4AOVA

Dpidh-nadp. the complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
sequence length
402
structure length
401
Chain Sequence
MKIQMKTPLVELDGDEMTRVLWPLIKDKLLLPFIDLQTEYYDLGIEERDRTNDQITIDAAEAIKKYGVGVKNATITPNQDRVEEYGLKEQWKSPNATVRAMLDGTVFRKPIMVKNIKPSVRSWQKPIVVGRHAYGDFYKNAEIFAEAGGKLEIVVTDKNGKETRQTIMEVDEPAIVQGIHNTVASIGHFARACFEYSLDQKIDCWFATKDTISKQYDQRFKIIFEEIFAQEYKEKFAAAGIEYFYTLIDDVVARMMKTEGGMLWACKNYDGDVMSDMVASAFGSLAMMSSVLVSPYGYFEYEAAHGTVQRHYYQHLKGERTSTNPVALIYAWTGALRKRGELDGTPDLCAFCDSLEAITIECIESGYMTGDLARICEPAAIKVLDSIEFIDELGKRLQQLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords ISOCITRATE DEHYDROGENASE [NADP]
publication title The Complex Structures of Isocitrate Dehydrogenase from Clostridium Thermocellum and Desulfotalea Psychrophila Suggest a New Active Site Locking Mechanism
pubmed doi rcsb
source organism Desulfotalea psychrophila
total genus 153
structure length 401
sequence length 402
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4aovA00
4JQPA 4IWHA 1A05A 2Y42A 5GRIB 3WZYA 5GRLB 4AOUA 4XRXA 3MAPA 1PS6A 5GREB 2DHTA 4L03A 4ICDA 2Y41A 1ISOA 3VMLA 1AI2A 2AYQA 4JA8A 1VI1A 3VMJA 1BL5A 1HJ6A 1WPWA 1HEXA 4F7IA 3BLVA 5L58A 3TSNA 1XACA 1ZORA 3VL3A 5K11A 4I3LA 6ICDA 5ICDA 4P69C 2G4OA 1GC9A 1PB3A 5GRHA 5LGEA 1GRPA 4UMYA 4XXVA 3BLXB 3UDUA 1V94A 3TNGA 3VL7A 1SJSA 2QFYA 1CW4A 3R8WA 4L04A 4ATYA 1YCOA 1IDFA 3U9EA 1T09A 1GROA 1PTMA 4AJ3A 3LCBC 1XAAA 5I96A 2IV0A 2UXRA 4AOVA 2QFWA 3BLVB 3VL2A 3ICDA 1IKAA 2QFVA 3MASB 3AH3A 4UMXA 3WZWA 1VLCA 2E5MA 2Y40A 3VMKA 5GRIA 1CW7A 3ASJA 4WUOA 5GRHB 1XADA 4AJRA 1IDCA 3FLKA 2D1CA 1X0LA 3FMXX 3WZVA 5L57A 1HQSA 2Y3ZA 4XS3A 5I95A 5HN3A 1WALA 1CNZA 1AI3A 3VL4A 2ZTWA 4YB4A 1R8KA 2QFXA 5DE1A 1TYOA 1XGVA 5GRFA 1DR0A 3INMA 5HN6A 5J33A 1G2UA 4AOYA 1XKDA 4KZOA 4I3KA 5HN4A 1YXOA 3MARA 5J32A 1IDEA 1GC8A 1T0LA 5K10A 3UF6A 4AJBA 1IPDA 4L06A 1IDMA 3DMSA 4BNPA 1XABA 3BLXA 3US8A 1PS7A 3WZXA 5GRLA 1DPZA 1CW1A 1PB1A 1IDDA 9ICDA 3LXYA 5GREA 4AJSA 2D4VA 7ICDA 1U7NA 8ICDA 3UDOA 1LWDA 4HCXA 2E0CA 5GRFB 3U1HA 5HN5A 3VKZA 1DR8A 1OSJA 1P8FA 3TY3A 3MASA 1OSIA 4AJCA 2UXQA 2HI1A 3VL6A 1V5BA 1W0DA 1V53A 3TY4A 4Y1PA 5J34A 1CM7A 4AJAA
chains in the Genus database with same CATH superfamily
4JQPA 4IWHA 1A05A 2Y42A 5GRIB 3WZYA 5GRLB 4AOUA 4XRXA 3MAPA 1PS6A 5GREB 2DHTA 4L03A 4ICDA 2Y41A 1ISOA 3VMLA 1AI2A 2AYQA 4JA8A 1VI1A 3VMJA 1BL5A 1HJ6A 1WPWA 1HEXA 4F7IA 3BLVA 5L58A 3TSNA 1XACA 1ZORA 3VL3A 5K11A 4I3LA 6ICDA 5ICDA 4P69C 2G4OA 1GC9A 1PB3A 5GRHA 5LGEA 1GRPA 4UMYA 4XXVA 3BLXB 3UDUA 1V94A 3TNGA 3VL7A 1SJSA 2QFYA 1CW4A 3R8WA 4L04A 4ATYA 1YCOA 1IDFA 3U9EA 1T09A 1GROA 1PTMA 4AJ3A 3LCBC 1XAAA 5I96A 2IV0A 2UXRA 4AOVA 2QFWA 3BLVB 3VL2A 3ICDA 1IKAA 2QFVA 3MASB 3AH3A 4UMXA 3WZWA 1VLCA 2E5MA 2Y40A 3VMKA 5GRIA 1CW7A 3ASJA 4WUOA 5GRHB 1XADA 4AJRA 1IDCA 3FLKA 2D1CA 1X0LA 3FMXX 3WZVA 5L57A 1HQSA 2Y3ZA 4XS3A 5I95A 5HN3A 1WALA 1CNZA 1AI3A 3VL4A 2ZTWA 4YB4A 1R8KA 2QFXA 5DE1A 1TYOA 1XGVA 5GRFA 1DR0A 3INMA 5HN6A 5J33A 1G2UA 4AOYA 1XKDA 4KZOA 4I3KA 5HN4A 1YXOA 3MARA 5J32A 1IDEA 1GC8A 1T0LA 5K10A 3UF6A 4AJBA 1IPDA 4L06A 1IDMA 3DMSA 4BNPA 1XABA 3BLXA 3US8A 1PS7A 3WZXA 5GRLA 1DPZA 1CW1A 1PB1A 1IDDA 9ICDA 3LXYA 5GREA 4AJSA 2D4VA 7ICDA 1U7NA 8ICDA 3UDOA 1LWDA 4HCXA 2E0CA 5GRFB 3U1HA 5HN5A 3VKZA 1DR8A 1OSJA 1P8FA 3TY3A 3MASA 1OSIA 4AJCA 2UXQA 2HI1A 3VL6A 1V5BA 1W0DA 1V53A 3TY4A 4Y1PA 5J34A 1CM7A 4AJAA
chains in the Genus database with same CATH topology
4JQPA 4IWHA 1A05A 2Y42A 5GRIB 3WZYA 5GRLB 4AOUA 4XRXA 3MAPA 1PS6A 5GREB 2DHTA 4L03A 4ICDA 2Y41A 1ISOA 3VMLA 1AI2A 2AYQA 4JA8A 1VI1A 3VMJA 1BL5A 1HJ6A 1WPWA 1HEXA 4F7IA 3BLVA 5L58A 3TSNA 1XACA 1ZORA 3VL3A 5K11A 4I3LA 6ICDA 5ICDA 4P69C 2G4OA 1GC9A 1PB3A 5GRHA 5LGEA 1GRPA 4UMYA 4XXVA 3BLXB 3UDUA 1V94A 3TNGA 3VL7A 1SJSA 2QFYA 1CW4A 3R8WA 4L04A 4ATYA 1YCOA 1IDFA 3U9EA 1T09A 1GROA 1PTMA 4AJ3A 3LCBC 1XAAA 5I96A 2IV0A 2UXRA 4AOVA 2QFWA 3BLVB 3VL2A 3ICDA 1IKAA 2QFVA 3MASB 3AH3A 4UMXA 3WZWA 1VLCA 2E5MA 2Y40A 3VMKA 5GRIA 1CW7A 3ASJA 4WUOA 5GRHB 1XADA 4AJRA 1IDCA 3FLKA 2D1CA 1X0LA 3FMXX 3WZVA 5L57A 1HQSA 2Y3ZA 4XS3A 5I95A 5HN3A 1WALA 1CNZA 1AI3A 3VL4A 2ZTWA 4YB4A 1R8KA 2QFXA 5DE1A 1TYOA 1XGVA 5GRFA 1DR0A 3INMA 5HN6A 5J33A 1G2UA 4AOYA 1XKDA 4KZOA 4I3KA 5HN4A 1YXOA 3MARA 5J32A 1IDEA 1GC8A 1T0LA 5K10A 3UF6A 4AJBA 1IPDA 4L06A 1IDMA 3DMSA 4BNPA 1XABA 3BLXA 3US8A 1PS7A 3WZXA 5GRLA 1DPZA 1CW1A 1PB1A 1IDDA 9ICDA 3LXYA 5GREA 4AJSA 2D4VA 7ICDA 1U7NA 8ICDA 3UDOA 1LWDA 4HCXA 2E0CA 5GRFB 3U1HA 5HN5A 3VKZA 1DR8A 1OSJA 1P8FA 3TY3A 3MASA 1OSIA 4AJCA 2UXQA 2HI1A 3VL6A 1V5BA 1W0DA 1V53A 3TY4A 4Y1PA 5J34A 1CM7A 4AJAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JQP A;  4IWH A;  1A05 A;  2Y42 A;  5GRI B;  3WZY A;  5GRL B;  4AOU A;  4XRX A;  3MAP A;  1PS6 A;  5GRE B;  2DHT A;  4L03 A;  4ICD A;  2Y41 A;  1ISO A;  3VML A;  1AI2 A;  2AYQ A;  4JA8 A;  1VI1 A;  3VMJ A;  1BL5 A;  1HJ6 A;  1WPW A;  1HEX A;  4F7I A;  3BLV A;  5L58 A;  3TSN A;  1XAC A;  1ZOR A;  3VL3 A;  5K11 A;  4I3L A;  6ICD A;  5ICD A;  4P69 C;  2G4O A;  1GC9 A;  1PB3 A;  5GRH A;  5LGE A;  1GRP A;  4UMY A;  4XXV A;  3BLX B;  3UDU A;  1V94 A;  3TNG A;  3VL7 A;  1SJS A;  2QFY A;  1CW4 A;  3R8W A;  4L04 A;  4ATY A;  1YCO A;  1IDF A;  3U9E A;  1T09 A;  1GRO A;  1PTM A;  4AJ3 A;  3LCB C;  1XAA A;  5I96 A;  2IV0 A;  2UXR A;  4AOV A;  2QFW A;  3BLV B;  3VL2 A;  3ICD A;  1IKA A;  2QFV A;  3MAS B;  3AH3 A;  4UMX A;  3WZW A;  1VLC A;  2E5M A;  2Y40 A;  3VMK A;  5GRI A;  1CW7 A;  3ASJ A;  4WUO A;  5GRH B;  1XAD A;  4AJR A;  1IDC A;  3FLK A;  2D1C A;  1X0L A;  3FMX X;  3WZV A;  5L57 A;  1HQS A;  2Y3Z A;  4XS3 A;  5I95 A;  5HN3 A;  1WAL A;  1CNZ A;  1AI3 A;  3VL4 A;  2ZTW A;  4YB4 A;  1R8K A;  2QFX A;  5DE1 A;  1TYO A;  1XGV A;  5GRF A;  1DR0 A;  3INM A;  5HN6 A;  5J33 A;  1G2U A;  4AOY A;  1XKD A;  4KZO A;  4I3K A;  5HN4 A;  1YXO A;  3MAR A;  5J32 A;  1IDE A;  1GC8 A;  1T0L A;  5K10 A;  3UF6 A;  4AJB A;  1IPD A;  4L06 A;  1IDM A;  3DMS A;  4BNP A;  1XAB A;  3BLX A;  3US8 A;  1PS7 A;  3WZX A;  5GRL A;  1DPZ A;  1CW1 A;  1PB1 A;  1IDD A;  9ICD A;  3LXY A;  5GRE A;  4AJS A;  2D4V A;  7ICD A;  1U7N A;  8ICD A;  3UDO A;  1LWD A;  4HCX A;  2E0C A;  5GRF B;  3U1H A;  5HN5 A;  3VKZ A;  1DR8 A;  1OSJ A;  1P8F A;  3TY3 A;  3MAS A;  1OSI A;  4AJC A;  2UXQ A;  2HI1 A;  3VL6 A;  1V5B A;  1W0D A;  1V53 A;  3TY4 A;  4Y1P A;  5J34 A;  1CM7 A;  4AJA A; 
#chains in the Genus database with same CATH topology
 4JQP A;  4IWH A;  1A05 A;  2Y42 A;  5GRI B;  3WZY A;  5GRL B;  4AOU A;  4XRX A;  3MAP A;  1PS6 A;  5GRE B;  2DHT A;  4L03 A;  4ICD A;  2Y41 A;  1ISO A;  3VML A;  1AI2 A;  2AYQ A;  4JA8 A;  1VI1 A;  3VMJ A;  1BL5 A;  1HJ6 A;  1WPW A;  1HEX A;  4F7I A;  3BLV A;  5L58 A;  3TSN A;  1XAC A;  1ZOR A;  3VL3 A;  5K11 A;  4I3L A;  6ICD A;  5ICD A;  4P69 C;  2G4O A;  1GC9 A;  1PB3 A;  5GRH A;  5LGE A;  1GRP A;  4UMY A;  4XXV A;  3BLX B;  3UDU A;  1V94 A;  3TNG A;  3VL7 A;  1SJS A;  2QFY A;  1CW4 A;  3R8W A;  4L04 A;  4ATY A;  1YCO A;  1IDF A;  3U9E A;  1T09 A;  1GRO A;  1PTM A;  4AJ3 A;  3LCB C;  1XAA A;  5I96 A;  2IV0 A;  2UXR A;  4AOV A;  2QFW A;  3BLV B;  3VL2 A;  3ICD A;  1IKA A;  2QFV A;  3MAS B;  3AH3 A;  4UMX A;  3WZW A;  1VLC A;  2E5M A;  2Y40 A;  3VMK A;  5GRI A;  1CW7 A;  3ASJ A;  4WUO A;  5GRH B;  1XAD A;  4AJR A;  1IDC A;  3FLK A;  2D1C A;  1X0L A;  3FMX X;  3WZV A;  5L57 A;  1HQS A;  2Y3Z A;  4XS3 A;  5I95 A;  5HN3 A;  1WAL A;  1CNZ A;  1AI3 A;  3VL4 A;  2ZTW A;  4YB4 A;  1R8K A;  2QFX A;  5DE1 A;  1TYO A;  1XGV A;  5GRF A;  1DR0 A;  3INM A;  5HN6 A;  5J33 A;  1G2U A;  4AOY A;  1XKD A;  4KZO A;  4I3K A;  5HN4 A;  1YXO A;  3MAR A;  5J32 A;  1IDE A;  1GC8 A;  1T0L A;  5K10 A;  3UF6 A;  4AJB A;  1IPD A;  4L06 A;  1IDM A;  3DMS A;  4BNP A;  1XAB A;  3BLX A;  3US8 A;  1PS7 A;  3WZX A;  5GRL A;  1DPZ A;  1CW1 A;  1PB1 A;  1IDD A;  9ICD A;  3LXY A;  5GRE A;  4AJS A;  2D4V A;  7ICD A;  1U7N A;  8ICD A;  3UDO A;  1LWD A;  4HCX A;  2E0C A;  5GRF B;  3U1H A;  5HN5 A;  3VKZ A;  1DR8 A;  1OSJ A;  1P8F A;  3TY3 A;  3MAS A;  1OSI A;  4AJC A;  2UXQ A;  2HI1 A;  3VL6 A;  1V5B A;  1W0D A;  1V53 A;  3TY4 A;  4Y1P A;  5J34 A;  1CM7 A;  4AJA A; 
#chains in the Genus database with same CATH homology
 4JQP A;  4IWH A;  1A05 A;  2Y42 A;  5GRI B;  3WZY A;  5GRL B;  4AOU A;  4XRX A;  3MAP A;  1PS6 A;  5GRE B;  2DHT A;  4L03 A;  4ICD A;  2Y41 A;  1ISO A;  3VML A;  1AI2 A;  2AYQ A;  4JA8 A;  1VI1 A;  3VMJ A;  1BL5 A;  1HJ6 A;  1WPW A;  1HEX A;  4F7I A;  3BLV A;  5L58 A;  3TSN A;  1XAC A;  1ZOR A;  3VL3 A;  5K11 A;  4I3L A;  6ICD A;  5ICD A;  4P69 C;  2G4O A;  1GC9 A;  1PB3 A;  5GRH A;  5LGE A;  1GRP A;  4UMY A;  4XXV A;  3BLX B;  3UDU A;  1V94 A;  3TNG A;  3VL7 A;  1SJS A;  2QFY A;  1CW4 A;  3R8W A;  4L04 A;  4ATY A;  1YCO A;  1IDF A;  3U9E A;  1T09 A;  1GRO A;  1PTM A;  4AJ3 A;  3LCB C;  1XAA A;  5I96 A;  2IV0 A;  2UXR A;  4AOV A;  2QFW A;  3BLV B;  3VL2 A;  3ICD A;  1IKA A;  2QFV A;  3MAS B;  3AH3 A;  4UMX A;  3WZW A;  1VLC A;  2E5M A;  2Y40 A;  3VMK A;  5GRI A;  1CW7 A;  3ASJ A;  4WUO A;  5GRH B;  1XAD A;  4AJR A;  1IDC A;  3FLK A;  2D1C A;  1X0L A;  3FMX X;  3WZV A;  5L57 A;  1HQS A;  2Y3Z A;  4XS3 A;  5I95 A;  5HN3 A;  1WAL A;  1CNZ A;  1AI3 A;  3VL4 A;  2ZTW A;  4YB4 A;  1R8K A;  2QFX A;  5DE1 A;  1TYO A;  1XGV A;  5GRF A;  1DR0 A;  3INM A;  5HN6 A;  5J33 A;  1G2U A;  4AOY A;  1XKD A;  4KZO A;  4I3K A;  5HN4 A;  1YXO A;  3MAR A;  5J32 A;  1IDE A;  1GC8 A;  1T0L A;  5K10 A;  3UF6 A;  4AJB A;  1IPD A;  4L06 A;  1IDM A;  3DMS A;  4BNP A;  1XAB A;  3BLX A;  3US8 A;  1PS7 A;  3WZX A;  5GRL A;  1DPZ A;  1CW1 A;  1PB1 A;  1IDD A;  9ICD A;  3LXY A;  5GRE A;  4AJS A;  2D4V A;  7ICD A;  1U7N A;  8ICD A;  3UDO A;  1LWD A;  4HCX A;  2E0C A;  5GRF B;  3U1H A;  5HN5 A;  3VKZ A;  1DR8 A;  1OSJ A;  1P8F A;  3TY3 A;  3MAS A;  1OSI A;  4AJC A;  2UXQ A;  2HI1 A;  3VL6 A;  1V5B A;  1W0D A;  1V53 A;  3TY4 A;  4Y1P A;  5J34 A;  1CM7 A;  4AJA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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