4EREA

Crystal structure of mdm2 (17-111) in complex with compound 23
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
90
structure length
85
Chain Sequence
SEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Ligase/ligase inhibitor
molecule keywords E3 ubiquitin-protein ligase Mdm2
publication title Structure-based design of novel inhibitors of the MDM2-p53 interaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 25
structure length 85
sequence length 90
chains with identical sequence B
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2012-04-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 4ereA00
3JZKA 4RXZA 4HBMA 4UE1A 4J7DA 2MPSA 5HMIA 3JZQA 3TU1A 2RUHA 4J7EA 5HMHA 4ODEA 3DACA 3JZOA 4ZYIA 4OBAA 5LAYA 4HFZA 3JZPA 2N14A 4J74A 4LWUA 4UMNA 3EQYA 4ERFA 1UHRA 4HG7A 3DABA 3EQSA 4JWRA 1T4FM 2N06A 4EREA 4OGNA 5AFGA 4ZYCA 1YCRA 1T4EA 3V3BA 4MDNA 3W69A 4JSCA 3LNJA 4JRGA 1V32A 4OASA 4OQ3A 4OGTA 5HMKA 4LWTA 4QO4A 2Z5TM 4IPFA 4ZGKA 4WT2A 1RV1A 1Z1MA 5LAZA 4ZYFA 4ODFA 1YCQA 2LZGA 5TRFA 4N5TA 5LN2A 2MWYA 4OGVA 3G03A 3LNZA 3FE7A 3TPXA 3LBKA 4QOCA 4ZFIA 1V31A 4LWVA 2N0WA 3LBLA 3VBGA 3JZSA 3IUXA 4JVRA 4MDQA 2AXIA 3FEAA 4DIJA 2Z5SM 3JZRA 3LBJE 5LAVA 1TTVA 4OCCA 3U15A 5C5AA 3TJ2A 4JV9A 5LAWA 2GV2A 3IWYA 4JV7A 4JVEA 3FDOA 2N0UA 3VZVA 2VYRA 4J3EA 2M86B 4UD7A
chains in the Genus database with same CATH superfamily
3JZKA 4RXZA 4HBMA 4UE1A 4J7DA 2MPSA 5HMIA 3JZQA 3TU1A 2RUHA 4J7EA 5HMHA 4ODEA 3DACA 3JZOA 4ZYIA 4OBAA 5LAYA 4HFZA 3JZPA 2N14A 4J74A 4LWUA 4UMNA 3EQYA 4ERFA 1UHRA 4HG7A 3DABA 3EQSA 4JWRA 1T4FM 2N06A 4EREA 4OGNA 5AFGA 4ZYCA 1YCRA 1T4EA 3V3BA 4MDNA 3W69A 4JSCA 3LNJA 4JRGA 1V32A 4OASA 4OQ3A 4OGTA 5HMKA 4LWTA 4QO4A 2Z5TM 4IPFA 4ZGKA 4WT2A 1RV1A 1Z1MA 5LAZA 4ZYFA 4ODFA 1YCQA 2LZGA 5TRFA 4N5TA 5LN2A 2MWYA 4OGVA 3G03A 3LNZA 3FE7A 3TPXA 3LBKA 4QOCA 4ZFIA 1V31A 4LWVA 2N0WA 3LBLA 3VBGA 3JZSA 3IUXA 4JVRA 4MDQA 2AXIA 3FEAA 4DIJA 2Z5SM 3JZRA 3LBJE 5LAVA 1TTVA 4OCCA 3U15A 5C5AA 3TJ2A 4JV9A 5LAWA 2GV2A 3IWYA 4JV7A 4JVEA 3FDOA 2N0UA 3VZVA 2VYRA 4J3EA 2M86B 4UD7A
chains in the Genus database with same CATH topology
3JZKA 4RXZA 4HBMA 4UE1A 4J7DA 2MPSA 5HMIA 3JZQA 3TU1A 2RUHA 4J7EA 5HMHA 4ODEA 3DACA 3JZOA 4ZYIA 4OBAA 5LAYA 4HFZA 3JZPA 2N14A 4J74A 4LWUA 4UMNA 3EQYA 4ERFA 1UHRA 4HG7A 3DABA 3EQSA 4JWRA 1T4FM 2N06A 4EREA 4OGNA 5AFGA 4ZYCA 1YCRA 1T4EA 3V3BA 4MDNA 3W69A 4JSCA 3LNJA 4JRGA 1V32A 4OASA 4OQ3A 4OGTA 5HMKA 4LWTA 4QO4A 2Z5TM 4IPFA 4ZGKA 4WT2A 1RV1A 1Z1MA 5LAZA 4ZYFA 4ODFA 1YCQA 2LZGA 5TRFA 4N5TA 5LN2A 2MWYA 4OGVA 3G03A 3LNZA 3FE7A 3TPXA 3LBKA 4QOCA 4ZFIA 1V31A 4LWVA 2N0WA 3LBLA 3VBGA 3JZSA 3IUXA 4JVRA 4MDQA 2AXIA 3FEAA 4DIJA 2Z5SM 3JZRA 3LBJE 5LAVA 1TTVA 4OCCA 3U15A 5C5AA 3TJ2A 4JV9A 5LAWA 2GV2A 3IWYA 4JV7A 4JVEA 3FDOA 2N0UA 3VZVA 2VYRA 4J3EA 2M86B 4UD7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3JZK A;  4RXZ A;  4HBM A;  4UE1 A;  4J7D A;  2MPS A;  5HMI A;  3JZQ A;  3TU1 A;  2RUH A;  4J7E A;  5HMH A;  4ODE A;  3DAC A;  3JZO A;  4ZYI A;  4OBA A;  5LAY A;  4HFZ A;  3JZP A;  2N14 A;  4J74 A;  4LWU A;  4UMN A;  3EQY A;  4ERF A;  1UHR A;  4HG7 A;  3DAB A;  3EQS A;  4JWR A;  1T4F M;  2N06 A;  4ERE A;  4OGN A;  5AFG A;  4ZYC A;  1YCR A;  1T4E A;  3V3B A;  4MDN A;  3W69 A;  4JSC A;  3LNJ A;  4JRG A;  1V32 A;  4OAS A;  4OQ3 A;  4OGT A;  5HMK A;  4LWT A;  4QO4 A;  2Z5T M;  4IPF A;  4ZGK A;  4WT2 A;  1RV1 A;  1Z1M A;  5LAZ A;  4ZYF A;  4ODF A;  1YCQ A;  2LZG A;  5TRF A;  4N5T A;  5LN2 A;  2MWY A;  4OGV A;  3G03 A;  3LNZ A;  3FE7 A;  3TPX A;  3LBK A;  4QOC A;  4ZFI A;  1V31 A;  4LWV A;  2N0W A;  3LBL A;  3VBG A;  3JZS A;  3IUX A;  4JVR A;  4MDQ A;  2AXI A;  3FEA A;  4DIJ A;  2Z5S M;  3JZR A;  3LBJ E;  5LAV A;  1TTV A;  4OCC A;  3U15 A;  5C5A A;  3TJ2 A;  4JV9 A;  5LAW A;  2GV2 A;  3IWY A;  4JV7 A;  4JVE A;  3FDO A;  2N0U A;  3VZV A;  2VYR A;  4J3E A;  2M86 B;  4UD7 A; 
#chains in the Genus database with same CATH topology
 3JZK A;  4RXZ A;  4HBM A;  4UE1 A;  4J7D A;  2MPS A;  5HMI A;  3JZQ A;  3TU1 A;  2RUH A;  4J7E A;  5HMH A;  4ODE A;  3DAC A;  3JZO A;  4ZYI A;  4OBA A;  5LAY A;  4HFZ A;  3JZP A;  2N14 A;  4J74 A;  4LWU A;  4UMN A;  3EQY A;  4ERF A;  1UHR A;  4HG7 A;  3DAB A;  3EQS A;  4JWR A;  1T4F M;  2N06 A;  4ERE A;  4OGN A;  5AFG A;  4ZYC A;  1YCR A;  1T4E A;  3V3B A;  4MDN A;  3W69 A;  4JSC A;  3LNJ A;  4JRG A;  1V32 A;  4OAS A;  4OQ3 A;  4OGT A;  5HMK A;  4LWT A;  4QO4 A;  2Z5T M;  4IPF A;  4ZGK A;  4WT2 A;  1RV1 A;  1Z1M A;  5LAZ A;  4ZYF A;  4ODF A;  1YCQ A;  2LZG A;  5TRF A;  4N5T A;  5LN2 A;  2MWY A;  4OGV A;  3G03 A;  3LNZ A;  3FE7 A;  3TPX A;  3LBK A;  4QOC A;  4ZFI A;  1V31 A;  4LWV A;  2N0W A;  3LBL A;  3VBG A;  3JZS A;  3IUX A;  4JVR A;  4MDQ A;  2AXI A;  3FEA A;  4DIJ A;  2Z5S M;  3JZR A;  3LBJ E;  5LAV A;  1TTV A;  4OCC A;  3U15 A;  5C5A A;  3TJ2 A;  4JV9 A;  5LAW A;  2GV2 A;  3IWY A;  4JV7 A;  4JVE A;  3FDO A;  2N0U A;  3VZV A;  2VYR A;  4J3E A;  2M86 B;  4UD7 A; 
#chains in the Genus database with same CATH homology
 3JZK A;  4RXZ A;  4HBM A;  4UE1 A;  4J7D A;  2MPS A;  5HMI A;  3JZQ A;  3TU1 A;  2RUH A;  4J7E A;  5HMH A;  4ODE A;  3DAC A;  3JZO A;  4ZYI A;  4OBA A;  5LAY A;  4HFZ A;  3JZP A;  2N14 A;  4J74 A;  4LWU A;  4UMN A;  3EQY A;  4ERF A;  1UHR A;  4HG7 A;  3DAB A;  3EQS A;  4JWR A;  1T4F M;  2N06 A;  4ERE A;  4OGN A;  5AFG A;  4ZYC A;  1YCR A;  1T4E A;  3V3B A;  4MDN A;  3W69 A;  4JSC A;  3LNJ A;  4JRG A;  1V32 A;  4OAS A;  4OQ3 A;  4OGT A;  5HMK A;  4LWT A;  4QO4 A;  2Z5T M;  4IPF A;  4ZGK A;  4WT2 A;  1RV1 A;  1Z1M A;  5LAZ A;  4ZYF A;  4ODF A;  1YCQ A;  2LZG A;  5TRF A;  4N5T A;  5LN2 A;  2MWY A;  4OGV A;  3G03 A;  3LNZ A;  3FE7 A;  3TPX A;  3LBK A;  4QOC A;  4ZFI A;  1V31 A;  4LWV A;  2N0W A;  3LBL A;  3VBG A;  3JZS A;  3IUX A;  4JVR A;  4MDQ A;  2AXI A;  3FEA A;  4DIJ A;  2Z5S M;  3JZR A;  3LBJ E;  5LAV A;  1TTV A;  4OCC A;  3U15 A;  5C5A A;  3TJ2 A;  4JV9 A;  5LAW A;  2GV2 A;  3IWY A;  4JV7 A;  4JVE A;  3FDO A;  2N0U A;  3VZV A;  2VYR A;  4J3E A;  2M86 B;  4UD7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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