4BDTB

Human acetylcholinesterase in complex with huprine w and fasciculin 2
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/inhibitor
molecule keywords ACETYLCHOLINESTERASE
total genus 11
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2012-10-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4bdtB00
2MJYA 2MUPA 3BT1U 1CREA 2H7ZA 2K3GA 5EBXA 5DZ5A 1CODA 5IMYC 2H5FA 1F94A 1LJZA 1IDLA 1BTEA 4QTIU 1BXPA 4LFTA 3BT2U 1F8UB 1XT3A 1B41B 2H8UA 2CCXA 2CDXA 1IQ9A 2CTXA 2CRTA 1ABTA 2JVEA 1IKCA 3NEQA 3PLCA 6EBXA 1VB0A 1KL8A 2ABXA 1LXHA 1CXOA 2N99A 1LX5B 2MHYA 3EBXA 2MUOA 3HH7A 2H7ZB 1CDQA 2QC1A 1V6PA 1CDSA 1IJCA 1G6MA 1LXGA 2H64B 1KTZB 3KFDE 2LA1A 1DRSA 2X8BB 1CB9A 2GOOB 1KBSA 4BDTB 1NYUA 5DO6A 1LSIA 1IDHA 1CDTA 2HLQA 1ONJA 4ZQYA 3NH7A 1NTNA 2JQPA 2QJAC 1QKEA 1NORA 4XJJA 1RGJA 1IDIA 1PLOA 2NBTA 3KFDI 1FASA 4FAOC 1FSSB 1NYSA 1UG4A 4EY8B 1HAAA 2QJBC 1KU6B 1TXAA 2VLWA 1KXIA 4DO8A 2FD6U 1MR6A 4FAOE 1NXBA 1QM7A 1CTXA 2MJ4A 2QJ9C 4OM5A 1JBDA 1KBAA 2UX2A 4IYEA 1HOYA 1HC9A 2PJYB 2H62C 1M9ZA 4OM4A 1YWHA 1CHVS 5IMTD 1RL5A 2H62D 1KBTA 1S4YA 2OFSA 1H0JA 1REWC 2BHIA 2BTXA 1KS6A 1CXNA 1W6BA 1ERGA 5DU1A 1HAJA 1JGKA 1ERAA 2I9BE 4HQPF 2ERAA 3ERAA 3LAQU 1TGXA 1CVOA 1NTXA 1FFJA 1L4WA 1IDGA 4RUDA 1COEA 1I02A 2CRSA 1CDRA 2L03A 1IK8A 3U74U 2L5SA 2PJYC 1CCQA 1CRFA 1FF4A 1MAHF 1QKDA 4P7UA 3FEVA 3EVSC 1ZADA 3U73U 1HC9B 1JE9A 1NEAA 1TFSA 4BIKB 2MJ0A 4UY2C 1KFHA 1ES7B 2H64C 1KC4A 1FRAA 3NDSA 4AEAA 2MFAA 3QB4B 1FSCA 1TXBA 2J8BA 2GOOC 2HLRA 2UWRA 3VTSA 2LCRA
chains in the Genus database with same CATH superfamily
2MJYA 2MUPA 3BT1U 1CREA 2H7ZA 2K3GA 5EBXA 5DZ5A 1CODA 5IMYC 2H5FA 1F94A 1LJZA 1IDLA 1BTEA 4QTIU 1BXPA 4LFTA 3BT2U 1F8UB 1XT3A 1B41B 2H8UA 2CCXA 2CDXA 1IQ9A 2CTXA 2CRTA 1ABTA 2JVEA 1IKCA 3NEQA 3PLCA 6EBXA 1VB0A 1KL8A 2ABXA 1LXHA 1CXOA 2N99A 1LX5B 2MHYA 3EBXA 2MUOA 3HH7A 2H7ZB 1CDQA 2QC1A 1V6PA 1CDSA 1IJCA 1G6MA 1LXGA 2H64B 1KTZB 3KFDE 2LA1A 1DRSA 2X8BB 1CB9A 2GOOB 1KBSA 4BDTB 1NYUA 5DO6A 1LSIA 1IDHA 1CDTA 2HLQA 1ONJA 4ZQYA 3NH7A 1NTNA 2JQPA 2QJAC 1QKEA 1NORA 4XJJA 1RGJA 1IDIA 1PLOA 2NBTA 3KFDI 1FASA 4FAOC 1FSSB 1NYSA 1UG4A 4EY8B 1HAAA 2QJBC 1KU6B 1TXAA 2VLWA 1KXIA 4DO8A 2FD6U 1MR6A 4FAOE 1NXBA 1QM7A 1CTXA 2MJ4A 2QJ9C 4OM5A 1JBDA 1KBAA 2UX2A 4IYEA 1HOYA 1HC9A 2PJYB 2H62C 1M9ZA 4OM4A 1YWHA 4KSNA 1CHVS 5IMTD 1RL5A 2H62D 1KBTA 1S4YA 2OFSA 1H0JA 1REWC 2BHIA 2BTXA 1KS6A 1CXNA 1W6BA 1ERGA 5DU1A 1HAJA 1JGKA 1ERAA 2I9BE 4HQPF 2ERAA 3ERAA 3LAQU 1TGXA 1CVOA 1NTXA 1FFJA 1L4WA 1IDGA 4RUDA 1COEA 1I02A 2CRSA 1CDRA 2L03A 1IK8A 3U74U 2L5SA 2PJYC 1CCQA 1CRFA 1FF4A 1MAHF 1QKDA 4P7UA 3FEVA 3EVSC 1ZADA 3U73U 1HC9B 1JE9A 1NEAA 1TFSA 4BIKB 2MJ0A 4UY2C 1KFHA 1ES7B 2H64C 1KC4A 1FRAA 3NDSA 4AEAA 2MFAA 3QB4B 1FSCA 1TXBA 2J8BA 2GOOC 2HLRA 2UWRA 3VTSA 2LCRA
chains in the Genus database with same CATH topology
2MJYA 2MUPA 3BT1U 1CREA 2H7ZA 2K3GA 5EBXA 5DZ5A 1CODA 5IMYC 2H5FA 1F94A 1LJZA 1IDLA 1BTEA 4QTIU 1BXPA 4LFTA 3BT2U 1F8UB 1XT3A 1B41B 2H8UA 2CCXA 2CDXA 1IQ9A 2CTXA 2CRTA 1ABTA 2JVEA 1IKCA 3NEQA 3PLCA 6EBXA 1VB0A 1KL8A 2ABXA 1LXHA 1CXOA 2N99A 1LX5B 2MHYA 3EBXA 2MUOA 3HH7A 2H7ZB 1CDQA 2QC1A 1V6PA 1CDSA 1IJCA 1G6MA 1LXGA 2H64B 1KTZB 3KFDE 2LA1A 1DRSA 2X8BB 1CB9A 2GOOB 1KBSA 4BDTB 1NYUA 5DO6A 1LSIA 1IDHA 1CDTA 2HLQA 1ONJA 4ZQYA 3NH7A 1NTNA 2JQPA 2QJAC 1QKEA 1NORA 4XJJA 1RGJA 1IDIA 1PLOA 2NBTA 3KFDI 1FASA 4FAOC 1FSSB 1NYSA 1UG4A 4EY8B 1HAAA 2QJBC 1KU6B 1TXAA 2VLWA 1KXIA 4DO8A 2FD6U 1MR6A 4FAOE 1NXBA 1QM7A 1CTXA 2MJ4A 2QJ9C 4OM5A 1JBDA 1KBAA 2UX2A 4IYEA 1HOYA 1HC9A 2PJYB 2H62C 1M9ZA 4OM4A 1YWHA 4KSNA 1CHVS 5IMTD 1RL5A 2H62D 1KBTA 1S4YA 2OFSA 1H0JA 1REWC 2BHIA 2BTXA 1KS6A 1CXNA 1W6BA 1ERGA 5DU1A 1HAJA 1JGKA 1ERAA 2I9BE 4HQPF 2ERAA 3ERAA 3LAQU 1TGXA 1CVOA 1NTXA 1FFJA 1L4WA 1IDGA 4RUDA 1COEA 1I02A 2CRSA 1CDRA 2L03A 1IK8A 3U74U 2L5SA 2PJYC 1CCQA 1CRFA 1FF4A 1MAHF 1QKDA 4P7UA 3FEVA 3EVSC 1ZADA 3U73U 1HC9B 1JE9A 1NEAA 1TFSA 4BIKB 2MJ0A 4UY2C 1KFHA 1ES7B 2H64C 1KC4A 1FRAA 3NDSA 4AEAA 2MFAA 3QB4B 1FSCA 1TXBA 2J8BA 2GOOC 2HLRA 2UWRA 3VTSA 2LCRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MJY A;  2MUP A;  3BT1 U;  1CRE A;  2H7Z A;  2K3G A;  5EBX A;  5DZ5 A;  1COD A;  5IMY C;  2H5F A;  1F94 A;  1LJZ A;  1IDL A;  1BTE A;  4QTI U;  1BXP A;  4LFT A;  3BT2 U;  1F8U B;  1XT3 A;  1B41 B;  2H8U A;  2CCX A;  2CDX A;  1IQ9 A;  2CTX A;  2CRT A;  1ABT A;  2JVE A;  1IKC A;  3NEQ A;  3PLC A;  6EBX A;  1VB0 A;  1KL8 A;  2ABX A;  1LXH A;  1CXO A;  2N99 A;  1LX5 B;  2MHY A;  3EBX A;  2MUO A;  3HH7 A;  2H7Z B;  1CDQ A;  2QC1 A;  1V6P A;  1CDS A;  1IJC A;  1G6M A;  1LXG A;  2H64 B;  1KTZ B;  3KFD E;  2LA1 A;  1DRS A;  2X8B B;  1CB9 A;  2GOO B;  1KBS A;  4BDT B;  1NYU A;  5DO6 A;  1LSI A;  1IDH A;  1CDT A;  2HLQ A;  1ONJ A;  4ZQY A;  3NH7 A;  1NTN A;  2JQP A;  2QJA C;  1QKE A;  1NOR A;  4XJJ A;  1RGJ A;  1IDI A;  1PLO A;  2NBT A;  3KFD I;  1FAS A;  4FAO C;  1FSS B;  1NYS A;  1UG4 A;  4EY8 B;  1HAA A;  2QJB C;  1KU6 B;  1TXA A;  2VLW A;  1KXI A;  4DO8 A;  2FD6 U;  1MR6 A;  4FAO E;  1NXB A;  1QM7 A;  1CTX A;  2MJ4 A;  2QJ9 C;  4OM5 A;  1JBD A;  1KBA A;  2UX2 A;  4IYE A;  1HOY A;  1HC9 A;  2PJY B;  2H62 C;  1M9Z A;  4OM4 A;  1YWH A;  1CHV S;  5IMT D;  1RL5 A;  2H62 D;  1KBT A;  1S4Y A;  2OFS A;  1H0J A;  1REW C;  2BHI A;  2BTX A;  1KS6 A;  1CXN A;  1W6B A;  1ERG A;  5DU1 A;  1HAJ A;  1JGK A;  1ERA A;  2I9B E;  4HQP F;  2ERA A;  3ERA A;  3LAQ U;  1TGX A;  1CVO A;  1NTX A;  1FFJ A;  1L4W A;  1IDG A;  4RUD A;  1COE A;  1I02 A;  2CRS A;  1CDR A;  2L03 A;  1IK8 A;  3U74 U;  2L5S A;  2PJY C;  1CCQ A;  1CRF A;  1FF4 A;  1MAH F;  1QKD A;  4P7U A;  3FEV A;  3EVS C;  1ZAD A;  3U73 U;  1HC9 B;  1JE9 A;  1NEA A;  1TFS A;  4BIK B;  2MJ0 A;  4UY2 C;  1KFH A;  1ES7 B;  2H64 C;  1KC4 A;  1FRA A;  3NDS A;  4AEA A;  2MFA A;  3QB4 B;  1FSC A;  1TXB A;  2J8B A;  2GOO C;  2HLR A;  2UWR A;  3VTS A;  2LCR A; 
#chains in the Genus database with same CATH topology
 2MJY A;  2MUP A;  3BT1 U;  1CRE A;  2H7Z A;  2K3G A;  5EBX A;  5DZ5 A;  1COD A;  5IMY C;  2H5F A;  1F94 A;  1LJZ A;  1IDL A;  1BTE A;  4QTI U;  1BXP A;  4LFT A;  3BT2 U;  1F8U B;  1XT3 A;  1B41 B;  2H8U A;  2CCX A;  2CDX A;  1IQ9 A;  2CTX A;  2CRT A;  1ABT A;  2JVE A;  1IKC A;  3NEQ A;  3PLC A;  6EBX A;  1VB0 A;  1KL8 A;  2ABX A;  1LXH A;  1CXO A;  2N99 A;  1LX5 B;  2MHY A;  3EBX A;  2MUO A;  3HH7 A;  2H7Z B;  1CDQ A;  2QC1 A;  1V6P A;  1CDS A;  1IJC A;  1G6M A;  1LXG A;  2H64 B;  1KTZ B;  3KFD E;  2LA1 A;  1DRS A;  2X8B B;  1CB9 A;  2GOO B;  1KBS A;  4BDT B;  1NYU A;  5DO6 A;  1LSI A;  1IDH A;  1CDT A;  2HLQ A;  1ONJ A;  4ZQY A;  3NH7 A;  1NTN A;  2JQP A;  2QJA C;  1QKE A;  1NOR A;  4XJJ A;  1RGJ A;  1IDI A;  1PLO A;  2NBT A;  3KFD I;  1FAS A;  4FAO C;  1FSS B;  1NYS A;  1UG4 A;  4EY8 B;  1HAA A;  2QJB C;  1KU6 B;  1TXA A;  2VLW A;  1KXI A;  4DO8 A;  2FD6 U;  1MR6 A;  4FAO E;  1NXB A;  1QM7 A;  1CTX A;  2MJ4 A;  2QJ9 C;  4OM5 A;  1JBD A;  1KBA A;  2UX2 A;  4IYE A;  1HOY A;  1HC9 A;  2PJY B;  2H62 C;  1M9Z A;  4OM4 A;  1YWH A;  4KSN A;  1CHV S;  5IMT D;  1RL5 A;  2H62 D;  1KBT A;  1S4Y A;  2OFS A;  1H0J A;  1REW C;  2BHI A;  2BTX A;  1KS6 A;  1CXN A;  1W6B A;  1ERG A;  5DU1 A;  1HAJ A;  1JGK A;  1ERA A;  2I9B E;  4HQP F;  2ERA A;  3ERA A;  3LAQ U;  1TGX A;  1CVO A;  1NTX A;  1FFJ A;  1L4W A;  1IDG A;  4RUD A;  1COE A;  1I02 A;  2CRS A;  1CDR A;  2L03 A;  1IK8 A;  3U74 U;  2L5S A;  2PJY C;  1CCQ A;  1CRF A;  1FF4 A;  1MAH F;  1QKD A;  4P7U A;  3FEV A;  3EVS C;  1ZAD A;  3U73 U;  1HC9 B;  1JE9 A;  1NEA A;  1TFS A;  4BIK B;  2MJ0 A;  4UY2 C;  1KFH A;  1ES7 B;  2H64 C;  1KC4 A;  1FRA A;  3NDS A;  4AEA A;  2MFA A;  3QB4 B;  1FSC A;  1TXB A;  2J8B A;  2GOO C;  2HLR A;  2UWR A;  3VTS A;  2LCR A; 
#chains in the Genus database with same CATH homology
 2MJY A;  2MUP A;  3BT1 U;  1CRE A;  2H7Z A;  2K3G A;  5EBX A;  5DZ5 A;  1COD A;  5IMY C;  2H5F A;  1F94 A;  1LJZ A;  1IDL A;  1BTE A;  4QTI U;  1BXP A;  4LFT A;  3BT2 U;  1F8U B;  1XT3 A;  1B41 B;  2H8U A;  2CCX A;  2CDX A;  1IQ9 A;  2CTX A;  2CRT A;  1ABT A;  2JVE A;  1IKC A;  3NEQ A;  3PLC A;  6EBX A;  1VB0 A;  1KL8 A;  2ABX A;  1LXH A;  1CXO A;  2N99 A;  1LX5 B;  2MHY A;  3EBX A;  2MUO A;  3HH7 A;  2H7Z B;  1CDQ A;  2QC1 A;  1V6P A;  1CDS A;  1IJC A;  1G6M A;  1LXG A;  2H64 B;  1KTZ B;  3KFD E;  2LA1 A;  1DRS A;  2X8B B;  1CB9 A;  2GOO B;  1KBS A;  4BDT B;  1NYU A;  5DO6 A;  1LSI A;  1IDH A;  1CDT A;  2HLQ A;  1ONJ A;  4ZQY A;  3NH7 A;  1NTN A;  2JQP A;  2QJA C;  1QKE A;  1NOR A;  4XJJ A;  1RGJ A;  1IDI A;  1PLO A;  2NBT A;  3KFD I;  1FAS A;  4FAO C;  1FSS B;  1NYS A;  1UG4 A;  4EY8 B;  1HAA A;  2QJB C;  1KU6 B;  1TXA A;  2VLW A;  1KXI A;  4DO8 A;  2FD6 U;  1MR6 A;  4FAO E;  1NXB A;  1QM7 A;  1CTX A;  2MJ4 A;  2QJ9 C;  4OM5 A;  1JBD A;  1KBA A;  2UX2 A;  4IYE A;  1HOY A;  1HC9 A;  2PJY B;  2H62 C;  1M9Z A;  4OM4 A;  1YWH A;  4KSN A;  1CHV S;  5IMT D;  1RL5 A;  2H62 D;  1KBT A;  1S4Y A;  2OFS A;  1H0J A;  1REW C;  2BHI A;  2BTX A;  1KS6 A;  1CXN A;  1W6B A;  1ERG A;  5DU1 A;  1HAJ A;  1JGK A;  1ERA A;  2I9B E;  4HQP F;  2ERA A;  3ERA A;  3LAQ U;  1TGX A;  1CVO A;  1NTX A;  1FFJ A;  1L4W A;  1IDG A;  4RUD A;  1COE A;  1I02 A;  2CRS A;  1CDR A;  2L03 A;  1IK8 A;  3U74 U;  2L5S A;  2PJY C;  1CCQ A;  1CRF A;  1FF4 A;  1MAH F;  1QKD A;  4P7U A;  3FEV A;  3EVS C;  1ZAD A;  3U73 U;  1HC9 B;  1JE9 A;  1NEA A;  1TFS A;  4BIK B;  2MJ0 A;  4UY2 C;  1KFH A;  1ES7 B;  2H64 C;  1KC4 A;  1FRA A;  3NDS A;  4AEA A;  2MFA A;  3QB4 B;  1FSC A;  1TXB A;  2J8B A;  2GOO C;  2HLR A;  2UWR A;  3VTS A;  2LCR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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