4CQFA

Crystal structure of schistosoma mansoni hdac8 complexed with a mercaptoacetamide inhibitor
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
sequence length
434
structure length
398
Chain Sequence
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNMIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords HISTONE DEACETYLASE 8
publication title Molecular Basis for the Anti-Parasitic Activity of a Mercaptoacetamide Derivative that Inhibits Histone Deacetylase 8 (Hdac8) from the Human Pathogen Schistosoma Mansoni
pubmed doi rcsb
source organism Schistosoma mansoni
total genus 153
structure length 398
sequence length 434
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-02-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4cqfA00
3F0RA 5EF8A 5G3WA 5IX0A 5EEKA 5EF7A 3C0ZA 5BWZA 1W22A 2VCGA 5DC5A 5EFGA 4ZURA 5FUEA 5EFBD 4BZ8A 4RN2A 5EFNA 4BKXB 1C3SA 1ZZ3A 5D1CA 5G0HA 4CQFA 3SFHA 2VQQA 4QA3A 4ZUQA 5EEIA 4LY1A 5G11A 4BZ9A 2VQOA 1T64A 3MZ4A 5EFKB 4QA7A 3SFFA 1ZZ1A 5THTA 2V5WA 5G13A 3F07A 3Q9BA 5D1DA 5G1BA 5THVA 1C3PA 3F06A 3ZNRA 4RN1A 4A69A 3C0YA 4QA6A 2VQVA 4QA4A 5G0GA 5EFHA 5G1AA 3ZNSA 3EZTA 4BZ7A 2VQJA 5THUA 4QA5A 1T69A 5EFJD 4CBTA 3EWFA 4ZUOA 5G0YA 3Q9CA 1VKGA 3MENA 3EW8A 5DC6A 3MZ6A 5G0JA 5LI3A 3MZ3A 1T67A 5DC8A 5D1BA 3Q9EA 4ZUMA 5G10A 3RQDA 5THSA 5ICNB 5EEMA 3Q9FA 3C10A 2VQMA 5G1CA 4BZ5A 4RN0A 5G12A 1ZZ0A 1C3RA 2VQWG 3MAXA 4QA0A 4QA1A 4ZUPA 3MZ7A 5G0IA 5G0XA 5JI5A 5EENA 2V5XA 5G17A 4ZUNA 4CBYA 4LXZA 3EZPA 5EEFA 2GH6A 5DC7A 5FCWA 4QA2A 4BZ6A 5A2SA 5IWGA
chains in the Genus database with same CATH superfamily
4Q3VA 4IXUA 3F0RA 2A0MA 3SKKA 5EF8A 4RHIA 5G3WA 4Q3SA 4RHQA 4RLAA 5IX0A 3NIQA 5EEKA 5EF7A 1ZPGA 3E8ZA 3C0ZA 1P8OA 5BWZA 4GWDA 4RHLA 1W22A 2PHAA 2VCGA 5DC5A 5EFGA 5RLAA 3SL0A 4ZURA 3GMZA 5FUEA 1T5FA 1GQ7A 5EFBD 1GQ6A 4BZ8A 4RN2A 3DJ8A 4IE2A 5EFNA 3MJLA 4MYNA 1P8QA 1C3SA 4BKXB 3THJA 1ZZ3A 4MYKA 5D1CA 3CEVA 5G0HA 1T4PA 4CQFA 2RLAA 3SFHA 2VQQA 4QA3A 4CEVA 4RHKA 1P8NA 3E8QA 4ZUQA 5EEIA 3M1RA 4Q3PA 4LY1A 5G11A 4GSVA 4BZ9A 2VQOA 1WVBA 1PQ3A 1T64A 3MZ4A 5EFKB 4QA7A 3SFFA 2ZAVA 3LHLA 3GN0A 2CEVA 3LP4A 4MYFA 1ZZ1A 3E6VA 4G3HA 1T4SA 3SL1A 3THEA 4Q3QA 5THTA 2V5WA 5G13A 3F07A 3Q9BA 5D1DA 3KV2A 4HZEA 5G1BA 5THVA 1C3PA 5CEVA 3F06A 3ZNRA 4RHJA 3F80A 4RN1A 4A69A 3C0YA 4QA6A 3NIPA 2VQVA 2PHOA 4QA4A 4IU0A 5G0GA 1CEVA 1ZPEA 5HJAA 1T5GA 5EFHA 1HQXA 2AEBA 5G1AA 4Q41A 3RLAA 3ZNSA 3EZTA 3MMRA 4BZ7A 2VQJA 5THUA 4FCIA 4QA5A 3MFWA 4GSZA 1HQ5A 3TH7A 2EF4A 1TBHA 1T69A 4Q3UA 3E6KA 5EFJD 1P8RA 3EWFA 4CBTA 4ZUOA 5G0YA 3Q9CA 1T4RA 1VKGA 1WOIA 3EW8A 3MENA 5DC6A 1XFKA 3MZ6A 1WOGA 2PLLA 4IU4A 3SJTA 4HWWA 4ITYA 1TBLA 4Q3TA 3MZ3A 5G0JA 1T67A 5LI3A 1P8MA 4IE1A 4IU1A 4Q42A 5DC8A 4MYLA 1HQGA 5D1BA 3Q9EA 4ZUMA 5G10A 3RQDA 5THSA 5ICNB 1HQHA 1R1OA 2EIVA 5EEMA 3Q9FA 3C10A 2VQMA 1D3VA 4FCKA 4GWCA 4RN0A 1HQFA 1ZZ0A 5G1CA 1C3RA 5G12A 4BZ5A 2VQWG 4IU5A 3MAXA 3TF3A 3E9BA 4MXRA 4QA0A 4QA1A 3NIOA 1RLAA 4GSMA 4IE3A 4ZUPA 2EF5A 1TA1A 1T4TA 3MZ7A 1P8PA 5G0IA 4Q3RA 5HJ9A 1WOHA 1WVAA 4IXVA 4RHMA 4DZ4A 4Q40A 4Q3RC 1P8SA 1TBJA 3THHA 4HXQA 5G0XA 5JI5A 5EENA 2V5XA 5G17A 4ZUNA 4CBYA 4LXZA 3EZPA 5EEFA 2GH6A 3MFVA 5DC7A 4QA2A 4I06A 5FCWA 4BZ6A 5A2SA 3LP7A 5IWGA 3PZLA
chains in the Genus database with same CATH topology
3F0RA 5EF8A 5G3WA 5IX0A 5EEKA 5EF7A 3C0ZA 5BWZA 1W22A 2VCGA 5DC5A 5EFGA 4ZURA 5FUEA 5EFBD 4BZ8A 4RN2A 5EFNA 4BKXB 1C3SA 1ZZ3A 5D1CA 5G0HA 4CQFA 3SFHA 2VQQA 4QA3A 4ZUQA 5EEIA 4LY1A 5G11A 4BZ9A 2VQOA 1T64A 3MZ4A 5EFKB 4QA7A 3SFFA 1ZZ1A 5THTA 2V5WA 5G13A 3F07A 3Q9BA 5D1DA 5G1BA 5THVA 1C3PA 3F06A 3ZNRA 4RN1A 4A69A 3C0YA 4QA6A 2VQVA 4QA4A 5G0GA 5EFHA 5G1AA 3ZNSA 3EZTA 4BZ7A 2VQJA 5THUA 4QA5A 1T69A 5EFJD 4CBTA 3EWFA 4ZUOA 5G0YA 3Q9CA 1VKGA 3MENA 3EW8A 5DC6A 3MZ6A 5G0JA 5LI3A 3MZ3A 1T67A 5DC8A 5D1BA 3Q9EA 4ZUMA 5G10A 3RQDA 5THSA 5ICNB 5EEMA 3Q9FA 3C10A 2VQMA 5G1CA 4BZ5A 4RN0A 5G12A 1ZZ0A 1C3RA 2VQWG 3MAXA 4QA0A 4QA1A 4ZUPA 3MZ7A 5G0IA 5G0XA 5JI5A 5EENA 2V5XA 5G17A 4ZUNA 4CBYA 4LXZA 3EZPA 5EEFA 2GH6A 5DC7A 5FCWA 4QA2A 4BZ6A 5A2SA 5IWGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F0R A;  5EF8 A;  5G3W A;  5IX0 A;  5EEK A;  5EF7 A;  3C0Z A;  5BWZ A;  1W22 A;  2VCG A;  5DC5 A;  5EFG A;  4ZUR A;  5FUE A;  5EFB D;  4BZ8 A;  4RN2 A;  5EFN A;  4BKX B;  1C3S A;  1ZZ3 A;  5D1C A;  5G0H A;  4CQF A;  3SFH A;  2VQQ A;  4QA3 A;  4ZUQ A;  5EEI A;  4LY1 A;  5G11 A;  4BZ9 A;  2VQO A;  1T64 A;  3MZ4 A;  5EFK B;  4QA7 A;  3SFF A;  1ZZ1 A;  5THT A;  2V5W A;  5G13 A;  3F07 A;  3Q9B A;  5D1D A;  5G1B A;  5THV A;  1C3P A;  3F06 A;  3ZNR A;  4RN1 A;  4A69 A;  3C0Y A;  4QA6 A;  2VQV A;  4QA4 A;  5G0G A;  5EFH A;  5G1A A;  3ZNS A;  3EZT A;  4BZ7 A;  2VQJ A;  5THU A;  4QA5 A;  1T69 A;  5EFJ D;  4CBT A;  3EWF A;  4ZUO A;  5G0Y A;  3Q9C A;  1VKG A;  3MEN A;  3EW8 A;  5DC6 A;  3MZ6 A;  5G0J A;  5LI3 A;  3MZ3 A;  1T67 A;  5DC8 A;  5D1B A;  3Q9E A;  4ZUM A;  5G10 A;  3RQD A;  5THS A;  5ICN B;  5EEM A;  3Q9F A;  3C10 A;  2VQM A;  5G1C A;  4BZ5 A;  4RN0 A;  5G12 A;  1ZZ0 A;  1C3R A;  2VQW G;  3MAX A;  4QA0 A;  4QA1 A;  4ZUP A;  3MZ7 A;  5G0I A;  5G0X A;  5JI5 A;  5EEN A;  2V5X A;  5G17 A;  4ZUN A;  4CBY A;  4LXZ A;  3EZP A;  5EEF A;  2GH6 A;  5DC7 A;  5FCW A;  4QA2 A;  4BZ6 A;  5A2S A;  5IWG A; 
#chains in the Genus database with same CATH topology
 4Q3V A;  4IXU A;  3F0R A;  2A0M A;  3SKK A;  5EF8 A;  4RHI A;  5G3W A;  4Q3S A;  4RHQ A;  4RLA A;  5IX0 A;  3NIQ A;  5EEK A;  5EF7 A;  1ZPG A;  3E8Z A;  3C0Z A;  1P8O A;  5BWZ A;  4GWD A;  4RHL A;  1W22 A;  2PHA A;  2VCG A;  5DC5 A;  5EFG A;  5RLA A;  3SL0 A;  4ZUR A;  3GMZ A;  5FUE A;  1T5F A;  1GQ7 A;  5EFB D;  1GQ6 A;  4BZ8 A;  4RN2 A;  3DJ8 A;  4IE2 A;  5EFN A;  3MJL A;  4MYN A;  1P8Q A;  1C3S A;  4BKX B;  3THJ A;  1ZZ3 A;  4MYK A;  5D1C A;  3CEV A;  5G0H A;  1T4P A;  4CQF A;  2RLA A;  3SFH A;  2VQQ A;  4QA3 A;  4CEV A;  4RHK A;  1P8N A;  3E8Q A;  4ZUQ A;  5EEI A;  3M1R A;  4Q3P A;  4LY1 A;  5G11 A;  4GSV A;  4BZ9 A;  2VQO A;  1WVB A;  1PQ3 A;  1T64 A;  3MZ4 A;  5EFK B;  4QA7 A;  3SFF A;  2ZAV A;  3LHL A;  3GN0 A;  2CEV A;  3LP4 A;  4MYF A;  1ZZ1 A;  3E6V A;  4G3H A;  1T4S A;  3SL1 A;  3THE A;  4Q3Q A;  5THT A;  2V5W A;  5G13 A;  3F07 A;  3Q9B A;  5D1D A;  3KV2 A;  4HZE A;  5G1B A;  5THV A;  1C3P A;  5CEV A;  3F06 A;  3ZNR A;  4RHJ A;  3F80 A;  4RN1 A;  4A69 A;  3C0Y A;  4QA6 A;  3NIP A;  2VQV A;  2PHO A;  4QA4 A;  4IU0 A;  5G0G A;  1CEV A;  1ZPE A;  5HJA A;  1T5G A;  5EFH A;  1HQX A;  2AEB A;  5G1A A;  4Q41 A;  3RLA A;  3ZNS A;  3EZT A;  3MMR A;  4BZ7 A;  2VQJ A;  5THU A;  4FCI A;  4QA5 A;  3MFW A;  4GSZ A;  1HQ5 A;  3TH7 A;  2EF4 A;  1TBH A;  1T69 A;  4Q3U A;  3E6K A;  5EFJ D;  1P8R A;  3EWF A;  4CBT A;  4ZUO A;  5G0Y A;  3Q9C A;  1T4R A;  1VKG A;  1WOI A;  3EW8 A;  3MEN A;  5DC6 A;  1XFK A;  3MZ6 A;  1WOG A;  2PLL A;  4IU4 A;  3SJT A;  4HWW A;  4ITY A;  1TBL A;  4Q3T A;  3MZ3 A;  5G0J A;  1T67 A;  5LI3 A;  1P8M A;  4IE1 A;  4IU1 A;  4Q42 A;  5DC8 A;  4MYL A;  1HQG A;  5D1B A;  3Q9E A;  4ZUM A;  5G10 A;  3RQD A;  5THS A;  5ICN B;  1HQH A;  1R1O A;  2EIV A;  5EEM A;  3Q9F A;  3C10 A;  2VQM A;  1D3V A;  4FCK A;  4GWC A;  4RN0 A;  1HQF A;  1ZZ0 A;  5G1C A;  1C3R A;  5G12 A;  4BZ5 A;  2VQW G;  4IU5 A;  3MAX A;  3TF3 A;  3E9B A;  4MXR A;  4QA0 A;  4QA1 A;  3NIO A;  1RLA A;  4GSM A;  4IE3 A;  4ZUP A;  2EF5 A;  1TA1 A;  1T4T A;  3MZ7 A;  1P8P A;  5G0I A;  4Q3R A;  5HJ9 A;  1WOH A;  1WVA A;  4IXV A;  4RHM A;  4DZ4 A;  4Q40 A;  4Q3R C;  1P8S A;  1TBJ A;  3THH A;  4HXQ A;  5G0X A;  5JI5 A;  5EEN A;  2V5X A;  5G17 A;  4ZUN A;  4CBY A;  4LXZ A;  3EZP A;  5EEF A;  2GH6 A;  3MFV A;  5DC7 A;  4QA2 A;  4I06 A;  5FCW A;  4BZ6 A;  5A2S A;  3LP7 A;  5IWG A;  3PZL A; 
#chains in the Genus database with same CATH homology
 3F0R A;  5EF8 A;  5G3W A;  5IX0 A;  5EEK A;  5EF7 A;  3C0Z A;  5BWZ A;  1W22 A;  2VCG A;  5DC5 A;  5EFG A;  4ZUR A;  5FUE A;  5EFB D;  4BZ8 A;  4RN2 A;  5EFN A;  4BKX B;  1C3S A;  1ZZ3 A;  5D1C A;  5G0H A;  4CQF A;  3SFH A;  2VQQ A;  4QA3 A;  4ZUQ A;  5EEI A;  4LY1 A;  5G11 A;  4BZ9 A;  2VQO A;  1T64 A;  3MZ4 A;  5EFK B;  4QA7 A;  3SFF A;  1ZZ1 A;  5THT A;  2V5W A;  5G13 A;  3F07 A;  3Q9B A;  5D1D A;  5G1B A;  5THV A;  1C3P A;  3F06 A;  3ZNR A;  4RN1 A;  4A69 A;  3C0Y A;  4QA6 A;  2VQV A;  4QA4 A;  5G0G A;  5EFH A;  5G1A A;  3ZNS A;  3EZT A;  4BZ7 A;  2VQJ A;  5THU A;  4QA5 A;  1T69 A;  5EFJ D;  4CBT A;  3EWF A;  4ZUO A;  5G0Y A;  3Q9C A;  1VKG A;  3MEN A;  3EW8 A;  5DC6 A;  3MZ6 A;  5G0J A;  5LI3 A;  3MZ3 A;  1T67 A;  5DC8 A;  5D1B A;  3Q9E A;  4ZUM A;  5G10 A;  3RQD A;  5THS A;  5ICN B;  5EEM A;  3Q9F A;  3C10 A;  2VQM A;  5G1C A;  4BZ5 A;  4RN0 A;  5G12 A;  1ZZ0 A;  1C3R A;  2VQW G;  3MAX A;  4QA0 A;  4QA1 A;  4ZUP A;  3MZ7 A;  5G0I A;  5G0X A;  5JI5 A;  5EEN A;  2V5X A;  5G17 A;  4ZUN A;  4CBY A;  4LXZ A;  3EZP A;  5EEF A;  2GH6 A;  5DC7 A;  5FCW A;  4QA2 A;  4BZ6 A;  5A2S A;  5IWG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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