The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
122
|
sequence length |
325
|
structure length |
325
|
Chain Sequence |
GASMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYAN
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
pubmed doi rcsb |
| molecule keywords |
Serine/threonine-protein phosphatase 5
|
| source organism |
Homo sapiens
|
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| total genus |
122
|
| structure length |
325
|
| sequence length |
325
|
| ec nomenclature |
ec
3.1.3.16: Protein-serine/threonine phosphatase. |
| pdb deposition date | 2015-05-19 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00149 | Metallophos | Calcineurin-like phosphoesterase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 4-Layer Sandwich | Purple Acid Phosphatase; chain A, domain 2 | Purple Acid Phosphatase; chain A, domain 2 |
#chains in the Genus database with same CATH superfamily 4G9J A; 3EGG A; 5C1V A; 2O8G A; 1W24 A; 3RL4 A; 2KKN A; 1NNW A; 2R17 A; 3P71 C; 4MOV A; 4ORB A; 2WDD A; 1XZW A; 5J28 A; 1SU1 A; 4H2G A; 1USH A; 4H1Y P; 3QG5 C; 1QHW A; 1T71 A; 2A22 A; 5JJT A; 4H1S A; 3QFO A; 1TCO A; 2GJU A; 4IYP C; 3QFN A; 1OI8 A; 4KBP A; 3FGA C; 3T1I A; 4DHL A; 1FJM A; 2HYO A; 4LAC C; 4XPN A; 3DSD A; 4O5G A; 4WWL A; 2NPP C; 1HPU A; 3PSO A; 3E7A A; 1IT6 A; 4KKZ A; 2BDX A; 2BQ8 X; 3LL8 A; 3DSC A; 2DFJ A; 2Z1A A; 2IE3 C; 5EQV A; 2QFR A; 4FBW A; 4V0W A; 3E7B A; 3CK2 A; 3H66 A; 3IVD A; 2WDC A; 1II7 A; 3AUZ A; 4H2F A; 1Z2X A; 4HD0 A; 1S3N A; 3K7V C; 4UT3 A; 4NZV A; 1WAR A; 4F0Z A; 2HYP A; 2NYL C; 4LU9 A; 2BCD A; 4ORC A; 2XMO A; 3K7W C; 2IE4 C; 1OID A; 5IOH A; 4DT2 A; 2HY1 A; 2Q8U A; 3IVE A; 2WDE A; 4FBQ A; 4O43 A; 3H63 A; 1S8E A; 3KBP A; 3IB7 A; 4DSY A; 5INB A; 4I5L C; 4V0V A; 2YVT A; 2QJC A; 2ZBM A; 5B8I A; 4OR9 A; 4ZX2 A; 4JA9 A; 3H61 A; 1JK7 A; 4FCX A; 1HO5 A; 4LTY A; 1M63 A; 4I5N C; 3N5U A; 2Z06 A; 2CV9 A; 2Z72 A; 1UTE A; 2IAE C; 3H62 B; 1U32 A; 1AUI A; 3H68 A; 4FBK A; 4M0V A; 2QFP A; 4H2B A; 3ZU0 A; 5GTU A; 2JOG A; 1MF8 A; 3HVQ A; 1XM7 A; 1HP1 A; 4J6O A; 3ZTV A; 4UT2 A; 3QFK A; 3AV0 A; 4UWQ A; 3TGH A; 3RL5 A; 4YKE A; 4TUI A; 4B2O A; 4IL1 A; 1S95 A; 3JYF A; 5F3W A; 4H2I A; 3QFM A; 4V0X A; 1UF3 A; 4MOY A; 5JPE A; 2USH A; 2P6B A; 1Z2W A; 3PSN A; 4JA7 A; 4ORA A; 3H64 A; 3RQZ A; 4O24 A; 3RL3 A; 5JPF A; 3H60 A; 3THN A; 3C5W C; 1QFC A; 3EGH A; 2NYM C; 1T70 A; 4ZVZ A; 4TUG A; 5DNY A; 3C9F A; 1G5B A; 3THO B; 1KBP A; 3H69 A; 4O4K A; 3IB8 A; 4Q7F A; 2NXF A; 1S3L A; 3GVE A; 4UT3 B; 3V4Y A; 1OIE A; 1V73 A; 1S3M A; 1S70 A; 1WAO 1; 3ICF A; 5HPE A; 3H67 A; 2WDF A; 3DW8 C; 2AHD A; 4MP0 A; 2O8A A; #chains in the Genus database with same CATH topology 4G9J A; 3EGG A; 5C1V A; 2O8G A; 1W24 A; 3RL4 A; 2KKN A; 1NNW A; 2R17 A; 3P71 C; 4MOV A; 4ORB A; 2WDD A; 1XZW A; 5J28 A; 1SU1 A; 4H2G A; 1USH A; 4H1Y P; 3QG5 C; 1QHW A; 1T71 A; 2A22 A; 5JJT A; 4H1S A; 3QFO A; 1TCO A; 2GJU A; 4IYP C; 2DXN A; 3QFN A; 1OI8 A; 3D03 A; 3FGA C; 4KBP A; 3T1I A; 1FJM A; 2HYO A; 4DHL A; 4LAC C; 4XPN A; 3DSD A; 4O5G A; 4WWL A; 2NPP C; 1HPU A; 3PSO A; 3E7A A; 1IT6 A; 4KKZ A; 2BDX A; 2BQ8 X; 3LL8 A; 3DSC A; 2DFJ A; 2Z1A A; 2IE3 C; 5EQV A; 2QFR A; 4FBW A; 4V0W A; 3E7B A; 3CK2 A; 3H66 A; 3IVD A; 2WDC A; 1II7 A; 3AUZ A; 4H2F A; 1Z2X A; 4HD0 A; 1S3N A; 3K7V C; 4UT3 A; 4NZV A; 1WAR A; 4F0Z A; 2HYP A; 2NYL C; 4LU9 A; 2BCD A; 4ORC A; 2XMO A; 3K7W C; 2IE4 C; 1OID A; 5IOH A; 2YEQ A; 4DT2 A; 2HY1 A; 2Q8U A; 3IVE A; 2WDE A; 4FBQ A; 4O43 A; 3H63 A; 1S8E A; 3KBP A; 3IB7 A; 4DSY A; 5INB A; 4I5L C; 4V0V A; 2YVT A; 2QJC A; 2ZBM A; 5B8I A; 4OR9 A; 3E0J A; 4ZX2 A; 4JA9 A; 3H61 A; 1JK7 A; 4FCX A; 1HO5 A; 4LTY A; 1M63 A; 4I5N C; 3N5U A; 2Z06 A; 2ZO9 B; 2CV9 A; 2Z72 A; 1UTE A; 2IAE C; 3H62 B; 1U32 A; 1AUI A; 3H68 A; 4FBK A; 4M0V A; 2QFP A; 3FLO A; 4H2B A; 5GTU A; 3ZU0 A; 2JOG A; 1MF8 A; 3HVQ A; 1XM7 A; 1HP1 A; 2ZOA A; 4J6O A; 3ZTV A; 4UT2 A; 3QFK A; 3AV0 A; 4UWQ A; 3TGH A; 3RL5 A; 4YKE A; 4TUI A; 4B2O A; 4IL1 A; 1S95 A; 3JYF A; 5F3W A; 4H2I A; 3QFM A; 4V0X A; 1UF3 A; 4MOY A; 5JPE A; 2USH A; 2P6B A; 1Z2W A; 3PSN A; 4JA7 A; 4ORA A; 3H64 A; 3RQZ A; 4O24 A; 3RL3 A; 5JPF A; 3H60 A; 3THN A; 3C5W C; 1QFC A; 3EGH A; 2NYM C; 1T70 A; 2DXL A; 4ZVZ A; 4TUG A; 5DNY A; 3C9F A; 1G5B A; 3THO B; 1KBP A; 3H69 A; 4O4K A; 3IB8 A; 4Q7F A; 2NXF A; 1S3L A; 3GVE A; 4UT3 B; 3V4Y A; 1OIE A; 1V73 A; 1S3M A; 1S70 A; 1WAO 1; 3ICF A; 5HPE A; 3H67 A; 2WDF A; 3DW8 C; 2AHD A; 4MP0 A; 2O8A A; #chains in the Genus database with same CATH homology 4G9J A; 3EGG A; 5C1V A; 2O8G A; 1W24 A; 3RL4 A; 2KKN A; 1NNW A; 2R17 A; 3P71 C; 4MOV A; 4ORB A; 2WDD A; 1XZW A; 5J28 A; 1SU1 A; 4H2G A; 1USH A; 4H1Y P; 3QG5 C; 1QHW A; 1T71 A; 2A22 A; 5JJT A; 4H1S A; 3QFO A; 1TCO A; 2GJU A; 4IYP C; 2DXN A; 3QFN A; 1OI8 A; 3D03 A; 3FGA C; 4KBP A; 3T1I A; 1FJM A; 2HYO A; 4DHL A; 4LAC C; 4XPN A; 3DSD A; 4O5G A; 4WWL A; 2NPP C; 1HPU A; 3PSO A; 3E7A A; 1IT6 A; 4KKZ A; 2BDX A; 2BQ8 X; 3LL8 A; 3DSC A; 2DFJ A; 2Z1A A; 2IE3 C; 5EQV A; 2QFR A; 4FBW A; 4V0W A; 3E7B A; 3CK2 A; 3H66 A; 3IVD A; 2WDC A; 1II7 A; 3AUZ A; 4H2F A; 1Z2X A; 4HD0 A; 1S3N A; 3K7V C; 4UT3 A; 4NZV A; 1WAR A; 4F0Z A; 2HYP A; 2NYL C; 4LU9 A; 2BCD A; 4ORC A; 2XMO A; 3K7W C; 2IE4 C; 1OID A; 5IOH A; 2YEQ A; 4DT2 A; 2HY1 A; 2Q8U A; 3IVE A; 2WDE A; 4FBQ A; 4O43 A; 3H63 A; 1S8E A; 3KBP A; 3IB7 A; 4DSY A; 5INB A; 4I5L C; 4V0V A; 2YVT A; 2QJC A; 2ZBM A; 5B8I A; 4OR9 A; 3E0J A; 4ZX2 A; 4JA9 A; 3H61 A; 1JK7 A; 4FCX A; 1HO5 A; 4LTY A; 1M63 A; 4I5N C; 3N5U A; 2Z06 A; 2ZO9 B; 2CV9 A; 2Z72 A; 1UTE A; 2IAE C; 3H62 B; 1U32 A; 1AUI A; 3H68 A; 4FBK A; 4M0V A; 2QFP A; 3FLO A; 4H2B A; 5GTU A; 3ZU0 A; 2JOG A; 1MF8 A; 3HVQ A; 1XM7 A; 1HP1 A; 2ZOA A; 4J6O A; 3ZTV A; 4UT2 A; 3QFK A; 3AV0 A; 4UWQ A; 3TGH A; 3RL5 A; 4YKE A; 4TUI A; 4B2O A; 4IL1 A; 1S95 A; 3JYF A; 5F3W A; 4H2I A; 3QFM A; 4V0X A; 1UF3 A; 4MOY A; 5JPE A; 2USH A; 2P6B A; 1Z2W A; 3PSN A; 4JA7 A; 4ORA A; 3H64 A; 3RQZ A; 4O24 A; 3RL3 A; 5JPF A; 3H60 A; 3THN A; 3C5W C; 1QFC A; 3EGH A; 2NYM C; 1T70 A; 2DXL A; 4ZVZ A; 4TUG A; 5DNY A; 3C9F A; 1G5B A; 3THO B; 1KBP A; 3H69 A; 4O4K A; 3IB8 A; 4Q7F A; 2NXF A; 1S3L A; 3GVE A; 4UT3 B; 3V4Y A; 1OIE A; 1V73 A; 1S3M A; 1S70 A; 1WAO 1; 3ICF A; 5HPE A; 3H67 A; 2WDF A; 3DW8 C; 2AHD A; 4MP0 A; 2O8A A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
