4ZH1D

Complement factor h in complex with the gm1 glycan
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
126
structure length
126
Chain Sequence
FGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement C3
total genus 23
structure length 126
sequence length 126
chains with identical sequence E, F
ec nomenclature
pdb deposition date 2015-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4zh1D01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4zh1D02
1GPZA 1CKLA 4AYIA 4B2RA 1OK3A 3T5OA 3SW0X 1Z92B 3OXUD 4K12A 1SS2A 3GXEA 2RLPA 1H04P 4AYEA 1H03P 4B2SA 1GKGA 5HYTB 3IX0A 2WIIC 3KZJA 1GHQB 1O9AA 5HYUB 4KKDA 1QO6A 4DJZA 2IZ3A 2XWJI 4LOSA 4ZH1D 2RKZA 3TVJA 2QY0A 3OEDC 2A55A 1E88A 2KMSA 1VVCA 2ERJA 2EHFA 1H2PP 1HCCA 1ELVA 4ONTD 2XRDA 1OK2A 2UWNA 2XQWC 3IU3I 2W81A 1TPNA 1NWVA 3ZRZA 1E5GA 2XRBA 1G4FA 1TPGA 1PPQA 2G7IA 1E8BA 4AYMA 2CG7A 1FBRA 4CSYA 1G4GA 1H2QP 4LOTA 3O8EB 1MD7A 1MD8A 1U5MA 2CG6A 2YRAA 1UOTP 4J38B 2XWBF 5HYPA 3EJHA 4IGDA 2LOJA 3NFPI 3ZD2A 4A5WB 4C16A 3ZD1A 1OJYA 3CALA 2KRIA 1LY2A 4YNXA 1OK1A 2CKUA 1QUBA 5HZPB 2V8EA 4FXGG 5JPMG 1HFHA 2MCZA 1OK9A 2IZ4A 3INBC 1SRZA 2BZMA 4WJG2 3R62A 2EC3A 2RL0A 1GKNA 2JGXA 3M7PA 4PZ5A 1VVDA 2MCYA 2RLQA 3KXVA 4F4OC 5FO8C 1ZJKA 3GOVA 1OJVA 1QGBA 1TPMA 1OJWA 3MQLA 3RJ3D 2JGWA 2YBYA 3ERBA 3L89M 2JRAA 1HFIA 3OP8A 1C1ZA 4AYDA 4MUCA 2B5ID 2W80A 1Q3XA 2O39C 4JHSA 2RKYA 5I0QB
chains in the Genus database with same CATH superfamily
1GPZA 1CKLA 4AYIA 4B2RA 1OK3A 3T5OA 2X2ZA 3SW0X 1Z92B 3OXUD 4K12A 1SS2A 3GXEA 2RLPA 1H04P 3F6KA 4AYEA 3CI0J 1H03P 4B2SA 1GKGA 5HYTB 3IX0A 2WIIC 3KZJA 1GHQB 1O9AA 4MSLA 2ZYCA 5DN4A 5HYUB 4KKDA 1QO6A 4DJZA 2IZ3A 2XWJI 1RLHA 4LOSA 4ZH1D 4N7EA 2RKZA 3WSXA 3TVJA 2QY0A 3OEDC 2A55A 1E88A 2KMSA 1VVCA 2ERJA 2EHFA 1H2PP 1HCCA 1ELVA 4ONTD 2XRDA 1OK2A 2UWNA 2XQWC 3IU3I 3ZLDA 2W81A 1TPNA 1NWVA 3FGRA 3ZRZA 1E5GA 2XRBA 1G4FA 1TPGA 1PPQA 2G7IA 1E8BA 4AYMA 2CG7A 1FBRA 4CSYA 1G4GA 1H2QP 4LOTA 3O8EB 1MD7A 1MD8A 1U5MA 2CG6A 2YRAA 1UOTP 4J38B 2XWBF 5HYPA 3EJHA 3FGTA 4IGDA 2LOJA 3NFPI 3ZD2A 4A5WB 4C16A 3ZD1A 2Y8SA 1OJYA 3CALA 2KRIA 2Y8RA 1LY2A 4YNXA 1OK1A 2CKUA 1QUBA 5HZPB 2V8EA 4YIZA 4FXGG 5JPMG 1HFHA 2MCZA 1OK9A 2IZ4A 3K3TA 3INBC 1SRZA 2BZMA 4WJG2 3R62A 2EC3A 4BWCA 2RL0A 1GKNA 2JGXA 3M7PA 4PZ5A 3NJAA 1VVDA 2MCYA 2RLQA 2Y8TA 3KXVA 5FO8C 4F4OC 1ZJKA 3ZLEA 3GOVA 1OJVA 1QGBA 1TPMA 1OJWA 3MQLA 3VWOA 3RJ3D 2JGWA 2YBYA 3ERBA 3L89M 2JRAA 1HFIA 3OP8A 1C1ZA 2I2LA 3WSYA 5DN5A 4AYDA 4MUCA 2B5ID 2W80A 4PO7A 1Q3XA 2O39C 4APLA 4JHSA 2RKYA 5I0QB
chains in the Genus database with same CATH topology
1GPZA 1CKLA 4AYIA 4B2RA 1OK3A 3T5OA 3SW0X 1Z92B 3OXUD 4K12A 1SS2A 3GXEA 2RLPA 1H04P 4AYEA 1H03P 4B2SA 1GKGA 5HYTB 3IX0A 2WIIC 3KZJA 1GHQB 1O9AA 5HYUB 4KKDA 1QO6A 4DJZA 2IZ3A 2XWJI 4LOSA 4ZH1D 2RKZA 3TVJA 2QY0A 3OEDC 2A55A 1E88A 2KMSA 1VVCA 2ERJA 2EHFA 1H2PP 1HCCA 1ELVA 4ONTD 2XRDA 1OK2A 2UWNA 2XQWC 3IU3I 2W81A 1TPNA 1NWVA 3ZRZA 1E5GA 2XRBA 1G4FA 1TPGA 1PPQA 2G7IA 1E8BA 4AYMA 2CG7A 1FBRA 4CSYA 1G4GA 1H2QP 4LOTA 3O8EB 1MD7A 1MD8A 1U5MA 2CG6A 2YRAA 1UOTP 4J38B 2XWBF 5HYPA 3EJHA 4IGDA 2LOJA 3NFPI 3ZD2A 4A5WB 4C16A 3ZD1A 1OJYA 3CALA 2KRIA 1LY2A 4YNXA 1OK1A 2CKUA 1QUBA 5HZPB 2V8EA 4FXGG 5JPMG 1HFHA 2MCZA 1OK9A 2IZ4A 3INBC 1SRZA 2BZMA 4WJG2 3R62A 2EC3A 2RL0A 1GKNA 2JGXA 3M7PA 4PZ5A 1VVDA 2MCYA 2RLQA 3KXVA 4F4OC 5FO8C 1ZJKA 3GOVA 1OJVA 1QGBA 1TPMA 1OJWA 3MQLA 3RJ3D 2JGWA 2YBYA 3ERBA 3L89M 2JRAA 1HFIA 3OP8A 1C1ZA 4AYDA 4MUCA 2B5ID 2W80A 1Q3XA 2O39C 4JHSA 2RKYA 5I0QB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GPZ A;  1CKL A;  4AYI A;  4B2R A;  1OK3 A;  3T5O A;  3SW0 X;  1Z92 B;  3OXU D;  4K12 A;  1SS2 A;  3GXE A;  2RLP A;  1H04 P;  4AYE A;  1H03 P;  4B2S A;  1GKG A;  5HYT B;  3IX0 A;  2WII C;  3KZJ A;  1GHQ B;  1O9A A;  5HYU B;  4KKD A;  1QO6 A;  4DJZ A;  2IZ3 A;  2XWJ I;  4LOS A;  4ZH1 D;  2RKZ A;  3TVJ A;  2QY0 A;  3OED C;  2A55 A;  1E88 A;  2KMS A;  1VVC A;  2ERJ A;  2EHF A;  1H2P P;  1HCC A;  1ELV A;  4ONT D;  2XRD A;  1OK2 A;  2UWN A;  2XQW C;  3IU3 I;  2W81 A;  1TPN A;  1NWV A;  3ZRZ A;  1E5G A;  2XRB A;  1G4F A;  1TPG A;  1PPQ A;  2G7I A;  1E8B A;  4AYM A;  2CG7 A;  1FBR A;  4CSY A;  1G4G A;  1H2Q P;  4LOT A;  3O8E B;  1MD7 A;  1MD8 A;  1U5M A;  2CG6 A;  2YRA A;  1UOT P;  4J38 B;  2XWB F;  5HYP A;  3EJH A;  4IGD A;  2LOJ A;  3NFP I;  3ZD2 A;  4A5W B;  4C16 A;  3ZD1 A;  1OJY A;  3CAL A;  2KRI A;  1LY2 A;  4YNX A;  1OK1 A;  2CKU A;  1QUB A;  5HZP B;  2V8E A;  4FXG G;  5JPM G;  1HFH A;  2MCZ A;  1OK9 A;  2IZ4 A;  3INB C;  1SRZ A;  2BZM A;  4WJG 2;  3R62 A;  2EC3 A;  2RL0 A;  1GKN A;  2JGX A;  3M7P A;  4PZ5 A;  1VVD A;  2MCY A;  2RLQ A;  3KXV A;  4F4O C;  5FO8 C;  1ZJK A;  3GOV A;  1OJV A;  1QGB A;  1TPM A;  1OJW A;  3MQL A;  3RJ3 D;  2JGW A;  2YBY A;  3ERB A;  3L89 M;  2JRA A;  1HFI A;  3OP8 A;  1C1Z A;  4AYD A;  4MUC A;  2B5I D;  2W80 A;  1Q3X A;  2O39 C;  4JHS A;  2RKY A;  5I0Q B; 
#chains in the Genus database with same CATH topology
 1GPZ A;  1CKL A;  4AYI A;  4B2R A;  1OK3 A;  3T5O A;  2X2Z A;  3SW0 X;  1Z92 B;  3OXU D;  4K12 A;  1SS2 A;  3GXE A;  2RLP A;  1H04 P;  3F6K A;  4AYE A;  3CI0 J;  1H03 P;  4B2S A;  1GKG A;  5HYT B;  3IX0 A;  2WII C;  3KZJ A;  1GHQ B;  1O9A A;  4MSL A;  2ZYC A;  5DN4 A;  5HYU B;  4KKD A;  1QO6 A;  4DJZ A;  2IZ3 A;  2XWJ I;  1RLH A;  4LOS A;  4ZH1 D;  4N7E A;  2RKZ A;  3WSX A;  3TVJ A;  2QY0 A;  3OED C;  2A55 A;  1E88 A;  2KMS A;  1VVC A;  2ERJ A;  2EHF A;  1H2P P;  1HCC A;  1ELV A;  4ONT D;  2XRD A;  1OK2 A;  2UWN A;  2XQW C;  3IU3 I;  3ZLD A;  2W81 A;  1TPN A;  1NWV A;  3FGR A;  3ZRZ A;  1E5G A;  2XRB A;  1G4F A;  1TPG A;  1PPQ A;  2G7I A;  1E8B A;  4AYM A;  2CG7 A;  1FBR A;  4CSY A;  1G4G A;  1H2Q P;  4LOT A;  3O8E B;  1MD7 A;  1MD8 A;  1U5M A;  2CG6 A;  2YRA A;  1UOT P;  4J38 B;  2XWB F;  5HYP A;  3EJH A;  3FGT A;  4IGD A;  2LOJ A;  3NFP I;  3ZD2 A;  4A5W B;  4C16 A;  3ZD1 A;  2Y8S A;  1OJY A;  3CAL A;  2KRI A;  2Y8R A;  1LY2 A;  4YNX A;  1OK1 A;  2CKU A;  1QUB A;  5HZP B;  2V8E A;  4YIZ A;  4FXG G;  5JPM G;  1HFH A;  2MCZ A;  1OK9 A;  2IZ4 A;  3K3T A;  3INB C;  1SRZ A;  2BZM A;  4WJG 2;  3R62 A;  2EC3 A;  4BWC A;  2RL0 A;  1GKN A;  2JGX A;  3M7P A;  4PZ5 A;  3NJA A;  1VVD A;  2MCY A;  2RLQ A;  2Y8T A;  3KXV A;  5FO8 C;  4F4O C;  1ZJK A;  3ZLE A;  3GOV A;  1OJV A;  1QGB A;  1TPM A;  1OJW A;  3MQL A;  3VWO A;  3RJ3 D;  2JGW A;  2YBY A;  3ERB A;  3L89 M;  2JRA A;  1HFI A;  3OP8 A;  1C1Z A;  2I2L A;  3WSY A;  5DN5 A;  4AYD A;  4MUC A;  2B5I D;  2W80 A;  4PO7 A;  1Q3X A;  2O39 C;  4APL A;  4JHS A;  2RKY A;  5I0Q B; 
#chains in the Genus database with same CATH homology
 1GPZ A;  1CKL A;  4AYI A;  4B2R A;  1OK3 A;  3T5O A;  3SW0 X;  1Z92 B;  3OXU D;  4K12 A;  1SS2 A;  3GXE A;  2RLP A;  1H04 P;  4AYE A;  1H03 P;  4B2S A;  1GKG A;  5HYT B;  3IX0 A;  2WII C;  3KZJ A;  1GHQ B;  1O9A A;  5HYU B;  4KKD A;  1QO6 A;  4DJZ A;  2IZ3 A;  2XWJ I;  4LOS A;  4ZH1 D;  2RKZ A;  3TVJ A;  2QY0 A;  3OED C;  2A55 A;  1E88 A;  2KMS A;  1VVC A;  2ERJ A;  2EHF A;  1H2P P;  1HCC A;  1ELV A;  4ONT D;  2XRD A;  1OK2 A;  2UWN A;  2XQW C;  3IU3 I;  2W81 A;  1TPN A;  1NWV A;  3ZRZ A;  1E5G A;  2XRB A;  1G4F A;  1TPG A;  1PPQ A;  2G7I A;  1E8B A;  4AYM A;  2CG7 A;  1FBR A;  4CSY A;  1G4G A;  1H2Q P;  4LOT A;  3O8E B;  1MD7 A;  1MD8 A;  1U5M A;  2CG6 A;  2YRA A;  1UOT P;  4J38 B;  2XWB F;  5HYP A;  3EJH A;  4IGD A;  2LOJ A;  3NFP I;  3ZD2 A;  4A5W B;  4C16 A;  3ZD1 A;  1OJY A;  3CAL A;  2KRI A;  1LY2 A;  4YNX A;  1OK1 A;  2CKU A;  1QUB A;  5HZP B;  2V8E A;  4FXG G;  5JPM G;  1HFH A;  2MCZ A;  1OK9 A;  2IZ4 A;  3INB C;  1SRZ A;  2BZM A;  4WJG 2;  3R62 A;  2EC3 A;  2RL0 A;  1GKN A;  2JGX A;  3M7P A;  4PZ5 A;  1VVD A;  2MCY A;  2RLQ A;  3KXV A;  4F4O C;  5FO8 C;  1ZJK A;  3GOV A;  1OJV A;  1QGB A;  1TPM A;  1OJW A;  3MQL A;  3RJ3 D;  2JGW A;  2YBY A;  3ERB A;  3L89 M;  2JRA A;  1HFI A;  3OP8 A;  1C1Z A;  4AYD A;  4MUC A;  2B5I D;  2W80 A;  1Q3X A;  2O39 C;  4JHS A;  2RKY A;  5I0Q B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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