;  3VR8 C;  5C2T D;  4KX6 D;  4YSX C;  3AE1 C;  3SFE D;  3VR9 C;  4KX6 C;  2WS3 D;  4YTP D;  3AED D;  4YT0 D;  2FBW D;  3P4R D;  2BS4 C;  3AE7 D;  4YTM D;  3AE3 C;  1ZP0 D;  2H89 C;  4YTP C;  3P4Q D;  2FBW C;  3AEG D;  3ABV C;  3P4R C;  3AEA D;  1ZOY D;  2WDV C;  4YTM C;  3P4Q C;  3AE1 D;  3AEF C;  3VR9 D;  3AEA C;  3AE5 D;  3AE9 D;  1QLB C;  1NEK C;  2BS2 C;  3AEB C;  3AE5 C;  1YQ4 C;  2WDQ C;  3AE9 C;  2H88 C;  3AE3 D;  2H89 D;  3AE8 C;  3P4P D;  3ABV D;  3AE2 C;  2WDV D;  2WU5 D;  2BS3 C;  3P4P C;  3AEF D;  4YTN C;  2WDR C;  2WU5 C;  1NEK D;  2ACZ C;  3AEB D;  1NEN C;  2WQY D;  3VRA C;  1YQ4 D;  2WDQ D;  4YSZ C;  3SFD C;  2H88 D;  2WQY C;  3AE8 D;  3VRB C;  3AE2 D;  3AEE C;  3AEC C;  3AE6 C;  2WU2 C;  3AE4 C;  4YTN D;  1E7P C;  4YSY D;  1YQ3 C;  2WDR D;  4YXD C;  2B76 C;  1KFY D;  1KF6 D;  4YSY C;  2ACZ D;  1NEN D;  2WP9 C;  3VRA D;  3P4S C;  4YSZ D;  1KFY C;  1KF6 C;  1L0V C;  3SFD D;  3VRB D;  5C3J C; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...