4DG4C

Human mesotrypsin-s39y complexed with bovine pancreatic trypsin inhibitor (bpti)
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords PRSS3 protein
total genus 11
structure length 58
sequence length 58
chains with identical sequence E, F, H
ec nomenclature
pdb deposition date 2012-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4dg4C00
3FP7J 1P2JI 4Y11I 3BTQI 3FP8I 5JB5A 4Y0ZI 2KCRA 4NTWB 3AUHA 1CBWD 4BNRI 3GYMI 1P2OB 1JC6A 1MTND 2FTLI 3AUEA 4NTXB 1CA0D 1JV9A 2M99A 2FTMB 3LDIA 1AALA 1F7ZI 3BTGI 5JB4A 2ODYE 1T8NB 2J6DA 1LD6A 1TCPA 1UUBA 3L3TE 4ISLB 1P2NB 2FI4I 3BTWI 1BUNB 4U30W 4WXVC 4NTYB 3TPII 2LFLA 1AAPA 4BQDA 1IRHA 2HEXA 4Y0YI 3WNYA 5JB6A 2FI5I 2PTCI 1BHCA 1FANA 3P92E 3P95E 1TFXC 1T8OB 1T7CB 1EAWB 3D65I 3FP6I 4TPII 1OA65 1KIGI 1G6XA 1YLCB 2RA3C 1PITA 1P2QB 1KNTA 1LD5A 3LDJA 1KUNA 4Y10I 3BTKI 1YC0I 1B0CA 1BTHP 3BTTI 3BYBA 1QLQA 3OFWA 3AUDA 1BZXI 2FI3I 3AUBA 1DENA 3UIRC 3BTDI 3TGJI 5PTIA 6PTIA 1D0DA 1OA55 1YKTB 3AUIA 1CO7I 1T8MB 1D0DB 2DDIA 2JOTA 3TGII 2CA7A 1BPIA 2TPII 3OTJI 1BPTA 2DDJA 1KTHA 1FY8I 3BTFI 5JB7A 3LDMA 4U32X 1T8LB 2IJOI 2KAII 4BD9B 2UUXA 1K6UA 2UUYB 3L33E 8PTIA 4DG4C 1BRCI 4ISNB 4WWYC 1YLDB 1UUAA 1BTIA 2M01A 2R9PE 2KNTA 1Y62A 3BTMI 1BRBI 1DTXA 2TGPI 1NAGA 1FAKI 1P2MB 7PTIA 1BZ5A 1JV8A 3U1JE 3UOUB 1DEMA 3AUGA 4ISOB 1P2II 1TAWB 1ZR0B 1EJMB 1BIKA 5C67C 2W8XA 3M7QB 2ZJXA 3BTHI 3TGKI 1BF0A 1DTKA 2LFKA 3BTEI 1F5RI 1ZJDB 3AUCA 4DTGK 1TPAI 3T62D 9PTIA 1SHPA 4PTIA 3CI7A 2ZVXA 1TAPA 1P2KI 1ADZA 1TOCR
chains in the Genus database with same CATH superfamily
3FP7J 1P2JI 4Y11I 3BTQI 3FP8I 5JB5A 4Y0ZI 2KCRA 4NTWB 3AUHA 1CBWD 4BNRI 3GYMI 1P2OB 1JC6A 1MTND 2FTLI 3AUEA 4NTXB 1CA0D 1JV9A 2M99A 2FTMB 3LDIA 1AALA 1F7ZI 3BTGI 5JB4A 2ODYE 1T8NB 2J6DA 1LD6A 1TCPA 1UUBA 3L3TE 4ISLB 1P2NB 2FI4I 3BTWI 1BUNB 4U30W 4WXVC 4NTYB 3TPII 2LFLA 1AAPA 4BQDA 1IRHA 2HEXA 4Y0YI 3WNYA 5JB6A 2FI5I 2PTCI 1BHCA 1FANA 3P92E 3P95E 1TFXC 1T8OB 1T7CB 1EAWB 3D65I 3FP6I 4TPII 1OA65 1KIGI 1G6XA 1YLCB 2RA3C 1PITA 1P2QB 1KNTA 1LD5A 3LDJA 1KUNA 4Y10I 3BTKI 1YC0I 1B0CA 1BTHP 3BTTI 3BYBA 1QLQA 3OFWA 3AUDA 1BZXI 2FI3I 3AUBA 1DENA 3UIRC 3BTDI 3TGJI 5PTIA 6PTIA 1D0DA 1OA55 1YKTB 3AUIA 1CO7I 1T8MB 1D0DB 2DDIA 2JOTA 3TGII 2CA7A 1BPIA 2TPII 3OTJI 1BPTA 2DDJA 1KTHA 1FY8I 3BTFI 5JB7A 3LDMA 4U32X 1T8LB 2IJOI 2KAII 4BD9B 2UUXA 1K6UA 2UUYB 3L33E 8PTIA 4DG4C 1BRCI 4ISNB 4WWYC 1YLDB 1UUAA 1BTIA 2M01A 2R9PE 2KNTA 1Y62A 3BTMI 1BRBI 1DTXA 2TGPI 1NAGA 1FAKI 1P2MB 7PTIA 1BZ5A 1JV8A 3U1JE 3UOUB 1DEMA 3AUGA 4ISOB 1P2II 1TAWB 1ZR0B 1EJMB 1BIKA 5C67C 2W8XA 3M7QB 2ZJXA 3BTHI 3TGKI 1BF0A 1DTKA 2LFKA 3BTEI 1F5RI 1ZJDB 3AUCA 4DTGK 1TPAI 3T62D 9PTIA 1SHPA 4PTIA 3CI7A 2ZVXA 1TAPA 1P2KI 1ADZA 1TOCR
chains in the Genus database with same CATH topology
3FP7J 1P2JI 4Y11I 3BTQI 3FP8I 5JB5A 4Y0ZI 2KCRA 4NTWB 3AUHA 1CBWD 4BNRI 3GYMI 1P2OB 1JC6A 1MTND 2FTLI 3AUEA 4NTXB 1CA0D 1JV9A 2M99A 2FTMB 3LDIA 1AALA 1F7ZI 3BTGI 5JB4A 2ODYE 1T8NB 2J6DA 1LD6A 1TCPA 1UUBA 3L3TE 4ISLB 1P2NB 2FI4I 3BTWI 1BUNB 4U30W 4WXVC 4NTYB 3TPII 2LFLA 1AAPA 4BQDA 1IRHA 2HEXA 4Y0YI 3WNYA 5JB6A 2FI5I 2PTCI 1BHCA 1FANA 3P92E 3P95E 1TFXC 1T8OB 1T7CB 1EAWB 3D65I 3FP6I 4TPII 1OA65 1KIGI 1G6XA 1YLCB 2RA3C 1PITA 1P2QB 1KNTA 1LD5A 3LDJA 1KUNA 4Y10I 3BTKI 1YC0I 1B0CA 1BTHP 3BTTI 3BYBA 1QLQA 3OFWA 3AUDA 1BZXI 2FI3I 3AUBA 1DENA 3UIRC 3BTDI 3TGJI 5PTIA 6PTIA 1D0DA 1OA55 1YKTB 3AUIA 1CO7I 1T8MB 1D0DB 2DDIA 2JOTA 3TGII 2CA7A 1BPIA 2TPII 3OTJI 1BPTA 2DDJA 1KTHA 1FY8I 3BTFI 5JB7A 3LDMA 4U32X 1T8LB 2IJOI 2KAII 4BD9B 2UUXA 1K6UA 2UUYB 3L33E 8PTIA 4DG4C 1BRCI 4ISNB 4WWYC 1YLDB 1UUAA 1BTIA 2M01A 2R9PE 2KNTA 1Y62A 3BTMI 1BRBI 1DTXA 2TGPI 1NAGA 1FAKI 1P2MB 7PTIA 1BZ5A 1JV8A 3U1JE 3UOUB 1DEMA 3AUGA 4ISOB 1P2II 1TAWB 1ZR0B 1EJMB 1BIKA 5C67C 2W8XA 3M7QB 2ZJXA 3BTHI 3TGKI 1BF0A 1DTKA 2LFKA 3BTEI 1F5RI 1ZJDB 3AUCA 4DTGK 1TPAI 3T62D 9PTIA 1SHPA 4PTIA 3CI7A 2ZVXA 1TAPA 1P2KI 1ADZA 1TOCR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FP7 J;  1P2J I;  4Y11 I;  3BTQ I;  3FP8 I;  5JB5 A;  4Y0Z I;  2KCR A;  4NTW B;  3AUH A;  1CBW D;  4BNR I;  3GYM I;  1P2O B;  1JC6 A;  1MTN D;  2FTL I;  3AUE A;  4NTX B;  1CA0 D;  1JV9 A;  2M99 A;  2FTM B;  3LDI A;  1AAL A;  1F7Z I;  3BTG I;  5JB4 A;  2ODY E;  1T8N B;  2J6D A;  1LD6 A;  1TCP A;  1UUB A;  3L3T E;  4ISL B;  1P2N B;  2FI4 I;  3BTW I;  1BUN B;  4U30 W;  4WXV C;  4NTY B;  3TPI I;  2LFL A;  1AAP A;  4BQD A;  1IRH A;  2HEX A;  4Y0Y I;  3WNY A;  5JB6 A;  2FI5 I;  2PTC I;  1BHC A;  1FAN A;  3P92 E;  3P95 E;  1TFX C;  1T8O B;  1T7C B;  1EAW B;  3D65 I;  3FP6 I;  4TPI I;  1OA6 5;  1KIG I;  1G6X A;  1YLC B;  2RA3 C;  1PIT A;  1P2Q B;  1KNT A;  1LD5 A;  3LDJ A;  1KUN A;  4Y10 I;  3BTK I;  1YC0 I;  1B0C A;  1BTH P;  3BTT I;  3BYB A;  1QLQ A;  3OFW A;  3AUD A;  1BZX I;  2FI3 I;  3AUB A;  1DEN A;  3UIR C;  3BTD I;  3TGJ I;  5PTI A;  6PTI A;  1D0D A;  1OA5 5;  1YKT B;  3AUI A;  1CO7 I;  1T8M B;  1D0D B;  2DDI A;  2JOT A;  3TGI I;  2CA7 A;  1BPI A;  2TPI I;  3OTJ I;  1BPT A;  2DDJ A;  1KTH A;  1FY8 I;  3BTF I;  5JB7 A;  3LDM A;  4U32 X;  1T8L B;  2IJO I;  2KAI I;  4BD9 B;  2UUX A;  1K6U A;  2UUY B;  3L33 E;  8PTI A;  4DG4 C;  1BRC I;  4ISN B;  4WWY C;  1YLD B;  1UUA A;  1BTI A;  2M01 A;  2R9P E;  2KNT A;  1Y62 A;  3BTM I;  1BRB I;  1DTX A;  2TGP I;  1NAG A;  1FAK I;  1P2M B;  7PTI A;  1BZ5 A;  1JV8 A;  3U1J E;  3UOU B;  1DEM A;  3AUG A;  4ISO B;  1P2I I;  1TAW B;  1ZR0 B;  1EJM B;  1BIK A;  5C67 C;  2W8X A;  3M7Q B;  2ZJX A;  3BTH I;  3TGK I;  1BF0 A;  1DTK A;  2LFK A;  3BTE I;  1F5R I;  1ZJD B;  3AUC A;  4DTG K;  1TPA I;  3T62 D;  9PTI A;  1SHP A;  4PTI A;  3CI7 A;  2ZVX A;  1TAP A;  1P2K I;  1ADZ A;  1TOC R; 
#chains in the Genus database with same CATH topology
 3FP7 J;  1P2J I;  4Y11 I;  3BTQ I;  3FP8 I;  5JB5 A;  4Y0Z I;  2KCR A;  4NTW B;  3AUH A;  1CBW D;  4BNR I;  3GYM I;  1P2O B;  1JC6 A;  1MTN D;  2FTL I;  3AUE A;  4NTX B;  1CA0 D;  1JV9 A;  2M99 A;  2FTM B;  3LDI A;  1AAL A;  1F7Z I;  3BTG I;  5JB4 A;  2ODY E;  1T8N B;  2J6D A;  1LD6 A;  1TCP A;  1UUB A;  3L3T E;  4ISL B;  1P2N B;  2FI4 I;  3BTW I;  1BUN B;  4U30 W;  4WXV C;  4NTY B;  3TPI I;  2LFL A;  1AAP A;  4BQD A;  1IRH A;  2HEX A;  4Y0Y I;  3WNY A;  5JB6 A;  2FI5 I;  2PTC I;  1BHC A;  1FAN A;  3P92 E;  3P95 E;  1TFX C;  1T8O B;  1T7C B;  1EAW B;  3D65 I;  3FP6 I;  4TPI I;  1OA6 5;  1KIG I;  1G6X A;  1YLC B;  2RA3 C;  1PIT A;  1P2Q B;  1KNT A;  1LD5 A;  3LDJ A;  1KUN A;  4Y10 I;  3BTK I;  1YC0 I;  1B0C A;  1BTH P;  3BTT I;  3BYB A;  1QLQ A;  3OFW A;  3AUD A;  1BZX I;  2FI3 I;  3AUB A;  1DEN A;  3UIR C;  3BTD I;  3TGJ I;  5PTI A;  6PTI A;  1D0D A;  1OA5 5;  1YKT B;  3AUI A;  1CO7 I;  1T8M B;  1D0D B;  2DDI A;  2JOT A;  3TGI I;  2CA7 A;  1BPI A;  2TPI I;  3OTJ I;  1BPT A;  2DDJ A;  1KTH A;  1FY8 I;  3BTF I;  5JB7 A;  3LDM A;  4U32 X;  1T8L B;  2IJO I;  2KAI I;  4BD9 B;  2UUX A;  1K6U A;  2UUY B;  3L33 E;  8PTI A;  4DG4 C;  1BRC I;  4ISN B;  4WWY C;  1YLD B;  1UUA A;  1BTI A;  2M01 A;  2R9P E;  2KNT A;  1Y62 A;  3BTM I;  1BRB I;  1DTX A;  2TGP I;  1NAG A;  1FAK I;  1P2M B;  7PTI A;  1BZ5 A;  1JV8 A;  3U1J E;  3UOU B;  1DEM A;  3AUG A;  4ISO B;  1P2I I;  1TAW B;  1ZR0 B;  1EJM B;  1BIK A;  5C67 C;  2W8X A;  3M7Q B;  2ZJX A;  3BTH I;  3TGK I;  1BF0 A;  1DTK A;  2LFK A;  3BTE I;  1F5R I;  1ZJD B;  3AUC A;  4DTG K;  1TPA I;  3T62 D;  9PTI A;  1SHP A;  4PTI A;  3CI7 A;  2ZVX A;  1TAP A;  1P2K I;  1ADZ A;  1TOC R; 
#chains in the Genus database with same CATH homology
 3FP7 J;  1P2J I;  4Y11 I;  3BTQ I;  3FP8 I;  5JB5 A;  4Y0Z I;  2KCR A;  4NTW B;  3AUH A;  1CBW D;  4BNR I;  3GYM I;  1P2O B;  1JC6 A;  1MTN D;  2FTL I;  3AUE A;  4NTX B;  1CA0 D;  1JV9 A;  2M99 A;  2FTM B;  3LDI A;  1AAL A;  1F7Z I;  3BTG I;  5JB4 A;  2ODY E;  1T8N B;  2J6D A;  1LD6 A;  1TCP A;  1UUB A;  3L3T E;  4ISL B;  1P2N B;  2FI4 I;  3BTW I;  1BUN B;  4U30 W;  4WXV C;  4NTY B;  3TPI I;  2LFL A;  1AAP A;  4BQD A;  1IRH A;  2HEX A;  4Y0Y I;  3WNY A;  5JB6 A;  2FI5 I;  2PTC I;  1BHC A;  1FAN A;  3P92 E;  3P95 E;  1TFX C;  1T8O B;  1T7C B;  1EAW B;  3D65 I;  3FP6 I;  4TPI I;  1OA6 5;  1KIG I;  1G6X A;  1YLC B;  2RA3 C;  1PIT A;  1P2Q B;  1KNT A;  1LD5 A;  3LDJ A;  1KUN A;  4Y10 I;  3BTK I;  1YC0 I;  1B0C A;  1BTH P;  3BTT I;  3BYB A;  1QLQ A;  3OFW A;  3AUD A;  1BZX I;  2FI3 I;  3AUB A;  1DEN A;  3UIR C;  3BTD I;  3TGJ I;  5PTI A;  6PTI A;  1D0D A;  1OA5 5;  1YKT B;  3AUI A;  1CO7 I;  1T8M B;  1D0D B;  2DDI A;  2JOT A;  3TGI I;  2CA7 A;  1BPI A;  2TPI I;  3OTJ I;  1BPT A;  2DDJ A;  1KTH A;  1FY8 I;  3BTF I;  5JB7 A;  3LDM A;  4U32 X;  1T8L B;  2IJO I;  2KAI I;  4BD9 B;  2UUX A;  1K6U A;  2UUY B;  3L33 E;  8PTI A;  4DG4 C;  1BRC I;  4ISN B;  4WWY C;  1YLD B;  1UUA A;  1BTI A;  2M01 A;  2R9P E;  2KNT A;  1Y62 A;  3BTM I;  1BRB I;  1DTX A;  2TGP I;  1NAG A;  1FAK I;  1P2M B;  7PTI A;  1BZ5 A;  1JV8 A;  3U1J E;  3UOU B;  1DEM A;  3AUG A;  4ISO B;  1P2I I;  1TAW B;  1ZR0 B;  1EJM B;  1BIK A;  5C67 C;  2W8X A;  3M7Q B;  2ZJX A;  3BTH I;  3TGK I;  1BF0 A;  1DTK A;  2LFK A;  3BTE I;  1F5R I;  1ZJD B;  3AUC A;  4DTG K;  1TPA I;  3T62 D;  9PTI A;  1SHP A;  4PTI A;  3CI7 A;  2ZVX A;  1TAP A;  1P2K I;  1ADZ A;  1TOC R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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