4ZWPA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 148
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
438
structure length
422
Chain Sequence
KLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords OPAA organophosphate prolidase anhydrolase
total genus 148
structure length 422
sequence length 438
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwpA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwpA02
4U1BA 5E2CA 1W7VA 3PN9A 5E5BA 4RZYA 3IU8A 4IECA 4U76A 4IKUA 3RVAA 1R5GA 4EGEA 1YW8A 3BIPA 2BWTA 4R60A 2GG8A 1BOAA 4IKSA 3OOOA 1B59A 3MX6A 3FMQA 2EVCA 1C22A 3BIQA 2GG7A 2NQ7A 3MR1A 2BH3A 4OOKA 3PKDA 2EVOA 5CIKA 4PNCA 4U73A 3IG4A 2Q96A 1XGOA 3CTZA 2DFIA 2GA2A 5JFRA 4ZWUA 1PV9A 2ZSGA 2G6PA 2V6CA 4FO7A 5JI6A 2BWSA 1WBQA 3OVKA 2EA4A 2P99A 3PKEA 4A6WA 4PV4A 2BHAA 5D6FA 3QOCA 2GU4A 5CDLA 1CHMA 1XNZA 3S6BA 2P98A 5CLSA 2B3KA 2V3YA 4B28A 5D6EA 2Q95A 1WKMA 1O0XA 2GTXA 3BITA 5FCFA 4IDYA 1XGNA 1WN1A 2IW2A 1MATA 2GZ5A 4FLKA 4U75A 4MATA 3O5VA 4S2RP 2B3HA 1KQ0A 5CNXA 1KQ9A 2BB7A 4U6ZA 4A6VA 5CDVA 1QXWA 3TAVA 2BWUA 3PEBA 1YJ3A 1YW9A 4S00A 3CB5A 1YVMA 1M35A 4IPAA 4IU6A 4JUQA 4ZWPA 1WY2A 1Y1NA 2BHDA 2MATA 2GG0A 4Z7MA 4FLJA 2BWWA 2GG5A 2HOWA 3PKAA 3IU7A 3Q6DA 3D27A 1C27A 1QXZA 3IU9A 4FLLA 2Q93A 3L24A 4IF7A 1KP0A 1WL6A 3I7MA 1WL9A 1WLRA 3IL0A 1C23A 4U70A 1B6AA 1W2MA 1C24A 2Q8KA 4RZZA 4FO8A 4KM3A 2GU6A 1A16A 4FKCA 4RGZ1 2BWVA 2P9AA 3PKCA 1XGSA 2Q92A 2V3XA 4U6WA 5FCHA 2GGCA 1JAWA 2GU5A 4ZNGA 3TB5A 4S2TP 1BN5A 4IKTA 3MATA 4IKRA 4ZWOA 2GG2A 1QXYA 4FUKA 2GG3A 4U6JA 1R5HA 2BWYA 2B3LA 2ADUA 3FMRA 1R58A 2GU7A 2OAZA 3CB6A 4QR8A 2BHCA 4U6EA 2BWXA 5CDEA 3PKBA 1YW7A 4U71A 4HXXA 5JHUA 2NQ6A 2OKNA 1QZYA 4FLIA 1N51A 2V3ZA 3L7GA 5CE6A 4S01A 2GGBA 2BN7A 2EA2A 2GG9A 3FM3A 4U69A 2Q94A 4U6CA 2EVMA 3RORA 1XGMA 1C21A 2BHBA
chains in the Genus database with same CATH superfamily
4U1BA 5E2CA 1W7VA 3PN9A 5E5BA 4RZYA 3IU8A 4IECA 4U76A 4IKUA 3RVAA 1R5GA 4EGEA 1YW8A 3BIPA 2BWTA 4R60A 2GG8A 1BOAA 4IKSA 3OOOA 1B59A 3MX6A 3FMQA 2EVCA 1C22A 3BIQA 2GG7A 2NQ7A 3MR1A 2BH3A 4OOKA 3PKDA 2EVOA 5CIKA 4PNCA 4U73A 3IG4A 2Q96A 1XGOA 3CTZA 2DFIA 2GA2A 5JFRA 4ZWUA 1PV9A 2ZSGA 2G6PA 2V6CA 4FO7A 5JI6A 2BWSA 1WBQA 3OVKA 2EA4A 2P99A 3PKEA 4A6WA 4PV4A 2BHAA 5D6FA 3QOCA 2GU4A 5CDLA 1CHMA 1XNZA 3S6BA 2P98A 5CLSA 2B3KA 2V3YA 4B28A 5D6EA 2Q95A 1WKMA 1O0XA 2GTXA 3BITA 5FCFA 4IDYA 1XGNA 1WN1A 2IW2A 1MATA 2GZ5A 4FLKA 4U75A 4MATA 3O5VA 4S2RP 2B3HA 1KQ0A 5CNXA 1KQ9A 2BB7A 4U6ZA 4A6VA 5CDVA 1QXWA 3TAVA 2BWUA 3PEBA 1YJ3A 1YW9A 4S00A 3CB5A 1YVMA 1M35A 4IPAA 4IU6A 4JUQA 4ZWPA 1WY2A 1Y1NA 2BHDA 2MATA 2GG0A 4Z7MA 4FLJA 2BWWA 2GG5A 2HOWA 3PKAA 3IU7A 3Q6DA 3D27A 1C27A 1QXZA 3IU9A 4FLLA 2Q93A 3L24A 4IF7A 1KP0A 1WL6A 3I7MA 1WL9A 1WLRA 3IL0A 1C23A 4U70A 1B6AA 1W2MA 1C24A 2Q8KA 4RZZA 4FO8A 4KM3A 2GU6A 1A16A 4FKCA 4RGZ1 2BWVA 2P9AA 3PKCA 1XGSA 2Q92A 2V3XA 4U6WA 5FCHA 2GGCA 1JAWA 2GU5A 4ZNGA 3TB5A 4S2TP 1BN5A 4IKTA 3MATA 4IKRA 4ZWOA 2GG2A 1QXYA 4FUKA 2GG3A 4U6JA 1R5HA 2BWYA 2B3LA 2ADUA 3FMRA 1R58A 2GU7A 2OAZA 3CB6A 4QR8A 2BHCA 4U6EA 2BWXA 5CDEA 3PKBA 1YW7A 4U71A 4HXXA 5JHUA 2NQ6A 2OKNA 1QZYA 4FLIA 1N51A 2V3ZA 3L7GA 5CE6A 4S01A 2GGBA 2BN7A 2EA2A 2GG9A 3FM3A 4U69A 2Q94A 4U6CA 2EVMA 3RORA 1XGMA 1C21A 2BHBA
chains in the Genus database with same CATH topology
4U1BA 5E2CA 1W7VA 3PN9A 5E5BA 4RZYA 3IU8A 4IECA 4U76A 4IKUA 3RVAA 1R5GA 4EGEA 1YW8A 3BIPA 2BWTA 4R60A 2GG8A 1BOAA 4IKSA 3OOOA 1B59A 3MX6A 3FMQA 2EVCA 1C22A 3BIQA 2GG7A 2NQ7A 3MR1A 2BH3A 4OOKA 3PKDA 2EVOA 5CIKA 4PNCA 4U73A 3IG4A 2Q96A 1XGOA 3CTZA 2DFIA 2GA2A 5JFRA 4ZWUA 1PV9A 2ZSGA 2G6PA 2V6CA 4FO7A 5JI6A 2BWSA 1WBQA 3OVKA 2EA4A 2P99A 3PKEA 4A6WA 4PV4A 2BHAA 5D6FA 3QOCA 2GU4A 5CDLA 1CHMA 1XNZA 3S6BA 2P98A 5CLSA 2B3KA 2V3YA 4B28A 5D6EA 2Q95A 1WKMA 1O0XA 2GTXA 3BITA 5FCFA 4IDYA 1XGNA 1WN1A 2IW2A 1MATA 2GZ5A 4FLKA 4U75A 4MATA 3O5VA 4S2RP 2B3HA 1KQ0A 5CNXA 1KQ9A 2BB7A 4U6ZA 4A6VA 5CDVA 1QXWA 3TAVA 2BWUA 3PEBA 1YJ3A 1YW9A 4S00A 3CB5A 1YVMA 1M35A 4IPAA 4IU6A 4JUQA 4ZWPA 1WY2A 1Y1NA 2BHDA 2MATA 2GG0A 4Z7MA 4FLJA 2BWWA 2GG5A 2HOWA 3PKAA 3IU7A 3Q6DA 3D27A 1C27A 1QXZA 3IU9A 4FLLA 2Q93A 3L24A 4IF7A 1KP0A 1WL6A 3I7MA 1WL9A 1WLRA 3IL0A 1C23A 4U70A 1B6AA 1W2MA 1C24A 2Q8KA 4RZZA 4FO8A 4KM3A 2GU6A 1A16A 4FKCA 4RGZ1 2BWVA 2P9AA 3PKCA 1XGSA 2Q92A 2V3XA 4U6WA 5FCHA 2GGCA 1JAWA 2GU5A 4ZNGA 3TB5A 4S2TP 1BN5A 4IKTA 3MATA 4IKRA 4ZWOA 2GG2A 1QXYA 4FUKA 2GG3A 4U6JA 1R5HA 2BWYA 2B3LA 2ADUA 3FMRA 1R58A 2GU7A 2OAZA 3CB6A 4QR8A 2BHCA 4U6EA 2BWXA 5CDEA 3PKBA 1YW7A 4U71A 4HXXA 5JHUA 2NQ6A 2OKNA 1QZYA 4FLIA 1N51A 2V3ZA 3L7GA 5CE6A 4S01A 2GGBA 2BN7A 2EA2A 2GG9A 3FM3A 4U69A 2Q94A 4U6CA 2EVMA 3RORA 1XGMA 1C21A 2BHBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U1B A;  5E2C A;  1W7V A;  3PN9 A;  5E5B A;  4RZY A;  3IU8 A;  4IEC A;  4U76 A;  4IKU A;  3RVA A;  1R5G A;  4EGE A;  1YW8 A;  3BIP A;  2BWT A;  4R60 A;  2GG8 A;  1BOA A;  4IKS A;  3OOO A;  1B59 A;  3MX6 A;  3FMQ A;  2EVC A;  1C22 A;  3BIQ A;  2GG7 A;  2NQ7 A;  3MR1 A;  2BH3 A;  4OOK A;  3PKD A;  2EVO A;  5CIK A;  4PNC A;  4U73 A;  3IG4 A;  2Q96 A;  1XGO A;  3CTZ A;  2DFI A;  2GA2 A;  5JFR A;  4ZWU A;  1PV9 A;  2ZSG A;  2G6P A;  2V6C A;  4FO7 A;  5JI6 A;  2BWS A;  1WBQ A;  3OVK A;  2EA4 A;  2P99 A;  3PKE A;  4A6W A;  4PV4 A;  2BHA A;  5D6F A;  3QOC A;  2GU4 A;  5CDL A;  1CHM A;  1XNZ A;  3S6B A;  2P98 A;  5CLS A;  2B3K A;  2V3Y A;  4B28 A;  5D6E A;  2Q95 A;  1WKM A;  1O0X A;  2GTX A;  3BIT A;  5FCF A;  4IDY A;  1XGN A;  1WN1 A;  2IW2 A;  1MAT A;  2GZ5 A;  4FLK A;  4U75 A;  4MAT A;  3O5V A;  4S2R P;  2B3H A;  1KQ0 A;  5CNX A;  1KQ9 A;  2BB7 A;  4U6Z A;  4A6V A;  5CDV A;  1QXW A;  3TAV A;  2BWU A;  3PEB A;  1YJ3 A;  1YW9 A;  4S00 A;  3CB5 A;  1YVM A;  1M35 A;  4IPA A;  4IU6 A;  4JUQ A;  4ZWP A;  1WY2 A;  1Y1N A;  2BHD A;  2MAT A;  2GG0 A;  4Z7M A;  4FLJ A;  2BWW A;  2GG5 A;  2HOW A;  3PKA A;  3IU7 A;  3Q6D A;  3D27 A;  1C27 A;  1QXZ A;  3IU9 A;  4FLL A;  2Q93 A;  3L24 A;  4IF7 A;  1KP0 A;  1WL6 A;  3I7M A;  1WL9 A;  1WLR A;  3IL0 A;  1C23 A;  4U70 A;  1B6A A;  1W2M A;  1C24 A;  2Q8K A;  4RZZ A;  4FO8 A;  4KM3 A;  2GU6 A;  1A16 A;  4FKC A;  4RGZ 1;  2BWV A;  2P9A A;  3PKC A;  1XGS A;  2Q92 A;  2V3X A;  4U6W A;  5FCH A;  2GGC A;  1JAW A;  2GU5 A;  4ZNG A;  3TB5 A;  4S2T P;  1BN5 A;  4IKT A;  3MAT A;  4IKR A;  4ZWO A;  2GG2 A;  1QXY A;  4FUK A;  2GG3 A;  4U6J A;  1R5H A;  2BWY A;  2B3L A;  2ADU A;  3FMR A;  1R58 A;  2GU7 A;  2OAZ A;  3CB6 A;  4QR8 A;  2BHC A;  4U6E A;  2BWX A;  5CDE A;  3PKB A;  1YW7 A;  4U71 A;  4HXX A;  5JHU A;  2NQ6 A;  2OKN A;  1QZY A;  4FLI A;  1N51 A;  2V3Z A;  3L7G A;  5CE6 A;  4S01 A;  2GGB A;  2BN7 A;  2EA2 A;  2GG9 A;  3FM3 A;  4U69 A;  2Q94 A;  4U6C A;  2EVM A;  3ROR A;  1XGM A;  1C21 A;  2BHB A; 
#chains in the Genus database with same CATH topology
 4U1B A;  5E2C A;  1W7V A;  3PN9 A;  5E5B A;  4RZY A;  3IU8 A;  4IEC A;  4U76 A;  4IKU A;  3RVA A;  1R5G A;  4EGE A;  1YW8 A;  3BIP A;  2BWT A;  4R60 A;  2GG8 A;  1BOA A;  4IKS A;  3OOO A;  1B59 A;  3MX6 A;  3FMQ A;  2EVC A;  1C22 A;  3BIQ A;  2GG7 A;  2NQ7 A;  3MR1 A;  2BH3 A;  4OOK A;  3PKD A;  2EVO A;  5CIK A;  4PNC A;  4U73 A;  3IG4 A;  2Q96 A;  1XGO A;  3CTZ A;  2DFI A;  2GA2 A;  5JFR A;  4ZWU A;  1PV9 A;  2ZSG A;  2G6P A;  2V6C A;  4FO7 A;  5JI6 A;  2BWS A;  1WBQ A;  3OVK A;  2EA4 A;  2P99 A;  3PKE A;  4A6W A;  4PV4 A;  2BHA A;  5D6F A;  3QOC A;  2GU4 A;  5CDL A;  1CHM A;  1XNZ A;  3S6B A;  2P98 A;  5CLS A;  2B3K A;  2V3Y A;  4B28 A;  5D6E A;  2Q95 A;  1WKM A;  1O0X A;  2GTX A;  3BIT A;  5FCF A;  4IDY A;  1XGN A;  1WN1 A;  2IW2 A;  1MAT A;  2GZ5 A;  4FLK A;  4U75 A;  4MAT A;  3O5V A;  4S2R P;  2B3H A;  1KQ0 A;  5CNX A;  1KQ9 A;  2BB7 A;  4U6Z A;  4A6V A;  5CDV A;  1QXW A;  3TAV A;  2BWU A;  3PEB A;  1YJ3 A;  1YW9 A;  4S00 A;  3CB5 A;  1YVM A;  1M35 A;  4IPA A;  4IU6 A;  4JUQ A;  4ZWP A;  1WY2 A;  1Y1N A;  2BHD A;  2MAT A;  2GG0 A;  4Z7M A;  4FLJ A;  2BWW A;  2GG5 A;  2HOW A;  3PKA A;  3IU7 A;  3Q6D A;  3D27 A;  1C27 A;  1QXZ A;  3IU9 A;  4FLL A;  2Q93 A;  3L24 A;  4IF7 A;  1KP0 A;  1WL6 A;  3I7M A;  1WL9 A;  1WLR A;  3IL0 A;  1C23 A;  4U70 A;  1B6A A;  1W2M A;  1C24 A;  2Q8K A;  4RZZ A;  4FO8 A;  4KM3 A;  2GU6 A;  1A16 A;  4FKC A;  4RGZ 1;  2BWV A;  2P9A A;  3PKC A;  1XGS A;  2Q92 A;  2V3X A;  4U6W A;  5FCH A;  2GGC A;  1JAW A;  2GU5 A;  4ZNG A;  3TB5 A;  4S2T P;  1BN5 A;  4IKT A;  3MAT A;  4IKR A;  4ZWO A;  2GG2 A;  1QXY A;  4FUK A;  2GG3 A;  4U6J A;  1R5H A;  2BWY A;  2B3L A;  2ADU A;  3FMR A;  1R58 A;  2GU7 A;  2OAZ A;  3CB6 A;  4QR8 A;  2BHC A;  4U6E A;  2BWX A;  5CDE A;  3PKB A;  1YW7 A;  4U71 A;  4HXX A;  5JHU A;  2NQ6 A;  2OKN A;  1QZY A;  4FLI A;  1N51 A;  2V3Z A;  3L7G A;  5CE6 A;  4S01 A;  2GGB A;  2BN7 A;  2EA2 A;  2GG9 A;  3FM3 A;  4U69 A;  2Q94 A;  4U6C A;  2EVM A;  3ROR A;  1XGM A;  1C21 A;  2BHB A; 
#chains in the Genus database with same CATH homology
 4U1B A;  5E2C A;  1W7V A;  3PN9 A;  5E5B A;  4RZY A;  3IU8 A;  4IEC A;  4U76 A;  4IKU A;  3RVA A;  1R5G A;  4EGE A;  1YW8 A;  3BIP A;  2BWT A;  4R60 A;  2GG8 A;  1BOA A;  4IKS A;  3OOO A;  1B59 A;  3MX6 A;  3FMQ A;  2EVC A;  1C22 A;  3BIQ A;  2GG7 A;  2NQ7 A;  3MR1 A;  2BH3 A;  4OOK A;  3PKD A;  2EVO A;  5CIK A;  4PNC A;  4U73 A;  3IG4 A;  2Q96 A;  1XGO A;  3CTZ A;  2DFI A;  2GA2 A;  5JFR A;  4ZWU A;  1PV9 A;  2ZSG A;  2G6P A;  2V6C A;  4FO7 A;  5JI6 A;  2BWS A;  1WBQ A;  3OVK A;  2EA4 A;  2P99 A;  3PKE A;  4A6W A;  4PV4 A;  2BHA A;  5D6F A;  3QOC A;  2GU4 A;  5CDL A;  1CHM A;  1XNZ A;  3S6B A;  2P98 A;  5CLS A;  2B3K A;  2V3Y A;  4B28 A;  5D6E A;  2Q95 A;  1WKM A;  1O0X A;  2GTX A;  3BIT A;  5FCF A;  4IDY A;  1XGN A;  1WN1 A;  2IW2 A;  1MAT A;  2GZ5 A;  4FLK A;  4U75 A;  4MAT A;  3O5V A;  4S2R P;  2B3H A;  1KQ0 A;  5CNX A;  1KQ9 A;  2BB7 A;  4U6Z A;  4A6V A;  5CDV A;  1QXW A;  3TAV A;  2BWU A;  3PEB A;  1YJ3 A;  1YW9 A;  4S00 A;  3CB5 A;  1YVM A;  1M35 A;  4IPA A;  4IU6 A;  4JUQ A;  4ZWP A;  1WY2 A;  1Y1N A;  2BHD A;  2MAT A;  2GG0 A;  4Z7M A;  4FLJ A;  2BWW A;  2GG5 A;  2HOW A;  3PKA A;  3IU7 A;  3Q6D A;  3D27 A;  1C27 A;  1QXZ A;  3IU9 A;  4FLL A;  2Q93 A;  3L24 A;  4IF7 A;  1KP0 A;  1WL6 A;  3I7M A;  1WL9 A;  1WLR A;  3IL0 A;  1C23 A;  4U70 A;  1B6A A;  1W2M A;  1C24 A;  2Q8K A;  4RZZ A;  4FO8 A;  4KM3 A;  2GU6 A;  1A16 A;  4FKC A;  4RGZ 1;  2BWV A;  2P9A A;  3PKC A;  1XGS A;  2Q92 A;  2V3X A;  4U6W A;  5FCH A;  2GGC A;  1JAW A;  2GU5 A;  4ZNG A;  3TB5 A;  4S2T P;  1BN5 A;  4IKT A;  3MAT A;  4IKR A;  4ZWO A;  2GG2 A;  1QXY A;  4FUK A;  2GG3 A;  4U6J A;  1R5H A;  2BWY A;  2B3L A;  2ADU A;  3FMR A;  1R58 A;  2GU7 A;  2OAZ A;  3CB6 A;  4QR8 A;  2BHC A;  4U6E A;  2BWX A;  5CDE A;  3PKB A;  1YW7 A;  4U71 A;  4HXX A;  5JHU A;  2NQ6 A;  2OKN A;  1QZY A;  4FLI A;  1N51 A;  2V3Z A;  3L7G A;  5CE6 A;  4S01 A;  2GGB A;  2BN7 A;  2EA2 A;  2GG9 A;  3FM3 A;  4U69 A;  2Q94 A;  4U6C A;  2EVM A;  3ROR A;  1XGM A;  1C21 A;  2BHB A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...