4DQYA

Structure of human parp-1 bound to a dna double strand break
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
86
structure length
86
Chain Sequence
DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/dna
molecule keywords Poly [ADP-ribose] polymerase 1
publication title Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.
pubmed doi rcsb
source organism Homo sapiens
total genus 18
structure length 86
sequence length 86
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00645 zf-PARP Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1740.10 Alpha Beta 2-Layer Sandwich first zn-finger domain of poly(adp-ribose) polymerase-1 Zinc finger, PARP-type 4dqyA00
3OD8A 2L30A 4AV1A 1V9XA 4OQAA 4OQBA 2CS2A 4OPXA 3ODAA 3ODCA 3ODEA 4DQYA 2L31A 2DMJA 1UW0A 2N8AA
chains in the Genus database with same CATH superfamily
3OD8A 4OPXA 3JAMa 3ODAA 3J7A3 2L31A 5LL6e 3J81a 5A2Qa 5IT9a 1UW0A 2L30A 4OQAA 2CS2A 3J80a 5FLXa 2DMJA 4DQYA 4AV1A 1V9XA 2N8AA 3ODEA 4OQBA 3ODCA
chains in the Genus database with same CATH topology
3OD8A 2L30A 4AV1A 1V9XA 4OQAA 4OQBA 2CS2A 4OPXA 3ODAA 3ODCA 3ODEA 4DQYA 2L31A 2DMJA 1UW0A 2N8AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OD8 A;  2L30 A;  4AV1 A;  1V9X A;  4OQA A;  4OQB A;  2CS2 A;  4OPX A;  3ODA A;  3ODC A;  3ODE A;  4DQY A;  2L31 A;  2DMJ A;  1UW0 A;  2N8A A; 
#chains in the Genus database with same CATH topology
 3OD8 A;  4OPX A;  3JAM a;  3ODA A;  3J7A 3;  2L31 A;  5LL6 e;  3J81 a;  5A2Q a;  5IT9 a;  1UW0 A;  2L30 A;  4OQA A;  2CS2 A;  3J80 a;  5FLX a;  2DMJ A;  4DQY A;  4AV1 A;  1V9X A;  2N8A A;  3ODE A;  4OQB A;  3ODC A; 
#chains in the Genus database with same CATH homology
 3OD8 A;  2L30 A;  4AV1 A;  1V9X A;  4OQA A;  4OQB A;  2CS2 A;  4OPX A;  3ODA A;  3ODC A;  3ODE A;  4DQY A;  2L31 A;  2DMJ A;  1UW0 A;  2N8A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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