4ZWPA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
438
structure length
422
Chain Sequence
KLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords OPAA organophosphate prolidase anhydrolase
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 148
structure length 422
sequence length 438
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwpA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwpA02
2MATA 3FMRA 3CTZA 4FKCA 4U1BA 3IG4A 4IDYA 4PNCA 2Q94A 2BWSA 3OOOA 2BWUA 4U69A 4IU6A 4ZWOA 4EGEA 1YW9A 4RZZA 1XNZA 4KM3A 4PV4A 1QZYA 5D6EA 2Q96A 4IF7A 1WLRA 1CHMA 3TB5A 4U6EA 4OOKA 2GGCA 2GG0A 4S2RP 2GZ5A 1C23A 3IL0A 4U6CA 1WN1A 1R58A 2V6CA 1C27A 2EVOA 1O0XA 4FO8A 3PN9A 1B6AA 5CDEA 2V3YA 3TAVA 2V3XA 2EA2A 4MATA 1B59A 4U73A 3OVKA 3MX6A 5CE6A 1Y1NA 2GG9A 3I7MA 5JFRA 2B3LA 1YW8A 4FUKA 5E5BA 3RVAA 3IU7A 4U6ZA 2EA4A 5JI6A 2ZSGA 1YVMA 4ZWUA 1XGMA 4S00A 2GA2A 2GTXA 3FMQA 3PKBA 4B28A 3D27A 2BWTA 4U6WA 4IPAA 2GG3A 3BITA 4FO7A 2BHDA 2BH3A 4Z7MA 3L24A 1WL9A 2Q8KA 4R60A 4HXXA 1XGOA 3CB5A 2GU5A 1BN5A 4FLJA 4QR8A 2P98A 4RZYA 2ADUA 3IU8A 1KP0A 1WY2A 2V3ZA 3BIPA 5JHUA 3PEBA 5CLSA 4FLKA 1WKMA 3L7GA 1XGNA 2NQ7A 5D6FA 4FLLA 4ZWPA 5CNXA 1R5GA 2BB7A 4IKSA 2BWXA 2GU6A 3MATA 4JUQA 1MATA 2BWYA 1BOAA 2DFIA 2G6PA 2P9AA 1QXZA 5E2CA 2HOWA 3IU9A 3S6BA 4U76A 3PKAA 2IW2A 1KQ9A 2P99A 2BHAA 1JAWA 2GG8A 4U71A 2GG5A 2GG7A 4IKRA 4U75A 3Q6DA 3MR1A 2GG2A 1PV9A 1QXYA 1QXWA 2NQ6A 2Q93A 2GGBA 3FM3A 5CDLA 3PKCA 1C21A 2BHCA 4S01A 1YJ3A 2BN7A 1R5HA 4IKUA 4U70A 2B3KA 4ZNGA 2EVCA 4RGZ1 2BHBA 5FCHA 2EVMA 4FLIA 4A6WA 1W2MA 2BWWA 2Q92A 1M35A 5CDVA 4S2TP 5FCFA 1KQ0A 4IKTA 2OKNA 2GU7A 1YW7A 1A16A 4IECA 3PKDA 2B3HA 2Q95A 3RORA 1C24A 3CB6A 1W7VA 3BIQA 3QOCA 4U6JA 1WL6A 1C22A 5CIKA 1WBQA 4A6VA 2GU4A 2OAZA 1N51A 1XGSA 3PKEA 3O5VA 2BWVA
chains in the Genus database with same CATH superfamily
2MATA 3FMRA 3CTZA 4FKCA 4U1BA 3IG4A 4IDYA 4PNCA 2Q94A 2BWSA 3OOOA 2BWUA 4U69A 4IU6A 4ZWOA 4EGEA 1YW9A 4RZZA 1XNZA 4KM3A 4PV4A 1QZYA 5D6EA 2Q96A 4IF7A 1WLRA 1CHMA 3TB5A 4U6EA 4OOKA 2GGCA 2GG0A 4S2RP 2GZ5A 1C23A 3IL0A 4U6CA 1WN1A 1R58A 2V6CA 1C27A 2EVOA 1O0XA 4FO8A 3PN9A 1B6AA 5CDEA 2V3YA 3TAVA 2V3XA 2EA2A 4MATA 1B59A 4U73A 3OVKA 3MX6A 5CE6A 1Y1NA 2GG9A 3I7MA 5JFRA 2B3LA 1YW8A 4FUKA 5E5BA 3RVAA 3IU7A 4U6ZA 2EA4A 5JI6A 2ZSGA 1YVMA 4ZWUA 1XGMA 4S00A 2GA2A 2GTXA 3FMQA 3PKBA 4B28A 3D27A 2BWTA 4U6WA 4IPAA 2GG3A 3BITA 4FO7A 2BHDA 2BH3A 4Z7MA 3L24A 1WL9A 2Q8KA 4R60A 4HXXA 1XGOA 3CB5A 2GU5A 1BN5A 4FLJA 4QR8A 2P98A 4RZYA 2ADUA 3IU8A 1KP0A 1WY2A 2V3ZA 3BIPA 5JHUA 3PEBA 5CLSA 4FLKA 1WKMA 3L7GA 1XGNA 2NQ7A 5D6FA 4FLLA 4ZWPA 5CNXA 1R5GA 2BB7A 4IKSA 2BWXA 2GU6A 3MATA 4JUQA 1MATA 2BWYA 1BOAA 2DFIA 2G6PA 2P9AA 1QXZA 5E2CA 2HOWA 3IU9A 3S6BA 4U76A 3PKAA 2IW2A 1KQ9A 2P99A 2BHAA 1JAWA 2GG8A 4U71A 2GG5A 2GG7A 4IKRA 4U75A 3Q6DA 3MR1A 2GG2A 1PV9A 1QXYA 1QXWA 2NQ6A 2Q93A 2GGBA 3FM3A 5CDLA 3PKCA 1C21A 2BHCA 4S01A 1YJ3A 2BN7A 1R5HA 4IKUA 4U70A 2B3KA 4ZNGA 2EVCA 4RGZ1 2BHBA 5FCHA 2EVMA 4FLIA 4A6WA 1W2MA 2BWWA 2Q92A 1M35A 5CDVA 4S2TP 5FCFA 1KQ0A 4IKTA 2OKNA 2GU7A 1YW7A 1A16A 4IECA 3PKDA 2B3HA 2Q95A 3RORA 1C24A 3CB6A 1W7VA 3BIQA 3QOCA 4U6JA 1WL6A 1C22A 5CIKA 1WBQA 4A6VA 2GU4A 2OAZA 1N51A 1XGSA 3PKEA 3O5VA 2BWVA
chains in the Genus database with same CATH topology
2MATA 3FMRA 3CTZA 4FKCA 4U1BA 3IG4A 4IDYA 4PNCA 2Q94A 2BWSA 3OOOA 2BWUA 4U69A 4IU6A 4ZWOA 4EGEA 1YW9A 4RZZA 1XNZA 4KM3A 4PV4A 1QZYA 5D6EA 2Q96A 4IF7A 1WLRA 1CHMA 3TB5A 4U6EA 4OOKA 2GGCA 2GG0A 4S2RP 2GZ5A 1C23A 3IL0A 4U6CA 1WN1A 1R58A 2V6CA 1C27A 2EVOA 1O0XA 4FO8A 3PN9A 1B6AA 5CDEA 2V3YA 3TAVA 2V3XA 2EA2A 4MATA 1B59A 4U73A 3OVKA 3MX6A 5CE6A 1Y1NA 2GG9A 3I7MA 5JFRA 2B3LA 1YW8A 4FUKA 5E5BA 3RVAA 3IU7A 4U6ZA 2EA4A 5JI6A 2ZSGA 1YVMA 4ZWUA 1XGMA 4S00A 2GA2A 2GTXA 3FMQA 3PKBA 4B28A 3D27A 2BWTA 4U6WA 4IPAA 2GG3A 3BITA 4FO7A 2BHDA 2BH3A 4Z7MA 3L24A 1WL9A 2Q8KA 4R60A 4HXXA 1XGOA 3CB5A 2GU5A 1BN5A 4FLJA 4QR8A 2P98A 4RZYA 2ADUA 3IU8A 1KP0A 1WY2A 2V3ZA 3BIPA 5JHUA 3PEBA 5CLSA 4FLKA 1WKMA 3L7GA 1XGNA 2NQ7A 5D6FA 4FLLA 4ZWPA 5CNXA 1R5GA 2BB7A 4IKSA 2BWXA 2GU6A 3MATA 4JUQA 1MATA 2BWYA 1BOAA 2DFIA 2G6PA 2P9AA 1QXZA 5E2CA 2HOWA 3IU9A 3S6BA 4U76A 3PKAA 2IW2A 1KQ9A 2P99A 2BHAA 1JAWA 2GG8A 4U71A 2GG5A 2GG7A 4IKRA 4U75A 3Q6DA 3MR1A 2GG2A 1PV9A 1QXYA 1QXWA 2NQ6A 2Q93A 2GGBA 3FM3A 5CDLA 3PKCA 1C21A 2BHCA 4S01A 1YJ3A 2BN7A 1R5HA 4IKUA 4U70A 2B3KA 4ZNGA 2EVCA 4RGZ1 2BHBA 5FCHA 2EVMA 4FLIA 4A6WA 1W2MA 2BWWA 2Q92A 1M35A 5CDVA 4S2TP 5FCFA 1KQ0A 4IKTA 2OKNA 2GU7A 1YW7A 1A16A 4IECA 3PKDA 2B3HA 2Q95A 3RORA 1C24A 3CB6A 1W7VA 3BIQA 3QOCA 4U6JA 1WL6A 1C22A 5CIKA 1WBQA 4A6VA 2GU4A 2OAZA 1N51A 1XGSA 3PKEA 3O5VA 2BWVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MAT A;  3FMR A;  3CTZ A;  4FKC A;  4U1B A;  3IG4 A;  4IDY A;  4PNC A;  2Q94 A;  2BWS A;  3OOO A;  2BWU A;  4U69 A;  4IU6 A;  4ZWO A;  4EGE A;  1YW9 A;  4RZZ A;  1XNZ A;  4KM3 A;  4PV4 A;  1QZY A;  5D6E A;  2Q96 A;  4IF7 A;  1WLR A;  1CHM A;  3TB5 A;  4U6E A;  4OOK A;  2GGC A;  2GG0 A;  4S2R P;  2GZ5 A;  1C23 A;  3IL0 A;  4U6C A;  1WN1 A;  1R58 A;  2V6C A;  1C27 A;  2EVO A;  1O0X A;  4FO8 A;  3PN9 A;  1B6A A;  5CDE A;  2V3Y A;  3TAV A;  2V3X A;  2EA2 A;  4MAT A;  1B59 A;  4U73 A;  3OVK A;  3MX6 A;  5CE6 A;  1Y1N A;  2GG9 A;  3I7M A;  5JFR A;  2B3L A;  1YW8 A;  4FUK A;  5E5B A;  3RVA A;  3IU7 A;  4U6Z A;  2EA4 A;  5JI6 A;  2ZSG A;  1YVM A;  4ZWU A;  1XGM A;  4S00 A;  2GA2 A;  2GTX A;  3FMQ A;  3PKB A;  4B28 A;  3D27 A;  2BWT A;  4U6W A;  4IPA A;  2GG3 A;  3BIT A;  4FO7 A;  2BHD A;  2BH3 A;  4Z7M A;  3L24 A;  1WL9 A;  2Q8K A;  4R60 A;  4HXX A;  1XGO A;  3CB5 A;  2GU5 A;  1BN5 A;  4FLJ A;  4QR8 A;  2P98 A;  4RZY A;  2ADU A;  3IU8 A;  1KP0 A;  1WY2 A;  2V3Z A;  3BIP A;  5JHU A;  3PEB A;  5CLS A;  4FLK A;  1WKM A;  3L7G A;  1XGN A;  2NQ7 A;  5D6F A;  4FLL A;  4ZWP A;  5CNX A;  1R5G A;  2BB7 A;  4IKS A;  2BWX A;  2GU6 A;  3MAT A;  4JUQ A;  1MAT A;  2BWY A;  1BOA A;  2DFI A;  2G6P A;  2P9A A;  1QXZ A;  5E2C A;  2HOW A;  3IU9 A;  3S6B A;  4U76 A;  3PKA A;  2IW2 A;  1KQ9 A;  2P99 A;  2BHA A;  1JAW A;  2GG8 A;  4U71 A;  2GG5 A;  2GG7 A;  4IKR A;  4U75 A;  3Q6D A;  3MR1 A;  2GG2 A;  1PV9 A;  1QXY A;  1QXW A;  2NQ6 A;  2Q93 A;  2GGB A;  3FM3 A;  5CDL A;  3PKC A;  1C21 A;  2BHC A;  4S01 A;  1YJ3 A;  2BN7 A;  1R5H A;  4IKU A;  4U70 A;  2B3K A;  4ZNG A;  2EVC A;  4RGZ 1;  2BHB A;  5FCH A;  2EVM A;  4FLI A;  4A6W A;  1W2M A;  2BWW A;  2Q92 A;  1M35 A;  5CDV A;  4S2T P;  5FCF A;  1KQ0 A;  4IKT A;  2OKN A;  2GU7 A;  1YW7 A;  1A16 A;  4IEC A;  3PKD A;  2B3H A;  2Q95 A;  3ROR A;  1C24 A;  3CB6 A;  1W7V A;  3BIQ A;  3QOC A;  4U6J A;  1WL6 A;  1C22 A;  5CIK A;  1WBQ A;  4A6V A;  2GU4 A;  2OAZ A;  1N51 A;  1XGS A;  3PKE A;  3O5V A;  2BWV A; 
#chains in the Genus database with same CATH topology
 2MAT A;  3FMR A;  3CTZ A;  4FKC A;  4U1B A;  3IG4 A;  4IDY A;  4PNC A;  2Q94 A;  2BWS A;  3OOO A;  2BWU A;  4U69 A;  4IU6 A;  4ZWO A;  4EGE A;  1YW9 A;  4RZZ A;  1XNZ A;  4KM3 A;  4PV4 A;  1QZY A;  5D6E A;  2Q96 A;  4IF7 A;  1WLR A;  1CHM A;  3TB5 A;  4U6E A;  4OOK A;  2GGC A;  2GG0 A;  4S2R P;  2GZ5 A;  1C23 A;  3IL0 A;  4U6C A;  1WN1 A;  1R58 A;  2V6C A;  1C27 A;  2EVO A;  1O0X A;  4FO8 A;  3PN9 A;  1B6A A;  5CDE A;  2V3Y A;  3TAV A;  2V3X A;  2EA2 A;  4MAT A;  1B59 A;  4U73 A;  3OVK A;  3MX6 A;  5CE6 A;  1Y1N A;  2GG9 A;  3I7M A;  5JFR A;  2B3L A;  1YW8 A;  4FUK A;  5E5B A;  3RVA A;  3IU7 A;  4U6Z A;  2EA4 A;  5JI6 A;  2ZSG A;  1YVM A;  4ZWU A;  1XGM A;  4S00 A;  2GA2 A;  2GTX A;  3FMQ A;  3PKB A;  4B28 A;  3D27 A;  2BWT A;  4U6W A;  4IPA A;  2GG3 A;  3BIT A;  4FO7 A;  2BHD A;  2BH3 A;  4Z7M A;  3L24 A;  1WL9 A;  2Q8K A;  4R60 A;  4HXX A;  1XGO A;  3CB5 A;  2GU5 A;  1BN5 A;  4FLJ A;  4QR8 A;  2P98 A;  4RZY A;  2ADU A;  3IU8 A;  1KP0 A;  1WY2 A;  2V3Z A;  3BIP A;  5JHU A;  3PEB A;  5CLS A;  4FLK A;  1WKM A;  3L7G A;  1XGN A;  2NQ7 A;  5D6F A;  4FLL A;  4ZWP A;  5CNX A;  1R5G A;  2BB7 A;  4IKS A;  2BWX A;  2GU6 A;  3MAT A;  4JUQ A;  1MAT A;  2BWY A;  1BOA A;  2DFI A;  2G6P A;  2P9A A;  1QXZ A;  5E2C A;  2HOW A;  3IU9 A;  3S6B A;  4U76 A;  3PKA A;  2IW2 A;  1KQ9 A;  2P99 A;  2BHA A;  1JAW A;  2GG8 A;  4U71 A;  2GG5 A;  2GG7 A;  4IKR A;  4U75 A;  3Q6D A;  3MR1 A;  2GG2 A;  1PV9 A;  1QXY A;  1QXW A;  2NQ6 A;  2Q93 A;  2GGB A;  3FM3 A;  5CDL A;  3PKC A;  1C21 A;  2BHC A;  4S01 A;  1YJ3 A;  2BN7 A;  1R5H A;  4IKU A;  4U70 A;  2B3K A;  4ZNG A;  2EVC A;  4RGZ 1;  2BHB A;  5FCH A;  2EVM A;  4FLI A;  4A6W A;  1W2M A;  2BWW A;  2Q92 A;  1M35 A;  5CDV A;  4S2T P;  5FCF A;  1KQ0 A;  4IKT A;  2OKN A;  2GU7 A;  1YW7 A;  1A16 A;  4IEC A;  3PKD A;  2B3H A;  2Q95 A;  3ROR A;  1C24 A;  3CB6 A;  1W7V A;  3BIQ A;  3QOC A;  4U6J A;  1WL6 A;  1C22 A;  5CIK A;  1WBQ A;  4A6V A;  2GU4 A;  2OAZ A;  1N51 A;  1XGS A;  3PKE A;  3O5V A;  2BWV A; 
#chains in the Genus database with same CATH homology
 2MAT A;  3FMR A;  3CTZ A;  4FKC A;  4U1B A;  3IG4 A;  4IDY A;  4PNC A;  2Q94 A;  2BWS A;  3OOO A;  2BWU A;  4U69 A;  4IU6 A;  4ZWO A;  4EGE A;  1YW9 A;  4RZZ A;  1XNZ A;  4KM3 A;  4PV4 A;  1QZY A;  5D6E A;  2Q96 A;  4IF7 A;  1WLR A;  1CHM A;  3TB5 A;  4U6E A;  4OOK A;  2GGC A;  2GG0 A;  4S2R P;  2GZ5 A;  1C23 A;  3IL0 A;  4U6C A;  1WN1 A;  1R58 A;  2V6C A;  1C27 A;  2EVO A;  1O0X A;  4FO8 A;  3PN9 A;  1B6A A;  5CDE A;  2V3Y A;  3TAV A;  2V3X A;  2EA2 A;  4MAT A;  1B59 A;  4U73 A;  3OVK A;  3MX6 A;  5CE6 A;  1Y1N A;  2GG9 A;  3I7M A;  5JFR A;  2B3L A;  1YW8 A;  4FUK A;  5E5B A;  3RVA A;  3IU7 A;  4U6Z A;  2EA4 A;  5JI6 A;  2ZSG A;  1YVM A;  4ZWU A;  1XGM A;  4S00 A;  2GA2 A;  2GTX A;  3FMQ A;  3PKB A;  4B28 A;  3D27 A;  2BWT A;  4U6W A;  4IPA A;  2GG3 A;  3BIT A;  4FO7 A;  2BHD A;  2BH3 A;  4Z7M A;  3L24 A;  1WL9 A;  2Q8K A;  4R60 A;  4HXX A;  1XGO A;  3CB5 A;  2GU5 A;  1BN5 A;  4FLJ A;  4QR8 A;  2P98 A;  4RZY A;  2ADU A;  3IU8 A;  1KP0 A;  1WY2 A;  2V3Z A;  3BIP A;  5JHU A;  3PEB A;  5CLS A;  4FLK A;  1WKM A;  3L7G A;  1XGN A;  2NQ7 A;  5D6F A;  4FLL A;  4ZWP A;  5CNX A;  1R5G A;  2BB7 A;  4IKS A;  2BWX A;  2GU6 A;  3MAT A;  4JUQ A;  1MAT A;  2BWY A;  1BOA A;  2DFI A;  2G6P A;  2P9A A;  1QXZ A;  5E2C A;  2HOW A;  3IU9 A;  3S6B A;  4U76 A;  3PKA A;  2IW2 A;  1KQ9 A;  2P99 A;  2BHA A;  1JAW A;  2GG8 A;  4U71 A;  2GG5 A;  2GG7 A;  4IKR A;  4U75 A;  3Q6D A;  3MR1 A;  2GG2 A;  1PV9 A;  1QXY A;  1QXW A;  2NQ6 A;  2Q93 A;  2GGB A;  3FM3 A;  5CDL A;  3PKC A;  1C21 A;  2BHC A;  4S01 A;  1YJ3 A;  2BN7 A;  1R5H A;  4IKU A;  4U70 A;  2B3K A;  4ZNG A;  2EVC A;  4RGZ 1;  2BHB A;  5FCH A;  2EVM A;  4FLI A;  4A6W A;  1W2M A;  2BWW A;  2Q92 A;  1M35 A;  5CDV A;  4S2T P;  5FCF A;  1KQ0 A;  4IKT A;  2OKN A;  2GU7 A;  1YW7 A;  1A16 A;  4IEC A;  3PKD A;  2B3H A;  2Q95 A;  3ROR A;  1C24 A;  3CB6 A;  1W7V A;  3BIQ A;  3QOC A;  4U6J A;  1WL6 A;  1C22 A;  5CIK A;  1WBQ A;  4A6V A;  2GU4 A;  2OAZ A;  1N51 A;  1XGS A;  3PKE A;  3O5V A;  2BWV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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