4ZWPA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
438
structure length
422
Chain Sequence
KLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords OPAA organophosphate prolidase anhydrolase
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 148
structure length 422
sequence length 438
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwpA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwpA02
4U69A 2BHAA 3IU7A 2BB7A 1KQ0A 1CHMA 3RORA 4EGEA 4S2TP 5D6FA 2GG2A 4U71A 3TB5A 1WBQA 2B3LA 3O5VA 2GGCA 3PKEA 1JAWA 5CIKA 4S00A 1BOAA 3CB5A 4U75A 2GG8A 4S01A 4U73A 1R5HA 4RZZA 1XGSA 2IW2A 2V3YA 1B59A 3IU8A 4A6VA 3PKCA 1YW9A 4U70A 4IDYA 1WL9A 2GG3A 2BWUA 4FUKA 4QR8A 2GU4A 2OAZA 3Q6DA 5FCFA 1W2MA 3PEBA 1XGNA 2GG7A 2P98A 4FO8A 4PV4A 2BWYA 1WN1A 4FKCA 4A6WA 2GU7A 3OVKA 5CDEA 3IU9A 3S6BA 1A16A 1B6AA 1QZYA 2BWVA 1YW8A 2EVCA 1O0XA 1YW7A 5D6EA 5JFRA 1KP0A 4IKRA 2V6CA 2B3KA 3QOCA 1WL6A 3PN9A 4FO7A 2GG0A 5CDVA 2P99A 3MX6A 2G6PA 1XNZA 2Q95A 4U76A 1C27A 1WKMA 5CLSA 4U6JA 4HXXA 1YJ3A 1BN5A 3L7GA 3CB6A 4ZNGA 4U6WA 2BWTA 1XGOA 4ZWPA 2BH3A 1N51A 2GZ5A 3I7MA 4MATA 3OOOA 1QXYA 2BWWA 3FM3A 1C21A 3BIPA 4IKTA 1W7VA 3BIQA 3RVAA 2BN7A 1QXZA 3MR1A 2Q93A 2GU6A 5CDLA 3IL0A 4IPAA 2ADUA 4Z7MA 2GU5A 4U1BA 4ZWUA 1M35A 4IU6A 4FLIA 2OKNA 4PNCA 2BHCA 5FCHA 1WY2A 1C24A 1KQ9A 1YVMA 3PKBA 5CE6A 1MATA 1Y1NA 2NQ7A 2B3HA 4U6EA 4U6CA 1WLRA 2BWSA 4KM3A 3FMRA 3PKDA 3D27A 4B28A 4S2RP 4JUQA 3TAVA 2P9AA 2GGBA 4RZYA 2GA2A 3IG4A 2Q92A 2Q8KA 4ZWOA 2V3XA 2EA2A 2GTXA 2NQ6A 3L24A 4RGZ1 1C22A 2DFIA 2Q96A 4FLLA 1XGMA 4FLJA 4IKSA 5CNXA 1PV9A 2GG5A 2GG9A 2EVOA 2EVMA 4OOKA 4R60A 2HOWA 4U6ZA 5JI6A 3CTZA 2BHDA 1R5GA 2BHBA 2BWXA 5E5BA 2EA4A 3FMQA 1C23A 1R58A 2Q94A 2V3ZA 1QXWA 4FLKA 2MATA 5E2CA 4IECA 5JHUA 4IKUA 3MATA 3BITA 4IF7A 3PKAA 2ZSGA
chains in the Genus database with same CATH superfamily
4U69A 2BHAA 3IU7A 2BB7A 1KQ0A 1CHMA 3RORA 4EGEA 4S2TP 5D6FA 2GG2A 4U71A 3TB5A 1WBQA 2B3LA 3O5VA 2GGCA 3PKEA 1JAWA 5CIKA 4S00A 1BOAA 3CB5A 4U75A 2GG8A 4S01A 4U73A 1R5HA 4RZZA 1XGSA 2IW2A 2V3YA 1B59A 3IU8A 4A6VA 3PKCA 1YW9A 4U70A 4IDYA 1WL9A 2GG3A 2BWUA 4FUKA 4QR8A 2GU4A 2OAZA 3Q6DA 5FCFA 1W2MA 3PEBA 1XGNA 2GG7A 2P98A 4FO8A 4PV4A 2BWYA 1WN1A 4FKCA 4A6WA 2GU7A 3OVKA 5CDEA 3IU9A 3S6BA 1A16A 1B6AA 1QZYA 2BWVA 1YW8A 2EVCA 1O0XA 1YW7A 5D6EA 5JFRA 1KP0A 4IKRA 2V6CA 2B3KA 3QOCA 1WL6A 3PN9A 4FO7A 2GG0A 5CDVA 2P99A 3MX6A 2G6PA 1XNZA 2Q95A 4U76A 1C27A 1WKMA 5CLSA 4U6JA 4HXXA 1YJ3A 1BN5A 3L7GA 3CB6A 4ZNGA 4U6WA 2BWTA 1XGOA 4ZWPA 2BH3A 1N51A 2GZ5A 3I7MA 4MATA 3OOOA 1QXYA 2BWWA 3FM3A 1C21A 3BIPA 4IKTA 1W7VA 3BIQA 3RVAA 2BN7A 1QXZA 3MR1A 2Q93A 2GU6A 5CDLA 3IL0A 4IPAA 2ADUA 4Z7MA 2GU5A 4U1BA 4ZWUA 1M35A 4IU6A 4FLIA 2OKNA 4PNCA 2BHCA 5FCHA 1WY2A 1C24A 1KQ9A 1YVMA 3PKBA 5CE6A 1MATA 1Y1NA 2NQ7A 2B3HA 4U6EA 4U6CA 1WLRA 2BWSA 4KM3A 3FMRA 3PKDA 3D27A 4B28A 4S2RP 4JUQA 3TAVA 2P9AA 2GGBA 4RZYA 2GA2A 3IG4A 2Q92A 2Q8KA 4ZWOA 2V3XA 2EA2A 2GTXA 2NQ6A 3L24A 4RGZ1 1C22A 2DFIA 2Q96A 4FLLA 1XGMA 4FLJA 4IKSA 5CNXA 1PV9A 2GG5A 2GG9A 2EVOA 2EVMA 4OOKA 4R60A 2HOWA 4U6ZA 5JI6A 3CTZA 2BHDA 1R5GA 2BHBA 2BWXA 5E5BA 2EA4A 3FMQA 1C23A 1R58A 2Q94A 2V3ZA 1QXWA 4FLKA 2MATA 5E2CA 4IECA 5JHUA 4IKUA 3MATA 3BITA 4IF7A 3PKAA 2ZSGA
chains in the Genus database with same CATH topology
4U69A 2BHAA 3IU7A 2BB7A 1KQ0A 1CHMA 3RORA 4EGEA 4S2TP 5D6FA 2GG2A 4U71A 3TB5A 1WBQA 2B3LA 3O5VA 2GGCA 3PKEA 1JAWA 5CIKA 4S00A 1BOAA 3CB5A 4U75A 2GG8A 4S01A 4U73A 1R5HA 4RZZA 1XGSA 2IW2A 2V3YA 1B59A 3IU8A 4A6VA 3PKCA 1YW9A 4U70A 4IDYA 1WL9A 2GG3A 2BWUA 4FUKA 4QR8A 2GU4A 2OAZA 3Q6DA 5FCFA 1W2MA 3PEBA 1XGNA 2GG7A 2P98A 4FO8A 4PV4A 2BWYA 1WN1A 4FKCA 4A6WA 2GU7A 3OVKA 5CDEA 3IU9A 3S6BA 1A16A 1B6AA 1QZYA 2BWVA 1YW8A 2EVCA 1O0XA 1YW7A 5D6EA 5JFRA 1KP0A 4IKRA 2V6CA 2B3KA 3QOCA 1WL6A 3PN9A 4FO7A 2GG0A 5CDVA 2P99A 3MX6A 2G6PA 1XNZA 2Q95A 4U76A 1C27A 1WKMA 5CLSA 4U6JA 4HXXA 1YJ3A 1BN5A 3L7GA 3CB6A 4ZNGA 4U6WA 2BWTA 1XGOA 4ZWPA 2BH3A 1N51A 2GZ5A 3I7MA 4MATA 3OOOA 1QXYA 2BWWA 3FM3A 1C21A 3BIPA 4IKTA 1W7VA 3BIQA 3RVAA 2BN7A 1QXZA 3MR1A 2Q93A 2GU6A 5CDLA 3IL0A 4IPAA 2ADUA 4Z7MA 2GU5A 4U1BA 4ZWUA 1M35A 4IU6A 4FLIA 2OKNA 4PNCA 2BHCA 5FCHA 1WY2A 1C24A 1KQ9A 1YVMA 3PKBA 5CE6A 1MATA 1Y1NA 2NQ7A 2B3HA 4U6EA 4U6CA 1WLRA 2BWSA 4KM3A 3FMRA 3PKDA 3D27A 4B28A 4S2RP 4JUQA 3TAVA 2P9AA 2GGBA 4RZYA 2GA2A 3IG4A 2Q92A 2Q8KA 4ZWOA 2V3XA 2EA2A 2GTXA 2NQ6A 3L24A 4RGZ1 1C22A 2DFIA 2Q96A 4FLLA 1XGMA 4FLJA 4IKSA 5CNXA 1PV9A 2GG5A 2GG9A 2EVOA 2EVMA 4OOKA 4R60A 2HOWA 4U6ZA 5JI6A 3CTZA 2BHDA 1R5GA 2BHBA 2BWXA 5E5BA 2EA4A 3FMQA 1C23A 1R58A 2Q94A 2V3ZA 1QXWA 4FLKA 2MATA 5E2CA 4IECA 5JHUA 4IKUA 3MATA 3BITA 4IF7A 3PKAA 2ZSGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U69 A;  2BHA A;  3IU7 A;  2BB7 A;  1KQ0 A;  1CHM A;  3ROR A;  4EGE A;  4S2T P;  5D6F A;  2GG2 A;  4U71 A;  3TB5 A;  1WBQ A;  2B3L A;  3O5V A;  2GGC A;  3PKE A;  1JAW A;  5CIK A;  4S00 A;  1BOA A;  3CB5 A;  4U75 A;  2GG8 A;  4S01 A;  4U73 A;  1R5H A;  4RZZ A;  1XGS A;  2IW2 A;  2V3Y A;  1B59 A;  3IU8 A;  4A6V A;  3PKC A;  1YW9 A;  4U70 A;  4IDY A;  1WL9 A;  2GG3 A;  2BWU A;  4FUK A;  4QR8 A;  2GU4 A;  2OAZ A;  3Q6D A;  5FCF A;  1W2M A;  3PEB A;  1XGN A;  2GG7 A;  2P98 A;  4FO8 A;  4PV4 A;  2BWY A;  1WN1 A;  4FKC A;  4A6W A;  2GU7 A;  3OVK A;  5CDE A;  3IU9 A;  3S6B A;  1A16 A;  1B6A A;  1QZY A;  2BWV A;  1YW8 A;  2EVC A;  1O0X A;  1YW7 A;  5D6E A;  5JFR A;  1KP0 A;  4IKR A;  2V6C A;  2B3K A;  3QOC A;  1WL6 A;  3PN9 A;  4FO7 A;  2GG0 A;  5CDV A;  2P99 A;  3MX6 A;  2G6P A;  1XNZ A;  2Q95 A;  4U76 A;  1C27 A;  1WKM A;  5CLS A;  4U6J A;  4HXX A;  1YJ3 A;  1BN5 A;  3L7G A;  3CB6 A;  4ZNG A;  4U6W A;  2BWT A;  1XGO A;  4ZWP A;  2BH3 A;  1N51 A;  2GZ5 A;  3I7M A;  4MAT A;  3OOO A;  1QXY A;  2BWW A;  3FM3 A;  1C21 A;  3BIP A;  4IKT A;  1W7V A;  3BIQ A;  3RVA A;  2BN7 A;  1QXZ A;  3MR1 A;  2Q93 A;  2GU6 A;  5CDL A;  3IL0 A;  4IPA A;  2ADU A;  4Z7M A;  2GU5 A;  4U1B A;  4ZWU A;  1M35 A;  4IU6 A;  4FLI A;  2OKN A;  4PNC A;  2BHC A;  5FCH A;  1WY2 A;  1C24 A;  1KQ9 A;  1YVM A;  3PKB A;  5CE6 A;  1MAT A;  1Y1N A;  2NQ7 A;  2B3H A;  4U6E A;  4U6C A;  1WLR A;  2BWS A;  4KM3 A;  3FMR A;  3PKD A;  3D27 A;  4B28 A;  4S2R P;  4JUQ A;  3TAV A;  2P9A A;  2GGB A;  4RZY A;  2GA2 A;  3IG4 A;  2Q92 A;  2Q8K A;  4ZWO A;  2V3X A;  2EA2 A;  2GTX A;  2NQ6 A;  3L24 A;  4RGZ 1;  1C22 A;  2DFI A;  2Q96 A;  4FLL A;  1XGM A;  4FLJ A;  4IKS A;  5CNX A;  1PV9 A;  2GG5 A;  2GG9 A;  2EVO A;  2EVM A;  4OOK A;  4R60 A;  2HOW A;  4U6Z A;  5JI6 A;  3CTZ A;  2BHD A;  1R5G A;  2BHB A;  2BWX A;  5E5B A;  2EA4 A;  3FMQ A;  1C23 A;  1R58 A;  2Q94 A;  2V3Z A;  1QXW A;  4FLK A;  2MAT A;  5E2C A;  4IEC A;  5JHU A;  4IKU A;  3MAT A;  3BIT A;  4IF7 A;  3PKA A;  2ZSG A; 
#chains in the Genus database with same CATH topology
 4U69 A;  2BHA A;  3IU7 A;  2BB7 A;  1KQ0 A;  1CHM A;  3ROR A;  4EGE A;  4S2T P;  5D6F A;  2GG2 A;  4U71 A;  3TB5 A;  1WBQ A;  2B3L A;  3O5V A;  2GGC A;  3PKE A;  1JAW A;  5CIK A;  4S00 A;  1BOA A;  3CB5 A;  4U75 A;  2GG8 A;  4S01 A;  4U73 A;  1R5H A;  4RZZ A;  1XGS A;  2IW2 A;  2V3Y A;  1B59 A;  3IU8 A;  4A6V A;  3PKC A;  1YW9 A;  4U70 A;  4IDY A;  1WL9 A;  2GG3 A;  2BWU A;  4FUK A;  4QR8 A;  2GU4 A;  2OAZ A;  3Q6D A;  5FCF A;  1W2M A;  3PEB A;  1XGN A;  2GG7 A;  2P98 A;  4FO8 A;  4PV4 A;  2BWY A;  1WN1 A;  4FKC A;  4A6W A;  2GU7 A;  3OVK A;  5CDE A;  3IU9 A;  3S6B A;  1A16 A;  1B6A A;  1QZY A;  2BWV A;  1YW8 A;  2EVC A;  1O0X A;  1YW7 A;  5D6E A;  5JFR A;  1KP0 A;  4IKR A;  2V6C A;  2B3K A;  3QOC A;  1WL6 A;  3PN9 A;  4FO7 A;  2GG0 A;  5CDV A;  2P99 A;  3MX6 A;  2G6P A;  1XNZ A;  2Q95 A;  4U76 A;  1C27 A;  1WKM A;  5CLS A;  4U6J A;  4HXX A;  1YJ3 A;  1BN5 A;  3L7G A;  3CB6 A;  4ZNG A;  4U6W A;  2BWT A;  1XGO A;  4ZWP A;  2BH3 A;  1N51 A;  2GZ5 A;  3I7M A;  4MAT A;  3OOO A;  1QXY A;  2BWW A;  3FM3 A;  1C21 A;  3BIP A;  4IKT A;  1W7V A;  3BIQ A;  3RVA A;  2BN7 A;  1QXZ A;  3MR1 A;  2Q93 A;  2GU6 A;  5CDL A;  3IL0 A;  4IPA A;  2ADU A;  4Z7M A;  2GU5 A;  4U1B A;  4ZWU A;  1M35 A;  4IU6 A;  4FLI A;  2OKN A;  4PNC A;  2BHC A;  5FCH A;  1WY2 A;  1C24 A;  1KQ9 A;  1YVM A;  3PKB A;  5CE6 A;  1MAT A;  1Y1N A;  2NQ7 A;  2B3H A;  4U6E A;  4U6C A;  1WLR A;  2BWS A;  4KM3 A;  3FMR A;  3PKD A;  3D27 A;  4B28 A;  4S2R P;  4JUQ A;  3TAV A;  2P9A A;  2GGB A;  4RZY A;  2GA2 A;  3IG4 A;  2Q92 A;  2Q8K A;  4ZWO A;  2V3X A;  2EA2 A;  2GTX A;  2NQ6 A;  3L24 A;  4RGZ 1;  1C22 A;  2DFI A;  2Q96 A;  4FLL A;  1XGM A;  4FLJ A;  4IKS A;  5CNX A;  1PV9 A;  2GG5 A;  2GG9 A;  2EVO A;  2EVM A;  4OOK A;  4R60 A;  2HOW A;  4U6Z A;  5JI6 A;  3CTZ A;  2BHD A;  1R5G A;  2BHB A;  2BWX A;  5E5B A;  2EA4 A;  3FMQ A;  1C23 A;  1R58 A;  2Q94 A;  2V3Z A;  1QXW A;  4FLK A;  2MAT A;  5E2C A;  4IEC A;  5JHU A;  4IKU A;  3MAT A;  3BIT A;  4IF7 A;  3PKA A;  2ZSG A; 
#chains in the Genus database with same CATH homology
 4U69 A;  2BHA A;  3IU7 A;  2BB7 A;  1KQ0 A;  1CHM A;  3ROR A;  4EGE A;  4S2T P;  5D6F A;  2GG2 A;  4U71 A;  3TB5 A;  1WBQ A;  2B3L A;  3O5V A;  2GGC A;  3PKE A;  1JAW A;  5CIK A;  4S00 A;  1BOA A;  3CB5 A;  4U75 A;  2GG8 A;  4S01 A;  4U73 A;  1R5H A;  4RZZ A;  1XGS A;  2IW2 A;  2V3Y A;  1B59 A;  3IU8 A;  4A6V A;  3PKC A;  1YW9 A;  4U70 A;  4IDY A;  1WL9 A;  2GG3 A;  2BWU A;  4FUK A;  4QR8 A;  2GU4 A;  2OAZ A;  3Q6D A;  5FCF A;  1W2M A;  3PEB A;  1XGN A;  2GG7 A;  2P98 A;  4FO8 A;  4PV4 A;  2BWY A;  1WN1 A;  4FKC A;  4A6W A;  2GU7 A;  3OVK A;  5CDE A;  3IU9 A;  3S6B A;  1A16 A;  1B6A A;  1QZY A;  2BWV A;  1YW8 A;  2EVC A;  1O0X A;  1YW7 A;  5D6E A;  5JFR A;  1KP0 A;  4IKR A;  2V6C A;  2B3K A;  3QOC A;  1WL6 A;  3PN9 A;  4FO7 A;  2GG0 A;  5CDV A;  2P99 A;  3MX6 A;  2G6P A;  1XNZ A;  2Q95 A;  4U76 A;  1C27 A;  1WKM A;  5CLS A;  4U6J A;  4HXX A;  1YJ3 A;  1BN5 A;  3L7G A;  3CB6 A;  4ZNG A;  4U6W A;  2BWT A;  1XGO A;  4ZWP A;  2BH3 A;  1N51 A;  2GZ5 A;  3I7M A;  4MAT A;  3OOO A;  1QXY A;  2BWW A;  3FM3 A;  1C21 A;  3BIP A;  4IKT A;  1W7V A;  3BIQ A;  3RVA A;  2BN7 A;  1QXZ A;  3MR1 A;  2Q93 A;  2GU6 A;  5CDL A;  3IL0 A;  4IPA A;  2ADU A;  4Z7M A;  2GU5 A;  4U1B A;  4ZWU A;  1M35 A;  4IU6 A;  4FLI A;  2OKN A;  4PNC A;  2BHC A;  5FCH A;  1WY2 A;  1C24 A;  1KQ9 A;  1YVM A;  3PKB A;  5CE6 A;  1MAT A;  1Y1N A;  2NQ7 A;  2B3H A;  4U6E A;  4U6C A;  1WLR A;  2BWS A;  4KM3 A;  3FMR A;  3PKD A;  3D27 A;  4B28 A;  4S2R P;  4JUQ A;  3TAV A;  2P9A A;  2GGB A;  4RZY A;  2GA2 A;  3IG4 A;  2Q92 A;  2Q8K A;  4ZWO A;  2V3X A;  2EA2 A;  2GTX A;  2NQ6 A;  3L24 A;  4RGZ 1;  1C22 A;  2DFI A;  2Q96 A;  4FLL A;  1XGM A;  4FLJ A;  4IKS A;  5CNX A;  1PV9 A;  2GG5 A;  2GG9 A;  2EVO A;  2EVM A;  4OOK A;  4R60 A;  2HOW A;  4U6Z A;  5JI6 A;  3CTZ A;  2BHD A;  1R5G A;  2BHB A;  2BWX A;  5E5B A;  2EA4 A;  3FMQ A;  1C23 A;  1R58 A;  2Q94 A;  2V3Z A;  1QXW A;  4FLK A;  2MAT A;  5E2C A;  4IEC A;  5JHU A;  4IKU A;  3MAT A;  3BIT A;  4IF7 A;  3PKA A;  2ZSG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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