4ZWPA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
438
structure length
422
Chain Sequence
b'KLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords OPAA organophosphate prolidase anhydrolase
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 148
structure length 422
sequence length 438
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwpA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwpA02
1QXYA 3PKDA 3IL0A 2BWVA 3PKCA 5FCHA 4U6JA 2GGBA 2V3XA 2Q95A 2GG9A 1M35A 1WKMA 1XGOA 3MX6A 2BHBA 4MATA 2BWWA 1YW8A 1KQ9A 1CHMA 2Q94A 2BWTA 3Q6DA 5JI6A 3PKEA 4RZYA 2GZ5A 3BITA 5JFRA 3CB5A 2BB7A 1C27A 2ZSGA 4U6EA 2Q8KA 4PV4A 4U6CA 1WLRA 2GG3A 1QXZA 4U1BA 2BHCA 2V6CA 4Z7MA 1XNZA 1QXWA 5D6FA 1XGNA 2GG5A 2ADUA 1B6AA 1B59A 4U69A 2NQ6A 2V3ZA 2GU5A 2OKNA 5CIKA 5D6EA 2BWSA 1Y1NA 1R58A 2GU4A 3PKBA 2BWYA 3BIPA 1WL9A 2GG2A 3L7GA 5CDLA 1XGSA 2NQ7A 3FMRA 4KM3A 2EVMA 3IG4A 4IECA 1WY2A 4IDYA 1KP0A 3IU8A 2GU6A 4JUQA 2GTXA 5E2CA 4RGZ1 2DFIA 4IU6A 2B3KA 4S01A 4ZWPA 4U73A 1WL6A 1JAWA 4U6WA 1PV9A 4IPAA 1C22A 4R60A 3L24A 4U76A 3OVKA 3OOOA 4IKRA 5CDEA 5JHUA 2B3LA 2Q92A 2GG8A 2BH3A 3QOCA 2BHAA 4A6WA 1KQ0A 5CDVA 1O0XA 3FM3A 3IU7A 1WN1A 2BHDA 2EA2A 4HXXA 1C24A 4S00A 4A6VA 5CE6A 1WBQA 3D27A 5CLSA 4FLKA 1BOAA 4PNCA 4QR8A 1BN5A 2EVCA 4B28A 3FMQA 3CB6A 5CNXA 4S2RP 4FUKA 1C23A 4OOKA 4U6ZA 3IU9A 1C21A 1YW7A 2MATA 2BN7A 2Q93A 1W2MA 1R5GA 2EA4A 1XGMA 3S6BA 2EVOA 4IF7A 1MATA 3RVAA 2GU7A 3CTZA 2BWXA 2P99A 4IKUA 3TAVA 3PKAA 2G6PA 1R5HA 3PN9A 4FKCA 4FLJA 4ZWUA 2IW2A 3I7MA 4EGEA 2Q96A 2BWUA 2GGCA 4U70A 4RZZA 3MATA 4FO8A 2P98A 5FCFA 4FLIA 2HOWA 4ZWOA 4S2TP 4ZNGA 1QZYA 4U75A 4FO7A 3MR1A 3RORA 4IKTA 2GG0A 4IKSA 3TB5A 2P9AA 4U71A 1A16A 3PEBA 5E5BA 2GG7A 1N51A 1YJ3A 1YVMA 3O5VA 2B3HA 2GA2A 4FLLA 2V3YA 3BIQA 2OAZA 1YW9A 1W7VA
chains in the Genus database with same CATH superfamily
1QXYA 3PKDA 3IL0A 2BWVA 3PKCA 5FCHA 4U6JA 2GGBA 2V3XA 2Q95A 2GG9A 1M35A 1WKMA 1XGOA 3MX6A 2BHBA 4MATA 2BWWA 1YW8A 1KQ9A 1CHMA 2Q94A 2BWTA 3Q6DA 5JI6A 3PKEA 4RZYA 2GZ5A 3BITA 5JFRA 3CB5A 2BB7A 1C27A 2ZSGA 4U6EA 2Q8KA 4PV4A 4U6CA 1WLRA 2GG3A 1QXZA 4U1BA 2BHCA 2V6CA 4Z7MA 1XNZA 1QXWA 5D6FA 1XGNA 2GG5A 2ADUA 1B6AA 1B59A 4U69A 2NQ6A 2V3ZA 2GU5A 2OKNA 5CIKA 5D6EA 2BWSA 1Y1NA 1R58A 2GU4A 3PKBA 2BWYA 3BIPA 1WL9A 2GG2A 3L7GA 5CDLA 1XGSA 2NQ7A 3FMRA 4KM3A 2EVMA 3IG4A 4IECA 1WY2A 4IDYA 1KP0A 3IU8A 2GU6A 4JUQA 2GTXA 5E2CA 4RGZ1 2DFIA 4IU6A 2B3KA 4S01A 4ZWPA 4U73A 1WL6A 1JAWA 4U6WA 1PV9A 4IPAA 1C22A 4R60A 3L24A 4U76A 3OVKA 3OOOA 4IKRA 5CDEA 5JHUA 2B3LA 2Q92A 2GG8A 2BH3A 3QOCA 2BHAA 4A6WA 1KQ0A 5CDVA 1O0XA 3FM3A 3IU7A 1WN1A 2BHDA 2EA2A 4HXXA 1C24A 4S00A 4A6VA 5CE6A 1WBQA 3D27A 5CLSA 4FLKA 1BOAA 4PNCA 4QR8A 1BN5A 2EVCA 4B28A 3FMQA 3CB6A 5CNXA 4S2RP 4FUKA 1C23A 4OOKA 4U6ZA 3IU9A 1C21A 1YW7A 2MATA 2BN7A 2Q93A 1W2MA 1R5GA 2EA4A 1XGMA 3S6BA 2EVOA 4IF7A 1MATA 3RVAA 2GU7A 3CTZA 2BWXA 2P99A 4IKUA 3TAVA 3PKAA 2G6PA 1R5HA 3PN9A 4FKCA 4FLJA 4ZWUA 2IW2A 3I7MA 4EGEA 2Q96A 2BWUA 2GGCA 4U70A 4RZZA 3MATA 4FO8A 2P98A 5FCFA 4FLIA 2HOWA 4ZWOA 4S2TP 4ZNGA 1QZYA 4U75A 4FO7A 3MR1A 3RORA 4IKTA 2GG0A 4IKSA 3TB5A 2P9AA 4U71A 1A16A 3PEBA 5E5BA 2GG7A 1N51A 1YJ3A 1YVMA 3O5VA 2B3HA 2GA2A 4FLLA 2V3YA 3BIQA 2OAZA 1YW9A 1W7VA
chains in the Genus database with same CATH topology
1QXYA 3PKDA 3IL0A 2BWVA 3PKCA 5FCHA 4U6JA 2GGBA 2V3XA 2Q95A 2GG9A 1M35A 1WKMA 1XGOA 3MX6A 2BHBA 4MATA 2BWWA 1YW8A 1KQ9A 1CHMA 2Q94A 2BWTA 3Q6DA 5JI6A 3PKEA 4RZYA 2GZ5A 3BITA 5JFRA 3CB5A 2BB7A 1C27A 2ZSGA 4U6EA 2Q8KA 4PV4A 4U6CA 1WLRA 2GG3A 1QXZA 4U1BA 2BHCA 2V6CA 4Z7MA 1XNZA 1QXWA 5D6FA 1XGNA 2GG5A 2ADUA 1B6AA 1B59A 4U69A 2NQ6A 2V3ZA 2GU5A 2OKNA 5CIKA 5D6EA 2BWSA 1Y1NA 1R58A 2GU4A 3PKBA 2BWYA 3BIPA 1WL9A 2GG2A 3L7GA 5CDLA 1XGSA 2NQ7A 3FMRA 4KM3A 2EVMA 3IG4A 4IECA 1WY2A 4IDYA 1KP0A 3IU8A 2GU6A 4JUQA 2GTXA 5E2CA 4RGZ1 2DFIA 4IU6A 2B3KA 4S01A 4ZWPA 4U73A 1WL6A 1JAWA 4U6WA 1PV9A 4IPAA 1C22A 4R60A 3L24A 4U76A 3OVKA 3OOOA 4IKRA 5CDEA 5JHUA 2B3LA 2Q92A 2GG8A 2BH3A 3QOCA 2BHAA 4A6WA 1KQ0A 5CDVA 1O0XA 3FM3A 3IU7A 1WN1A 2BHDA 2EA2A 4HXXA 1C24A 4S00A 4A6VA 5CE6A 1WBQA 3D27A 5CLSA 4FLKA 1BOAA 4PNCA 4QR8A 1BN5A 2EVCA 4B28A 3FMQA 3CB6A 5CNXA 4S2RP 4FUKA 1C23A 4OOKA 4U6ZA 3IU9A 1C21A 1YW7A 2MATA 2BN7A 2Q93A 1W2MA 1R5GA 2EA4A 1XGMA 3S6BA 2EVOA 4IF7A 1MATA 3RVAA 2GU7A 3CTZA 2BWXA 2P99A 4IKUA 3TAVA 3PKAA 2G6PA 1R5HA 3PN9A 4FKCA 4FLJA 4ZWUA 2IW2A 3I7MA 4EGEA 2Q96A 2BWUA 2GGCA 4U70A 4RZZA 3MATA 4FO8A 2P98A 5FCFA 4FLIA 2HOWA 4ZWOA 4S2TP 4ZNGA 1QZYA 4U75A 4FO7A 3MR1A 3RORA 4IKTA 2GG0A 4IKSA 3TB5A 2P9AA 4U71A 1A16A 3PEBA 5E5BA 2GG7A 1N51A 1YJ3A 1YVMA 3O5VA 2B3HA 2GA2A 4FLLA 2V3YA 3BIQA 2OAZA 1YW9A 1W7VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QXY A;  3PKD A;  3IL0 A;  2BWV A;  3PKC A;  5FCH A;  4U6J A;  2GGB A;  2V3X A;  2Q95 A;  2GG9 A;  1M35 A;  1WKM A;  1XGO A;  3MX6 A;  2BHB A;  4MAT A;  2BWW A;  1YW8 A;  1KQ9 A;  1CHM A;  2Q94 A;  2BWT A;  3Q6D A;  5JI6 A;  3PKE A;  4RZY A;  2GZ5 A;  3BIT A;  5JFR A;  3CB5 A;  2BB7 A;  1C27 A;  2ZSG A;  4U6E A;  2Q8K A;  4PV4 A;  4U6C A;  1WLR A;  2GG3 A;  1QXZ A;  4U1B A;  2BHC A;  2V6C A;  4Z7M A;  1XNZ A;  1QXW A;  5D6F A;  1XGN A;  2GG5 A;  2ADU A;  1B6A A;  1B59 A;  4U69 A;  2NQ6 A;  2V3Z A;  2GU5 A;  2OKN A;  5CIK A;  5D6E A;  2BWS A;  1Y1N A;  1R58 A;  2GU4 A;  3PKB A;  2BWY A;  3BIP A;  1WL9 A;  2GG2 A;  3L7G A;  5CDL A;  1XGS A;  2NQ7 A;  3FMR A;  4KM3 A;  2EVM A;  3IG4 A;  4IEC A;  1WY2 A;  4IDY A;  1KP0 A;  3IU8 A;  2GU6 A;  4JUQ A;  2GTX A;  5E2C A;  4RGZ 1;  2DFI A;  4IU6 A;  2B3K A;  4S01 A;  4ZWP A;  4U73 A;  1WL6 A;  1JAW A;  4U6W A;  1PV9 A;  4IPA A;  1C22 A;  4R60 A;  3L24 A;  4U76 A;  3OVK A;  3OOO A;  4IKR A;  5CDE A;  5JHU A;  2B3L A;  2Q92 A;  2GG8 A;  2BH3 A;  3QOC A;  2BHA A;  4A6W A;  1KQ0 A;  5CDV A;  1O0X A;  3FM3 A;  3IU7 A;  1WN1 A;  2BHD A;  2EA2 A;  4HXX A;  1C24 A;  4S00 A;  4A6V A;  5CE6 A;  1WBQ A;  3D27 A;  5CLS A;  4FLK A;  1BOA A;  4PNC A;  4QR8 A;  1BN5 A;  2EVC A;  4B28 A;  3FMQ A;  3CB6 A;  5CNX A;  4S2R P;  4FUK A;  1C23 A;  4OOK A;  4U6Z A;  3IU9 A;  1C21 A;  1YW7 A;  2MAT A;  2BN7 A;  2Q93 A;  1W2M A;  1R5G A;  2EA4 A;  1XGM A;  3S6B A;  2EVO A;  4IF7 A;  1MAT A;  3RVA A;  2GU7 A;  3CTZ A;  2BWX A;  2P99 A;  4IKU A;  3TAV A;  3PKA A;  2G6P A;  1R5H A;  3PN9 A;  4FKC A;  4FLJ A;  4ZWU A;  2IW2 A;  3I7M A;  4EGE A;  2Q96 A;  2BWU A;  2GGC A;  4U70 A;  4RZZ A;  3MAT A;  4FO8 A;  2P98 A;  5FCF A;  4FLI A;  2HOW A;  4ZWO A;  4S2T P;  4ZNG A;  1QZY A;  4U75 A;  4FO7 A;  3MR1 A;  3ROR A;  4IKT A;  2GG0 A;  4IKS A;  3TB5 A;  2P9A A;  4U71 A;  1A16 A;  3PEB A;  5E5B A;  2GG7 A;  1N51 A;  1YJ3 A;  1YVM A;  3O5V A;  2B3H A;  2GA2 A;  4FLL A;  2V3Y A;  3BIQ A;  2OAZ A;  1YW9 A;  1W7V A; 
#chains in the Genus database with same CATH topology
 1QXY A;  3PKD A;  3IL0 A;  2BWV A;  3PKC A;  5FCH A;  4U6J A;  2GGB A;  2V3X A;  2Q95 A;  2GG9 A;  1M35 A;  1WKM A;  1XGO A;  3MX6 A;  2BHB A;  4MAT A;  2BWW A;  1YW8 A;  1KQ9 A;  1CHM A;  2Q94 A;  2BWT A;  3Q6D A;  5JI6 A;  3PKE A;  4RZY A;  2GZ5 A;  3BIT A;  5JFR A;  3CB5 A;  2BB7 A;  1C27 A;  2ZSG A;  4U6E A;  2Q8K A;  4PV4 A;  4U6C A;  1WLR A;  2GG3 A;  1QXZ A;  4U1B A;  2BHC A;  2V6C A;  4Z7M A;  1XNZ A;  1QXW A;  5D6F A;  1XGN A;  2GG5 A;  2ADU A;  1B6A A;  1B59 A;  4U69 A;  2NQ6 A;  2V3Z A;  2GU5 A;  2OKN A;  5CIK A;  5D6E A;  2BWS A;  1Y1N A;  1R58 A;  2GU4 A;  3PKB A;  2BWY A;  3BIP A;  1WL9 A;  2GG2 A;  3L7G A;  5CDL A;  1XGS A;  2NQ7 A;  3FMR A;  4KM3 A;  2EVM A;  3IG4 A;  4IEC A;  1WY2 A;  4IDY A;  1KP0 A;  3IU8 A;  2GU6 A;  4JUQ A;  2GTX A;  5E2C A;  4RGZ 1;  2DFI A;  4IU6 A;  2B3K A;  4S01 A;  4ZWP A;  4U73 A;  1WL6 A;  1JAW A;  4U6W A;  1PV9 A;  4IPA A;  1C22 A;  4R60 A;  3L24 A;  4U76 A;  3OVK A;  3OOO A;  4IKR A;  5CDE A;  5JHU A;  2B3L A;  2Q92 A;  2GG8 A;  2BH3 A;  3QOC A;  2BHA A;  4A6W A;  1KQ0 A;  5CDV A;  1O0X A;  3FM3 A;  3IU7 A;  1WN1 A;  2BHD A;  2EA2 A;  4HXX A;  1C24 A;  4S00 A;  4A6V A;  5CE6 A;  1WBQ A;  3D27 A;  5CLS A;  4FLK A;  1BOA A;  4PNC A;  4QR8 A;  1BN5 A;  2EVC A;  4B28 A;  3FMQ A;  3CB6 A;  5CNX A;  4S2R P;  4FUK A;  1C23 A;  4OOK A;  4U6Z A;  3IU9 A;  1C21 A;  1YW7 A;  2MAT A;  2BN7 A;  2Q93 A;  1W2M A;  1R5G A;  2EA4 A;  1XGM A;  3S6B A;  2EVO A;  4IF7 A;  1MAT A;  3RVA A;  2GU7 A;  3CTZ A;  2BWX A;  2P99 A;  4IKU A;  3TAV A;  3PKA A;  2G6P A;  1R5H A;  3PN9 A;  4FKC A;  4FLJ A;  4ZWU A;  2IW2 A;  3I7M A;  4EGE A;  2Q96 A;  2BWU A;  2GGC A;  4U70 A;  4RZZ A;  3MAT A;  4FO8 A;  2P98 A;  5FCF A;  4FLI A;  2HOW A;  4ZWO A;  4S2T P;  4ZNG A;  1QZY A;  4U75 A;  4FO7 A;  3MR1 A;  3ROR A;  4IKT A;  2GG0 A;  4IKS A;  3TB5 A;  2P9A A;  4U71 A;  1A16 A;  3PEB A;  5E5B A;  2GG7 A;  1N51 A;  1YJ3 A;  1YVM A;  3O5V A;  2B3H A;  2GA2 A;  4FLL A;  2V3Y A;  3BIQ A;  2OAZ A;  1YW9 A;  1W7V A; 
#chains in the Genus database with same CATH homology
 1QXY A;  3PKD A;  3IL0 A;  2BWV A;  3PKC A;  5FCH A;  4U6J A;  2GGB A;  2V3X A;  2Q95 A;  2GG9 A;  1M35 A;  1WKM A;  1XGO A;  3MX6 A;  2BHB A;  4MAT A;  2BWW A;  1YW8 A;  1KQ9 A;  1CHM A;  2Q94 A;  2BWT A;  3Q6D A;  5JI6 A;  3PKE A;  4RZY A;  2GZ5 A;  3BIT A;  5JFR A;  3CB5 A;  2BB7 A;  1C27 A;  2ZSG A;  4U6E A;  2Q8K A;  4PV4 A;  4U6C A;  1WLR A;  2GG3 A;  1QXZ A;  4U1B A;  2BHC A;  2V6C A;  4Z7M A;  1XNZ A;  1QXW A;  5D6F A;  1XGN A;  2GG5 A;  2ADU A;  1B6A A;  1B59 A;  4U69 A;  2NQ6 A;  2V3Z A;  2GU5 A;  2OKN A;  5CIK A;  5D6E A;  2BWS A;  1Y1N A;  1R58 A;  2GU4 A;  3PKB A;  2BWY A;  3BIP A;  1WL9 A;  2GG2 A;  3L7G A;  5CDL A;  1XGS A;  2NQ7 A;  3FMR A;  4KM3 A;  2EVM A;  3IG4 A;  4IEC A;  1WY2 A;  4IDY A;  1KP0 A;  3IU8 A;  2GU6 A;  4JUQ A;  2GTX A;  5E2C A;  4RGZ 1;  2DFI A;  4IU6 A;  2B3K A;  4S01 A;  4ZWP A;  4U73 A;  1WL6 A;  1JAW A;  4U6W A;  1PV9 A;  4IPA A;  1C22 A;  4R60 A;  3L24 A;  4U76 A;  3OVK A;  3OOO A;  4IKR A;  5CDE A;  5JHU A;  2B3L A;  2Q92 A;  2GG8 A;  2BH3 A;  3QOC A;  2BHA A;  4A6W A;  1KQ0 A;  5CDV A;  1O0X A;  3FM3 A;  3IU7 A;  1WN1 A;  2BHD A;  2EA2 A;  4HXX A;  1C24 A;  4S00 A;  4A6V A;  5CE6 A;  1WBQ A;  3D27 A;  5CLS A;  4FLK A;  1BOA A;  4PNC A;  4QR8 A;  1BN5 A;  2EVC A;  4B28 A;  3FMQ A;  3CB6 A;  5CNX A;  4S2R P;  4FUK A;  1C23 A;  4OOK A;  4U6Z A;  3IU9 A;  1C21 A;  1YW7 A;  2MAT A;  2BN7 A;  2Q93 A;  1W2M A;  1R5G A;  2EA4 A;  1XGM A;  3S6B A;  2EVO A;  4IF7 A;  1MAT A;  3RVA A;  2GU7 A;  3CTZ A;  2BWX A;  2P99 A;  4IKU A;  3TAV A;  3PKA A;  2G6P A;  1R5H A;  3PN9 A;  4FKC A;  4FLJ A;  4ZWU A;  2IW2 A;  3I7M A;  4EGE A;  2Q96 A;  2BWU A;  2GGC A;  4U70 A;  4RZZ A;  3MAT A;  4FO8 A;  2P98 A;  5FCF A;  4FLI A;  2HOW A;  4ZWO A;  4S2T P;  4ZNG A;  1QZY A;  4U75 A;  4FO7 A;  3MR1 A;  3ROR A;  4IKT A;  2GG0 A;  4IKS A;  3TB5 A;  2P9A A;  4U71 A;  1A16 A;  3PEB A;  5E5B A;  2GG7 A;  1N51 A;  1YJ3 A;  1YVM A;  3O5V A;  2B3H A;  2GA2 A;  4FLL A;  2V3Y A;  3BIQ A;  2OAZ A;  1YW9 A;  1W7V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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