4AQHA

Plasminogen activator inhibitor type-1 in complex with the inhibitor az3976
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
382
structure length
382
Chain Sequence
SHMVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 that Accelerates the Transition Into the Latent Conformation
pubmed doi rcsb
molecule keywords PLASMINOGEN ACTIVATOR INHIBITOR 1
molecule tags Hydolase inhibitor
source organism Homo sapiens
total genus 121
structure length 382
sequence length 382
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2012-04-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4aqhA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4aqhA01
1ANTI 2XN7A 4AJUA 5BRRI 1LK6I 2XN6A 1JJOC 1YXAA 2VDXA 3NE4A 1OVAC 1B3KA 2PEFA 2WY1A 1DVMA 4ROAA 3CVMA 4DY7C 1DZGL 1BY7A 3DRUA 4CAAA 1JRRA 2V95A 3STOA 4AU2A 1QLPA 2PEEA 1XQJA 2ANTI 1HP7A 4RSQA 1C8OA 3LW2A 4GA7A 1IMVA 1E05I 7APIA 4ROBA 2QUGA 4X30A 2HIJL 2BEHL 3PZFA 4PYWA 4ZK3A 2BEHI 1OPHA 2H4QA 1K9OI 1OO8A 2GD4C 2R9YA 2CEOA 1WZ9A 3H5CA 1OC0A 1M93B 8APIA 4ZK0A 2VH4A 3PB1I 4Y40A 5IO1A 5CDXA 5INWA 1DVNA 2XN3A 1HLEA 1BR8I 5CE0A 1AS4A 3CAAA 4DTEA 3F1SA 3F5NA 1KCTA 4IC0A 4YIAA 3F02A 2WXYC 4C49A 4KDSA 1TB6I 5C98A 1LQ8A 1R1LI 2RIWA 1QMNA 1NQ9I 4RO9A 2B4XI 1E03I 3UT3A 4P0FA 4AU4A 4DY0A 2WXZA 4AFXA 2ZNHA 2RIVA 3ZHAA 3Q02A 2XN5A 3KCGI 5CDZA 4Y3KA 2H4RA 1SNGA 3T1PA 4AQHA 3DRMA 2D26A 1E04I 1DZHI 3NDFA 1UHGA 5EI0A 1OYHI 4IF8A 1ATHA 3Q03A 4P0OA 5HGCA 1D5SA 2B5TI 2ZV6A 1ATUA 4AU3B 3EOXA 3CWMA 1MTPA 3LE2A 4BB2A 1DB2A 4C41A 2WXZC 1OVAB 3NDDA 2B4XL 2OL2A 2OAYA 2DUTA 1XQGA 1XU8A 1PSIA 2HI9A 1C5GA 1LJ5A 4G8OA 1ATTA 3OZQA 9PAIA 2ACHA 3NDAA 1A7CA 9APIA 4G8RA 1QMBA 2ARQA 4EB1L 1DZHL 2VDYA 3EVJI 1JMOA 1OYHL 1IZ2A 4EB1I 1AZXI 1JTIA 4AU3A 2ARRA 1SEKA 1DZGI 1JMJA 1SR5A 3VVJA 3DLWA 1OVAA 3R4LA 2WXXA 4AJTA 3FGQA 3B9FI 2H4PA 2WXWA 3CWLA 2HIJI 1JVQI 4R9IA 1F0CA 1T1FA 2WY0C 3DY0A 1EZXA
chains in the Genus database with same CATH superfamily
1ANTI 2XN7A 4AJUA 5BRRI 1LK6I 2XN6A 1JJOC 1YXAA 2VDXA 3NE4A 1OVAC 1B3KA 2PEFA 2WY1A 1DVMA 4ROAA 3CVMA 4DY7C 1DZGL 1BY7A 3DRUA 4CAAA 1JRRA 2V95A 3STOA 4AU2A 1QLPA 2PEEA 1XQJA 2ANTI 1HP7A 4RSQA 1C8OA 3LW2A 4GA7A 1IMVA 1E05I 7APIA 4ROBA 2QUGA 4X30A 2HIJL 2BEHL 3PZFA 4PYWA 4ZK3A 2BEHI 1OPHA 2H4QA 1K9OI 1OO8A 2GD4C 2R9YA 2CEOA 1WZ9A 3H5CA 1OC0A 1M93B 8APIA 4ZK0A 2VH4A 3PB1I 4Y40A 5IO1A 5CDXA 5INWA 1DVNA 2XN3A 1HLEA 1BR8I 5CE0A 1AS4A 3CAAA 4DTEA 3F1SA 3F5NA 1KCTA 4IC0A 4YIAA 3F02A 2WXYC 4C49A 4KDSA 1TB6I 5C98A 1LQ8A 1R1LI 2RIWA 1QMNA 1NQ9I 4RO9A 2B4XI 1E03I 3UT3A 4P0FA 4AU4A 4DY0A 2WXZA 4AFXA 2ZNHA 2RIVA 3ZHAA 3Q02A 2XN5A 3KCGI 5CDZA 4Y3KA 2H4RA 1SNGA 3T1PA 4AQHA 3DRMA 2D26A 1E04I 1DZHI 3NDFA 1UHGA 5EI0A 1OYHI 4IF8A 1ATHA 3Q03A 4P0OA 5HGCA 1D5SA 2B5TI 2ZV6A 1ATUA 4AU3B 3EOXA 3CWMA 1MTPA 3LE2A 4BB2A 1DB2A 4C41A 2WXZC 1OVAB 3NDDA 2B4XL 2OL2A 2OAYA 2DUTA 1XQGA 1XU8A 1PSIA 2HI9A 1C5GA 1LJ5A 4G8OA 1ATTA 3OZQA 9PAIA 2ACHA 3NDAA 1A7CA 9APIA 4G8RA 1QMBA 2ARQA 4EB1L 1DZHL 2VDYA 3EVJI 1JMOA 1OYHL 1IZ2A 4EB1I 1AZXI 1JTIA 4AU3A 2ARRA 1SEKA 1DZGI 1JMJA 1SR5A 3VVJA 3DLWA 1OVAA 3R4LA 2WXXA 4AJTA 3FGQA 3B9FI 2H4PA 2WXWA 3CWLA 2HIJI 1JVQI 4R9IA 1F0CA 1T1FA 2WY0C 3DY0A 1EZXA
chains in the Genus database with same CATH topology
1ANTI 2XN7A 4AJUA 5BRRI 1LK6I 2XN6A 1JJOC 1YXAA 2VDXA 3NE4A 1OVAC 1B3KA 2PEFA 2WY1A 1DVMA 4ROAA 3CVMA 4DY7C 1DZGL 1BY7A 3DRUA 4CAAA 1JRRA 2V95A 3STOA 4AU2A 1QLPA 2PEEA 1XQJA 2ANTI 1HP7A 4RSQA 1C8OA 3LW2A 4GA7A 1IMVA 1E05I 7APIA 4ROBA 2QUGA 4X30A 2HIJL 2BEHL 3PZFA 4PYWA 4ZK3A 2BEHI 1OPHA 2H4QA 1K9OI 1OO8A 2GD4C 2R9YA 2CEOA 1WZ9A 3H5CA 1OC0A 1M93B 8APIA 4ZK0A 2VH4A 3PB1I 4Y40A 5IO1A 5CDXA 5INWA 1DVNA 2XN3A 1HLEA 1BR8I 5CE0A 1AS4A 3CAAA 4DTEA 3F1SA 3F5NA 1KCTA 4IC0A 4YIAA 3F02A 2WXYC 4C49A 4KDSA 1TB6I 5C98A 1LQ8A 1R1LI 2RIWA 1QMNA 1NQ9I 4RO9A 2B4XI 1E03I 3UT3A 4P0FA 4AU4A 4DY0A 2WXZA 4AFXA 2ZNHA 2RIVA 3ZHAA 3Q02A 2XN5A 3KCGI 5CDZA 4Y3KA 2H4RA 1SNGA 3T1PA 4AQHA 3DRMA 2D26A 1E04I 1DZHI 3NDFA 1UHGA 5EI0A 1OYHI 4IF8A 1ATHA 3Q03A 4P0OA 5HGCA 1D5SA 2B5TI 2ZV6A 1ATUA 4AU3B 3EOXA 3CWMA 1MTPA 3LE2A 4BB2A 1DB2A 4C41A 2WXZC 1OVAB 3NDDA 2B4XL 2OL2A 2OAYA 2DUTA 1XQGA 1XU8A 1PSIA 2HI9A 1C5GA 1LJ5A 4G8OA 1ATTA 3OZQA 9PAIA 2ACHA 3NDAA 1A7CA 9APIA 4G8RA 1QMBA 2ARQA 4EB1L 1DZHL 2VDYA 3EVJI 1JMOA 1OYHL 1IZ2A 4EB1I 1AZXI 1JTIA 4AU3A 2ARRA 1SEKA 1DZGI 1JMJA 1SR5A 3VVJA 3DLWA 1OVAA 3R4LA 2WXXA 4AJTA 3FGQA 3B9FI 2H4PA 2WXWA 3CWLA 2HIJI 1JVQI 4R9IA 1F0CA 1T1FA 2WY0C 3DY0A 1EZXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ANT I;  2XN7 A;  4AJU A;  5BRR I;  1LK6 I;  2XN6 A;  1JJO C;  1YXA A;  2VDX A;  3NE4 A;  1OVA C;  1B3K A;  2PEF A;  2WY1 A;  1DVM A;  4ROA A;  3CVM A;  4DY7 C;  1DZG L;  1BY7 A;  3DRU A;  4CAA A;  1JRR A;  2V95 A;  3STO A;  4AU2 A;  1QLP A;  2PEE A;  1XQJ A;  2ANT I;  1HP7 A;  4RSQ A;  1C8O A;  3LW2 A;  4GA7 A;  1IMV A;  1E05 I;  7API A;  4ROB A;  2QUG A;  4X30 A;  2HIJ L;  2BEH L;  3PZF A;  4PYW A;  4ZK3 A;  2BEH I;  1OPH A;  2H4Q A;  1K9O I;  1OO8 A;  2GD4 C;  2R9Y A;  2CEO A;  1WZ9 A;  3H5C A;  1OC0 A;  1M93 B;  8API A;  4ZK0 A;  2VH4 A;  3PB1 I;  4Y40 A;  5IO1 A;  5CDX A;  5INW A;  1DVN A;  2XN3 A;  1HLE A;  1BR8 I;  5CE0 A;  1AS4 A;  3CAA A;  4DTE A;  3F1S A;  3F5N A;  1KCT A;  4IC0 A;  4YIA A;  3F02 A;  2WXY C;  4C49 A;  4KDS A;  1TB6 I;  5C98 A;  1LQ8 A;  1R1L I;  2RIW A;  1QMN A;  1NQ9 I;  4RO9 A;  2B4X I;  1E03 I;  3UT3 A;  4P0F A;  4AU4 A;  4DY0 A;  2WXZ A;  4AFX A;  2ZNH A;  2RIV A;  3ZHA A;  3Q02 A;  2XN5 A;  3KCG I;  5CDZ A;  4Y3K A;  2H4R A;  1SNG A;  3T1P A;  4AQH A;  3DRM A;  2D26 A;  1E04 I;  1DZH I;  3NDF A;  1UHG A;  5EI0 A;  1OYH I;  4IF8 A;  1ATH A;  3Q03 A;  4P0O A;  5HGC A;  1D5S A;  2B5T I;  2ZV6 A;  1ATU A;  4AU3 B;  3EOX A;  3CWM A;  1MTP A;  3LE2 A;  4BB2 A;  1DB2 A;  4C41 A;  2WXZ C;  1OVA B;  3NDD A;  2B4X L;  2OL2 A;  2OAY A;  2DUT A;  1XQG A;  1XU8 A;  1PSI A;  2HI9 A;  1C5G A;  1LJ5 A;  4G8O A;  1ATT A;  3OZQ A;  9PAI A;  2ACH A;  3NDA A;  1A7C A;  9API A;  4G8R A;  1QMB A;  2ARQ A;  4EB1 L;  1DZH L;  2VDY A;  3EVJ I;  1JMO A;  1OYH L;  1IZ2 A;  4EB1 I;  1AZX I;  1JTI A;  4AU3 A;  2ARR A;  1SEK A;  1DZG I;  1JMJ A;  1SR5 A;  3VVJ A;  3DLW A;  1OVA A;  3R4L A;  2WXX A;  4AJT A;  3FGQ A;  3B9F I;  2H4P A;  2WXW A;  3CWL A;  2HIJ I;  1JVQ I;  4R9I A;  1F0C A;  1T1F A;  2WY0 C;  3DY0 A;  1EZX A; 
#chains in the Genus database with same CATH topology
 1ANT I;  2XN7 A;  4AJU A;  5BRR I;  1LK6 I;  2XN6 A;  1JJO C;  1YXA A;  2VDX A;  3NE4 A;  1OVA C;  1B3K A;  2PEF A;  2WY1 A;  1DVM A;  4ROA A;  3CVM A;  4DY7 C;  1DZG L;  1BY7 A;  3DRU A;  4CAA A;  1JRR A;  2V95 A;  3STO A;  4AU2 A;  1QLP A;  2PEE A;  1XQJ A;  2ANT I;  1HP7 A;  4RSQ A;  1C8O A;  3LW2 A;  4GA7 A;  1IMV A;  1E05 I;  7API A;  4ROB A;  2QUG A;  4X30 A;  2HIJ L;  2BEH L;  3PZF A;  4PYW A;  4ZK3 A;  2BEH I;  1OPH A;  2H4Q A;  1K9O I;  1OO8 A;  2GD4 C;  2R9Y A;  2CEO A;  1WZ9 A;  3H5C A;  1OC0 A;  1M93 B;  8API A;  4ZK0 A;  2VH4 A;  3PB1 I;  4Y40 A;  5IO1 A;  5CDX A;  5INW A;  1DVN A;  2XN3 A;  1HLE A;  1BR8 I;  5CE0 A;  1AS4 A;  3CAA A;  4DTE A;  3F1S A;  3F5N A;  1KCT A;  4IC0 A;  4YIA A;  3F02 A;  2WXY C;  4C49 A;  4KDS A;  1TB6 I;  5C98 A;  1LQ8 A;  1R1L I;  2RIW A;  1QMN A;  1NQ9 I;  4RO9 A;  2B4X I;  1E03 I;  3UT3 A;  4P0F A;  4AU4 A;  4DY0 A;  2WXZ A;  4AFX A;  2ZNH A;  2RIV A;  3ZHA A;  3Q02 A;  2XN5 A;  3KCG I;  5CDZ A;  4Y3K A;  2H4R A;  1SNG A;  3T1P A;  4AQH A;  3DRM A;  2D26 A;  1E04 I;  1DZH I;  3NDF A;  1UHG A;  5EI0 A;  1OYH I;  4IF8 A;  1ATH A;  3Q03 A;  4P0O A;  5HGC A;  1D5S A;  2B5T I;  2ZV6 A;  1ATU A;  4AU3 B;  3EOX A;  3CWM A;  1MTP A;  3LE2 A;  4BB2 A;  1DB2 A;  4C41 A;  2WXZ C;  1OVA B;  3NDD A;  2B4X L;  2OL2 A;  2OAY A;  2DUT A;  1XQG A;  1XU8 A;  1PSI A;  2HI9 A;  1C5G A;  1LJ5 A;  4G8O A;  1ATT A;  3OZQ A;  9PAI A;  2ACH A;  3NDA A;  1A7C A;  9API A;  4G8R A;  1QMB A;  2ARQ A;  4EB1 L;  1DZH L;  2VDY A;  3EVJ I;  1JMO A;  1OYH L;  1IZ2 A;  4EB1 I;  1AZX I;  1JTI A;  4AU3 A;  2ARR A;  1SEK A;  1DZG I;  1JMJ A;  1SR5 A;  3VVJ A;  3DLW A;  1OVA A;  3R4L A;  2WXX A;  4AJT A;  3FGQ A;  3B9F I;  2H4P A;  2WXW A;  3CWL A;  2HIJ I;  1JVQ I;  4R9I A;  1F0C A;  1T1F A;  2WY0 C;  3DY0 A;  1EZX A; 
#chains in the Genus database with same CATH homology
 1ANT I;  2XN7 A;  4AJU A;  5BRR I;  1LK6 I;  2XN6 A;  1JJO C;  1YXA A;  2VDX A;  3NE4 A;  1OVA C;  1B3K A;  2PEF A;  2WY1 A;  1DVM A;  4ROA A;  3CVM A;  4DY7 C;  1DZG L;  1BY7 A;  3DRU A;  4CAA A;  1JRR A;  2V95 A;  3STO A;  4AU2 A;  1QLP A;  2PEE A;  1XQJ A;  2ANT I;  1HP7 A;  4RSQ A;  1C8O A;  3LW2 A;  4GA7 A;  1IMV A;  1E05 I;  7API A;  4ROB A;  2QUG A;  4X30 A;  2HIJ L;  2BEH L;  3PZF A;  4PYW A;  4ZK3 A;  2BEH I;  1OPH A;  2H4Q A;  1K9O I;  1OO8 A;  2GD4 C;  2R9Y A;  2CEO A;  1WZ9 A;  3H5C A;  1OC0 A;  1M93 B;  8API A;  4ZK0 A;  2VH4 A;  3PB1 I;  4Y40 A;  5IO1 A;  5CDX A;  5INW A;  1DVN A;  2XN3 A;  1HLE A;  1BR8 I;  5CE0 A;  1AS4 A;  3CAA A;  4DTE A;  3F1S A;  3F5N A;  1KCT A;  4IC0 A;  4YIA A;  3F02 A;  2WXY C;  4C49 A;  4KDS A;  1TB6 I;  5C98 A;  1LQ8 A;  1R1L I;  2RIW A;  1QMN A;  1NQ9 I;  4RO9 A;  2B4X I;  1E03 I;  3UT3 A;  4P0F A;  4AU4 A;  4DY0 A;  2WXZ A;  4AFX A;  2ZNH A;  2RIV A;  3ZHA A;  3Q02 A;  2XN5 A;  3KCG I;  5CDZ A;  4Y3K A;  2H4R A;  1SNG A;  3T1P A;  4AQH A;  3DRM A;  2D26 A;  1E04 I;  1DZH I;  3NDF A;  1UHG A;  5EI0 A;  1OYH I;  4IF8 A;  1ATH A;  3Q03 A;  4P0O A;  5HGC A;  1D5S A;  2B5T I;  2ZV6 A;  1ATU A;  4AU3 B;  3EOX A;  3CWM A;  1MTP A;  3LE2 A;  4BB2 A;  1DB2 A;  4C41 A;  2WXZ C;  1OVA B;  3NDD A;  2B4X L;  2OL2 A;  2OAY A;  2DUT A;  1XQG A;  1XU8 A;  1PSI A;  2HI9 A;  1C5G A;  1LJ5 A;  4G8O A;  1ATT A;  3OZQ A;  9PAI A;  2ACH A;  3NDA A;  1A7C A;  9API A;  4G8R A;  1QMB A;  2ARQ A;  4EB1 L;  1DZH L;  2VDY A;  3EVJ I;  1JMO A;  1OYH L;  1IZ2 A;  4EB1 I;  1AZX I;  1JTI A;  4AU3 A;  2ARR A;  1SEK A;  1DZG I;  1JMJ A;  1SR5 A;  3VVJ A;  3DLW A;  1OVA A;  3R4L A;  2WXX A;  4AJT A;  3FGQ A;  3B9F I;  2H4P A;  2WXW A;  3CWL A;  2HIJ I;  1JVQ I;  4R9I A;  1F0C A;  1T1F A;  2WY0 C;  3DY0 A;  1EZX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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