4ZWPA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
438
structure length
422
Chain Sequence
KLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords OPAA organophosphate prolidase anhydrolase
total genus 148
structure length 422
sequence length 438
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwpA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwpA02
2EVCA 3RVAA 1XGSA 2NQ7A 1Y1NA 2MATA 2GGCA 3MX6A 1YW9A 1KQ0A 1C24A 1WKMA 3OOOA 4A6WA 4B28A 2GU5A 2P98A 2BN7A 4IU6A 3FMQA 1BN5A 4MATA 1W7VA 3L24A 2EVMA 2GTXA 4U70A 4RZYA 4Z7MA 1A16A 2Q93A 3FM3A 5JFRA 1MATA 4U71A 1WLRA 4FLKA 2GU7A 3IU9A 1WL6A 4U1BA 1JAWA 4U6JA 1XGOA 2Q8KA 2BH3A 3BIQA 4U6ZA 2BWYA 1R5HA 2V3ZA 1C23A 1O0XA 2GG5A 1W2MA 2B3LA 2GG0A 2P9AA 5E2CA 3IG4A 1WN1A 3CB6A 2GG9A 2BHBA 3PN9A 2Q94A 4IKUA 4IKRA 4RZZA 1QXZA 4IKSA 3L7GA 3FMRA 4ZWOA 3IL0A 4FUKA 2BWSA 4S01A 4ZWPA 2NQ6A 4S2TP 2GA2A 4U69A 4IF7A 2BWUA 2BHCA 3S6BA 5D6FA 2Q95A 4FLLA 1C22A 2GU4A 5CE6A 1N51A 2ZSGA 4S2RP 3IU7A 2V3YA 2EA4A 4IPAA 5E5BA 3MR1A 4U6CA 4IECA 5CIKA 4S00A 1XGMA 3OVKA 2G6PA 1R58A 3MATA 3PEBA 1XGNA 2GG2A 5FCHA 4FO7A 1B6AA 3TAVA 1C21A 1C27A 4QR8A 1CHMA 2Q96A 3PKCA 1YVMA 3PKBA 1YW8A 4R60A 1XNZA 3TB5A 3PKAA 2OAZA 2BB7A 5FCFA 4FLJA 2BWTA 2BWWA 1YJ3A 3RORA 1BOAA 4U76A 5CNXA 1KP0A 2HOWA 3D27A 4U6WA 4JUQA 2BHAA 4KM3A 4FKCA 3Q6DA 4IKTA 5CDLA 1QZYA 3BIPA 2GU6A 3QOCA 4HXXA 3PKDA 4PNCA 4U73A 1WBQA 2BWXA 3I7MA 4OOKA 2GG7A 4ZWUA 2B3HA 3CB5A 5CDEA 2EA2A 3BITA 2P99A 4IDYA 2EVOA 2OKNA 2GGBA 1R5GA 2BWVA 2B3KA 5JHUA 2GG3A 1YW7A 4PV4A 5CDVA 1WY2A 2IW2A 1QXYA 2Q92A 4FO8A 2GG8A 2ADUA 1QXWA 3CTZA 2BHDA 4RGZ1 3IU8A 4EGEA 2V6CA 4U6EA 1PV9A 4U75A 5D6EA 4A6VA 1M35A 3O5VA 1KQ9A 2DFIA 5CLSA 1B59A 2GZ5A 2V3XA 4ZNGA 3PKEA 4FLIA 1WL9A 5JI6A
chains in the Genus database with same CATH superfamily
2EVCA 3RVAA 1XGSA 2NQ7A 1Y1NA 2MATA 2GGCA 3MX6A 1YW9A 1KQ0A 1C24A 1WKMA 3OOOA 4A6WA 4B28A 2GU5A 2P98A 2BN7A 4IU6A 3FMQA 1BN5A 4MATA 1W7VA 3L24A 2EVMA 2GTXA 4U70A 4RZYA 4Z7MA 1A16A 2Q93A 3FM3A 5JFRA 1MATA 4U71A 1WLRA 4FLKA 2GU7A 3IU9A 1WL6A 4U1BA 1JAWA 4U6JA 1XGOA 2Q8KA 2BH3A 3BIQA 4U6ZA 2BWYA 1R5HA 2V3ZA 1C23A 1O0XA 2GG5A 1W2MA 2B3LA 2GG0A 2P9AA 5E2CA 3IG4A 1WN1A 3CB6A 2GG9A 2BHBA 3PN9A 2Q94A 4IKUA 4IKRA 4RZZA 1QXZA 4IKSA 3L7GA 3FMRA 4ZWOA 3IL0A 4FUKA 2BWSA 4S01A 4ZWPA 2NQ6A 4S2TP 2GA2A 4U69A 4IF7A 2BWUA 2BHCA 3S6BA 5D6FA 2Q95A 4FLLA 1C22A 2GU4A 5CE6A 1N51A 2ZSGA 4S2RP 3IU7A 2V3YA 2EA4A 4IPAA 5E5BA 3MR1A 4U6CA 4IECA 5CIKA 4S00A 1XGMA 3OVKA 2G6PA 1R58A 3MATA 3PEBA 1XGNA 2GG2A 5FCHA 4FO7A 1B6AA 3TAVA 1C21A 1C27A 4QR8A 1CHMA 2Q96A 3PKCA 1YVMA 3PKBA 1YW8A 4R60A 1XNZA 3TB5A 3PKAA 2OAZA 2BB7A 5FCFA 4FLJA 2BWTA 2BWWA 1YJ3A 3RORA 1BOAA 4U76A 5CNXA 1KP0A 2HOWA 3D27A 4U6WA 4JUQA 2BHAA 4KM3A 4FKCA 3Q6DA 4IKTA 5CDLA 1QZYA 3BIPA 2GU6A 3QOCA 4HXXA 3PKDA 4PNCA 4U73A 1WBQA 2BWXA 3I7MA 4OOKA 2GG7A 4ZWUA 2B3HA 3CB5A 5CDEA 2EA2A 3BITA 2P99A 4IDYA 2EVOA 2OKNA 2GGBA 1R5GA 2BWVA 2B3KA 5JHUA 2GG3A 1YW7A 4PV4A 5CDVA 1WY2A 2IW2A 1QXYA 2Q92A 4FO8A 2GG8A 2ADUA 1QXWA 3CTZA 2BHDA 4RGZ1 3IU8A 4EGEA 2V6CA 4U6EA 1PV9A 4U75A 5D6EA 4A6VA 1M35A 3O5VA 1KQ9A 2DFIA 5CLSA 1B59A 2GZ5A 2V3XA 4ZNGA 3PKEA 4FLIA 1WL9A 5JI6A
chains in the Genus database with same CATH topology
2EVCA 3RVAA 1XGSA 2NQ7A 1Y1NA 2MATA 2GGCA 3MX6A 1YW9A 1KQ0A 1C24A 1WKMA 3OOOA 4A6WA 4B28A 2GU5A 2P98A 2BN7A 4IU6A 3FMQA 1BN5A 4MATA 1W7VA 3L24A 2EVMA 2GTXA 4U70A 4RZYA 4Z7MA 1A16A 2Q93A 3FM3A 5JFRA 1MATA 4U71A 1WLRA 4FLKA 2GU7A 3IU9A 1WL6A 4U1BA 1JAWA 4U6JA 1XGOA 2Q8KA 2BH3A 3BIQA 4U6ZA 2BWYA 1R5HA 2V3ZA 1C23A 1O0XA 2GG5A 1W2MA 2B3LA 2GG0A 2P9AA 5E2CA 3IG4A 1WN1A 3CB6A 2GG9A 2BHBA 3PN9A 2Q94A 4IKUA 4IKRA 4RZZA 1QXZA 4IKSA 3L7GA 3FMRA 4ZWOA 3IL0A 4FUKA 2BWSA 4S01A 4ZWPA 2NQ6A 4S2TP 2GA2A 4U69A 4IF7A 2BWUA 2BHCA 3S6BA 5D6FA 2Q95A 4FLLA 1C22A 2GU4A 5CE6A 1N51A 2ZSGA 4S2RP 3IU7A 2V3YA 2EA4A 4IPAA 5E5BA 3MR1A 4U6CA 4IECA 5CIKA 4S00A 1XGMA 3OVKA 2G6PA 1R58A 3MATA 3PEBA 1XGNA 2GG2A 5FCHA 4FO7A 1B6AA 3TAVA 1C21A 1C27A 4QR8A 1CHMA 2Q96A 3PKCA 1YVMA 3PKBA 1YW8A 4R60A 1XNZA 3TB5A 3PKAA 2OAZA 2BB7A 5FCFA 4FLJA 2BWTA 2BWWA 1YJ3A 3RORA 1BOAA 4U76A 5CNXA 1KP0A 2HOWA 3D27A 4U6WA 4JUQA 2BHAA 4KM3A 4FKCA 3Q6DA 4IKTA 5CDLA 1QZYA 3BIPA 2GU6A 3QOCA 4HXXA 3PKDA 4PNCA 4U73A 1WBQA 2BWXA 3I7MA 4OOKA 2GG7A 4ZWUA 2B3HA 3CB5A 5CDEA 2EA2A 3BITA 2P99A 4IDYA 2EVOA 2OKNA 2GGBA 1R5GA 2BWVA 2B3KA 5JHUA 2GG3A 1YW7A 4PV4A 5CDVA 1WY2A 2IW2A 1QXYA 2Q92A 4FO8A 2GG8A 2ADUA 1QXWA 3CTZA 2BHDA 4RGZ1 3IU8A 4EGEA 2V6CA 4U6EA 1PV9A 4U75A 5D6EA 4A6VA 1M35A 3O5VA 1KQ9A 2DFIA 5CLSA 1B59A 2GZ5A 2V3XA 4ZNGA 3PKEA 4FLIA 1WL9A 5JI6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EVC A;  3RVA A;  1XGS A;  2NQ7 A;  1Y1N A;  2MAT A;  2GGC A;  3MX6 A;  1YW9 A;  1KQ0 A;  1C24 A;  1WKM A;  3OOO A;  4A6W A;  4B28 A;  2GU5 A;  2P98 A;  2BN7 A;  4IU6 A;  3FMQ A;  1BN5 A;  4MAT A;  1W7V A;  3L24 A;  2EVM A;  2GTX A;  4U70 A;  4RZY A;  4Z7M A;  1A16 A;  2Q93 A;  3FM3 A;  5JFR A;  1MAT A;  4U71 A;  1WLR A;  4FLK A;  2GU7 A;  3IU9 A;  1WL6 A;  4U1B A;  1JAW A;  4U6J A;  1XGO A;  2Q8K A;  2BH3 A;  3BIQ A;  4U6Z A;  2BWY A;  1R5H A;  2V3Z A;  1C23 A;  1O0X A;  2GG5 A;  1W2M A;  2B3L A;  2GG0 A;  2P9A A;  5E2C A;  3IG4 A;  1WN1 A;  3CB6 A;  2GG9 A;  2BHB A;  3PN9 A;  2Q94 A;  4IKU A;  4IKR A;  4RZZ A;  1QXZ A;  4IKS A;  3L7G A;  3FMR A;  4ZWO A;  3IL0 A;  4FUK A;  2BWS A;  4S01 A;  4ZWP A;  2NQ6 A;  4S2T P;  2GA2 A;  4U69 A;  4IF7 A;  2BWU A;  2BHC A;  3S6B A;  5D6F A;  2Q95 A;  4FLL A;  1C22 A;  2GU4 A;  5CE6 A;  1N51 A;  2ZSG A;  4S2R P;  3IU7 A;  2V3Y A;  2EA4 A;  4IPA A;  5E5B A;  3MR1 A;  4U6C A;  4IEC A;  5CIK A;  4S00 A;  1XGM A;  3OVK A;  2G6P A;  1R58 A;  3MAT A;  3PEB A;  1XGN A;  2GG2 A;  5FCH A;  4FO7 A;  1B6A A;  3TAV A;  1C21 A;  1C27 A;  4QR8 A;  1CHM A;  2Q96 A;  3PKC A;  1YVM A;  3PKB A;  1YW8 A;  4R60 A;  1XNZ A;  3TB5 A;  3PKA A;  2OAZ A;  2BB7 A;  5FCF A;  4FLJ A;  2BWT A;  2BWW A;  1YJ3 A;  3ROR A;  1BOA A;  4U76 A;  5CNX A;  1KP0 A;  2HOW A;  3D27 A;  4U6W A;  4JUQ A;  2BHA A;  4KM3 A;  4FKC A;  3Q6D A;  4IKT A;  5CDL A;  1QZY A;  3BIP A;  2GU6 A;  3QOC A;  4HXX A;  3PKD A;  4PNC A;  4U73 A;  1WBQ A;  2BWX A;  3I7M A;  4OOK A;  2GG7 A;  4ZWU A;  2B3H A;  3CB5 A;  5CDE A;  2EA2 A;  3BIT A;  2P99 A;  4IDY A;  2EVO A;  2OKN A;  2GGB A;  1R5G A;  2BWV A;  2B3K A;  5JHU A;  2GG3 A;  1YW7 A;  4PV4 A;  5CDV A;  1WY2 A;  2IW2 A;  1QXY A;  2Q92 A;  4FO8 A;  2GG8 A;  2ADU A;  1QXW A;  3CTZ A;  2BHD A;  4RGZ 1;  3IU8 A;  4EGE A;  2V6C A;  4U6E A;  1PV9 A;  4U75 A;  5D6E A;  4A6V A;  1M35 A;  3O5V A;  1KQ9 A;  2DFI A;  5CLS A;  1B59 A;  2GZ5 A;  2V3X A;  4ZNG A;  3PKE A;  4FLI A;  1WL9 A;  5JI6 A; 
#chains in the Genus database with same CATH topology
 2EVC A;  3RVA A;  1XGS A;  2NQ7 A;  1Y1N A;  2MAT A;  2GGC A;  3MX6 A;  1YW9 A;  1KQ0 A;  1C24 A;  1WKM A;  3OOO A;  4A6W A;  4B28 A;  2GU5 A;  2P98 A;  2BN7 A;  4IU6 A;  3FMQ A;  1BN5 A;  4MAT A;  1W7V A;  3L24 A;  2EVM A;  2GTX A;  4U70 A;  4RZY A;  4Z7M A;  1A16 A;  2Q93 A;  3FM3 A;  5JFR A;  1MAT A;  4U71 A;  1WLR A;  4FLK A;  2GU7 A;  3IU9 A;  1WL6 A;  4U1B A;  1JAW A;  4U6J A;  1XGO A;  2Q8K A;  2BH3 A;  3BIQ A;  4U6Z A;  2BWY A;  1R5H A;  2V3Z A;  1C23 A;  1O0X A;  2GG5 A;  1W2M A;  2B3L A;  2GG0 A;  2P9A A;  5E2C A;  3IG4 A;  1WN1 A;  3CB6 A;  2GG9 A;  2BHB A;  3PN9 A;  2Q94 A;  4IKU A;  4IKR A;  4RZZ A;  1QXZ A;  4IKS A;  3L7G A;  3FMR A;  4ZWO A;  3IL0 A;  4FUK A;  2BWS A;  4S01 A;  4ZWP A;  2NQ6 A;  4S2T P;  2GA2 A;  4U69 A;  4IF7 A;  2BWU A;  2BHC A;  3S6B A;  5D6F A;  2Q95 A;  4FLL A;  1C22 A;  2GU4 A;  5CE6 A;  1N51 A;  2ZSG A;  4S2R P;  3IU7 A;  2V3Y A;  2EA4 A;  4IPA A;  5E5B A;  3MR1 A;  4U6C A;  4IEC A;  5CIK A;  4S00 A;  1XGM A;  3OVK A;  2G6P A;  1R58 A;  3MAT A;  3PEB A;  1XGN A;  2GG2 A;  5FCH A;  4FO7 A;  1B6A A;  3TAV A;  1C21 A;  1C27 A;  4QR8 A;  1CHM A;  2Q96 A;  3PKC A;  1YVM A;  3PKB A;  1YW8 A;  4R60 A;  1XNZ A;  3TB5 A;  3PKA A;  2OAZ A;  2BB7 A;  5FCF A;  4FLJ A;  2BWT A;  2BWW A;  1YJ3 A;  3ROR A;  1BOA A;  4U76 A;  5CNX A;  1KP0 A;  2HOW A;  3D27 A;  4U6W A;  4JUQ A;  2BHA A;  4KM3 A;  4FKC A;  3Q6D A;  4IKT A;  5CDL A;  1QZY A;  3BIP A;  2GU6 A;  3QOC A;  4HXX A;  3PKD A;  4PNC A;  4U73 A;  1WBQ A;  2BWX A;  3I7M A;  4OOK A;  2GG7 A;  4ZWU A;  2B3H A;  3CB5 A;  5CDE A;  2EA2 A;  3BIT A;  2P99 A;  4IDY A;  2EVO A;  2OKN A;  2GGB A;  1R5G A;  2BWV A;  2B3K A;  5JHU A;  2GG3 A;  1YW7 A;  4PV4 A;  5CDV A;  1WY2 A;  2IW2 A;  1QXY A;  2Q92 A;  4FO8 A;  2GG8 A;  2ADU A;  1QXW A;  3CTZ A;  2BHD A;  4RGZ 1;  3IU8 A;  4EGE A;  2V6C A;  4U6E A;  1PV9 A;  4U75 A;  5D6E A;  4A6V A;  1M35 A;  3O5V A;  1KQ9 A;  2DFI A;  5CLS A;  1B59 A;  2GZ5 A;  2V3X A;  4ZNG A;  3PKE A;  4FLI A;  1WL9 A;  5JI6 A; 
#chains in the Genus database with same CATH homology
 2EVC A;  3RVA A;  1XGS A;  2NQ7 A;  1Y1N A;  2MAT A;  2GGC A;  3MX6 A;  1YW9 A;  1KQ0 A;  1C24 A;  1WKM A;  3OOO A;  4A6W A;  4B28 A;  2GU5 A;  2P98 A;  2BN7 A;  4IU6 A;  3FMQ A;  1BN5 A;  4MAT A;  1W7V A;  3L24 A;  2EVM A;  2GTX A;  4U70 A;  4RZY A;  4Z7M A;  1A16 A;  2Q93 A;  3FM3 A;  5JFR A;  1MAT A;  4U71 A;  1WLR A;  4FLK A;  2GU7 A;  3IU9 A;  1WL6 A;  4U1B A;  1JAW A;  4U6J A;  1XGO A;  2Q8K A;  2BH3 A;  3BIQ A;  4U6Z A;  2BWY A;  1R5H A;  2V3Z A;  1C23 A;  1O0X A;  2GG5 A;  1W2M A;  2B3L A;  2GG0 A;  2P9A A;  5E2C A;  3IG4 A;  1WN1 A;  3CB6 A;  2GG9 A;  2BHB A;  3PN9 A;  2Q94 A;  4IKU A;  4IKR A;  4RZZ A;  1QXZ A;  4IKS A;  3L7G A;  3FMR A;  4ZWO A;  3IL0 A;  4FUK A;  2BWS A;  4S01 A;  4ZWP A;  2NQ6 A;  4S2T P;  2GA2 A;  4U69 A;  4IF7 A;  2BWU A;  2BHC A;  3S6B A;  5D6F A;  2Q95 A;  4FLL A;  1C22 A;  2GU4 A;  5CE6 A;  1N51 A;  2ZSG A;  4S2R P;  3IU7 A;  2V3Y A;  2EA4 A;  4IPA A;  5E5B A;  3MR1 A;  4U6C A;  4IEC A;  5CIK A;  4S00 A;  1XGM A;  3OVK A;  2G6P A;  1R58 A;  3MAT A;  3PEB A;  1XGN A;  2GG2 A;  5FCH A;  4FO7 A;  1B6A A;  3TAV A;  1C21 A;  1C27 A;  4QR8 A;  1CHM A;  2Q96 A;  3PKC A;  1YVM A;  3PKB A;  1YW8 A;  4R60 A;  1XNZ A;  3TB5 A;  3PKA A;  2OAZ A;  2BB7 A;  5FCF A;  4FLJ A;  2BWT A;  2BWW A;  1YJ3 A;  3ROR A;  1BOA A;  4U76 A;  5CNX A;  1KP0 A;  2HOW A;  3D27 A;  4U6W A;  4JUQ A;  2BHA A;  4KM3 A;  4FKC A;  3Q6D A;  4IKT A;  5CDL A;  1QZY A;  3BIP A;  2GU6 A;  3QOC A;  4HXX A;  3PKD A;  4PNC A;  4U73 A;  1WBQ A;  2BWX A;  3I7M A;  4OOK A;  2GG7 A;  4ZWU A;  2B3H A;  3CB5 A;  5CDE A;  2EA2 A;  3BIT A;  2P99 A;  4IDY A;  2EVO A;  2OKN A;  2GGB A;  1R5G A;  2BWV A;  2B3K A;  5JHU A;  2GG3 A;  1YW7 A;  4PV4 A;  5CDV A;  1WY2 A;  2IW2 A;  1QXY A;  2Q92 A;  4FO8 A;  2GG8 A;  2ADU A;  1QXW A;  3CTZ A;  2BHD A;  4RGZ 1;  3IU8 A;  4EGE A;  2V6C A;  4U6E A;  1PV9 A;  4U75 A;  5D6E A;  4A6V A;  1M35 A;  3O5V A;  1KQ9 A;  2DFI A;  5CLS A;  1B59 A;  2GZ5 A;  2V3X A;  4ZNG A;  3PKE A;  4FLI A;  1WL9 A;  5JI6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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