4ZY3A

Crystal structure of keap1 in complex with a small chemical compound, k67
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
285
structure length
285
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
pubmed doi rcsb
molecule tags Transcription
source organism Mus musculus
molecule keywords Kelch-like ECH-associated protein 1
total genus 67
structure length 285
sequence length 285
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4zy3A00
3WN7A 5FZNA 4IFLX 2Z32A 4IFNX 2WOZA 5FNRA 4CHBA 4L7CA 3WDZA 4ZGCA 4L7DA 5FNQA 4XMBA 1X2RA 5CGJA 5FZJA 2VPJA 4IQKA 3VNGA 2FLUX 2ZWAA 4L7BA 1U6DX 3VNHA 5FNUA 2XN4A 3ZGCA 1ZGKA 2DYHA 4ASCA 4IN4A 4IFJA 5FNSA 3ADEA 3II7A 3ZGDA 4CH9A 4N1BA 2ZW9A 2ZZKA 1X2JA 5FNTA 4YY8A 4ZY3A 5F72C
chains in the Genus database with same CATH superfamily
3CYEA 3K38A 1CVMA 1F8BA 2B8HA 5D9CA 5HUGA 4CSDA 5GX1A 2HTVA 4QN7A 1XOGA 1BJIA 3VNGA 4HZXA 1MS5A 1RWLA 1INGA 1V2IA 3H71A 1MS4A 2W8BB 4YZ3A 4XJWA 4IN4A 1SUUA 4C1YB 2H2UA 1INHA 1K32A 2DSOA 4YW1A 1F8DA 2SIMA 4B7NA 2XZKA 2IAOA 4FPLA 1NSCA 4WA5A 2W20A 2BATA 2VW2A 2IAUA 3D11A 1NN2A 3Q6TA 1NMBN 2VSKA 4M3MA 2W5OA 3G4EA 2ZWAA 2C4AA 3LI4A 1INYA 2BERA 3L6VA 3LI5A 5H47A 3II7A 4K3YA 1IUBA 2VW0A 3U0SA 5GX2A 2QWFA 1N1VA 4D52A 5FZNA 3TI4A 2IASA 4GDIA 1ZI0A 5F9TA 1N1SA 3AMRA 1S1DA 4G3NA 1NCBN 1N6FA 1V0EA 2FLUX 2VAQA 4DGRA 5EO8A 3LI3A 2AGSA 2GVUA 3K39A 2HTWA 1CQ1A 4GNBA 4MC7A 3T1EA 4AHAA 2ZW9A 4HHOA 4HIZA 4Q1UA 3JU4A 4JMLA 3INBA 5F72C 5GX3A 3DASA 3H73A 2WOZA 2FP9A 2FHRA 3H6JA 4X4AA 4M4NA 1N1YA 5FZJA 3IAXA 2VPJA 4GZXA 4WA4A 3KGGA 1WP5A 3CL2A 1NNCA 1B9VA 2YA8A 3FVZA 2XN4A 4MWQA 1MS0A 3ZGCA 2IAQA 4ASCA 2HT8A 1NCCN 4CPZA 4GN7A 1IJQA 4HZYA 4X6KA 4XE9A 4FPFA 5B2CA 3K3AA 4ZLRA 3SOQA 2F28A 3TI3A 4MWYA 2IARA 1A14N 2F11A 2W5NA 3G4HA 4J9TA 3WN7A 4HZVA 4UOUA 4NN9A 1S0IA 4A0PA 1NSDA 1EURA 5D9DA 4IQKA 2YA6A 2HTQA 1L7FA 4UF7A 1MZ5A 1MS1A 3S2KA 2HTUA 3VNHA 3E5ZA 1MWEA 5GX5A 3K36A 4MZAA 4XJAA 2HTRA 4XJUA 2IAVA 2V91A 4QN4A 4MWVA 3V64C 3B69A 3ALXA 4O5TA 2C4LA 1W0PA 4MWXA 4WEGA 1E8TA 3SOBB 3NN9A 4XMBA 2F25A 3NSSA 2F27A 4QNPA 1NSBA 2P4OA 1E1AA 2VK5A 2YA7A 2POOA 2SILA 4FPGA 2F26A 1C9UA 4XMIA 1NNBA 3K37A 3B7EA 4FJ6A 5GTQA 3UC1A 4YZ1A 1EUUA 3D12A 5HUNA 1IVEA 2HU4A 4WEFA 2QWCA 1QBIA 4KS3A 4XMAA 2DG0A 4CPYA 4XHXA 2QWHA 3S8VA 2HU0A 4JF7A 2W38A 1Z4VA 3SANA 3WDZA 5D9BA 1W8NA 2VK7A 1KITA 3S8ZA 3WWAA 4D52B 2F0ZA 1XOEA 3O9KA 1N6DA 4KS5A 4D4UA 4MWLA 1B9SA 3A9HA 2FPBA 1L7GA 2ISMA 1E8VA 1Z4YA 5EX7A 1MS3A 3H72A 4FQ4A 5FNTA 2YA4A 4QN5A 4FZHA 4XIOA 4M4UA 2HT5A 4MZEA 3S94A 4IMBA 2VWDA 2F12A 3Q6PA 4NC5A 4XJRA 1Q7FA 2QWAA 4MX0A 4L7BA 4X47A 1CRZA 4D8SA 1V0ZA 3SREA 4AGIA 1V3BA 4GN8A 3V1SA 1A4QA 4FPKA 3TC9A 4R40A 1IVDA 4CPMA 2VW1A 4GNCA 4K1IA 2IAXA 3HRPA 1C5KA 1VCJA 4X49A 4CPNA 5HX0A 1MR5A 1Z4XA 3P5BL 1Z4ZA 1EUTA 4YZ5A 4WA3A 4FPOB 1INFA 3TICA 2IATA 3W09A 4MJUA 4FPJA 4HW6A 2F10A 3GVJA 1IUCA 5EO7A 2YA5A 4MWUA 4XJQA 5B2DA 6NN9A 1DIMA 4GZPA 2QWDA 2JKBA 1USRA 4K1KA 4CHBA 7NN9A 4XIKA 2XZIA 2HTYA 3TI6A 1W1XA 1S0JA 2QE8A 5FNQA 4FOYA 1X2RA 4DG6A 2QWBA 2A75A 4K1HA 1SNTA 4FOVA 1MS8A 4FPCA 1U6DX 1ZGKA 4GZWA 1RWIA 3TI5A 2OJHA 2VK6A 4CH9A 3ALWA 1E8UA 4GJTA 3Q6KA 4FPHA 1OFZA 1CRUA 2Z32A 3A9GA 5NN9A 5FNRA 4KS1A 4XYXA 3O4PA 4FP2A 4FPEA 4CPOA 1F8EA 1W20A 4FP3A 4H52A 1USXA 4XJZA 1EUSA 3FW0A 3OPZA 2QWJA 2G8SA 1SO7A 2DYHA 5HUKA 4AGTA 1N7DA 1V04A 1QLGA 1IVBA 4XJ8A 4N1BA 1W0OA 4M4VA 2ZZKA 4YW4A 1IVFA 4QN3A 1S18A 4ZY3A 4B7MA 1N6EA 3NO0A 4IFNX 4XHBA 2QWGA 4YW2A 3BYCA 3HLIA 4QN6A 4BBWA 3CKZA 5FWWA 4HZZA 5HUMA 2GHSA 2AH2A 3V65B 1SLLA 2ZB6A 1V3DA 1W21A 4IFJA 4GZOA 2DG1A 1POOA 2F29A 3ZGDA 2GVXA 2BF6A 2HT7A 3WW9A 4B7QA 3TIAA 1MS9A 4FOQA 1IVCA 4PWZA 1MZ6A 1V3CA 3SRGA 3SOVA 2W8BA 2IVZA 4YW5A 2VSMA 4L7DA 2AEPA 1NMCA 4C1YA 4B7RA 2IAWA 1NCDN 3BEQA 1INVA 3I1CA 2YDPA 4H53A 4HHQA 4GN9A 4YZ2A 1Z4WA 4KS2A 2CMLA 4GB1A 4HZWA 4GZSA 3SALA 1X2JA 4YY8A 4XOGA 1V0FA 3CL0A 4ZGCA 4GNAA 2AEQA 4GZQA 4XJ9A 1NPEA 4Q6KA 2FP8A 2BZDA 4FPYA 5JYYA 4NCSA 3KYAA 2QWEA 1Z50A 4CPLA 1NMAN 1V3EA 3ADEA 1INWA 2F13A 3A71A 5M1ZA 2GVVA 3O9JA 2XCYA 1A4GA 4FOWA 4GDJA 3SLIA 2F24A 4B7JA 4L7CA 1VCUA 2QWIA 1F8CA 1H6LA 1L7HA 4FVKA 1SLIA 4KS4A 5CGJA 3GVKA 1IVGA 2SLIA 2ZB5A 1N1TA 1DILA 2QWKA 3TI8A 4IYGA 2HQSA 5GX4A 3PJQA 1W8OA 4AH4A 1NCAN 2GVWA 2IAPA 1WCQA 3AMSA 1PJXA 2X9MA 2FPCA 4IFLX 4MWRA 2H2NA 2YDTA 2XZJA 4YZ4A 2RKCA 4YW3A 4GEZA 4MWJA 3HLHA 4MWWA 4O5SA 3A72A 4SLIA 4MJVA 3GVLA 4GZTA 3DR2A 4I00A 5FNUA 2VVZA 1WCSA 5FNSA 3SILA 4K1JA 1B9TA 4D52C 1NNAA 1INXA 4XILA 3TIBA
chains in the Genus database with same CATH topology
3WN7A 5FZNA 4IFLX 2Z32A 4IFNX 2WOZA 5FNRA 4CHBA 4L7CA 3WDZA 4ZGCA 4L7DA 5FNQA 4XMBA 1X2RA 5CGJA 5FZJA 2VPJA 4IQKA 3VNGA 2FLUX 2ZWAA 4L7BA 1U6DX 3VNHA 5FNUA 2XN4A 3ZGCA 1ZGKA 2DYHA 4ASCA 4IN4A 4IFJA 5FNSA 3ADEA 3II7A 3ZGDA 4CH9A 4N1BA 2ZW9A 2ZZKA 1X2JA 5FNTA 4YY8A 4ZY3A 5F72C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WN7 A;  5FZN A;  4IFL X;  2Z32 A;  4IFN X;  2WOZ A;  5FNR A;  4CHB A;  4L7C A;  3WDZ A;  4ZGC A;  4L7D A;  5FNQ A;  4XMB A;  1X2R A;  5CGJ A;  5FZJ A;  2VPJ A;  4IQK A;  3VNG A;  2FLU X;  2ZWA A;  4L7B A;  1U6D X;  3VNH A;  5FNU A;  2XN4 A;  3ZGC A;  1ZGK A;  2DYH A;  4ASC A;  4IN4 A;  4IFJ A;  5FNS A;  3ADE A;  3II7 A;  3ZGD A;  4CH9 A;  4N1B A;  2ZW9 A;  2ZZK A;  1X2J A;  5FNT A;  4YY8 A;  4ZY3 A;  5F72 C; 
#chains in the Genus database with same CATH topology
 3CYE A;  3K38 A;  1CVM A;  1F8B A;  2B8H A;  5D9C A;  5HUG A;  4CSD A;  5GX1 A;  2HTV A;  4QN7 A;  1XOG A;  1BJI A;  3VNG A;  4HZX A;  1MS5 A;  1RWL A;  1ING A;  1V2I A;  3H71 A;  1MS4 A;  2W8B B;  4YZ3 A;  4XJW A;  4IN4 A;  1SUU A;  4C1Y B;  2H2U A;  1INH A;  1K32 A;  2DSO A;  4YW1 A;  1F8D A;  2SIM A;  4B7N A;  2XZK A;  2IAO A;  4FPL A;  1NSC A;  4WA5 A;  2W20 A;  2BAT A;  2VW2 A;  2IAU A;  3D11 A;  1NN2 A;  3Q6T A;  1NMB N;  2VSK A;  4M3M A;  2W5O A;  3G4E A;  2ZWA A;  2C4A A;  3LI4 A;  1INY A;  2BER A;  3L6V A;  3LI5 A;  5H47 A;  3II7 A;  4K3Y A;  1IUB A;  2VW0 A;  3U0S A;  5GX2 A;  2QWF A;  1N1V A;  4D52 A;  5FZN A;  3TI4 A;  2IAS A;  4GDI A;  1ZI0 A;  5F9T A;  1N1S A;  3AMR A;  1S1D A;  4G3N A;  1NCB N;  1N6F A;  1V0E A;  2FLU X;  2VAQ A;  4DGR A;  5EO8 A;  3LI3 A;  2AGS A;  2GVU A;  3K39 A;  2HTW A;  1CQ1 A;  4GNB A;  4MC7 A;  3T1E A;  4AHA A;  2ZW9 A;  4HHO A;  4HIZ A;  4Q1U A;  3JU4 A;  4JML A;  3INB A;  5F72 C;  5GX3 A;  3DAS A;  3H73 A;  2WOZ A;  2FP9 A;  2FHR A;  3H6J A;  4X4A A;  4M4N A;  1N1Y A;  5FZJ A;  3IAX A;  2VPJ A;  4GZX A;  4WA4 A;  3KGG A;  1WP5 A;  3CL2 A;  1NNC A;  1B9V A;  2YA8 A;  3FVZ A;  2XN4 A;  4MWQ A;  1MS0 A;  3ZGC A;  2IAQ A;  4ASC A;  2HT8 A;  1NCC N;  4CPZ A;  4GN7 A;  1IJQ A;  4HZY A;  4X6K A;  4XE9 A;  4FPF A;  5B2C A;  3K3A A;  4ZLR A;  3SOQ A;  2F28 A;  3TI3 A;  4MWY A;  2IAR A;  1A14 N;  2F11 A;  2W5N A;  3G4H A;  4J9T A;  3WN7 A;  4HZV A;  4UOU A;  4NN9 A;  1S0I A;  4A0P A;  1NSD A;  1EUR A;  5D9D A;  4IQK A;  2YA6 A;  2HTQ A;  1L7F A;  4UF7 A;  1MZ5 A;  1MS1 A;  3S2K A;  2HTU A;  3VNH A;  3E5Z A;  1MWE A;  5GX5 A;  3K36 A;  4MZA A;  4XJA A;  2HTR A;  4XJU A;  2IAV A;  2V91 A;  4QN4 A;  4MWV A;  3V64 C;  3B69 A;  3ALX A;  4O5T A;  2C4L A;  1W0P A;  4MWX A;  4WEG A;  1E8T A;  3SOB B;  3NN9 A;  4XMB A;  2F25 A;  3NSS A;  2F27 A;  4QNP A;  1NSB A;  2P4O A;  1E1A A;  2VK5 A;  2YA7 A;  2POO A;  2SIL A;  4FPG A;  2F26 A;  1C9U A;  4XMI A;  1NNB A;  3K37 A;  3B7E A;  4FJ6 A;  5GTQ A;  3UC1 A;  4YZ1 A;  1EUU A;  3D12 A;  5HUN A;  1IVE A;  2HU4 A;  4WEF A;  2QWC A;  1QBI A;  4KS3 A;  4XMA A;  2DG0 A;  4CPY A;  4XHX A;  2QWH A;  3S8V A;  2HU0 A;  4JF7 A;  2W38 A;  1Z4V A;  3SAN A;  3WDZ A;  5D9B A;  1W8N A;  2VK7 A;  1KIT A;  3S8Z A;  3WWA A;  4D52 B;  2F0Z A;  1XOE A;  3O9K A;  1N6D A;  4KS5 A;  4D4U A;  4MWL A;  1B9S A;  3A9H A;  2FPB A;  1L7G A;  2ISM A;  1E8V A;  1Z4Y A;  5EX7 A;  1MS3 A;  3H72 A;  4FQ4 A;  5FNT A;  2YA4 A;  4QN5 A;  4FZH A;  4XIO A;  4M4U A;  2HT5 A;  4MZE A;  3S94 A;  4IMB A;  2VWD A;  2F12 A;  3Q6P A;  4NC5 A;  4XJR A;  1Q7F A;  2QWA A;  4MX0 A;  4L7B A;  4X47 A;  1CRZ A;  4D8S A;  1V0Z A;  3SRE A;  4AGI A;  1V3B A;  4GN8 A;  3V1S A;  1A4Q A;  4FPK A;  3TC9 A;  4R40 A;  1IVD A;  4CPM A;  2VW1 A;  4GNC A;  4K1I A;  2IAX A;  3HRP A;  1C5K A;  1VCJ A;  4X49 A;  4CPN A;  5HX0 A;  1MR5 A;  1Z4X A;  3P5B L;  1Z4Z A;  1EUT A;  4YZ5 A;  4WA3 A;  4FPO B;  1INF A;  3TIC A;  2IAT A;  3W09 A;  4MJU A;  4FPJ A;  4HW6 A;  2F10 A;  3GVJ A;  1IUC A;  5EO7 A;  2YA5 A;  4MWU A;  4XJQ A;  5B2D A;  6NN9 A;  1DIM A;  4GZP A;  2QWD A;  2JKB A;  1USR A;  4K1K A;  4CHB A;  7NN9 A;  4XIK A;  2XZI A;  2HTY A;  3TI6 A;  1W1X A;  1S0J A;  2QE8 A;  5FNQ A;  4FOY A;  1X2R A;  4DG6 A;  2QWB A;  2A75 A;  4K1H A;  1SNT A;  4FOV A;  1MS8 A;  4FPC A;  1U6D X;  1ZGK A;  4GZW A;  1RWI A;  3TI5 A;  2OJH A;  2VK6 A;  4CH9 A;  3ALW A;  1E8U A;  4GJT A;  3Q6K A;  4FPH A;  1OFZ A;  1CRU A;  2Z32 A;  3A9G A;  5NN9 A;  5FNR A;  4KS1 A;  4XYX A;  3O4P A;  4FP2 A;  4FPE A;  4CPO A;  1F8E A;  1W20 A;  4FP3 A;  4H52 A;  1USX A;  4XJZ A;  1EUS A;  3FW0 A;  3OPZ A;  2QWJ A;  2G8S A;  1SO7 A;  2DYH A;  5HUK A;  4AGT A;  1N7D A;  1V04 A;  1QLG A;  1IVB A;  4XJ8 A;  4N1B A;  1W0O A;  4M4V A;  2ZZK A;  4YW4 A;  1IVF A;  4QN3 A;  1S18 A;  4ZY3 A;  4B7M A;  1N6E A;  3NO0 A;  4IFN X;  4XHB A;  2QWG A;  4YW2 A;  3BYC A;  3HLI A;  4QN6 A;  4BBW A;  3CKZ A;  5FWW A;  4HZZ A;  5HUM A;  2GHS A;  2AH2 A;  3V65 B;  1SLL A;  2ZB6 A;  1V3D A;  1W21 A;  4IFJ A;  4GZO A;  2DG1 A;  1POO A;  2F29 A;  3ZGD A;  2GVX A;  2BF6 A;  2HT7 A;  3WW9 A;  4B7Q A;  3TIA A;  1MS9 A;  4FOQ A;  1IVC A;  4PWZ A;  1MZ6 A;  1V3C A;  3SRG A;  3SOV A;  2W8B A;  2IVZ A;  4YW5 A;  2VSM A;  4L7D A;  2AEP A;  1NMC A;  4C1Y A;  4B7R A;  2IAW A;  1NCD N;  3BEQ A;  1INV A;  3I1C A;  2YDP A;  4H53 A;  4HHQ A;  4GN9 A;  4YZ2 A;  1Z4W A;  4KS2 A;  2CML A;  4GB1 A;  4HZW A;  4GZS A;  3SAL A;  1X2J A;  4YY8 A;  4XOG A;  1V0F A;  3CL0 A;  4ZGC A;  4GNA A;  2AEQ A;  4GZQ A;  4XJ9 A;  1NPE A;  4Q6K A;  2FP8 A;  2BZD A;  4FPY A;  5JYY A;  4NCS A;  3KYA A;  2QWE A;  1Z50 A;  4CPL A;  1NMA N;  1V3E A;  3ADE A;  1INW A;  2F13 A;  3A71 A;  5M1Z A;  2GVV A;  3O9J A;  2XCY A;  1A4G A;  4FOW A;  4GDJ A;  3SLI A;  2F24 A;  4B7J A;  4L7C A;  1VCU A;  2QWI A;  1F8C A;  1H6L A;  1L7H A;  4FVK A;  1SLI A;  4KS4 A;  5CGJ A;  3GVK A;  1IVG A;  2SLI A;  2ZB5 A;  1N1T A;  1DIL A;  2QWK A;  3TI8 A;  4IYG A;  2HQS A;  5GX4 A;  3PJQ A;  1W8O A;  4AH4 A;  1NCA N;  2GVW A;  2IAP A;  1WCQ A;  3AMS A;  1PJX A;  2X9M A;  2FPC A;  4IFL X;  4MWR A;  2H2N A;  2YDT A;  2XZJ A;  4YZ4 A;  2RKC A;  4YW3 A;  4GEZ A;  4MWJ A;  3HLH A;  4MWW A;  4O5S A;  3A72 A;  4SLI A;  4MJV A;  3GVL A;  4GZT A;  3DR2 A;  4I00 A;  5FNU A;  2VVZ A;  1WCS A;  5FNS A;  3SIL A;  4K1J A;  1B9T A;  4D52 C;  1NNA A;  1INX A;  4XIL A;  3TIB A; 
#chains in the Genus database with same CATH homology
 3WN7 A;  5FZN A;  4IFL X;  2Z32 A;  4IFN X;  2WOZ A;  5FNR A;  4CHB A;  4L7C A;  3WDZ A;  4ZGC A;  4L7D A;  5FNQ A;  4XMB A;  1X2R A;  5CGJ A;  5FZJ A;  2VPJ A;  4IQK A;  3VNG A;  2FLU X;  2ZWA A;  4L7B A;  1U6D X;  3VNH A;  5FNU A;  2XN4 A;  3ZGC A;  1ZGK A;  2DYH A;  4ASC A;  4IN4 A;  4IFJ A;  5FNS A;  3ADE A;  3II7 A;  3ZGD A;  4CH9 A;  4N1B A;  2ZW9 A;  2ZZK A;  1X2J A;  5FNT A;  4YY8 A;  4ZY3 A;  5F72 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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