4ZRUA

X-ray crystal structure of lymnaea stagnalis acetylcholine binding protein (ls-achbp) in complex with 3-[2-[(2s)-pyrrolidin-2-yl]ethynyl]pyridine (ti-5180)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
212
structure length
211
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs, and Structural Features of a High-Affinity, Non-selective NNR Ligand-AChBP Co-crystal Structure
rcsb
molecule tags Acetylcholine binding protein
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 49
structure length 211
sequence length 212
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2015-05-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4zruA00
5L47A 5SYOA 4AFTA 3PMZA 3TLSA 4TWHA 4ZZBA 1I9BA 3LSVA 4ZJTA 4IREA 2PH9A 3JAEA 2XQ9A 4IL9A 5HEUA 4IL4A 5AFNA 3WTIA 2XNUA 3RQWA 4Z91A 2BYQA 5AFJA 3U8NA 3EI0A 3JAFA 4QH1A 3ZDHA 4QACA 5HEGA 4X5TA 2BYSA 5J5IA 3TLWA 4AFHA 2XQ7A 2BR7A 5J5HA 5J0ZA 4UY2A 3P4WA 4HFBA 2BG9C 3U8JA 3SIOA 2BYPA 2WN9A 4PIRA 3RHWA 3TLVA 4Z90A 5AFKA 5AFMA 2XQ8A 1UV6A 2QC1B 3U8LA 2XNTA 4UM1A 4LMLA 3UU5A 5L4EA 3EAMA 1UW6A 2YMEA 4TNVA 2XQ5A 4WV9A 3SQ9A 5BP0A 3JADA 2XYTA 3C84A 4TWFA 2Y7YA 4TWDA 3RIFA 4D01A 2BYNA 4HFHA 3U8MA 3WTMA 4F8HA 3WTOA 4UXUA 2BJ0A 2WNJA 4COFA 4QH4A 2XZ5A 3WTNA 2YMDA 3P50A 5AFMB 5LXBA 3TLTA 4UM3A 2YOEA 4UM3P 5LG3A 4FRRA 2BG9E 4A98A 3EHZA 5TVCA 3GUAA 3UU4A 4NZBA 2BR8A 2WZYA 5HEHA 2WNCA 2XQ4A 5FJVA 3T4MA 3U8KA 3C79A 2UZ6A 2ZJVA 2VL0A 5CFBA 4QAAA 2W8FA 4TNWA 3UU6A 5BW2A 4ZJSA 2PGZA 2XYSA 2X00D 5HEOA 2BYRA 5CO5A 4ILBA 2Y56A 4ALXA 4HFEA 4LMJA 4QABA 4EZ1A 2Y58A 3UQ7A 2C9TA 5L4HA 2W8GA 3TLUA 4ZK1A 5KE4A 5BRXA 4ZRUA 4UM3S 5AFLA 2XQ6A 3ZDGA 4ZK4A 3RQUA 2XZ6A 4ILCA 3UQ4A 3UUBA 3IGQA 2XQ3A 2XQAA 4BQTA 4HFDA 4A97A 3WTJA 3UU3A 3WIPA 5KZUA 4QH5A 5IUXA 4XHEA 4HQPA 2YN6A 4LMKA 3RI5A 2BG9B 4ILAA 2ZJUA 4BFQA 5J5GA 5HCJA 2XNVA 5J5FA 5AFHA 5HEJA 2Y57A 3ZKRA 3WTLA 1UX2A 2WNLA 2Y54A 4HFCA 4ZR6A 4XK9A 3PEOA 3SQ6A 2YKSA 3RIAA 2BG9A 4AFGA 4NPPA 3WTHA 4ZZCA 5AINA 4HFIA 2X00A 5JMEA 5HCMA 3SH1A 4DBMA 3WTKA 3UU8A 4B5DA
chains in the Genus database with same CATH superfamily
5L47A 5SYOA 4AFTA 3PMZA 3TLSA 4TWHA 4ZZBA 1I9BA 3LSVA 4ZJTA 4IREA 2PH9A 3JAEA 2XQ9A 4IL9A 5HEUA 4IL4A 5AFNA 3WTIA 2XNUA 3RQWA 4Z91A 2BYQA 5AFJA 3U8NA 3EI0A 3JAFA 4QH1A 3ZDHA 4QACA 5HEGA 4X5TA 2BYSA 5J5IA 3TLWA 4AFHA 2XQ7A 2BR7A 5J5HA 5J0ZA 4UY2A 3P4WA 4HFBA 2BG9C 3U8JA 3SIOA 2BYPA 2WN9A 4PIRA 3RHWA 3TLVA 4Z90A 5AFKA 5AFMA 2XQ8A 1UV6A 2QC1B 3U8LA 2XNTA 4UM1A 4LMLA 3UU5A 5L4EA 3EAMA 1UW6A 2YMEA 4TNVA 2XQ5A 4WV9A 3SQ9A 5BP0A 3JADA 2XYTA 3C84A 4TWFA 2Y7YA 4TWDA 3RIFA 4D01A 2BYNA 4HFHA 3U8MA 3WTMA 4F8HA 3WTOA 4UXUA 2BJ0A 2WNJA 4COFA 4QH4A 2XZ5A 3WTNA 2YMDA 3P50A 5AFMB 5LXBA 3TLTA 4UM3A 2YOEA 4UM3P 5LG3A 4FRRA 2BG9E 4A98A 3EHZA 5TVCA 3GUAA 3UU4A 4NZBA 2BR8A 2WZYA 5HEHA 2WNCA 2XQ4A 5FJVA 3T4MA 3U8KA 3C79A 2UZ6A 2ZJVA 2VL0A 5CFBA 4QAAA 2W8FA 4TNWA 3UU6A 5BW2A 4ZJSA 2PGZA 2XYSA 2X00D 5HEOA 2BYRA 5CO5A 4ILBA 2Y56A 4ALXA 4HFEA 4LMJA 4QABA 4EZ1A 2Y58A 3UQ7A 2C9TA 5L4HA 2W8GA 3TLUA 4ZK1A 5KE4A 5BRXA 4ZRUA 4UM3S 5AFLA 2XQ6A 3ZDGA 4ZK4A 3RQUA 2XZ6A 4ILCA 3UQ4A 3UUBA 3IGQA 2XQ3A 2XQAA 4BQTA 4HFDA 4A97A 3WTJA 3UU3A 3WIPA 5KZUA 4QH5A 5IUXA 4XHEA 4HQPA 2YN6A 4LMKA 3RI5A 2BG9B 4ILAA 2ZJUA 4BFQA 5J5GA 5HCJA 2XNVA 5J5FA 5AFHA 5HEJA 2Y57A 3ZKRA 3WTLA 1UX2A 2WNLA 2Y54A 4HFCA 4ZR6A 4XK9A 3PEOA 3SQ6A 2YKSA 3RIAA 2BG9A 4AFGA 4NPPA 3WTHA 4ZZCA 5AINA 4HFIA 2X00A 5JMEA 5HCMA 3SH1A 4DBMA 3WTKA 3UU8A 4B5DA
chains in the Genus database with same CATH topology
5L47A 5SYOA 4AFTA 3PMZA 3TLSA 4TWHA 4ZZBA 1I9BA 3LSVA 4ZJTA 4IREA 2PH9A 3JAEA 2XQ9A 4IL9A 5HEUA 4IL4A 5AFNA 3WTIA 2XNUA 3RQWA 4Z91A 2BYQA 5AFJA 3U8NA 3EI0A 3JAFA 4QH1A 3ZDHA 4QACA 5HEGA 4X5TA 2BYSA 5J5IA 3TLWA 4AFHA 2XQ7A 2BR7A 5J5HA 5J0ZA 4UY2A 3P4WA 4HFBA 2BG9C 3U8JA 3SIOA 2BYPA 2WN9A 4PIRA 3RHWA 3TLVA 4Z90A 5AFKA 5AFMA 2XQ8A 1UV6A 2QC1B 3U8LA 2XNTA 4UM1A 4LMLA 3UU5A 5L4EA 3EAMA 1UW6A 2YMEA 4TNVA 2XQ5A 4WV9A 3SQ9A 5BP0A 3JADA 2XYTA 3C84A 4TWFA 2Y7YA 4TWDA 3RIFA 4D01A 2BYNA 4HFHA 3U8MA 3WTMA 4F8HA 3WTOA 4UXUA 2BJ0A 2WNJA 4COFA 4QH4A 2XZ5A 3WTNA 2YMDA 3P50A 5AFMB 5LXBA 3TLTA 4UM3A 2YOEA 4UM3P 5LG3A 4FRRA 2BG9E 4A98A 3EHZA 5TVCA 3GUAA 3UU4A 4NZBA 2BR8A 2WZYA 5HEHA 2WNCA 2XQ4A 5FJVA 3T4MA 3U8KA 3C79A 2UZ6A 2ZJVA 2VL0A 5CFBA 4QAAA 2W8FA 4TNWA 3UU6A 5BW2A 4ZJSA 2PGZA 2XYSA 2X00D 5HEOA 2BYRA 5CO5A 4ILBA 2Y56A 4ALXA 4HFEA 4LMJA 4QABA 4EZ1A 2Y58A 3UQ7A 2C9TA 5L4HA 2W8GA 3TLUA 4ZK1A 5KE4A 5BRXA 4ZRUA 4UM3S 5AFLA 2XQ6A 3ZDGA 4ZK4A 3RQUA 2XZ6A 4ILCA 3UQ4A 3UUBA 3IGQA 2XQ3A 2XQAA 4BQTA 4HFDA 4A97A 3WTJA 3UU3A 3WIPA 5KZUA 4QH5A 5IUXA 4XHEA 4HQPA 2YN6A 4LMKA 3RI5A 2BG9B 4ILAA 2ZJUA 4BFQA 5J5GA 5HCJA 2XNVA 5J5FA 5AFHA 5HEJA 2Y57A 3ZKRA 3WTLA 1UX2A 2WNLA 2Y54A 4HFCA 4ZR6A 4XK9A 3PEOA 3SQ6A 2YKSA 3RIAA 2BG9A 4AFGA 4NPPA 3WTHA 4ZZCA 5AINA 4HFIA 2X00A 5JMEA 5HCMA 3SH1A 4DBMA 3WTKA 3UU8A 4B5DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L47 A;  5SYO A;  4AFT A;  3PMZ A;  3TLS A;  4TWH A;  4ZZB A;  1I9B A;  3LSV A;  4ZJT A;  4IRE A;  2PH9 A;  3JAE A;  2XQ9 A;  4IL9 A;  5HEU A;  4IL4 A;  5AFN A;  3WTI A;  2XNU A;  3RQW A;  4Z91 A;  2BYQ A;  5AFJ A;  3U8N A;  3EI0 A;  3JAF A;  4QH1 A;  3ZDH A;  4QAC A;  5HEG A;  4X5T A;  2BYS A;  5J5I A;  3TLW A;  4AFH A;  2XQ7 A;  2BR7 A;  5J5H A;  5J0Z A;  4UY2 A;  3P4W A;  4HFB A;  2BG9 C;  3U8J A;  3SIO A;  2BYP A;  2WN9 A;  4PIR A;  3RHW A;  3TLV A;  4Z90 A;  5AFK A;  5AFM A;  2XQ8 A;  1UV6 A;  2QC1 B;  3U8L A;  2XNT A;  4UM1 A;  4LML A;  3UU5 A;  5L4E A;  3EAM A;  1UW6 A;  2YME A;  4TNV A;  2XQ5 A;  4WV9 A;  3SQ9 A;  5BP0 A;  3JAD A;  2XYT A;  3C84 A;  4TWF A;  2Y7Y A;  4TWD A;  3RIF A;  4D01 A;  2BYN A;  4HFH A;  3U8M A;  3WTM A;  4F8H A;  3WTO A;  4UXU A;  2BJ0 A;  2WNJ A;  4COF A;  4QH4 A;  2XZ5 A;  3WTN A;  2YMD A;  3P50 A;  5AFM B;  5LXB A;  3TLT A;  4UM3 A;  2YOE A;  4UM3 P;  5LG3 A;  4FRR A;  2BG9 E;  4A98 A;  3EHZ A;  5TVC A;  3GUA A;  3UU4 A;  4NZB A;  2BR8 A;  2WZY A;  5HEH A;  2WNC A;  2XQ4 A;  5FJV A;  3T4M A;  3U8K A;  3C79 A;  2UZ6 A;  2ZJV A;  2VL0 A;  5CFB A;  4QAA A;  2W8F A;  4TNW A;  3UU6 A;  5BW2 A;  4ZJS A;  2PGZ A;  2XYS A;  2X00 D;  5HEO A;  2BYR A;  5CO5 A;  4ILB A;  2Y56 A;  4ALX A;  4HFE A;  4LMJ A;  4QAB A;  4EZ1 A;  2Y58 A;  3UQ7 A;  2C9T A;  5L4H A;  2W8G A;  3TLU A;  4ZK1 A;  5KE4 A;  5BRX A;  4ZRU A;  4UM3 S;  5AFL A;  2XQ6 A;  3ZDG A;  4ZK4 A;  3RQU A;  2XZ6 A;  4ILC A;  3UQ4 A;  3UUB A;  3IGQ A;  2XQ3 A;  2XQA A;  4BQT A;  4HFD A;  4A97 A;  3WTJ A;  3UU3 A;  3WIP A;  5KZU A;  4QH5 A;  5IUX A;  4XHE A;  4HQP A;  2YN6 A;  4LMK A;  3RI5 A;  2BG9 B;  4ILA A;  2ZJU A;  4BFQ A;  5J5G A;  5HCJ A;  2XNV A;  5J5F A;  5AFH A;  5HEJ A;  2Y57 A;  3ZKR A;  3WTL A;  1UX2 A;  2WNL A;  2Y54 A;  4HFC A;  4ZR6 A;  4XK9 A;  3PEO A;  3SQ6 A;  2YKS A;  3RIA A;  2BG9 A;  4AFG A;  4NPP A;  3WTH A;  4ZZC A;  5AIN A;  4HFI A;  2X00 A;  5JME A;  5HCM A;  3SH1 A;  4DBM A;  3WTK A;  3UU8 A;  4B5D A; 
#chains in the Genus database with same CATH topology
 5L47 A;  5SYO A;  4AFT A;  3PMZ A;  3TLS A;  4TWH A;  4ZZB A;  1I9B A;  3LSV A;  4ZJT A;  4IRE A;  2PH9 A;  3JAE A;  2XQ9 A;  4IL9 A;  5HEU A;  4IL4 A;  5AFN A;  3WTI A;  2XNU A;  3RQW A;  4Z91 A;  2BYQ A;  5AFJ A;  3U8N A;  3EI0 A;  3JAF A;  4QH1 A;  3ZDH A;  4QAC A;  5HEG A;  4X5T A;  2BYS A;  5J5I A;  3TLW A;  4AFH A;  2XQ7 A;  2BR7 A;  5J5H A;  5J0Z A;  4UY2 A;  3P4W A;  4HFB A;  2BG9 C;  3U8J A;  3SIO A;  2BYP A;  2WN9 A;  4PIR A;  3RHW A;  3TLV A;  4Z90 A;  5AFK A;  5AFM A;  2XQ8 A;  1UV6 A;  2QC1 B;  3U8L A;  2XNT A;  4UM1 A;  4LML A;  3UU5 A;  5L4E A;  3EAM A;  1UW6 A;  2YME A;  4TNV A;  2XQ5 A;  4WV9 A;  3SQ9 A;  5BP0 A;  3JAD A;  2XYT A;  3C84 A;  4TWF A;  2Y7Y A;  4TWD A;  3RIF A;  4D01 A;  2BYN A;  4HFH A;  3U8M A;  3WTM A;  4F8H A;  3WTO A;  4UXU A;  2BJ0 A;  2WNJ A;  4COF A;  4QH4 A;  2XZ5 A;  3WTN A;  2YMD A;  3P50 A;  5AFM B;  5LXB A;  3TLT A;  4UM3 A;  2YOE A;  4UM3 P;  5LG3 A;  4FRR A;  2BG9 E;  4A98 A;  3EHZ A;  5TVC A;  3GUA A;  3UU4 A;  4NZB A;  2BR8 A;  2WZY A;  5HEH A;  2WNC A;  2XQ4 A;  5FJV A;  3T4M A;  3U8K A;  3C79 A;  2UZ6 A;  2ZJV A;  2VL0 A;  5CFB A;  4QAA A;  2W8F A;  4TNW A;  3UU6 A;  5BW2 A;  4ZJS A;  2PGZ A;  2XYS A;  2X00 D;  5HEO A;  2BYR A;  5CO5 A;  4ILB A;  2Y56 A;  4ALX A;  4HFE A;  4LMJ A;  4QAB A;  4EZ1 A;  2Y58 A;  3UQ7 A;  2C9T A;  5L4H A;  2W8G A;  3TLU A;  4ZK1 A;  5KE4 A;  5BRX A;  4ZRU A;  4UM3 S;  5AFL A;  2XQ6 A;  3ZDG A;  4ZK4 A;  3RQU A;  2XZ6 A;  4ILC A;  3UQ4 A;  3UUB A;  3IGQ A;  2XQ3 A;  2XQA A;  4BQT A;  4HFD A;  4A97 A;  3WTJ A;  3UU3 A;  3WIP A;  5KZU A;  4QH5 A;  5IUX A;  4XHE A;  4HQP A;  2YN6 A;  4LMK A;  3RI5 A;  2BG9 B;  4ILA A;  2ZJU A;  4BFQ A;  5J5G A;  5HCJ A;  2XNV A;  5J5F A;  5AFH A;  5HEJ A;  2Y57 A;  3ZKR A;  3WTL A;  1UX2 A;  2WNL A;  2Y54 A;  4HFC A;  4ZR6 A;  4XK9 A;  3PEO A;  3SQ6 A;  2YKS A;  3RIA A;  2BG9 A;  4AFG A;  4NPP A;  3WTH A;  4ZZC A;  5AIN A;  4HFI A;  2X00 A;  5JME A;  5HCM A;  3SH1 A;  4DBM A;  3WTK A;  3UU8 A;  4B5D A; 
#chains in the Genus database with same CATH homology
 5L47 A;  5SYO A;  4AFT A;  3PMZ A;  3TLS A;  4TWH A;  4ZZB A;  1I9B A;  3LSV A;  4ZJT A;  4IRE A;  2PH9 A;  3JAE A;  2XQ9 A;  4IL9 A;  5HEU A;  4IL4 A;  5AFN A;  3WTI A;  2XNU A;  3RQW A;  4Z91 A;  2BYQ A;  5AFJ A;  3U8N A;  3EI0 A;  3JAF A;  4QH1 A;  3ZDH A;  4QAC A;  5HEG A;  4X5T A;  2BYS A;  5J5I A;  3TLW A;  4AFH A;  2XQ7 A;  2BR7 A;  5J5H A;  5J0Z A;  4UY2 A;  3P4W A;  4HFB A;  2BG9 C;  3U8J A;  3SIO A;  2BYP A;  2WN9 A;  4PIR A;  3RHW A;  3TLV A;  4Z90 A;  5AFK A;  5AFM A;  2XQ8 A;  1UV6 A;  2QC1 B;  3U8L A;  2XNT A;  4UM1 A;  4LML A;  3UU5 A;  5L4E A;  3EAM A;  1UW6 A;  2YME A;  4TNV A;  2XQ5 A;  4WV9 A;  3SQ9 A;  5BP0 A;  3JAD A;  2XYT A;  3C84 A;  4TWF A;  2Y7Y A;  4TWD A;  3RIF A;  4D01 A;  2BYN A;  4HFH A;  3U8M A;  3WTM A;  4F8H A;  3WTO A;  4UXU A;  2BJ0 A;  2WNJ A;  4COF A;  4QH4 A;  2XZ5 A;  3WTN A;  2YMD A;  3P50 A;  5AFM B;  5LXB A;  3TLT A;  4UM3 A;  2YOE A;  4UM3 P;  5LG3 A;  4FRR A;  2BG9 E;  4A98 A;  3EHZ A;  5TVC A;  3GUA A;  3UU4 A;  4NZB A;  2BR8 A;  2WZY A;  5HEH A;  2WNC A;  2XQ4 A;  5FJV A;  3T4M A;  3U8K A;  3C79 A;  2UZ6 A;  2ZJV A;  2VL0 A;  5CFB A;  4QAA A;  2W8F A;  4TNW A;  3UU6 A;  5BW2 A;  4ZJS A;  2PGZ A;  2XYS A;  2X00 D;  5HEO A;  2BYR A;  5CO5 A;  4ILB A;  2Y56 A;  4ALX A;  4HFE A;  4LMJ A;  4QAB A;  4EZ1 A;  2Y58 A;  3UQ7 A;  2C9T A;  5L4H A;  2W8G A;  3TLU A;  4ZK1 A;  5KE4 A;  5BRX A;  4ZRU A;  4UM3 S;  5AFL A;  2XQ6 A;  3ZDG A;  4ZK4 A;  3RQU A;  2XZ6 A;  4ILC A;  3UQ4 A;  3UUB A;  3IGQ A;  2XQ3 A;  2XQA A;  4BQT A;  4HFD A;  4A97 A;  3WTJ A;  3UU3 A;  3WIP A;  5KZU A;  4QH5 A;  5IUX A;  4XHE A;  4HQP A;  2YN6 A;  4LMK A;  3RI5 A;  2BG9 B;  4ILA A;  2ZJU A;  4BFQ A;  5J5G A;  5HCJ A;  2XNV A;  5J5F A;  5AFH A;  5HEJ A;  2Y57 A;  3ZKR A;  3WTL A;  1UX2 A;  2WNL A;  2Y54 A;  4HFC A;  4ZR6 A;  4XK9 A;  3PEO A;  3SQ6 A;  2YKS A;  3RIA A;  2BG9 A;  4AFG A;  4NPP A;  3WTH A;  4ZZC A;  5AIN A;  4HFI A;  2X00 A;  5JME A;  5HCM A;  3SH1 A;  4DBM A;  3WTK A;  3UU8 A;  4B5D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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