4YSXD

Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with the specific inhibitor nn23
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
129
structure length
129
Chain Sequence
TSAAVTGAAPPQFDPIAAEKGFKPLHSHGTLFKIERYFAAAMVPLIPAAYFIHGREMDLCLALALTLHVHWGVWGVVNDYGRPFVLGDTLAAAVRVGAYIFTACLLAGLLYFNEHDVGLTRAFEMVWEL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Succinate dehydrogenase flavoprotein
total genus 40
structure length 129
sequence length 129
chains with identical sequence H
ec nomenclature
pdb deposition date 2015-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF05328 CybS CybS, succinate dehydrogenase cytochrome B small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunit 4ysxD00
1YQ4C 3ABVC 3SFDC 1NEND 3AE4C 1KFYD 1NENC 2WS3C 2WDRC 3AE1D 1NEKD 3AE1C 3AE6D 3AE6C 4KX6C 4YSXD 3AEFC 3AECC 3CIRC 3VR8C 3AE3D 2B76D 2H89D 3AEGD 1KF6D 4YTMD 1KF6C 4YSZD 4YSZC 3AEBD 3VR9C 3P4QC 2WP9D 2WP9C 3SFED 4YTPD 4YTPC 3P4PD 1KFYC 3VRBD 1E7PC 1NEKC 2WQYD 4YSXC 2H88D 3AEED 4YTND 3AE3C 2ACZD 2B76C 2ACZC 2WDQD 2WU5D 4YXDD 4YXDC 3AE8D 2H89C 3AE7D 3AEGC 3AE7C 4YTMC 3AE9D 3AEBC 3AE2D 3AE2C 3SFEC 2BS3C 3P4RD 4YSYD 3P4PC 1L0VD 3VRBC 1QLBC 1YQ3D 3P4SD 3VRAD 3AEDD 2FBWD 2WQYC 2H88C 3AEEC 2BS2C 1ZP0D 4YT0D 2WDVD 2WU2D 3AE5D 2WU2C 2WU5C 2WDQC 3AE5C 4YT0C 4YTNC 5C3JD 3AE8C 3AE9C 1YQ4D 3ABVD 3SFDD 3AE4D 2WS3D 3P4RC 4YSYC 2BS4C 2WDRD 4KX6D 5C2TD 5C2TC 1L0VC 3AEFD 3AECD 3CIRD 3VR8D 1YQ3C 3P4SC 3VRAC 3AEDC 2FBWC 1ZOYD 1ZOYC 1ZP0C 2WDVC 3AEAD 3P4QD 3AEAC 3VR9D 5C3JC
chains in the Genus database with same CATH superfamily
1YQ4C 3ABVC 3SFDC 1NEND 3AE4C 1KFYD 1NENC 2WS3C 4DHZA 2WDRC 3AE1D 1NEKD 3AE1C 3AE6D 3AE6C 4KX6C 4YSXD 3AEFC 3AECC 3CIRC 3VR8C 3AE3D 2B76D 3VONA 2H89D 3AEGD 1KF6D 4YTMD 1KF6C 4YSZD 4YSZC 3AEBD 3VR9C 3P4QC 2WP9D 2WP9C 3SFED 4YTPD 4DDIA 4YTPC 3P4PD 4I6LA 1KFYC 3VRBD 1E7PC 1NEKC 2WQYD 4YSXC 2H88D 3AEED 2ZFYA 4YTND 3AE3C 2ACZD 2B76C 2ACZC 2WDQD 2WU5D 4YXDD 4YXDC 3AE8D 2H89C 3AE7D 3AEGC 3AE7C 4YTMC 4DHIB 3AE9D 3AEBC 3AE2D 3AE2C 3SFEC 2BS3C 3P4RD 4YSYD 3P4PC 1L0VD 3VRBC 1QLBC 1YQ3D 3P4SD 3VRAD 3AEDD 2FBWD 2WQYC 2H88C 3AEEC 2BS2C 4LDTA 4DDGA 1ZP0D 4YT0D 2WDVD 2WU2D 3AE5D 2WU2C 2WU5C 2WDQC 3AE5C 4YT0C 4YTNC 5C3JD 3AE8C 4FJVA 3AE9C 1YQ4D 3ABVD 3SFDD 3AE4D 2WS3D 3P4RC 4YSYC 2BS4C 2WDRD 4KX6D 5C2TD 5C2TC 1L0VC 3AEFD 3AECD 3CIRD 3VR8D 1TFFA 1YQ3C 3P4SC 3VRAC 3AEDC 2FBWC 1ZOYD 1ZOYC 1ZP0C 2WDVC 3AEAD 3P4QD 3AEAC 3VR9D 4DHJA 5C3JC
chains in the Genus database with same CATH topology
1YQ4C 3ABVC 3SFDC 1NEND 3AE4C 1KFYD 1NENC 2WS3C 2WDRC 3AE1D 1NEKD 3AE1C 3AE6D 3AE6C 4KX6C 4YSXD 3AEFC 3AECC 3CIRC 3VR8C 3AE3D 2B76D 2H89D 3AEGD 1KF6D 4YTMD 1KF6C 4YSZD 4YSZC 3AEBD 3VR9C 3P4QC 2WP9D 2WP9C 3SFED 4YTPD 4YTPC 3P4PD 1KFYC 3VRBD 1E7PC 1NEKC 2WQYD 4YSXC 2H88D 3AEED 4YTND 3AE3C 2ACZD 2B76C 2ACZC 2WDQD 2WU5D 4YXDD 4YXDC 3AE8D 2H89C 3AE7D 3AEGC 3AE7C 4YTMC 3AE9D 3AEBC 3AE2D 3AE2C 3SFEC 2BS3C 3P4RD 4YSYD 3P4PC 1L0VD 3VRBC 1QLBC 1YQ3D 3P4SD 3VRAD 3AEDD 2FBWD 2WQYC 2H88C 3AEEC 2BS2C 1ZP0D 4YT0D 2WDVD 2WU2D 3AE5D 2WU2C 2WU5C 2WDQC 3AE5C 4YT0C 4YTNC 5C3JD 3AE8C 3AE9C 1YQ4D 3ABVD 3SFDD 3AE4D 2WS3D 3P4RC 4YSYC 2BS4C 2WDRD 4KX6D 5C2TD 5C2TC 1L0VC 3AEFD 3AECD 3CIRD 3VR8D 1YQ3C 3P4SC 3VRAC 3AEDC 2FBWC 1ZOYD 1ZOYC 1ZP0C 2WDVC 3AEAD 3P4QD 3AEAC 3VR9D 5C3JC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YQ4 C;  3ABV C;  3SFD C;  1NEN D;  3AE4 C;  1KFY D;  1NEN C;  2WS3 C;  2WDR C;  3AE1 D;  1NEK D;  3AE1 C;  3AE6 D;  3AE6 C;  4KX6 C;  4YSX D;  3AEF C;  3AEC C;  3CIR C;  3VR8 C;  3AE3 D;  2B76 D;  2H89 D;  3AEG D;  1KF6 D;  4YTM D;  1KF6 C;  4YSZ D;  4YSZ C;  3AEB D;  3VR9 C;  3P4Q C;  2WP9 D;  2WP9 C;  3SFE D;  4YTP D;  4YTP C;  3P4P D;  1KFY C;  3VRB D;  1E7P C;  1NEK C;  2WQY D;  4YSX C;  2H88 D;  3AEE D;  4YTN D;  3AE3 C;  2ACZ D;  2B76 C;  2ACZ C;  2WDQ D;  2WU5 D;  4YXD D;  4YXD C;  3AE8 D;  2H89 C;  3AE7 D;  3AEG C;  3AE7 C;  4YTM C;  3AE9 D;  3AEB C;  3AE2 D;  3AE2 C;  3SFE C;  2BS3 C;  3P4R D;  4YSY D;  3P4P C;  1L0V D;  3VRB C;  1QLB C;  1YQ3 D;  3P4S D;  3VRA D;  3AED D;  2FBW D;  2WQY C;  2H88 C;  3AEE C;  2BS2 C;  1ZP0 D;  4YT0 D;  2WDV D;  2WU2 D;  3AE5 D;  2WU2 C;  2WU5 C;  2WDQ C;  3AE5 C;  4YT0 C;  4YTN C;  5C3J D;  3AE8 C;  3AE9 C;  1YQ4 D;  3ABV D;  3SFD D;  3AE4 D;  2WS3 D;  3P4R C;  4YSY C;  2BS4 C;  2WDR D;  4KX6 D;  5C2T D;  5C2T C;  1L0V C;  3AEF D;  3AEC D;  3CIR D;  3VR8 D;  1YQ3 C;  3P4S C;  3VRA C;  3AED C;  2FBW C;  1ZOY D;  1ZOY C;  1ZP0 C;  2WDV C;  3AEA D;  3P4Q D;  3AEA C;  3VR9 D;  5C3J C; 
#chains in the Genus database with same CATH topology
 1YQ4 C;  3ABV C;  3SFD C;  1NEN D;  3AE4 C;  1KFY D;  1NEN C;  2WS3 C;  4DHZ A;  2WDR C;  3AE1 D;  1NEK D;  3AE1 C;  3AE6 D;  3AE6 C;  4KX6 C;  4YSX D;  3AEF C;  3AEC C;  3CIR C;  3VR8 C;  3AE3 D;  2B76 D;  3VON A;  2H89 D;  3AEG D;  1KF6 D;  4YTM D;  1KF6 C;  4YSZ D;  4YSZ C;  3AEB D;  3VR9 C;  3P4Q C;  2WP9 D;  2WP9 C;  3SFE D;  4YTP D;  4DDI A;  4YTP C;  3P4P D;  4I6L A;  1KFY C;  3VRB D;  1E7P C;  1NEK C;  2WQY D;  4YSX C;  2H88 D;  3AEE D;  2ZFY A;  4YTN D;  3AE3 C;  2ACZ D;  2B76 C;  2ACZ C;  2WDQ D;  2WU5 D;  4YXD D;  4YXD C;  3AE8 D;  2H89 C;  3AE7 D;  3AEG C;  3AE7 C;  4YTM C;  4DHI B;  3AE9 D;  3AEB C;  3AE2 D;  3AE2 C;  3SFE C;  2BS3 C;  3P4R D;  4YSY D;  3P4P C;  1L0V D;  3VRB C;  1QLB C;  1YQ3 D;  3P4S D;  3VRA D;  3AED D;  2FBW D;  2WQY C;  2H88 C;  3AEE C;  2BS2 C;  4LDT A;  4DDG A;  1ZP0 D;  4YT0 D;  2WDV D;  2WU2 D;  3AE5 D;  2WU2 C;  2WU5 C;  2WDQ C;  3AE5 C;  4YT0 C;  4YTN C;  5C3J D;  3AE8 C;  4FJV A;  3AE9 C;  1YQ4 D;  3ABV D;  3SFD D;  3AE4 D;  2WS3 D;  3P4R C;  4YSY C;  2BS4 C;  2WDR D;  4KX6 D;  5C2T D;  5C2T C;  1L0V C;  3AEF D;  3AEC D;  3CIR D;  3VR8 D;  1TFF A;  1YQ3 C;  3P4S C;  3VRA C;  3AED C;  2FBW C;  1ZOY D;  1ZOY C;  1ZP0 C;  2WDV C;  3AEA D;  3P4Q D;  3AEA C;  3VR9 D;  4DHJ A;  5C3J C; 
#chains in the Genus database with same CATH homology
 1YQ4 C;  3ABV C;  3SFD C;  1NEN D;  3AE4 C;  1KFY D;  1NEN C;  2WS3 C;  2WDR C;  3AE1 D;  1NEK D;  3AE1 C;  3AE6 D;  3AE6 C;  4KX6 C;  4YSX D;  3AEF C;  3AEC C;  3CIR C;  3VR8 C;  3AE3 D;  2B76 D;  2H89 D;  3AEG D;  1KF6 D;  4YTM D;  1KF6 C;  4YSZ D;  4YSZ C;  3AEB D;  3VR9 C;  3P4Q C;  2WP9 D;  2WP9 C;  3SFE D;  4YTP D;  4YTP C;  3P4P D;  1KFY C;  3VRB D;  1E7P C;  1NEK C;  2WQY D;  4YSX C;  2H88 D;  3AEE D;  4YTN D;  3AE3 C;  2ACZ D;  2B76 C;  2ACZ C;  2WDQ D;  2WU5 D;  4YXD D;  4YXD C;  3AE8 D;  2H89 C;  3AE7 D;  3AEG C;  3AE7 C;  4YTM C;  3AE9 D;  3AEB C;  3AE2 D;  3AE2 C;  3SFE C;  2BS3 C;  3P4R D;  4YSY D;  3P4P C;  1L0V D;  3VRB C;  1QLB C;  1YQ3 D;  3P4S D;  3VRA D;  3AED D;  2FBW D;  2WQY C;  2H88 C;  3AEE C;  2BS2 C;  1ZP0 D;  4YT0 D;  2WDV D;  2WU2 D;  3AE5 D;  2WU2 C;  2WU5 C;  2WDQ C;  3AE5 C;  4YT0 C;  4YTN C;  5C3J D;  3AE8 C;  3AE9 C;  1YQ4 D;  3ABV D;  3SFD D;  3AE4 D;  2WS3 D;  3P4R C;  4YSY C;  2BS4 C;  2WDR D;  4KX6 D;  5C2T D;  5C2T C;  1L0V C;  3AEF D;  3AEC D;  3CIR D;  3VR8 D;  1YQ3 C;  3P4S C;  3VRA C;  3AED C;  2FBW C;  1ZOY D;  1ZOY C;  1ZP0 C;  2WDV C;  3AEA D;  3P4Q D;  3AEA C;  3VR9 D;  5C3J C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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