4ZWEA

Crystal structure of the dgtp-bound catalytic core of samhd1 t592v mutant
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
sequence length
486
structure length
480
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLIVPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
publication title Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592.
pubmed doi rcsb
source organism Homo sapiens
total genus 157
structure length 480
sequence length 486
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4zweA01
1U6ZA 4MLMA 2GZ4A 2PQ7A 4QG4A 4QG2A 4RXOA 4TO3A 4TNZA 4QFXA 4LRLA 2O08A 5AO2A 5TK7A 4TO2A 4QFZA 2Q14A 4DMBA 3MEMA 4QFYA 3IRHA 4TNQA 4MZ7A 1YOYA 4QG1A 1XX7A 3HC1A 3CCGA 4L7EA 3MZOA 4TNPA 3I7AA 2CQZA 4RXSA 4MCWA 4RXQA 4MDZA 5TKAA 5AO3A 2DQBA 3TMBA 4RXPA 3HI0A 3M1TA 4TO0A 4BZBA 2O6IA 5TK6A 3LJXA 3NR1A 4TO1A 3TMCA 4TO5A 2PGSA 5TK8A 3BG2A 4N6WA 4ME4A 4TNXA 4BZCA 3TMDA 4N71A 1VJ7A 4L1JA 3TM8A 2HEKA 4MLNA 2PAUA 1YNBA 2OGIA 4R8ZA 4L1JB 5TK9A 3P3QA 4Q7HA 4L7WA 3U1NA 5AO1A 5AO4A 4TNRA 3KH1A 2PARA 4RXRA 4ZWGA 4QG0A 5AO0A 1VQRA 4ZWEA 4TNYA 4TO4A 3NQWA 2PAQA 2FLOA 4XDSA 4X9EA 3RF0A 4TO6A
chains in the Genus database with same CATH superfamily
1U6ZA 4MLMA 2GZ4A 2PQ7A 4QG4A 4QG2A 4RXOA 4TO3A 4QQZA 4TNZA 4QFXA 4LRLA 2O08A 5AO2A 5TK7A 4TO2A 4QFZA 2Q14A 4DMBA 3MEMA 4QFYA 3IRHA 4TNQA 4MZ7A 1YOYA 4QG1A 1XX7A 3HC1A 3CCGA 4L7EA 3MZOA 4TNPA 4QQXA 3I7AA 4Q2DA 2CQZA 3GW7A 4RXSA 3S4LA 4MCWA 4RXQA 4MDZA 5TKAA 5AO3A 2DQBA 3TMBA 4RXPA 3HI0A 3M1TA 4TO0A 4BZBA 3SK9A 2O6IA 5TK6A 3LJXA 3NR1A 4TO1A 3TMCA 4TO5A 2PGSA 5TK8A 3BG2A 4N6WA 4ME4A 4TNXA 4BZCA 3TMDA 4N71A 1VJ7A 4L1JA 3TM8A 2HEKA 4MLNA 2PAUA 1YNBA 2OGIA 4R8ZA 4QQWA 3KQ5A 4L1JB 5TK9A 3P3QA 4Q7HA 4L7WA 3U1NA 5AO1A 4QQYA 3SKDA 5AO4A 4TNRA 3KH1A 2PARA 4RXRA 4Q2CA 4ZWGA 4QG0A 5AO0A 1VQRA 4ZWEA 4TNYA 4TO4A 3NQWA 2PAQA 2FLOA 4XDSA 4X9EA 3RF0A 4TO6A
chains in the Genus database with same CATH topology
1U6ZA 4MLMA 2GZ4A 2PQ7A 4QG4A 4QG2A 4RXOA 4TO3A 4QQZA 4TNZA 4QFXA 4LRLA 2O08A 5AO2A 5TK7A 4TO2A 4QFZA 2Q14A 4DMBA 3MEMA 4QFYA 3IRHA 4TNQA 4MZ7A 1YOYA 4QG1A 1XX7A 3HC1A 3CCGA 4L7EA 3MZOA 4TNPA 4QQXA 3I7AA 4Q2DA 2CQZA 3GW7A 4RXSA 3S4LA 4MCWA 4RXQA 4MDZA 5TKAA 5AO3A 2DQBA 3TMBA 4RXPA 3HI0A 3M1TA 4TO0A 4BZBA 3SK9A 2O6IA 5TK6A 3LJXA 3NR1A 4TO1A 3TMCA 4TO5A 2PGSA 5TK8A 3BG2A 4N6WA 4ME4A 4TNXA 4BZCA 3TMDA 4N71A 1VJ7A 4L1JA 3TM8A 2HEKA 4MLNA 2PAUA 1YNBA 2OGIA 4R8ZA 4QQWA 3KQ5A 4L1JB 5TK9A 3P3QA 4Q7HA 4L7WA 3U1NA 5AO1A 4QQYA 3SKDA 5AO4A 4TNRA 3KH1A 2PARA 4RXRA 4Q2CA 4ZWGA 4QG0A 5AO0A 1VQRA 4ZWEA 4TNYA 4TO4A 3NQWA 2PAQA 2FLOA 4XDSA 4X9EA 3RF0A 4TO6A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1U6Z A;  4MLM A;  2GZ4 A;  2PQ7 A;  4QG4 A;  4QG2 A;  4RXO A;  4TO3 A;  4TNZ A;  4QFX A;  4LRL A;  2O08 A;  5AO2 A;  5TK7 A;  4TO2 A;  4QFZ A;  2Q14 A;  4DMB A;  3MEM A;  4QFY A;  3IRH A;  4TNQ A;  4MZ7 A;  1YOY A;  4QG1 A;  1XX7 A;  3HC1 A;  3CCG A;  4L7E A;  3MZO A;  4TNP A;  3I7A A;  2CQZ A;  4RXS A;  4MCW A;  4RXQ A;  4MDZ A;  5TKA A;  5AO3 A;  2DQB A;  3TMB A;  4RXP A;  3HI0 A;  3M1T A;  4TO0 A;  4BZB A;  2O6I A;  5TK6 A;  3LJX A;  3NR1 A;  4TO1 A;  3TMC A;  4TO5 A;  2PGS A;  5TK8 A;  3BG2 A;  4N6W A;  4ME4 A;  4TNX A;  4BZC A;  3TMD A;  4N71 A;  1VJ7 A;  4L1J A;  3TM8 A;  2HEK A;  4MLN A;  2PAU A;  1YNB A;  2OGI A;  4R8Z A;  4L1J B;  5TK9 A;  3P3Q A;  4Q7H A;  4L7W A;  3U1N A;  5AO1 A;  5AO4 A;  4TNR A;  3KH1 A;  2PAR A;  4RXR A;  4ZWG A;  4QG0 A;  5AO0 A;  1VQR A;  4ZWE A;  4TNY A;  4TO4 A;  3NQW A;  2PAQ A;  2FLO A;  4XDS A;  4X9E A;  3RF0 A;  4TO6 A; 
#chains in the Genus database with same CATH topology
 1U6Z A;  4MLM A;  2GZ4 A;  2PQ7 A;  4QG4 A;  4QG2 A;  4RXO A;  4TO3 A;  4QQZ A;  4TNZ A;  4QFX A;  4LRL A;  2O08 A;  5AO2 A;  5TK7 A;  4TO2 A;  4QFZ A;  2Q14 A;  4DMB A;  3MEM A;  4QFY A;  3IRH A;  4TNQ A;  4MZ7 A;  1YOY A;  4QG1 A;  1XX7 A;  3HC1 A;  3CCG A;  4L7E A;  3MZO A;  4TNP A;  4QQX A;  3I7A A;  4Q2D A;  2CQZ A;  3GW7 A;  4RXS A;  3S4L A;  4MCW A;  4RXQ A;  4MDZ A;  5TKA A;  5AO3 A;  2DQB A;  3TMB A;  4RXP A;  3HI0 A;  3M1T A;  4TO0 A;  4BZB A;  3SK9 A;  2O6I A;  5TK6 A;  3LJX A;  3NR1 A;  4TO1 A;  3TMC A;  4TO5 A;  2PGS A;  5TK8 A;  3BG2 A;  4N6W A;  4ME4 A;  4TNX A;  4BZC A;  3TMD A;  4N71 A;  1VJ7 A;  4L1J A;  3TM8 A;  2HEK A;  4MLN A;  2PAU A;  1YNB A;  2OGI A;  4R8Z A;  4QQW A;  3KQ5 A;  4L1J B;  5TK9 A;  3P3Q A;  4Q7H A;  4L7W A;  3U1N A;  5AO1 A;  4QQY A;  3SKD A;  5AO4 A;  4TNR A;  3KH1 A;  2PAR A;  4RXR A;  4Q2C A;  4ZWG A;  4QG0 A;  5AO0 A;  1VQR A;  4ZWE A;  4TNY A;  4TO4 A;  3NQW A;  2PAQ A;  2FLO A;  4XDS A;  4X9E A;  3RF0 A;  4TO6 A; 
#chains in the Genus database with same CATH homology
 1U6Z A;  4MLM A;  2GZ4 A;  2PQ7 A;  4QG4 A;  4QG2 A;  4RXO A;  4TO3 A;  4QQZ A;  4TNZ A;  4QFX A;  4LRL A;  2O08 A;  5AO2 A;  5TK7 A;  4TO2 A;  4QFZ A;  2Q14 A;  4DMB A;  3MEM A;  4QFY A;  3IRH A;  4TNQ A;  4MZ7 A;  1YOY A;  4QG1 A;  1XX7 A;  3HC1 A;  3CCG A;  4L7E A;  3MZO A;  4TNP A;  4QQX A;  3I7A A;  4Q2D A;  2CQZ A;  3GW7 A;  4RXS A;  3S4L A;  4MCW A;  4RXQ A;  4MDZ A;  5TKA A;  5AO3 A;  2DQB A;  3TMB A;  4RXP A;  3HI0 A;  3M1T A;  4TO0 A;  4BZB A;  3SK9 A;  2O6I A;  5TK6 A;  3LJX A;  3NR1 A;  4TO1 A;  3TMC A;  4TO5 A;  2PGS A;  5TK8 A;  3BG2 A;  4N6W A;  4ME4 A;  4TNX A;  4BZC A;  3TMD A;  4N71 A;  1VJ7 A;  4L1J A;  3TM8 A;  2HEK A;  4MLN A;  2PAU A;  1YNB A;  2OGI A;  4R8Z A;  4QQW A;  3KQ5 A;  4L1J B;  5TK9 A;  3P3Q A;  4Q7H A;  4L7W A;  3U1N A;  5AO1 A;  4QQY A;  3SKD A;  5AO4 A;  4TNR A;  3KH1 A;  2PAR A;  4RXR A;  4Q2C A;  4ZWG A;  4QG0 A;  5AO0 A;  1VQR A;  4ZWE A;  4TNY A;  4TO4 A;  3NQW A;  2PAQ A;  2FLO A;  4XDS A;  4X9E A;  3RF0 A;  4TO6 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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