4AJRA

3d structure of e. coli isocitrate dehydrogenase k100m mutant in complex with alpha-ketoglutarate, magnesium(ii) and nadph - the product complex
Total Genus 137
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
137
sequence length
415
structure length
415
Chain Sequence
ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIMGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords ISOCITRATE DEHYDROGENASE [NADP]
publication title Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase.
pubmed doi rcsb
source organism Escherichia coli
total genus 137
structure length 415
sequence length 415
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2012-02-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4ajrA00
1IDCA 4WUOA 1IPDA 1GRPA 3FLKA 3MASB 4BNPA 1CW1A 4AJCA 2QFYA 4F7IA 7ICDA 3WZWA 2E5MA 3VMLA 5GRHA 9ICDA 5GRHB 4XXVA 3VL7A 3WZXA 4AJ3A 1PTMA 1CW4A 3AH3A 2Y3ZA 5HN6A 3MAPA 2Y40A 1LWDA 5K11A 3TSNA 1SJSA 3BLXA 4KZOA 2DHTA 1GC8A 1ZORA 4AJAA 3VKZA 2E0CA 1HJ6A 4I3LA 3LCBC 1U7NA 4XRXA 4UMXA 1P8FA 3TY4A 4JA8A 4ICDA 1G2UA 5LGEA 1WPWA 4HCXA 3MASA 1VLCA 5I96A 4AJRA 1XKDA 4I3KA 3U9EA 3WZVA 4UMYA 1ISOA 2Y41A 1IDMA 2HI1A 3VL6A 6ICDA 3R8WA 4AOYA 1A05A 1IDDA 2QFWA 4XS3A 3ASJA 1DR0A 4ATYA 1YXOA 1OSJA 3VMJA 1XGVA 5L58A 3BLVA 3BLVB 4Y1PA 1PS7A 3VMKA 1AI3A 2Y42A 5DE1A 5GREA 5GREB 1V53A 1BL5A 4L04A 4YB4A 1CM7A 1T0LA 2ZTWA 1CW7A 2IV0A 4JQPA 1W0DA 1AI2A 1DPZA 2G4OA 2AYQA 5HN5A 8ICDA 3U1HA 2QFVA 3VL2A 3INMA 2D4VA 1WALA 5GRLA 5GRLB 3VL4A 3UF6A 2D1CA 4L06A 3UDUA 3WZYA 1IDEA 1R8KA 3DMSA 4P69C 3UDOA 5ICDA 5HN3A 1XAAA 3LXYA 5HN4A 3VL3A 1PB3A 1YCOA 1XABA 2UXRA 2UXQA 3MARA 1IDFA 1HEXA 1T09A 5GRIA 5GRIB 1XACA 5J34A 4IWHA 4AJBA 3US8A 3FMXX 3TNGA 1CNZA 4AOUA 1GROA 1HQSA 1GC9A 1V94A 2QFXA 4AOVA 5L57A 4L03A 1TYOA 5K10A 4AJSA 5I95A 1XADA 3ICDA 1X0LA 3BLXB 5J32A 1PB1A 5GRFA 5J33A 1IKAA 1V5BA 1VI1A 5GRFB 3TY3A 1OSIA 1PS6A 1DR8A
chains in the Genus database with same CATH superfamily
1IDCA 4WUOA 1IPDA 1GRPA 3FLKA 3MASB 4BNPA 1CW1A 4AJCA 2QFYA 4F7IA 7ICDA 3WZWA 2E5MA 3VMLA 5GRHA 9ICDA 5GRHB 4XXVA 3VL7A 3WZXA 4AJ3A 1PTMA 1CW4A 3AH3A 2Y3ZA 5HN6A 3MAPA 2Y40A 1LWDA 5K11A 3TSNA 1SJSA 3BLXA 4KZOA 2DHTA 1GC8A 1ZORA 4AJAA 3VKZA 2E0CA 1HJ6A 4I3LA 3LCBC 1U7NA 4XRXA 4UMXA 1P8FA 3TY4A 4JA8A 4ICDA 1G2UA 5LGEA 1WPWA 4HCXA 3MASA 1VLCA 5I96A 4AJRA 1XKDA 4I3KA 3U9EA 3WZVA 4UMYA 1ISOA 2Y41A 1IDMA 2HI1A 3VL6A 6ICDA 3R8WA 4AOYA 1A05A 1IDDA 2QFWA 4XS3A 3ASJA 1DR0A 4ATYA 1YXOA 1OSJA 3VMJA 1XGVA 5L58A 3BLVA 3BLVB 4Y1PA 1PS7A 3VMKA 1AI3A 2Y42A 5DE1A 5GREA 5GREB 1V53A 1BL5A 4L04A 4YB4A 1CM7A 1T0LA 2ZTWA 1CW7A 2IV0A 4JQPA 1W0DA 1AI2A 1DPZA 2G4OA 2AYQA 5HN5A 8ICDA 3U1HA 2QFVA 3VL2A 3INMA 2D4VA 1WALA 5GRLA 5GRLB 3VL4A 3UF6A 2D1CA 4L06A 3UDUA 3WZYA 1IDEA 1R8KA 3DMSA 4P69C 3UDOA 5ICDA 5HN3A 1XAAA 3LXYA 5HN4A 3VL3A 1PB3A 1YCOA 1XABA 2UXRA 2UXQA 3MARA 1IDFA 1HEXA 1T09A 5GRIA 5GRIB 1XACA 5J34A 4IWHA 4AJBA 3US8A 3FMXX 3TNGA 1CNZA 4AOUA 1GROA 1HQSA 1GC9A 1V94A 2QFXA 4AOVA 5L57A 4L03A 1TYOA 5K10A 4AJSA 5I95A 1XADA 3ICDA 1X0LA 3BLXB 5J32A 1PB1A 5GRFA 5J33A 1IKAA 1V5BA 1VI1A 5GRFB 3TY3A 1OSIA 1PS6A 1DR8A
chains in the Genus database with same CATH topology
1IDCA 4WUOA 1IPDA 1GRPA 3FLKA 3MASB 4BNPA 1CW1A 4AJCA 2QFYA 4F7IA 7ICDA 3WZWA 2E5MA 3VMLA 5GRHA 9ICDA 5GRHB 4XXVA 3VL7A 3WZXA 4AJ3A 1PTMA 1CW4A 3AH3A 2Y3ZA 5HN6A 3MAPA 2Y40A 1LWDA 5K11A 3TSNA 1SJSA 3BLXA 4KZOA 2DHTA 1GC8A 1ZORA 4AJAA 3VKZA 2E0CA 1HJ6A 4I3LA 3LCBC 1U7NA 4XRXA 4UMXA 1P8FA 3TY4A 4JA8A 4ICDA 1G2UA 5LGEA 1WPWA 4HCXA 3MASA 1VLCA 5I96A 4AJRA 1XKDA 4I3KA 3U9EA 3WZVA 4UMYA 1ISOA 2Y41A 1IDMA 2HI1A 3VL6A 6ICDA 3R8WA 4AOYA 1A05A 1IDDA 2QFWA 4XS3A 3ASJA 1DR0A 4ATYA 1YXOA 1OSJA 3VMJA 1XGVA 5L58A 3BLVA 3BLVB 4Y1PA 1PS7A 3VMKA 1AI3A 2Y42A 5DE1A 5GREA 5GREB 1V53A 1BL5A 4L04A 4YB4A 1CM7A 1T0LA 2ZTWA 1CW7A 2IV0A 4JQPA 1W0DA 1AI2A 1DPZA 2G4OA 2AYQA 5HN5A 8ICDA 3U1HA 2QFVA 3VL2A 3INMA 2D4VA 1WALA 5GRLA 5GRLB 3VL4A 3UF6A 2D1CA 4L06A 3UDUA 3WZYA 1IDEA 1R8KA 3DMSA 4P69C 3UDOA 5ICDA 5HN3A 1XAAA 3LXYA 5HN4A 3VL3A 1PB3A 1YCOA 1XABA 2UXRA 2UXQA 3MARA 1IDFA 1HEXA 1T09A 5GRIA 5GRIB 1XACA 5J34A 4IWHA 4AJBA 3US8A 3FMXX 3TNGA 1CNZA 4AOUA 1GROA 1HQSA 1GC9A 1V94A 2QFXA 4AOVA 5L57A 4L03A 1TYOA 5K10A 4AJSA 5I95A 1XADA 3ICDA 1X0LA 3BLXB 5J32A 1PB1A 5GRFA 5J33A 1IKAA 1V5BA 1VI1A 5GRFB 3TY3A 1OSIA 1PS6A 1DR8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IDC A;  4WUO A;  1IPD A;  1GRP A;  3FLK A;  3MAS B;  4BNP A;  1CW1 A;  4AJC A;  2QFY A;  4F7I A;  7ICD A;  3WZW A;  2E5M A;  3VML A;  5GRH A;  9ICD A;  5GRH B;  4XXV A;  3VL7 A;  3WZX A;  4AJ3 A;  1PTM A;  1CW4 A;  3AH3 A;  2Y3Z A;  5HN6 A;  3MAP A;  2Y40 A;  1LWD A;  5K11 A;  3TSN A;  1SJS A;  3BLX A;  4KZO A;  2DHT A;  1GC8 A;  1ZOR A;  4AJA A;  3VKZ A;  2E0C A;  1HJ6 A;  4I3L A;  3LCB C;  1U7N A;  4XRX A;  4UMX A;  1P8F A;  3TY4 A;  4JA8 A;  4ICD A;  1G2U A;  5LGE A;  1WPW A;  4HCX A;  3MAS A;  1VLC A;  5I96 A;  4AJR A;  1XKD A;  4I3K A;  3U9E A;  3WZV A;  4UMY A;  1ISO A;  2Y41 A;  1IDM A;  2HI1 A;  3VL6 A;  6ICD A;  3R8W A;  4AOY A;  1A05 A;  1IDD A;  2QFW A;  4XS3 A;  3ASJ A;  1DR0 A;  4ATY A;  1YXO A;  1OSJ A;  3VMJ A;  1XGV A;  5L58 A;  3BLV A;  3BLV B;  4Y1P A;  1PS7 A;  3VMK A;  1AI3 A;  2Y42 A;  5DE1 A;  5GRE A;  5GRE B;  1V53 A;  1BL5 A;  4L04 A;  4YB4 A;  1CM7 A;  1T0L A;  2ZTW A;  1CW7 A;  2IV0 A;  4JQP A;  1W0D A;  1AI2 A;  1DPZ A;  2G4O A;  2AYQ A;  5HN5 A;  8ICD A;  3U1H A;  2QFV A;  3VL2 A;  3INM A;  2D4V A;  1WAL A;  5GRL A;  5GRL B;  3VL4 A;  3UF6 A;  2D1C A;  4L06 A;  3UDU A;  3WZY A;  1IDE A;  1R8K A;  3DMS A;  4P69 C;  3UDO A;  5ICD A;  5HN3 A;  1XAA A;  3LXY A;  5HN4 A;  3VL3 A;  1PB3 A;  1YCO A;  1XAB A;  2UXR A;  2UXQ A;  3MAR A;  1IDF A;  1HEX A;  1T09 A;  5GRI A;  5GRI B;  1XAC A;  5J34 A;  4IWH A;  4AJB A;  3US8 A;  3FMX X;  3TNG A;  1CNZ A;  4AOU A;  1GRO A;  1HQS A;  1GC9 A;  1V94 A;  2QFX A;  4AOV A;  5L57 A;  4L03 A;  1TYO A;  5K10 A;  4AJS A;  5I95 A;  1XAD A;  3ICD A;  1X0L A;  3BLX B;  5J32 A;  1PB1 A;  5GRF A;  5J33 A;  1IKA A;  1V5B A;  1VI1 A;  5GRF B;  3TY3 A;  1OSI A;  1PS6 A;  1DR8 A; 
#chains in the Genus database with same CATH topology
 1IDC A;  4WUO A;  1IPD A;  1GRP A;  3FLK A;  3MAS B;  4BNP A;  1CW1 A;  4AJC A;  2QFY A;  4F7I A;  7ICD A;  3WZW A;  2E5M A;  3VML A;  5GRH A;  9ICD A;  5GRH B;  4XXV A;  3VL7 A;  3WZX A;  4AJ3 A;  1PTM A;  1CW4 A;  3AH3 A;  2Y3Z A;  5HN6 A;  3MAP A;  2Y40 A;  1LWD A;  5K11 A;  3TSN A;  1SJS A;  3BLX A;  4KZO A;  2DHT A;  1GC8 A;  1ZOR A;  4AJA A;  3VKZ A;  2E0C A;  1HJ6 A;  4I3L A;  3LCB C;  1U7N A;  4XRX A;  4UMX A;  1P8F A;  3TY4 A;  4JA8 A;  4ICD A;  1G2U A;  5LGE A;  1WPW A;  4HCX A;  3MAS A;  1VLC A;  5I96 A;  4AJR A;  1XKD A;  4I3K A;  3U9E A;  3WZV A;  4UMY A;  1ISO A;  2Y41 A;  1IDM A;  2HI1 A;  3VL6 A;  6ICD A;  3R8W A;  4AOY A;  1A05 A;  1IDD A;  2QFW A;  4XS3 A;  3ASJ A;  1DR0 A;  4ATY A;  1YXO A;  1OSJ A;  3VMJ A;  1XGV A;  5L58 A;  3BLV A;  3BLV B;  4Y1P A;  1PS7 A;  3VMK A;  1AI3 A;  2Y42 A;  5DE1 A;  5GRE A;  5GRE B;  1V53 A;  1BL5 A;  4L04 A;  4YB4 A;  1CM7 A;  1T0L A;  2ZTW A;  1CW7 A;  2IV0 A;  4JQP A;  1W0D A;  1AI2 A;  1DPZ A;  2G4O A;  2AYQ A;  5HN5 A;  8ICD A;  3U1H A;  2QFV A;  3VL2 A;  3INM A;  2D4V A;  1WAL A;  5GRL A;  5GRL B;  3VL4 A;  3UF6 A;  2D1C A;  4L06 A;  3UDU A;  3WZY A;  1IDE A;  1R8K A;  3DMS A;  4P69 C;  3UDO A;  5ICD A;  5HN3 A;  1XAA A;  3LXY A;  5HN4 A;  3VL3 A;  1PB3 A;  1YCO A;  1XAB A;  2UXR A;  2UXQ A;  3MAR A;  1IDF A;  1HEX A;  1T09 A;  5GRI A;  5GRI B;  1XAC A;  5J34 A;  4IWH A;  4AJB A;  3US8 A;  3FMX X;  3TNG A;  1CNZ A;  4AOU A;  1GRO A;  1HQS A;  1GC9 A;  1V94 A;  2QFX A;  4AOV A;  5L57 A;  4L03 A;  1TYO A;  5K10 A;  4AJS A;  5I95 A;  1XAD A;  3ICD A;  1X0L A;  3BLX B;  5J32 A;  1PB1 A;  5GRF A;  5J33 A;  1IKA A;  1V5B A;  1VI1 A;  5GRF B;  3TY3 A;  1OSI A;  1PS6 A;  1DR8 A; 
#chains in the Genus database with same CATH homology
 1IDC A;  4WUO A;  1IPD A;  1GRP A;  3FLK A;  3MAS B;  4BNP A;  1CW1 A;  4AJC A;  2QFY A;  4F7I A;  7ICD A;  3WZW A;  2E5M A;  3VML A;  5GRH A;  9ICD A;  5GRH B;  4XXV A;  3VL7 A;  3WZX A;  4AJ3 A;  1PTM A;  1CW4 A;  3AH3 A;  2Y3Z A;  5HN6 A;  3MAP A;  2Y40 A;  1LWD A;  5K11 A;  3TSN A;  1SJS A;  3BLX A;  4KZO A;  2DHT A;  1GC8 A;  1ZOR A;  4AJA A;  3VKZ A;  2E0C A;  1HJ6 A;  4I3L A;  3LCB C;  1U7N A;  4XRX A;  4UMX A;  1P8F A;  3TY4 A;  4JA8 A;  4ICD A;  1G2U A;  5LGE A;  1WPW A;  4HCX A;  3MAS A;  1VLC A;  5I96 A;  4AJR A;  1XKD A;  4I3K A;  3U9E A;  3WZV A;  4UMY A;  1ISO A;  2Y41 A;  1IDM A;  2HI1 A;  3VL6 A;  6ICD A;  3R8W A;  4AOY A;  1A05 A;  1IDD A;  2QFW A;  4XS3 A;  3ASJ A;  1DR0 A;  4ATY A;  1YXO A;  1OSJ A;  3VMJ A;  1XGV A;  5L58 A;  3BLV A;  3BLV B;  4Y1P A;  1PS7 A;  3VMK A;  1AI3 A;  2Y42 A;  5DE1 A;  5GRE A;  5GRE B;  1V53 A;  1BL5 A;  4L04 A;  4YB4 A;  1CM7 A;  1T0L A;  2ZTW A;  1CW7 A;  2IV0 A;  4JQP A;  1W0D A;  1AI2 A;  1DPZ A;  2G4O A;  2AYQ A;  5HN5 A;  8ICD A;  3U1H A;  2QFV A;  3VL2 A;  3INM A;  2D4V A;  1WAL A;  5GRL A;  5GRL B;  3VL4 A;  3UF6 A;  2D1C A;  4L06 A;  3UDU A;  3WZY A;  1IDE A;  1R8K A;  3DMS A;  4P69 C;  3UDO A;  5ICD A;  5HN3 A;  1XAA A;  3LXY A;  5HN4 A;  3VL3 A;  1PB3 A;  1YCO A;  1XAB A;  2UXR A;  2UXQ A;  3MAR A;  1IDF A;  1HEX A;  1T09 A;  5GRI A;  5GRI B;  1XAC A;  5J34 A;  4IWH A;  4AJB A;  3US8 A;  3FMX X;  3TNG A;  1CNZ A;  4AOU A;  1GRO A;  1HQS A;  1GC9 A;  1V94 A;  2QFX A;  4AOV A;  5L57 A;  4L03 A;  1TYO A;  5K10 A;  4AJS A;  5I95 A;  1XAD A;  3ICD A;  1X0L A;  3BLX B;  5J32 A;  1PB1 A;  5GRF A;  5J33 A;  1IKA A;  1V5B A;  1VI1 A;  5GRF B;  3TY3 A;  1OSI A;  1PS6 A;  1DR8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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