4ERFA

Crystal structure of mdm2 (17-111) in complex with compound 29 (am-8553)
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
92
structure length
92
Chain Sequence
IPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Ligase/ligase inhibitor
molecule keywords E3 ubiquitin-protein ligase Mdm2
publication title Structure-based design of novel inhibitors of the MDM2-p53 interaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 27
structure length 92
sequence length 92
chains with identical sequence C, E
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2012-04-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 4erfA00
1T4EA 4ZYCA 4WT2A 5HMIA 3W69A 4ZFIA 4J7EA 3IWYA 2MPSA 4JWRA 1Z1MA 3LBKA 4JVEA 3TJ2A 3JZKA 3V3BA 4OASA 5LN2A 3FDOA 4LWVA 3EQYA 2AXIA 3JZPA 4HFZA 2N0UA 5AFGA 3JZOA 4RXZA 3FEAA 4JV7A 4N5TA 4OQ3A 3U15A 3VZVA 3JZQA 4JV9A 3VBGA 2MWYA 1YCRA 4UMNA 3JZSA 4ZYFA 5HMKA 4UD7A 2N14A 2Z5TM 3LNJA 4HG7A 5TRFA 4ZYIA 5LAYA 4JSCA 1UHRA 2GV2A 5HMHA 1RV1A 5LAWA 4HBMA 3TPXA 2N06A 3JZRA 4OGNA 4UE1A 5LAVA 3G03A 2RUHA 3FE7A 4EREA 3TU1A 4MDQA 3DABA 5LAZA 3LNZA 4OCCA 4OGVA 5C5AA 4QO4A 4J7DA 4ERFA 4J3EA 2LZGA 2VYRA 3LBJE 4ODFA 3LBLA 4ZGKA 2M86B 4IPFA 1V31A 4JVRA 2N0WA 3IUXA 4OBAA 3EQSA 4MDNA 4QOCA 1YCQA 4JRGA 4LWUA 1TTVA 1T4FM 1V32A 4DIJA 4ODEA 4LWTA 4OGTA 2Z5SM 3DACA 4J74A
chains in the Genus database with same CATH superfamily
1T4EA 4ZYCA 4WT2A 5HMIA 3W69A 4ZFIA 4J7EA 3IWYA 2MPSA 4JWRA 1Z1MA 3LBKA 4JVEA 3TJ2A 3JZKA 3V3BA 4OASA 5LN2A 3FDOA 4LWVA 3EQYA 2AXIA 3JZPA 4HFZA 2N0UA 5AFGA 3JZOA 4RXZA 3FEAA 4JV7A 4N5TA 4OQ3A 3U15A 3VZVA 3JZQA 4JV9A 3VBGA 2MWYA 1YCRA 4UMNA 3JZSA 4ZYFA 5HMKA 4UD7A 2N14A 2Z5TM 3LNJA 4HG7A 5TRFA 4ZYIA 5LAYA 4JSCA 1UHRA 2GV2A 5HMHA 1RV1A 5LAWA 4HBMA 3TPXA 2N06A 3JZRA 4OGNA 4UE1A 5LAVA 3G03A 2RUHA 3FE7A 4EREA 3TU1A 4MDQA 3DABA 5LAZA 3LNZA 4OCCA 4OGVA 5C5AA 4QO4A 4J7DA 4ERFA 4J3EA 2LZGA 2VYRA 3LBJE 4ODFA 3LBLA 4ZGKA 2M86B 4IPFA 1V31A 4JVRA 2N0WA 3IUXA 4OBAA 3EQSA 4MDNA 4QOCA 1YCQA 4JRGA 4LWUA 1TTVA 1T4FM 1V32A 4DIJA 4ODEA 4LWTA 4OGTA 2Z5SM 3DACA 4J74A
chains in the Genus database with same CATH topology
1T4EA 4ZYCA 4WT2A 5HMIA 3W69A 4ZFIA 4J7EA 3IWYA 2MPSA 4JWRA 1Z1MA 3LBKA 4JVEA 3TJ2A 3JZKA 3V3BA 4OASA 5LN2A 3FDOA 4LWVA 3EQYA 2AXIA 3JZPA 4HFZA 2N0UA 5AFGA 3JZOA 4RXZA 3FEAA 4JV7A 4N5TA 4OQ3A 3U15A 3VZVA 3JZQA 4JV9A 3VBGA 2MWYA 1YCRA 4UMNA 3JZSA 4ZYFA 5HMKA 4UD7A 2N14A 2Z5TM 3LNJA 4HG7A 5TRFA 4ZYIA 5LAYA 4JSCA 1UHRA 2GV2A 5HMHA 1RV1A 5LAWA 4HBMA 3TPXA 2N06A 3JZRA 4OGNA 4UE1A 5LAVA 3G03A 2RUHA 3FE7A 4EREA 3TU1A 4MDQA 3DABA 5LAZA 3LNZA 4OCCA 4OGVA 5C5AA 4QO4A 4J7DA 4ERFA 4J3EA 2LZGA 2VYRA 3LBJE 4ODFA 3LBLA 4ZGKA 2M86B 4IPFA 1V31A 4JVRA 2N0WA 3IUXA 4OBAA 3EQSA 4MDNA 4QOCA 1YCQA 4JRGA 4LWUA 1TTVA 1T4FM 1V32A 4DIJA 4ODEA 4LWTA 4OGTA 2Z5SM 3DACA 4J74A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T4E A;  4ZYC A;  4WT2 A;  5HMI A;  3W69 A;  4ZFI A;  4J7E A;  3IWY A;  2MPS A;  4JWR A;  1Z1M A;  3LBK A;  4JVE A;  3TJ2 A;  3JZK A;  3V3B A;  4OAS A;  5LN2 A;  3FDO A;  4LWV A;  3EQY A;  2AXI A;  3JZP A;  4HFZ A;  2N0U A;  5AFG A;  3JZO A;  4RXZ A;  3FEA A;  4JV7 A;  4N5T A;  4OQ3 A;  3U15 A;  3VZV A;  3JZQ A;  4JV9 A;  3VBG A;  2MWY A;  1YCR A;  4UMN A;  3JZS A;  4ZYF A;  5HMK A;  4UD7 A;  2N14 A;  2Z5T M;  3LNJ A;  4HG7 A;  5TRF A;  4ZYI A;  5LAY A;  4JSC A;  1UHR A;  2GV2 A;  5HMH A;  1RV1 A;  5LAW A;  4HBM A;  3TPX A;  2N06 A;  3JZR A;  4OGN A;  4UE1 A;  5LAV A;  3G03 A;  2RUH A;  3FE7 A;  4ERE A;  3TU1 A;  4MDQ A;  3DAB A;  5LAZ A;  3LNZ A;  4OCC A;  4OGV A;  5C5A A;  4QO4 A;  4J7D A;  4ERF A;  4J3E A;  2LZG A;  2VYR A;  3LBJ E;  4ODF A;  3LBL A;  4ZGK A;  2M86 B;  4IPF A;  1V31 A;  4JVR A;  2N0W A;  3IUX A;  4OBA A;  3EQS A;  4MDN A;  4QOC A;  1YCQ A;  4JRG A;  4LWU A;  1TTV A;  1T4F M;  1V32 A;  4DIJ A;  4ODE A;  4LWT A;  4OGT A;  2Z5S M;  3DAC A;  4J74 A; 
#chains in the Genus database with same CATH topology
 1T4E A;  4ZYC A;  4WT2 A;  5HMI A;  3W69 A;  4ZFI A;  4J7E A;  3IWY A;  2MPS A;  4JWR A;  1Z1M A;  3LBK A;  4JVE A;  3TJ2 A;  3JZK A;  3V3B A;  4OAS A;  5LN2 A;  3FDO A;  4LWV A;  3EQY A;  2AXI A;  3JZP A;  4HFZ A;  2N0U A;  5AFG A;  3JZO A;  4RXZ A;  3FEA A;  4JV7 A;  4N5T A;  4OQ3 A;  3U15 A;  3VZV A;  3JZQ A;  4JV9 A;  3VBG A;  2MWY A;  1YCR A;  4UMN A;  3JZS A;  4ZYF A;  5HMK A;  4UD7 A;  2N14 A;  2Z5T M;  3LNJ A;  4HG7 A;  5TRF A;  4ZYI A;  5LAY A;  4JSC A;  1UHR A;  2GV2 A;  5HMH A;  1RV1 A;  5LAW A;  4HBM A;  3TPX A;  2N06 A;  3JZR A;  4OGN A;  4UE1 A;  5LAV A;  3G03 A;  2RUH A;  3FE7 A;  4ERE A;  3TU1 A;  4MDQ A;  3DAB A;  5LAZ A;  3LNZ A;  4OCC A;  4OGV A;  5C5A A;  4QO4 A;  4J7D A;  4ERF A;  4J3E A;  2LZG A;  2VYR A;  3LBJ E;  4ODF A;  3LBL A;  4ZGK A;  2M86 B;  4IPF A;  1V31 A;  4JVR A;  2N0W A;  3IUX A;  4OBA A;  3EQS A;  4MDN A;  4QOC A;  1YCQ A;  4JRG A;  4LWU A;  1TTV A;  1T4F M;  1V32 A;  4DIJ A;  4ODE A;  4LWT A;  4OGT A;  2Z5S M;  3DAC A;  4J74 A; 
#chains in the Genus database with same CATH homology
 1T4E A;  4ZYC A;  4WT2 A;  5HMI A;  3W69 A;  4ZFI A;  4J7E A;  3IWY A;  2MPS A;  4JWR A;  1Z1M A;  3LBK A;  4JVE A;  3TJ2 A;  3JZK A;  3V3B A;  4OAS A;  5LN2 A;  3FDO A;  4LWV A;  3EQY A;  2AXI A;  3JZP A;  4HFZ A;  2N0U A;  5AFG A;  3JZO A;  4RXZ A;  3FEA A;  4JV7 A;  4N5T A;  4OQ3 A;  3U15 A;  3VZV A;  3JZQ A;  4JV9 A;  3VBG A;  2MWY A;  1YCR A;  4UMN A;  3JZS A;  4ZYF A;  5HMK A;  4UD7 A;  2N14 A;  2Z5T M;  3LNJ A;  4HG7 A;  5TRF A;  4ZYI A;  5LAY A;  4JSC A;  1UHR A;  2GV2 A;  5HMH A;  1RV1 A;  5LAW A;  4HBM A;  3TPX A;  2N06 A;  3JZR A;  4OGN A;  4UE1 A;  5LAV A;  3G03 A;  2RUH A;  3FE7 A;  4ERE A;  3TU1 A;  4MDQ A;  3DAB A;  5LAZ A;  3LNZ A;  4OCC A;  4OGV A;  5C5A A;  4QO4 A;  4J7D A;  4ERF A;  4J3E A;  2LZG A;  2VYR A;  3LBJ E;  4ODF A;  3LBL A;  4ZGK A;  2M86 B;  4IPF A;  1V31 A;  4JVR A;  2N0W A;  3IUX A;  4OBA A;  3EQS A;  4MDN A;  4QOC A;  1YCQ A;  4JRG A;  4LWU A;  1TTV A;  1T4F M;  1V32 A;  4DIJ A;  4ODE A;  4LWT A;  4OGT A;  2Z5S M;  3DAC A;  4J74 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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