4BZ8A

Crystal structure of schistosoma mansoni hdac8 complexed with j1038
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
426
structure length
393
Chain Sequence
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSTPTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPNSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords HISTONE DEACETYLASE 8
publication title Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
pubmed doi rcsb
source organism Schistosoma mansoni
total genus 144
structure length 393
sequence length 426
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-07-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4bz8A00
5EF7A 4QA4A 3EZPA 3Q9CA 5G12A 3ZNSA 5EFKB 5G10A 4LXZA 4QA3A 5D1CA 4ZUPA 5G3WA 4QA0A 3SFHA 4RN1A 5BWZA 5THUA 4ZUNA 5G0JA 4CQFA 5EEKA 5THSA 4CBYA 4RN2A 5G0YA 2GH6A 4BZ9A 5IX0A 1C3RA 4A69A 2VQQA 5IWGA 4ZUQA 2VQMA 5G1AA 5G0HA 3MZ6A 3C10A 5EF8A 4LY1A 4QA2A 3Q9FA 5G11A 2VQJA 5EEFA 3C0ZA 1C3SA 4QA6A 3EW8A 4BZ5A 3MZ7A 4ZUOA 5G13A 1C3PA 3F07A 3MAXA 5EFGA 5EFNA 5LI3A 4QA7A 5D1DA 4BZ6A 3Q9BA 2V5XA 4BZ8A 4CBTA 4QA1A 5G0IA 3RQDA 4BKXB 4BZ7A 5THVA 1ZZ0A 4ZURA 1T69A 2VQOA 5EEMA 5D1BA 2VQVA 3ZNRA 2VCGA 5THTA 5EFBD 5G0XA 1T67A 1ZZ3A 5G1BA 3Q9EA 5G1CA 1VKGA 3C0YA 5DC5A 3EZTA 3MZ3A 1W22A 5DC7A 3EWFA 5FUEA 5A2SA 5G0GA 5FCWA 2V5WA 3MZ4A 5EENA 5EFHA 5G17A 2VQWG 3F0RA 5EFJD 5JI5A 1ZZ1A 3MENA 5DC8A 3F06A 4RN0A 5EEIA 4ZUMA 3SFFA 4QA5A 5ICNB 5DC6A 1T64A
chains in the Genus database with same CATH superfamily
5EF7A 2A0MA 4QA4A 3EZPA 3Q9CA 2EF4A 2CEVA 3MJLA 4GSZA 5G12A 5EFKB 3ZNSA 4MXRA 5G10A 2RLAA 4GSMA 4LXZA 3MMRA 4QA3A 5D1CA 2PHAA 4ZUPA 5G3WA 1T4PA 3CEVA 4QA0A 3SFHA 3MFWA 3GMZA 4G3HA 4IE2A 3RLAA 4IU4A 1P8OA 1HQFA 4GSVA 4RN1A 5THUA 5BWZA 4ZUNA 5G0JA 4CQFA 5EEKA 5THSA 1T4RA 4Q3UA 4CBYA 3LP7A 4RN2A 5G0YA 2GH6A 4BZ9A 4IXVA 5IX0A 1C3RA 3SJTA 4A69A 1GQ6A 4Q41A 1WVAA 3THHA 1R1OA 2VQQA 3E9BA 2AEBA 5IWGA 4ZUQA 4RHKA 2VQMA 4Q3QA 3PZLA 4FCIA 5G1AA 2EIVA 5G0HA 3M1RA 1TBHA 5HJ9A 4IE3A 1T4SA 1WOIA 3MZ6A 4IU0A 1T5GA 3DJ8A 3C10A 1TA1A 5EF8A 4LY1A 4QA2A 3Q9FA 1P8RA 4DZ4A 5G11A 2VQJA 5EEFA 3C0ZA 5RLAA 1WVBA 3TF3A 1C3SA 4QA6A 3EW8A 1P8NA 3E8ZA 3MZ7A 4MYNA 4BZ5A 2PHOA 1RLAA 1P8PA 4CEVA 1PQ3A 4ZUOA 4ITYA 1P8QA 1HQHA 4GWDA 5G13A 3GN0A 1D3VA 1C3PA 3F07A 3MAXA 4IXUA 4MYFA 5EFGA 5EFNA 5CEVA 3KV2A 5HJAA 1WOHA 5LI3A 4QA7A 5D1DA 4BZ6A 3Q9BA 1HQGA 2V5XA 4BZ8A 3E6VA 2PLLA 1T4TA 1TBLA 4Q3TA 4Q42A 3MFVA 4QA1A 4RHLA 5G0IA 3RQDA 4BKXB 4CBTA 4BZ7A 3E6KA 5THVA 4GWCA 1ZZ0A 4ZURA 1T69A 2VQOA 5EEMA 4HZEA 3NIOA 4IU1A 5D1BA 4RHQA 2VQVA 3SKKA 3ZNRA 1XFKA 4IE1A 2ZAVA 4HXQA 2VCGA 4Q3VA 4Q3PA 4Q3RA 5THTA 1GQ7A 5EFBD 5G0XA 1T67A 1TBJA 1ZZ3A 5G1BA 3Q9EA 5G1CA 1ZPEA 4I06A 1VKGA 3C0YA 5DC5A 1HQXA 4Q40A 3EZTA 3MZ3A 1W22A 5DC7A 4RLAA 4RHJA 3EWFA 3SL0A 1P8SA 4HWWA 5FUEA 5A2SA 4RHMA 5G0GA 4MYLA 1T5FA 5FCWA 1P8MA 2V5WA 3LHLA 3MZ4A 4MYKA 5EFHA 5EENA 3TH7A 3F80A 4RHIA 5G17A 1HQ5A 2VQWG 3SL1A 3F0RA 1ZPGA 5EFJD 5JI5A 1ZZ1A 2EF5A 3MENA 3THEA 4Q3SA 5DC8A 3F06A 3LP4A 4RN0A 3E8QA 5EEIA 4ZUMA 1WOGA 4QA5A 3SFFA 5ICNB 3NIPA 3NIQA 4IU5A 5DC6A 4FCKA 1T64A 1CEVA 3THJA 4Q3RC
chains in the Genus database with same CATH topology
5EF7A 4QA4A 3EZPA 3Q9CA 5G12A 3ZNSA 5EFKB 5G10A 4LXZA 4QA3A 5D1CA 4ZUPA 5G3WA 4QA0A 3SFHA 4RN1A 5BWZA 5THUA 4ZUNA 5G0JA 4CQFA 5EEKA 5THSA 4CBYA 4RN2A 5G0YA 2GH6A 4BZ9A 5IX0A 1C3RA 4A69A 2VQQA 5IWGA 4ZUQA 2VQMA 5G1AA 5G0HA 3MZ6A 3C10A 5EF8A 4LY1A 4QA2A 3Q9FA 5G11A 2VQJA 5EEFA 3C0ZA 1C3SA 4QA6A 3EW8A 4BZ5A 3MZ7A 4ZUOA 5G13A 1C3PA 3F07A 3MAXA 5EFGA 5EFNA 5LI3A 4QA7A 5D1DA 4BZ6A 3Q9BA 2V5XA 4BZ8A 4CBTA 4QA1A 5G0IA 3RQDA 4BKXB 4BZ7A 5THVA 1ZZ0A 4ZURA 1T69A 2VQOA 5EEMA 5D1BA 2VQVA 3ZNRA 2VCGA 5THTA 5EFBD 5G0XA 1T67A 1ZZ3A 5G1BA 3Q9EA 5G1CA 1VKGA 3C0YA 5DC5A 3EZTA 3MZ3A 1W22A 5DC7A 3EWFA 5FUEA 5A2SA 5G0GA 5FCWA 2V5WA 3MZ4A 5EENA 5EFHA 5G17A 2VQWG 3F0RA 5EFJD 5JI5A 1ZZ1A 3MENA 5DC8A 3F06A 4RN0A 5EEIA 4ZUMA 3SFFA 4QA5A 5ICNB 5DC6A 1T64A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EF7 A;  4QA4 A;  3EZP A;  3Q9C A;  5G12 A;  3ZNS A;  5EFK B;  5G10 A;  4LXZ A;  4QA3 A;  5D1C A;  4ZUP A;  5G3W A;  4QA0 A;  3SFH A;  4RN1 A;  5BWZ A;  5THU A;  4ZUN A;  5G0J A;  4CQF A;  5EEK A;  5THS A;  4CBY A;  4RN2 A;  5G0Y A;  2GH6 A;  4BZ9 A;  5IX0 A;  1C3R A;  4A69 A;  2VQQ A;  5IWG A;  4ZUQ A;  2VQM A;  5G1A A;  5G0H A;  3MZ6 A;  3C10 A;  5EF8 A;  4LY1 A;  4QA2 A;  3Q9F A;  5G11 A;  2VQJ A;  5EEF A;  3C0Z A;  1C3S A;  4QA6 A;  3EW8 A;  4BZ5 A;  3MZ7 A;  4ZUO A;  5G13 A;  1C3P A;  3F07 A;  3MAX A;  5EFG A;  5EFN A;  5LI3 A;  4QA7 A;  5D1D A;  4BZ6 A;  3Q9B A;  2V5X A;  4BZ8 A;  4CBT A;  4QA1 A;  5G0I A;  3RQD A;  4BKX B;  4BZ7 A;  5THV A;  1ZZ0 A;  4ZUR A;  1T69 A;  2VQO A;  5EEM A;  5D1B A;  2VQV A;  3ZNR A;  2VCG A;  5THT A;  5EFB D;  5G0X A;  1T67 A;  1ZZ3 A;  5G1B A;  3Q9E A;  5G1C A;  1VKG A;  3C0Y A;  5DC5 A;  3EZT A;  3MZ3 A;  1W22 A;  5DC7 A;  3EWF A;  5FUE A;  5A2S A;  5G0G A;  5FCW A;  2V5W A;  3MZ4 A;  5EEN A;  5EFH A;  5G17 A;  2VQW G;  3F0R A;  5EFJ D;  5JI5 A;  1ZZ1 A;  3MEN A;  5DC8 A;  3F06 A;  4RN0 A;  5EEI A;  4ZUM A;  3SFF A;  4QA5 A;  5ICN B;  5DC6 A;  1T64 A; 
#chains in the Genus database with same CATH topology
 5EF7 A;  2A0M A;  4QA4 A;  3EZP A;  3Q9C A;  2EF4 A;  2CEV A;  3MJL A;  4GSZ A;  5G12 A;  5EFK B;  3ZNS A;  4MXR A;  5G10 A;  2RLA A;  4GSM A;  4LXZ A;  3MMR A;  4QA3 A;  5D1C A;  2PHA A;  4ZUP A;  5G3W A;  1T4P A;  3CEV A;  4QA0 A;  3SFH A;  3MFW A;  3GMZ A;  4G3H A;  4IE2 A;  3RLA A;  4IU4 A;  1P8O A;  1HQF A;  4GSV A;  4RN1 A;  5THU A;  5BWZ A;  4ZUN A;  5G0J A;  4CQF A;  5EEK A;  5THS A;  1T4R A;  4Q3U A;  4CBY A;  3LP7 A;  4RN2 A;  5G0Y A;  2GH6 A;  4BZ9 A;  4IXV A;  5IX0 A;  1C3R A;  3SJT A;  4A69 A;  1GQ6 A;  4Q41 A;  1WVA A;  3THH A;  1R1O A;  2VQQ A;  3E9B A;  2AEB A;  5IWG A;  4ZUQ A;  4RHK A;  2VQM A;  4Q3Q A;  3PZL A;  4FCI A;  5G1A A;  2EIV A;  5G0H A;  3M1R A;  1TBH A;  5HJ9 A;  4IE3 A;  1T4S A;  1WOI A;  3MZ6 A;  4IU0 A;  1T5G A;  3DJ8 A;  3C10 A;  1TA1 A;  5EF8 A;  4LY1 A;  4QA2 A;  3Q9F A;  1P8R A;  4DZ4 A;  5G11 A;  2VQJ A;  5EEF A;  3C0Z A;  5RLA A;  1WVB A;  3TF3 A;  1C3S A;  4QA6 A;  3EW8 A;  1P8N A;  3E8Z A;  3MZ7 A;  4MYN A;  4BZ5 A;  2PHO A;  1RLA A;  1P8P A;  4CEV A;  1PQ3 A;  4ZUO A;  4ITY A;  1P8Q A;  1HQH A;  4GWD A;  5G13 A;  3GN0 A;  1D3V A;  1C3P A;  3F07 A;  3MAX A;  4IXU A;  4MYF A;  5EFG A;  5EFN A;  5CEV A;  3KV2 A;  5HJA A;  1WOH A;  5LI3 A;  4QA7 A;  5D1D A;  4BZ6 A;  3Q9B A;  1HQG A;  2V5X A;  4BZ8 A;  3E6V A;  2PLL A;  1T4T A;  1TBL A;  4Q3T A;  4Q42 A;  3MFV A;  4QA1 A;  4RHL A;  5G0I A;  3RQD A;  4BKX B;  4CBT A;  4BZ7 A;  3E6K A;  5THV A;  4GWC A;  1ZZ0 A;  4ZUR A;  1T69 A;  2VQO A;  5EEM A;  4HZE A;  3NIO A;  4IU1 A;  5D1B A;  4RHQ A;  2VQV A;  3SKK A;  3ZNR A;  1XFK A;  4IE1 A;  2ZAV A;  4HXQ A;  2VCG A;  4Q3V A;  4Q3P A;  4Q3R A;  5THT A;  1GQ7 A;  5EFB D;  5G0X A;  1T67 A;  1TBJ A;  1ZZ3 A;  5G1B A;  3Q9E A;  5G1C A;  1ZPE A;  4I06 A;  1VKG A;  3C0Y A;  5DC5 A;  1HQX A;  4Q40 A;  3EZT A;  3MZ3 A;  1W22 A;  5DC7 A;  4RLA A;  4RHJ A;  3EWF A;  3SL0 A;  1P8S A;  4HWW A;  5FUE A;  5A2S A;  4RHM A;  5G0G A;  4MYL A;  1T5F A;  5FCW A;  1P8M A;  2V5W A;  3LHL A;  3MZ4 A;  4MYK A;  5EFH A;  5EEN A;  3TH7 A;  3F80 A;  4RHI A;  5G17 A;  1HQ5 A;  2VQW G;  3SL1 A;  3F0R A;  1ZPG A;  5EFJ D;  5JI5 A;  1ZZ1 A;  2EF5 A;  3MEN A;  3THE A;  4Q3S A;  5DC8 A;  3F06 A;  3LP4 A;  4RN0 A;  3E8Q A;  5EEI A;  4ZUM A;  1WOG A;  4QA5 A;  3SFF A;  5ICN B;  3NIP A;  3NIQ A;  4IU5 A;  5DC6 A;  4FCK A;  1T64 A;  1CEV A;  3THJ A;  4Q3R C; 
#chains in the Genus database with same CATH homology
 5EF7 A;  4QA4 A;  3EZP A;  3Q9C A;  5G12 A;  3ZNS A;  5EFK B;  5G10 A;  4LXZ A;  4QA3 A;  5D1C A;  4ZUP A;  5G3W A;  4QA0 A;  3SFH A;  4RN1 A;  5BWZ A;  5THU A;  4ZUN A;  5G0J A;  4CQF A;  5EEK A;  5THS A;  4CBY A;  4RN2 A;  5G0Y A;  2GH6 A;  4BZ9 A;  5IX0 A;  1C3R A;  4A69 A;  2VQQ A;  5IWG A;  4ZUQ A;  2VQM A;  5G1A A;  5G0H A;  3MZ6 A;  3C10 A;  5EF8 A;  4LY1 A;  4QA2 A;  3Q9F A;  5G11 A;  2VQJ A;  5EEF A;  3C0Z A;  1C3S A;  4QA6 A;  3EW8 A;  4BZ5 A;  3MZ7 A;  4ZUO A;  5G13 A;  1C3P A;  3F07 A;  3MAX A;  5EFG A;  5EFN A;  5LI3 A;  4QA7 A;  5D1D A;  4BZ6 A;  3Q9B A;  2V5X A;  4BZ8 A;  4CBT A;  4QA1 A;  5G0I A;  3RQD A;  4BKX B;  4BZ7 A;  5THV A;  1ZZ0 A;  4ZUR A;  1T69 A;  2VQO A;  5EEM A;  5D1B A;  2VQV A;  3ZNR A;  2VCG A;  5THT A;  5EFB D;  5G0X A;  1T67 A;  1ZZ3 A;  5G1B A;  3Q9E A;  5G1C A;  1VKG A;  3C0Y A;  5DC5 A;  3EZT A;  3MZ3 A;  1W22 A;  5DC7 A;  3EWF A;  5FUE A;  5A2S A;  5G0G A;  5FCW A;  2V5W A;  3MZ4 A;  5EEN A;  5EFH A;  5G17 A;  2VQW G;  3F0R A;  5EFJ D;  5JI5 A;  1ZZ1 A;  3MEN A;  5DC8 A;  3F06 A;  4RN0 A;  5EEI A;  4ZUM A;  3SFF A;  4QA5 A;  5ICN B;  5DC6 A;  1T64 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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