4ZX2A

Co-crystal structures of pp5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
325
structure length
325
Chain Sequence
GASMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYAN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Serine/threonine-protein phosphatase 5
total genus 122
structure length 325
sequence length 325
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4zx2A00
4V0XA 2HYOA 2Z1AA 4NZVA 1HO5A 3H62B 1G5BA 1JK7A 2HY1A 3HVQA 4DHLA 5B8IA 1TCOA 4JA9A 3IB8A 4IL1A 3AUZA 2O8AA 3QFOA 2BQ8X 3IVEA 4FBWA 4LTYA 1UTEA 4H2FA 3K7VC 1Z2XA 3RL4A 4MOYA 2AHDA 1AUIA 4ORAA 1UF3A 2HYPA 5JPEA 3P71C 2WDEA 4B2OA 2QFRA 3DSCA 1S8EA 3AV0A 2NPPC 2YVTA 3H67A 5F3WA 1T71A 3PSNA 4F0ZA 4ORCA 4MOVA 1KBPA 4FBKA 3H69A 4J6OA 2DFJA 4WWLA 4LACC 3ZU0A 1HPUA 3ZTVA 5C1VA 1II7A 3N5UA 3DSDA 2QFPA 1S95A 2NYMC 1HP1A 3IB7A 4JA7A 1S3LA 3TGHA 2A22A 1OI8A 2NXFA 3H66A 3RL5A 1IT6A 3RL3A 2P6BA 4LU9A 4HD0A 4M0VA 3QFKA 2CV9A 3CK2A 2KKNA 2XMOA 2QJCA 4O5GA 3C9FA 3RQZA 2JOGA 4I5LC 4H1YP 3KBPA 1W24A 4FBQA 4UT3B 5IOHA 4MP0A 1S70A 2IAEC 4FCXA 3DW8C 4UT3A 1SU1A 5JJTA 4DSYA 3T1IA 3QFMA 3EGGA 4IYPC 4UWQA 5GTUA 1V73A 4DT2A 1QFCA 1M63A 4YKEA 4I5NC 2BDXA 1OIEA 2WDFA 5JPFA 2WDDA 2Z72A 4ZX2A 2WDCA 2Z06A 3QFNA 1Z2WA 3H63A 3V4YA 1S3NA 1NNWA 2BCDA 3THOB 4H2BA 2IE3C 5J28A 5HPEA 1S3MA 3K7WC 1XZWA 5INBA 3H68A 1WAO1 3H60A 3LL8A 3PSOA 3THNA 4V0VA 1XM7A 2O8GA 1MF8A 4UT2A 2R17A 4H2GA 2USHA 4O24A 1USHA 4O43A 1WARA 1T70A 2IE4C 4H1SA 4H2IA 4KBPA 4KKZA 5DNYA 4ZVZA 3E7BA 2NYLC 3IVDA 3H61A 4XPNA 3FGAC 4ORBA 4OR9A 1QHWA 3C5WC 2Q8UA 3GVEA 1U32A 3QG5C 2GJUA 3EGHA 4G9JA 3ICFA 4Q7FA 1OIDA 4V0WA 4TUGA 3E7AA 4O4KA 3H64A 5EQVA 1FJMA 3JYFA 4TUIA 2ZBMA
chains in the Genus database with same CATH superfamily
4V0XA 2HYOA 2Z1AA 4NZVA 1HO5A 3H62B 1G5BA 1JK7A 2HY1A 3HVQA 4DHLA 5B8IA 1TCOA 4JA9A 3IB8A 4IL1A 3AUZA 2O8AA 3QFOA 2BQ8X 3IVEA 4FBWA 4LTYA 1UTEA 4H2FA 3K7VC 1Z2XA 3RL4A 2DXLA 4MOYA 2AHDA 1AUIA 4ORAA 1UF3A 2HYPA 5JPEA 3P71C 2WDEA 4B2OA 2QFRA 3DSCA 1S8EA 3AV0A 2NPPC 2YVTA 3H67A 5F3WA 1T71A 3PSNA 4F0ZA 2ZO9B 4ORCA 4MOVA 1KBPA 4FBKA 3H69A 4J6OA 2DFJA 4WWLA 4LACC 3ZU0A 1HPUA 3ZTVA 5C1VA 1II7A 3N5UA 3DSDA 2QFPA 1S95A 2NYMC 1HP1A 3IB7A 4JA7A 1S3LA 3TGHA 2A22A 1OI8A 2NXFA 3H66A 3RL5A 1IT6A 3RL3A 2P6BA 4LU9A 3E0JA 4HD0A 4M0VA 2ZOAA 3QFKA 2CV9A 3CK2A 2KKNA 2XMOA 2QJCA 4O5GA 3C9FA 3RQZA 2JOGA 4I5LC 4H1YP 3KBPA 1W24A 4FBQA 4UT3B 5IOHA 4MP0A 1S70A 2IAEC 4FCXA 3DW8C 4UT3A 1SU1A 5JJTA 4DSYA 3T1IA 3QFMA 3EGGA 4IYPC 4UWQA 5GTUA 1V73A 4DT2A 1QFCA 1M63A 4YKEA 4I5NC 2BDXA 1OIEA 2WDFA 5JPFA 2DXNA 2WDDA 2Z72A 4ZX2A 2WDCA 2Z06A 3QFNA 1Z2WA 3H63A 3V4YA 1S3NA 1NNWA 2BCDA 3THOB 4H2BA 2IE3C 5J28A 5HPEA 1S3MA 3K7WC 1XZWA 5INBA 3H68A 1WAO1 3H60A 3LL8A 3PSOA 3THNA 3FLOA 4V0VA 1XM7A 2O8GA 1MF8A 4UT2A 2R17A 2YEQA 4H2GA 2USHA 3D03A 1USHA 4O24A 4O43A 1WARA 1T70A 2IE4C 4H1SA 4H2IA 4KBPA 4KKZA 5DNYA 4ZVZA 3E7BA 2NYLC 3IVDA 3H61A 4XPNA 3FGAC 4ORBA 4OR9A 1QHWA 3C5WC 2Q8UA 3GVEA 1U32A 3QG5C 2GJUA 3EGHA 4G9JA 3ICFA 4Q7FA 1OIDA 4V0WA 4TUGA 3E7AA 4O4KA 3H64A 5EQVA 1FJMA 3JYFA 4TUIA 2ZBMA
chains in the Genus database with same CATH topology
4V0XA 2HYOA 2Z1AA 4NZVA 1HO5A 3H62B 1G5BA 1JK7A 2HY1A 3HVQA 4DHLA 5B8IA 1TCOA 4JA9A 3IB8A 4IL1A 3AUZA 2O8AA 3QFOA 2BQ8X 3IVEA 4FBWA 4LTYA 1UTEA 4H2FA 3K7VC 1Z2XA 3RL4A 2DXLA 4MOYA 2AHDA 1AUIA 4ORAA 1UF3A 2HYPA 5JPEA 3P71C 2WDEA 4B2OA 2QFRA 3DSCA 1S8EA 3AV0A 2NPPC 2YVTA 3H67A 5F3WA 1T71A 3PSNA 4F0ZA 2ZO9B 4ORCA 4MOVA 1KBPA 4FBKA 3H69A 4J6OA 2DFJA 4WWLA 4LACC 3ZU0A 1HPUA 3ZTVA 5C1VA 1II7A 3N5UA 3DSDA 2QFPA 1S95A 2NYMC 1HP1A 3IB7A 4JA7A 1S3LA 3TGHA 2A22A 1OI8A 2NXFA 3H66A 3RL5A 1IT6A 3RL3A 2P6BA 4LU9A 3E0JA 4HD0A 4M0VA 2ZOAA 3QFKA 2CV9A 3CK2A 2KKNA 2XMOA 2QJCA 4O5GA 3C9FA 3RQZA 2JOGA 4I5LC 4H1YP 3KBPA 1W24A 4FBQA 4UT3B 5IOHA 4MP0A 1S70A 2IAEC 4FCXA 3DW8C 4UT3A 1SU1A 5JJTA 4DSYA 3T1IA 3QFMA 3EGGA 4IYPC 4UWQA 5GTUA 1V73A 4DT2A 1QFCA 1M63A 4YKEA 4I5NC 2BDXA 1OIEA 2WDFA 5JPFA 2DXNA 2WDDA 2Z72A 4ZX2A 2WDCA 2Z06A 3QFNA 1Z2WA 3H63A 3V4YA 1S3NA 1NNWA 2BCDA 3THOB 4H2BA 2IE3C 5J28A 5HPEA 1S3MA 3K7WC 1XZWA 5INBA 3H68A 1WAO1 3H60A 3LL8A 3PSOA 3THNA 3FLOA 4V0VA 1XM7A 2O8GA 1MF8A 4UT2A 2R17A 2YEQA 4H2GA 2USHA 3D03A 1USHA 4O24A 4O43A 1WARA 1T70A 2IE4C 4H1SA 4H2IA 4KBPA 4KKZA 5DNYA 4ZVZA 3E7BA 2NYLC 3IVDA 3H61A 4XPNA 3FGAC 4ORBA 4OR9A 1QHWA 3C5WC 2Q8UA 3GVEA 1U32A 3QG5C 2GJUA 3EGHA 4G9JA 3ICFA 4Q7FA 1OIDA 4V0WA 4TUGA 3E7AA 4O4KA 3H64A 5EQVA 1FJMA 3JYFA 4TUIA 2ZBMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V0X A;  2HYO A;  2Z1A A;  4NZV A;  1HO5 A;  3H62 B;  1G5B A;  1JK7 A;  2HY1 A;  3HVQ A;  4DHL A;  5B8I A;  1TCO A;  4JA9 A;  3IB8 A;  4IL1 A;  3AUZ A;  2O8A A;  3QFO A;  2BQ8 X;  3IVE A;  4FBW A;  4LTY A;  1UTE A;  4H2F A;  3K7V C;  1Z2X A;  3RL4 A;  4MOY A;  2AHD A;  1AUI A;  4ORA A;  1UF3 A;  2HYP A;  5JPE A;  3P71 C;  2WDE A;  4B2O A;  2QFR A;  3DSC A;  1S8E A;  3AV0 A;  2NPP C;  2YVT A;  3H67 A;  5F3W A;  1T71 A;  3PSN A;  4F0Z A;  4ORC A;  4MOV A;  1KBP A;  4FBK A;  3H69 A;  4J6O A;  2DFJ A;  4WWL A;  4LAC C;  3ZU0 A;  1HPU A;  3ZTV A;  5C1V A;  1II7 A;  3N5U A;  3DSD A;  2QFP A;  1S95 A;  2NYM C;  1HP1 A;  3IB7 A;  4JA7 A;  1S3L A;  3TGH A;  2A22 A;  1OI8 A;  2NXF A;  3H66 A;  3RL5 A;  1IT6 A;  3RL3 A;  2P6B A;  4LU9 A;  4HD0 A;  4M0V A;  3QFK A;  2CV9 A;  3CK2 A;  2KKN A;  2XMO A;  2QJC A;  4O5G A;  3C9F A;  3RQZ A;  2JOG A;  4I5L C;  4H1Y P;  3KBP A;  1W24 A;  4FBQ A;  4UT3 B;  5IOH A;  4MP0 A;  1S70 A;  2IAE C;  4FCX A;  3DW8 C;  4UT3 A;  1SU1 A;  5JJT A;  4DSY A;  3T1I A;  3QFM A;  3EGG A;  4IYP C;  4UWQ A;  5GTU A;  1V73 A;  4DT2 A;  1QFC A;  1M63 A;  4YKE A;  4I5N C;  2BDX A;  1OIE A;  2WDF A;  5JPF A;  2WDD A;  2Z72 A;  4ZX2 A;  2WDC A;  2Z06 A;  3QFN A;  1Z2W A;  3H63 A;  3V4Y A;  1S3N A;  1NNW A;  2BCD A;  3THO B;  4H2B A;  2IE3 C;  5J28 A;  5HPE A;  1S3M A;  3K7W C;  1XZW A;  5INB A;  3H68 A;  1WAO 1;  3H60 A;  3LL8 A;  3PSO A;  3THN A;  4V0V A;  1XM7 A;  2O8G A;  1MF8 A;  4UT2 A;  2R17 A;  4H2G A;  2USH A;  4O24 A;  1USH A;  4O43 A;  1WAR A;  1T70 A;  2IE4 C;  4H1S A;  4H2I A;  4KBP A;  4KKZ A;  5DNY A;  4ZVZ A;  3E7B A;  2NYL C;  3IVD A;  3H61 A;  4XPN A;  3FGA C;  4ORB A;  4OR9 A;  1QHW A;  3C5W C;  2Q8U A;  3GVE A;  1U32 A;  3QG5 C;  2GJU A;  3EGH A;  4G9J A;  3ICF A;  4Q7F A;  1OID A;  4V0W A;  4TUG A;  3E7A A;  4O4K A;  3H64 A;  5EQV A;  1FJM A;  3JYF A;  4TUI A;  2ZBM A; 
#chains in the Genus database with same CATH topology
 4V0X A;  2HYO A;  2Z1A A;  4NZV A;  1HO5 A;  3H62 B;  1G5B A;  1JK7 A;  2HY1 A;  3HVQ A;  4DHL A;  5B8I A;  1TCO A;  4JA9 A;  3IB8 A;  4IL1 A;  3AUZ A;  2O8A A;  3QFO A;  2BQ8 X;  3IVE A;  4FBW A;  4LTY A;  1UTE A;  4H2F A;  3K7V C;  1Z2X A;  3RL4 A;  2DXL A;  4MOY A;  2AHD A;  1AUI A;  4ORA A;  1UF3 A;  2HYP A;  5JPE A;  3P71 C;  2WDE A;  4B2O A;  2QFR A;  3DSC A;  1S8E A;  3AV0 A;  2NPP C;  2YVT A;  3H67 A;  5F3W A;  1T71 A;  3PSN A;  4F0Z A;  2ZO9 B;  4ORC A;  4MOV A;  1KBP A;  4FBK A;  3H69 A;  4J6O A;  2DFJ A;  4WWL A;  4LAC C;  3ZU0 A;  1HPU A;  3ZTV A;  5C1V A;  1II7 A;  3N5U A;  3DSD A;  2QFP A;  1S95 A;  2NYM C;  1HP1 A;  3IB7 A;  4JA7 A;  1S3L A;  3TGH A;  2A22 A;  1OI8 A;  2NXF A;  3H66 A;  3RL5 A;  1IT6 A;  3RL3 A;  2P6B A;  4LU9 A;  3E0J A;  4HD0 A;  4M0V A;  2ZOA A;  3QFK A;  2CV9 A;  3CK2 A;  2KKN A;  2XMO A;  2QJC A;  4O5G A;  3C9F A;  3RQZ A;  2JOG A;  4I5L C;  4H1Y P;  3KBP A;  1W24 A;  4FBQ A;  4UT3 B;  5IOH A;  4MP0 A;  1S70 A;  2IAE C;  4FCX A;  3DW8 C;  4UT3 A;  1SU1 A;  5JJT A;  4DSY A;  3T1I A;  3QFM A;  3EGG A;  4IYP C;  4UWQ A;  5GTU A;  1V73 A;  4DT2 A;  1QFC A;  1M63 A;  4YKE A;  4I5N C;  2BDX A;  1OIE A;  2WDF A;  5JPF A;  2DXN A;  2WDD A;  2Z72 A;  4ZX2 A;  2WDC A;  2Z06 A;  3QFN A;  1Z2W A;  3H63 A;  3V4Y A;  1S3N A;  1NNW A;  2BCD A;  3THO B;  4H2B A;  2IE3 C;  5J28 A;  5HPE A;  1S3M A;  3K7W C;  1XZW A;  5INB A;  3H68 A;  1WAO 1;  3H60 A;  3LL8 A;  3PSO A;  3THN A;  3FLO A;  4V0V A;  1XM7 A;  2O8G A;  1MF8 A;  4UT2 A;  2R17 A;  2YEQ A;  4H2G A;  2USH A;  3D03 A;  1USH A;  4O24 A;  4O43 A;  1WAR A;  1T70 A;  2IE4 C;  4H1S A;  4H2I A;  4KBP A;  4KKZ A;  5DNY A;  4ZVZ A;  3E7B A;  2NYL C;  3IVD A;  3H61 A;  4XPN A;  3FGA C;  4ORB A;  4OR9 A;  1QHW A;  3C5W C;  2Q8U A;  3GVE A;  1U32 A;  3QG5 C;  2GJU A;  3EGH A;  4G9J A;  3ICF A;  4Q7F A;  1OID A;  4V0W A;  4TUG A;  3E7A A;  4O4K A;  3H64 A;  5EQV A;  1FJM A;  3JYF A;  4TUI A;  2ZBM A; 
#chains in the Genus database with same CATH homology
 4V0X A;  2HYO A;  2Z1A A;  4NZV A;  1HO5 A;  3H62 B;  1G5B A;  1JK7 A;  2HY1 A;  3HVQ A;  4DHL A;  5B8I A;  1TCO A;  4JA9 A;  3IB8 A;  4IL1 A;  3AUZ A;  2O8A A;  3QFO A;  2BQ8 X;  3IVE A;  4FBW A;  4LTY A;  1UTE A;  4H2F A;  3K7V C;  1Z2X A;  3RL4 A;  2DXL A;  4MOY A;  2AHD A;  1AUI A;  4ORA A;  1UF3 A;  2HYP A;  5JPE A;  3P71 C;  2WDE A;  4B2O A;  2QFR A;  3DSC A;  1S8E A;  3AV0 A;  2NPP C;  2YVT A;  3H67 A;  5F3W A;  1T71 A;  3PSN A;  4F0Z A;  2ZO9 B;  4ORC A;  4MOV A;  1KBP A;  4FBK A;  3H69 A;  4J6O A;  2DFJ A;  4WWL A;  4LAC C;  3ZU0 A;  1HPU A;  3ZTV A;  5C1V A;  1II7 A;  3N5U A;  3DSD A;  2QFP A;  1S95 A;  2NYM C;  1HP1 A;  3IB7 A;  4JA7 A;  1S3L A;  3TGH A;  2A22 A;  1OI8 A;  2NXF A;  3H66 A;  3RL5 A;  1IT6 A;  3RL3 A;  2P6B A;  4LU9 A;  3E0J A;  4HD0 A;  4M0V A;  2ZOA A;  3QFK A;  2CV9 A;  3CK2 A;  2KKN A;  2XMO A;  2QJC A;  4O5G A;  3C9F A;  3RQZ A;  2JOG A;  4I5L C;  4H1Y P;  3KBP A;  1W24 A;  4FBQ A;  4UT3 B;  5IOH A;  4MP0 A;  1S70 A;  2IAE C;  4FCX A;  3DW8 C;  4UT3 A;  1SU1 A;  5JJT A;  4DSY A;  3T1I A;  3QFM A;  3EGG A;  4IYP C;  4UWQ A;  5GTU A;  1V73 A;  4DT2 A;  1QFC A;  1M63 A;  4YKE A;  4I5N C;  2BDX A;  1OIE A;  2WDF A;  5JPF A;  2DXN A;  2WDD A;  2Z72 A;  4ZX2 A;  2WDC A;  2Z06 A;  3QFN A;  1Z2W A;  3H63 A;  3V4Y A;  1S3N A;  1NNW A;  2BCD A;  3THO B;  4H2B A;  2IE3 C;  5J28 A;  5HPE A;  1S3M A;  3K7W C;  1XZW A;  5INB A;  3H68 A;  1WAO 1;  3H60 A;  3LL8 A;  3PSO A;  3THN A;  3FLO A;  4V0V A;  1XM7 A;  2O8G A;  1MF8 A;  4UT2 A;  2R17 A;  2YEQ A;  4H2G A;  2USH A;  3D03 A;  1USH A;  4O24 A;  4O43 A;  1WAR A;  1T70 A;  2IE4 C;  4H1S A;  4H2I A;  4KBP A;  4KKZ A;  5DNY A;  4ZVZ A;  3E7B A;  2NYL C;  3IVD A;  3H61 A;  4XPN A;  3FGA C;  4ORB A;  4OR9 A;  1QHW A;  3C5W C;  2Q8U A;  3GVE A;  1U32 A;  3QG5 C;  2GJU A;  3EGH A;  4G9J A;  3ICF A;  4Q7F A;  1OID A;  4V0W A;  4TUG A;  3E7A A;  4O4K A;  3H64 A;  5EQV A;  1FJM A;  3JYF A;  4TUI A;  2ZBM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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