4BQDA

Kd1 of human tfpi in complex with a synthetic peptide
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
78
structure length
78
Chain Sequence
SEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor Viia by Tissue Factor Pathway Inhibitor (Tfpi)
pubmed doi rcsb
molecule tags Blood clotting
molecule keywords TISSUE FACTOR PATHWAY INHIBITOR (LIPOPROTEIN-ASSOCIATED COAG
total genus 13
structure length 78
sequence length 78
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4bqdA00
3FP6I 1P2NB 2KNTA 1T8NB 2FI5I 2RA3C 3TGJI 1ADZA 4U30W 4TPII 1TAWB 3AUEA 1BHCA 1P2OB 2ODYE 1TPAI 1BTIA 3OFWA 1P2QB 4NTYB 3BTWI 2DDJA 1AAPA 1TOCR 5JB6A 4WXVC 3WNYA 1CA0D 1UUBA 3TGKI 3BTKI 4Y0YI 1F7ZI 3D65I 4PTIA 1LD5A 1EAWB 1OA65 2TPII 1AALA 3UIRC 2M99A 2UUXA 1FY8I 1P2KI 1YLCB 1BUNB 3AUBA 4ISLB 3BTHI 4DG4C 1KIGI 1D0DB 3BTEI 1JV8A 2FTLI 3M7QB 1BZ5A 4U32X 1EJMB 2CA7A 1P2II 5JB7A 6PTIA 2R9PE 2ZVXA 1G6XA 1F5RI 1QLQA 1D0DA 1IRHA 1TAPA 2FI4I 2FTMB 1DENA 3GYMI 3TPII 3AUGA 1BRBI 5JB5A 1BRCI 2IJOI 3AUDA 1YKTB 3UOUB 1ZJDB 2TGPI 3BTGI 1JC6A 3L3TE 1BTHP 1BIKA 2W8XA 3BTFI 3OTJI 4NTWB 2DDIA 3LDJA 1DEMA 3T62D 2J6DA 1SHPA 5PTIA 1P2MB 3LDIA 3AUIA 1BF0A 4DTGK 4BNRI 3L33E 3BTDI 2LFKA 1CO7I 9PTIA 1CBWD 1ZR0B 3BYBA 1YC0I 1DTXA 1KNTA 4Y0ZI 5JB4A 1DTKA 4ISNB 1T8OB 4WWYC 1KTHA 2PTCI 1BPTA 1UUAA 3BTTI 8PTIA 2ZJXA 3AUHA 1P2JI 1TFXC 1PITA 1K6UA 2UUYB 1NAGA 1YLDB 1BPIA 2HEXA 1B0CA 3AUCA 2M01A 3BTQI 3BTMI 3P95E 3TGII 1FANA 4BQDA 3FP8I 2LFLA 1LD6A 3CI7A 3FP7J 3LDMA 3P92E 2KAII 4NTXB 1BZXI 1T8MB 1Y62A 7PTIA 1T7CB 1FAKI 1T8LB 5C67C 1KUNA 2KCRA 3U1JE 1MTND 1OA55 4BD9B 4Y11I 4ISOB 1JV9A 2FI3I 4Y10I 2JOTA 1TCPA
chains in the Genus database with same CATH superfamily
3FP6I 1P2NB 2KNTA 1T8NB 2FI5I 2RA3C 3TGJI 1ADZA 4U30W 4TPII 1TAWB 3AUEA 1BHCA 1P2OB 2ODYE 1TPAI 1BTIA 3OFWA 1P2QB 4NTYB 3BTWI 2DDJA 1AAPA 1TOCR 5JB6A 4WXVC 3WNYA 1CA0D 1UUBA 3TGKI 3BTKI 4Y0YI 1F7ZI 3D65I 4PTIA 1LD5A 1EAWB 1OA65 2TPII 1AALA 3UIRC 2M99A 2UUXA 1FY8I 1P2KI 1YLCB 1BUNB 3AUBA 4ISLB 3BTHI 4DG4C 1KIGI 1D0DB 3BTEI 1JV8A 2FTLI 3M7QB 1BZ5A 4U32X 1EJMB 2CA7A 1P2II 5JB7A 6PTIA 2R9PE 2ZVXA 1G6XA 1F5RI 1QLQA 1D0DA 1IRHA 1TAPA 2FI4I 2FTMB 1DENA 3GYMI 3TPII 3AUGA 1BRBI 5JB5A 1BRCI 2IJOI 3AUDA 1YKTB 3UOUB 1ZJDB 2TGPI 3BTGI 1JC6A 3L3TE 1BTHP 1BIKA 2W8XA 3BTFI 3OTJI 4NTWB 2DDIA 3LDJA 1DEMA 3T62D 2J6DA 1SHPA 5PTIA 1P2MB 3LDIA 3AUIA 1BF0A 4DTGK 4BNRI 3L33E 3BTDI 2LFKA 1CO7I 9PTIA 1CBWD 1ZR0B 3BYBA 1YC0I 1DTXA 1KNTA 4Y0ZI 5JB4A 1DTKA 4ISNB 1T8OB 4WWYC 1KTHA 2PTCI 1BPTA 1UUAA 3BTTI 8PTIA 2ZJXA 3AUHA 1P2JI 1TFXC 1PITA 1K6UA 2UUYB 1NAGA 1YLDB 1BPIA 2HEXA 1B0CA 3AUCA 2M01A 3BTQI 3BTMI 3P95E 3TGII 1FANA 4BQDA 3FP8I 2LFLA 1LD6A 3CI7A 3FP7J 3LDMA 3P92E 2KAII 4NTXB 1BZXI 1T8MB 1Y62A 7PTIA 1T7CB 1FAKI 1T8LB 5C67C 1KUNA 2KCRA 3U1JE 1MTND 1OA55 4BD9B 4Y11I 4ISOB 1JV9A 2FI3I 4Y10I 2JOTA 1TCPA
chains in the Genus database with same CATH topology
3FP6I 1P2NB 2KNTA 1T8NB 2FI5I 2RA3C 3TGJI 1ADZA 4U30W 4TPII 1TAWB 3AUEA 1BHCA 1P2OB 2ODYE 1TPAI 1BTIA 3OFWA 1P2QB 4NTYB 3BTWI 2DDJA 1AAPA 1TOCR 5JB6A 4WXVC 3WNYA 1CA0D 1UUBA 3TGKI 3BTKI 4Y0YI 1F7ZI 3D65I 4PTIA 1LD5A 1EAWB 1OA65 2TPII 1AALA 3UIRC 2M99A 2UUXA 1FY8I 1P2KI 1YLCB 1BUNB 3AUBA 4ISLB 3BTHI 4DG4C 1KIGI 1D0DB 3BTEI 1JV8A 2FTLI 3M7QB 1BZ5A 4U32X 1EJMB 2CA7A 1P2II 5JB7A 6PTIA 2R9PE 2ZVXA 1G6XA 1F5RI 1QLQA 1D0DA 1IRHA 1TAPA 2FI4I 2FTMB 1DENA 3GYMI 3TPII 3AUGA 1BRBI 5JB5A 1BRCI 2IJOI 3AUDA 1YKTB 3UOUB 1ZJDB 2TGPI 3BTGI 1JC6A 3L3TE 1BTHP 1BIKA 2W8XA 3BTFI 3OTJI 4NTWB 2DDIA 3LDJA 1DEMA 3T62D 2J6DA 1SHPA 5PTIA 1P2MB 3LDIA 3AUIA 1BF0A 4DTGK 4BNRI 3L33E 3BTDI 2LFKA 1CO7I 9PTIA 1CBWD 1ZR0B 3BYBA 1YC0I 1DTXA 1KNTA 4Y0ZI 5JB4A 1DTKA 4ISNB 1T8OB 4WWYC 1KTHA 2PTCI 1BPTA 1UUAA 3BTTI 8PTIA 2ZJXA 3AUHA 1P2JI 1TFXC 1PITA 1K6UA 2UUYB 1NAGA 1YLDB 1BPIA 2HEXA 1B0CA 3AUCA 2M01A 3BTQI 3BTMI 3P95E 3TGII 1FANA 4BQDA 3FP8I 2LFLA 1LD6A 3CI7A 3FP7J 3LDMA 3P92E 2KAII 4NTXB 1BZXI 1T8MB 1Y62A 7PTIA 1T7CB 1FAKI 1T8LB 5C67C 1KUNA 2KCRA 3U1JE 1MTND 1OA55 4BD9B 4Y11I 4ISOB 1JV9A 2FI3I 4Y10I 2JOTA 1TCPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FP6 I;  1P2N B;  2KNT A;  1T8N B;  2FI5 I;  2RA3 C;  3TGJ I;  1ADZ A;  4U30 W;  4TPI I;  1TAW B;  3AUE A;  1BHC A;  1P2O B;  2ODY E;  1TPA I;  1BTI A;  3OFW A;  1P2Q B;  4NTY B;  3BTW I;  2DDJ A;  1AAP A;  1TOC R;  5JB6 A;  4WXV C;  3WNY A;  1CA0 D;  1UUB A;  3TGK I;  3BTK I;  4Y0Y I;  1F7Z I;  3D65 I;  4PTI A;  1LD5 A;  1EAW B;  1OA6 5;  2TPI I;  1AAL A;  3UIR C;  2M99 A;  2UUX A;  1FY8 I;  1P2K I;  1YLC B;  1BUN B;  3AUB A;  4ISL B;  3BTH I;  4DG4 C;  1KIG I;  1D0D B;  3BTE I;  1JV8 A;  2FTL I;  3M7Q B;  1BZ5 A;  4U32 X;  1EJM B;  2CA7 A;  1P2I I;  5JB7 A;  6PTI A;  2R9P E;  2ZVX A;  1G6X A;  1F5R I;  1QLQ A;  1D0D A;  1IRH A;  1TAP A;  2FI4 I;  2FTM B;  1DEN A;  3GYM I;  3TPI I;  3AUG A;  1BRB I;  5JB5 A;  1BRC I;  2IJO I;  3AUD A;  1YKT B;  3UOU B;  1ZJD B;  2TGP I;  3BTG I;  1JC6 A;  3L3T E;  1BTH P;  1BIK A;  2W8X A;  3BTF I;  3OTJ I;  4NTW B;  2DDI A;  3LDJ A;  1DEM A;  3T62 D;  2J6D A;  1SHP A;  5PTI A;  1P2M B;  3LDI A;  3AUI A;  1BF0 A;  4DTG K;  4BNR I;  3L33 E;  3BTD I;  2LFK A;  1CO7 I;  9PTI A;  1CBW D;  1ZR0 B;  3BYB A;  1YC0 I;  1DTX A;  1KNT A;  4Y0Z I;  5JB4 A;  1DTK A;  4ISN B;  1T8O B;  4WWY C;  1KTH A;  2PTC I;  1BPT A;  1UUA A;  3BTT I;  8PTI A;  2ZJX A;  3AUH A;  1P2J I;  1TFX C;  1PIT A;  1K6U A;  2UUY B;  1NAG A;  1YLD B;  1BPI A;  2HEX A;  1B0C A;  3AUC A;  2M01 A;  3BTQ I;  3BTM I;  3P95 E;  3TGI I;  1FAN A;  4BQD A;  3FP8 I;  2LFL A;  1LD6 A;  3CI7 A;  3FP7 J;  3LDM A;  3P92 E;  2KAI I;  4NTX B;  1BZX I;  1T8M B;  1Y62 A;  7PTI A;  1T7C B;  1FAK I;  1T8L B;  5C67 C;  1KUN A;  2KCR A;  3U1J E;  1MTN D;  1OA5 5;  4BD9 B;  4Y11 I;  4ISO B;  1JV9 A;  2FI3 I;  4Y10 I;  2JOT A;  1TCP A; 
#chains in the Genus database with same CATH topology
 3FP6 I;  1P2N B;  2KNT A;  1T8N B;  2FI5 I;  2RA3 C;  3TGJ I;  1ADZ A;  4U30 W;  4TPI I;  1TAW B;  3AUE A;  1BHC A;  1P2O B;  2ODY E;  1TPA I;  1BTI A;  3OFW A;  1P2Q B;  4NTY B;  3BTW I;  2DDJ A;  1AAP A;  1TOC R;  5JB6 A;  4WXV C;  3WNY A;  1CA0 D;  1UUB A;  3TGK I;  3BTK I;  4Y0Y I;  1F7Z I;  3D65 I;  4PTI A;  1LD5 A;  1EAW B;  1OA6 5;  2TPI I;  1AAL A;  3UIR C;  2M99 A;  2UUX A;  1FY8 I;  1P2K I;  1YLC B;  1BUN B;  3AUB A;  4ISL B;  3BTH I;  4DG4 C;  1KIG I;  1D0D B;  3BTE I;  1JV8 A;  2FTL I;  3M7Q B;  1BZ5 A;  4U32 X;  1EJM B;  2CA7 A;  1P2I I;  5JB7 A;  6PTI A;  2R9P E;  2ZVX A;  1G6X A;  1F5R I;  1QLQ A;  1D0D A;  1IRH A;  1TAP A;  2FI4 I;  2FTM B;  1DEN A;  3GYM I;  3TPI I;  3AUG A;  1BRB I;  5JB5 A;  1BRC I;  2IJO I;  3AUD A;  1YKT B;  3UOU B;  1ZJD B;  2TGP I;  3BTG I;  1JC6 A;  3L3T E;  1BTH P;  1BIK A;  2W8X A;  3BTF I;  3OTJ I;  4NTW B;  2DDI A;  3LDJ A;  1DEM A;  3T62 D;  2J6D A;  1SHP A;  5PTI A;  1P2M B;  3LDI A;  3AUI A;  1BF0 A;  4DTG K;  4BNR I;  3L33 E;  3BTD I;  2LFK A;  1CO7 I;  9PTI A;  1CBW D;  1ZR0 B;  3BYB A;  1YC0 I;  1DTX A;  1KNT A;  4Y0Z I;  5JB4 A;  1DTK A;  4ISN B;  1T8O B;  4WWY C;  1KTH A;  2PTC I;  1BPT A;  1UUA A;  3BTT I;  8PTI A;  2ZJX A;  3AUH A;  1P2J I;  1TFX C;  1PIT A;  1K6U A;  2UUY B;  1NAG A;  1YLD B;  1BPI A;  2HEX A;  1B0C A;  3AUC A;  2M01 A;  3BTQ I;  3BTM I;  3P95 E;  3TGI I;  1FAN A;  4BQD A;  3FP8 I;  2LFL A;  1LD6 A;  3CI7 A;  3FP7 J;  3LDM A;  3P92 E;  2KAI I;  4NTX B;  1BZX I;  1T8M B;  1Y62 A;  7PTI A;  1T7C B;  1FAK I;  1T8L B;  5C67 C;  1KUN A;  2KCR A;  3U1J E;  1MTN D;  1OA5 5;  4BD9 B;  4Y11 I;  4ISO B;  1JV9 A;  2FI3 I;  4Y10 I;  2JOT A;  1TCP A; 
#chains in the Genus database with same CATH homology
 3FP6 I;  1P2N B;  2KNT A;  1T8N B;  2FI5 I;  2RA3 C;  3TGJ I;  1ADZ A;  4U30 W;  4TPI I;  1TAW B;  3AUE A;  1BHC A;  1P2O B;  2ODY E;  1TPA I;  1BTI A;  3OFW A;  1P2Q B;  4NTY B;  3BTW I;  2DDJ A;  1AAP A;  1TOC R;  5JB6 A;  4WXV C;  3WNY A;  1CA0 D;  1UUB A;  3TGK I;  3BTK I;  4Y0Y I;  1F7Z I;  3D65 I;  4PTI A;  1LD5 A;  1EAW B;  1OA6 5;  2TPI I;  1AAL A;  3UIR C;  2M99 A;  2UUX A;  1FY8 I;  1P2K I;  1YLC B;  1BUN B;  3AUB A;  4ISL B;  3BTH I;  4DG4 C;  1KIG I;  1D0D B;  3BTE I;  1JV8 A;  2FTL I;  3M7Q B;  1BZ5 A;  4U32 X;  1EJM B;  2CA7 A;  1P2I I;  5JB7 A;  6PTI A;  2R9P E;  2ZVX A;  1G6X A;  1F5R I;  1QLQ A;  1D0D A;  1IRH A;  1TAP A;  2FI4 I;  2FTM B;  1DEN A;  3GYM I;  3TPI I;  3AUG A;  1BRB I;  5JB5 A;  1BRC I;  2IJO I;  3AUD A;  1YKT B;  3UOU B;  1ZJD B;  2TGP I;  3BTG I;  1JC6 A;  3L3T E;  1BTH P;  1BIK A;  2W8X A;  3BTF I;  3OTJ I;  4NTW B;  2DDI A;  3LDJ A;  1DEM A;  3T62 D;  2J6D A;  1SHP A;  5PTI A;  1P2M B;  3LDI A;  3AUI A;  1BF0 A;  4DTG K;  4BNR I;  3L33 E;  3BTD I;  2LFK A;  1CO7 I;  9PTI A;  1CBW D;  1ZR0 B;  3BYB A;  1YC0 I;  1DTX A;  1KNT A;  4Y0Z I;  5JB4 A;  1DTK A;  4ISN B;  1T8O B;  4WWY C;  1KTH A;  2PTC I;  1BPT A;  1UUA A;  3BTT I;  8PTI A;  2ZJX A;  3AUH A;  1P2J I;  1TFX C;  1PIT A;  1K6U A;  2UUY B;  1NAG A;  1YLD B;  1BPI A;  2HEX A;  1B0C A;  3AUC A;  2M01 A;  3BTQ I;  3BTM I;  3P95 E;  3TGI I;  1FAN A;  4BQD A;  3FP8 I;  2LFL A;  1LD6 A;  3CI7 A;  3FP7 J;  3LDM A;  3P92 E;  2KAI I;  4NTX B;  1BZX I;  1T8M B;  1Y62 A;  7PTI A;  1T7C B;  1FAK I;  1T8L B;  5C67 C;  1KUN A;  2KCR A;  3U1J E;  1MTN D;  1OA5 5;  4BD9 B;  4Y11 I;  4ISO B;  1JV9 A;  2FI3 I;  4Y10 I;  2JOT A;  1TCP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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