4GS7D

Structure of the interleukin-15 quaternary complex
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
67
structure length
67
Chain Sequence
ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Interleukin-15
total genus 14
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2012-08-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.230 Mainly Beta Single Sheet Rubrerythrin, domain 2 Rubrerythrin, domain 2 4gs7D01
1Z92B 2B5ID 2ERJA 2Z3QB 3IU3I 3NFPI 4GS7D 2ERSA 2PSMC 2Z3RB
chains in the Genus database with same CATH superfamily
3SS2A 1E8JA 2JA6L 1VZHA 4AHXA 4WFN1 1BE7A 3WWLA 1QCVA 1TWAL 2V0FA 2CR8A 4AYBP 4A3JL 4BBRL 3PO2L 3S17L 5MFZA 1YK5A 5IYDL 3LPEB 4AI3A 1BQ9A 1NXEA 1BRFA 1LKOA 4AI2A 1PFYA 5FLML 3PIP1 4E6YA 3A44A 4JAFA 3VPBE 2B63L 1B2JA 2M6OA 5FJ8L 1I6HL 1ZRPA 2XJTA 4AHWA 4V196 1YUZA 1RDGA 1RWDA 4A3EL 4A3CL 2JI2A 1ODHA 3FKIL 3PIO1 1WJVA 3M3YL 3GTGL 5IP9L 1IW7D 3K35A 2B5ID 2CKAA 4C2M1 3H97A 3MQKB 4X6AL 1PFVA 2ERSA 2DSXA 5IYBL 5C4XL 2WB1P 4U671 2Z3RB 4AHYA 5C3EL 3RZOL 5GAHc 1R9TL 1R0HA 3S1ML 1F4LA 3J7Z1 3H3VM 3M4OL 5EINC 1CADA 1K83L 1SMUA 1PFWA 2ZIXA 2QL0A 3S16L 3P8BA 1B13A 3GTJL 1IU5A 3H0GL 4BY7L 1NXGA 2KKDA 4JADA 4AHZA 1S2ZA 2WAQP 1Y1WL 1TWFL 5M5WL 4YWMA 2R92L 1PZXA 3JR7A 2Y0SP 3ZG6A 3MPSA 1T9PA 3I4ML 4ZN3B 3LWVB 2NYDA 2RFKB 1YV1A 2Z3QB 3H99A 4AR4A 1LKMA 3FDJA 1YUXA 2V0EA 5H1Sc 1TWCL 3LWQB 2K2DA 4JAEA 2NVXL 1BFYA 3J7Y1 4YWLA 3S15L 4C3IL 2AQCA 1DX8A 4BY1L 3S1RL 2A6HD 3KYVA 2ERJA 2APOB 3MSUA 5JVG1 3CQZL 5DM61 3LWPB 1TWHL 4LHLA 1SFOL 2VUML 1IU6A 1Y1VL 2XJUA 4G6BA 2GMGA 2MS3A 1R0FA 4BXXL 1FHMA 2XJVA 2LCQA 3RZDL 4LHNA 3HOVL 3H9CA 2V3BB 4AI0A 2M4YA 1LTLA 5C44L 7RXNA 2PVEA 2C6BA 4XGHA 3GTML 3S2HL 1R0JA 4GS7D 3KYXA 2C6AA 2XJRA 3S2DL 1VCXA 3P2AA 5MLC3 5DM71 1LKPA 4AR5A 3GTLL 4ZN1B 4POFA 1SMWA 5M5YL 5K2ME 1IRNA 3KYUA 3HOWL 3HOUL 3S1QL 1OWCA 2HR5A 4AR3A 3B08B 1RDVA 3LWRB 1TWGL 4TPUA 1FHHA 3S14L 3GTPL 2JI3A 1SMMA 2A6ED 1Z92B 2AYJA 4AR6A 2L0ZA 1R0IA 4A3DL 2PMZP 3NFPI 2O5JD 4AI1A 2JA8L 2PVXA 2NVTL 1QQTA 4C3HL 2JA5L 2NVYL 4Y52L 4XXBB 1NNQA 2HVYC 3KYYA 6RXNA 1I3QL 5MFPA 4UY81 2R93L 1CAAA 1QYBA 3GTQL 3HAXC 2M4VA 5EIOC 3PL5A 4A3LL 4A3ML 5MF6A 1S30A 2JI1A 4A3FL 2BE5D 2EY4E 1WCML 5M3ML 4TVMA 2E2HL 1S24A 3K7AL 5MGNA 3HJYB 5IYCL 2E2JL 1RYTA 5M3FL 3RZ6A 3GTOL 5GAGc 2M6PA 1C09A 3LWOB 1I50L 3HOYL 1DVBA 2YU9L 2NVQL 3PKIA 2VL6A 1PFUA 1VZGA 2PSMC 1P7PA 4POGA 4B8CD 2A68D 1JYBA 1B2OA 4A93L 2J9UB 3QQCE 2AUSB 5IY0A 3HOXL 1VZIA 2CKCA 2PPTA 2XJSA 3RZTA 1R0GA 3KYWA 5AI2A 5AN9H 1RYQA 3WWNB 1T9QA 3S1NL 3B0AB 5AI3A 3GTKL 5RXNA 3I4NL 4K9FA 5GAEc 4A3KL 4QIWP 3QVDA 4C3JL 2JA7L 4BBSL 5JVH1 8RXNA 3HOZL 3PZAA 2H12A 3H9BA 1YK4A 3PWFA 5GADc 1BQ8A 4A3GL 3PO3L 5M5XL 4Y7NL 3HKZP 2A69D 1RB9A 2RDVA 4A3BL 4JAGA 3IU3I 3PKJA 1T9OA 1IROA 3LNLA 1OWBA 1H7VA 2XJPA 1B71A 3HJWB 2PYAA 5IP7L 2R7ZL 4ME3A 4A3IL 2E2IL 2XJQA 5C4JL 2KN9A 3RYGA 4RXNA
chains in the Genus database with same CATH topology
1VCXA 2ZIXA 3P2AA 3SS2A 5MLC3 5DM71 2QL0A 3RZ6A 1LKPA 3P8BA 1B13A 2M6PA 1C09A 4AR5A 1E8JA 4ZN1B 1IU5A 4POFA 1VZHA 1DVBA 1NXGA 1SMWA 2KKDA 4JADA 4AHXA 5K2ME 4WFN1 1BE7A 3WWLA 4AHZA 1S2ZA 3PKIA 1QCVA 1IRNA 2VL6A 3KYUA 2V0FA 2CR8A 1VZGA 2PSMC 4YWMA 1OWCA 4POGA 5MFZA 1YK5A 2HR5A 4AR3A 3B08B 1RDVA 3LPEB 3ZG6A 4AI3A 3MPSA 1T9PA 1BQ9A 4B8CD 2A68D 1NXEA 1JYBA 4TPUA 1B2OA 4ZN3B 1FHHA 2J9UB 2NYDA 1YV1A 1BRFA 3QQCE 1LKOA 2Z3QB 4AR4A 4AI2A 3PIP1 1LKMA 1YUXA 5IY0A 2V0EA 4E6YA 3A44A 4JAFA 3VPBE 1VZIA 5H1Sc 2CKCA 2JI3A 2PPTA 1SMMA 1B2JA 2K2DA 2M6OA 2XJSA 2A6ED 3RZTA 1Z92B 1R0GA 3KYWA 5AI2A 5AN9H 1RYQA 4JAEA 1ZRPA 2AYJA 2XJTA 3J7Y1 1BFYA 3WWNB 1T9QA 4YWLA 4AR6A 2L0ZA 1R0IA 4AHWA 3B0AB 3NFPI 2O5JD 4AI1A 2PVXA 4V196 1YUZA 5AI3A 1DX8A 1RDGA 1RWDA 2A6HD 5RXNA 3KYVA 2ERJA 3MSUA 2JI2A 4K9FA 5GAEc 1ODHA 3PIO1 4XXBB 5JVG1 1WJVA 3QVDA 1NNQA 5JVH1 3KYYA 8RXNA 5DM61 1IW7D 3PZAA 3K35A 2B5ID 2H12A 1YK4A 6RXNA 3PWFA 5MFPA 4UY81 2CKAA 5GADc 1BQ8A 1CAAA 1QYBA 4LHLA 4RXNA 2A69D 1IU6A 2ERSA 1RB9A 2M4VA 2XJUA 2RDVA 5EIOC 2DSXA 4JAGA 4G6BA 2GMGA 3IU3I 2MS3A 1R0FA 4U671 1FHMA 3PKJA 2Z3RB 5MF6A 4AHYA 1T9OA 1IROA 1S30A 2JI1A 2XJVA 2LCQA 5GAHc 3LNLA 1OWBA 1H7VA 4LHNA 2V3BB 4AI0A 2M4YA 1LTLA 2XJPA 1R0HA 1B71A 2BE5D 2PYAA 7RXNA 3J7Z1 4ME3A 2PVEA 4TVMA 3RYGA 2C6BA 4XGHA 1S24A 2XJQA 1R0JA 4GS7D 3KYXA 5EINC 2C6AA 5MGNA 5GAGc 2KN9A 1CADA 1SMUA 2XJRA 1RYTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Z92 B;  2B5I D;  2ERJ A;  2Z3Q B;  3IU3 I;  3NFP I;  4GS7 D;  2ERS A;  2PSM C;  2Z3R B; 
#chains in the Genus database with same CATH topology
 3SS2 A;  1E8J A;  2JA6 L;  1VZH A;  4AHX A;  4WFN 1;  1BE7 A;  3WWL A;  1QCV A;  1TWA L;  2V0F A;  2CR8 A;  4AYB P;  4A3J L;  4BBR L;  3PO2 L;  3S17 L;  5MFZ A;  1YK5 A;  5IYD L;  3LPE B;  4AI3 A;  1BQ9 A;  1NXE A;  1BRF A;  1LKO A;  4AI2 A;  1PFY A;  5FLM L;  3PIP 1;  4E6Y A;  3A44 A;  4JAF A;  3VPB E;  2B63 L;  1B2J A;  2M6O A;  5FJ8 L;  1I6H L;  1ZRP A;  2XJT A;  4AHW A;  4V19 6;  1YUZ A;  1RDG A;  1RWD A;  4A3E L;  4A3C L;  2JI2 A;  1ODH A;  3FKI L;  3PIO 1;  1WJV A;  3M3Y L;  3GTG L;  5IP9 L;  1IW7 D;  3K35 A;  2B5I D;  2CKA A;  4C2M 1;  3H97 A;  3MQK B;  4X6A L;  1PFV A;  2ERS A;  2DSX A;  5IYB L;  5C4X L;  2WB1 P;  4U67 1;  2Z3R B;  4AHY A;  5C3E L;  3RZO L;  5GAH c;  1R9T L;  1R0H A;  3S1M L;  1F4L A;  3J7Z 1;  3H3V M;  3M4O L;  5EIN C;  1CAD A;  1K83 L;  1SMU A;  1PFW A;  2ZIX A;  2QL0 A;  3S16 L;  3P8B A;  1B13 A;  3GTJ L;  1IU5 A;  3H0G L;  4BY7 L;  1NXG A;  2KKD A;  4JAD A;  4AHZ A;  1S2Z A;  2WAQ P;  1Y1W L;  1TWF L;  5M5W L;  4YWM A;  2R92 L;  1PZX A;  3JR7 A;  2Y0S P;  3ZG6 A;  3MPS A;  1T9P A;  3I4M L;  4ZN3 B;  3LWV B;  2NYD A;  2RFK B;  1YV1 A;  2Z3Q B;  3H99 A;  4AR4 A;  1LKM A;  3FDJ A;  1YUX A;  2V0E A;  5H1S c;  1TWC L;  3LWQ B;  2K2D A;  4JAE A;  2NVX L;  1BFY A;  3J7Y 1;  4YWL A;  3S15 L;  4C3I L;  2AQC A;  1DX8 A;  4BY1 L;  3S1R L;  2A6H D;  3KYV A;  2ERJ A;  2APO B;  3MSU A;  5JVG 1;  3CQZ L;  5DM6 1;  3LWP B;  1TWH L;  4LHL A;  1SFO L;  2VUM L;  1IU6 A;  1Y1V L;  2XJU A;  4G6B A;  2GMG A;  2MS3 A;  1R0F A;  4BXX L;  1FHM A;  2XJV A;  2LCQ A;  3RZD L;  4LHN A;  3HOV L;  3H9C A;  2V3B B;  4AI0 A;  2M4Y A;  1LTL A;  5C44 L;  7RXN A;  2PVE A;  2C6B A;  4XGH A;  3GTM L;  3S2H L;  1R0J A;  4GS7 D;  3KYX A;  2C6A A;  2XJR A;  3S2D L;  1VCX A;  3P2A A;  5MLC 3;  5DM7 1;  1LKP A;  4AR5 A;  3GTL L;  4ZN1 B;  4POF A;  1SMW A;  5M5Y L;  5K2M E;  1IRN A;  3KYU A;  3HOW L;  3HOU L;  3S1Q L;  1OWC A;  2HR5 A;  4AR3 A;  3B08 B;  1RDV A;  3LWR B;  1TWG L;  4TPU A;  1FHH A;  3S14 L;  3GTP L;  2JI3 A;  1SMM A;  2A6E D;  1Z92 B;  2AYJ A;  4AR6 A;  2L0Z A;  1R0I A;  4A3D L;  2PMZ P;  3NFP I;  2O5J D;  4AI1 A;  2JA8 L;  2PVX A;  2NVT L;  1QQT A;  4C3H L;  2JA5 L;  2NVY L;  4Y52 L;  4XXB B;  1NNQ A;  2HVY C;  3KYY A;  6RXN A;  1I3Q L;  5MFP A;  4UY8 1;  2R93 L;  1CAA A;  1QYB A;  3GTQ L;  3HAX C;  2M4V A;  5EIO C;  3PL5 A;  4A3L L;  4A3M L;  5MF6 A;  1S30 A;  2JI1 A;  4A3F L;  2BE5 D;  2EY4 E;  1WCM L;  5M3M L;  4TVM A;  2E2H L;  1S24 A;  3K7A L;  5MGN A;  3HJY B;  5IYC L;  2E2J L;  1RYT A;  5M3F L;  3RZ6 A;  3GTO L;  5GAG c;  2M6P A;  1C09 A;  3LWO B;  1I50 L;  3HOY L;  1DVB A;  2YU9 L;  2NVQ L;  3PKI A;  2VL6 A;  1PFU A;  1VZG A;  2PSM C;  1P7P A;  4POG A;  4B8C D;  2A68 D;  1JYB A;  1B2O A;  4A93 L;  2J9U B;  3QQC E;  2AUS B;  5IY0 A;  3HOX L;  1VZI A;  2CKC A;  2PPT A;  2XJS A;  3RZT A;  1R0G A;  3KYW A;  5AI2 A;  5AN9 H;  1RYQ A;  3WWN B;  1T9Q A;  3S1N L;  3B0A B;  5AI3 A;  3GTK L;  5RXN A;  3I4N L;  4K9F A;  5GAE c;  4A3K L;  4QIW P;  3QVD A;  4C3J L;  2JA7 L;  4BBS L;  5JVH 1;  8RXN A;  3HOZ L;  3PZA A;  2H12 A;  3H9B A;  1YK4 A;  3PWF A;  5GAD c;  1BQ8 A;  4A3G L;  3PO3 L;  5M5X L;  4Y7N L;  3HKZ P;  2A69 D;  1RB9 A;  2RDV A;  4A3B L;  4JAG A;  3IU3 I;  3PKJ A;  1T9O A;  1IRO A;  3LNL A;  1OWB A;  1H7V A;  2XJP A;  1B71 A;  3HJW B;  2PYA A;  5IP7 L;  2R7Z L;  4ME3 A;  4A3I L;  2E2I L;  2XJQ A;  5C4J L;  2KN9 A;  3RYG A;  4RXN A; 
#chains in the Genus database with same CATH homology
 1VCX A;  2ZIX A;  3P2A A;  3SS2 A;  5MLC 3;  5DM7 1;  2QL0 A;  3RZ6 A;  1LKP A;  3P8B A;  1B13 A;  2M6P A;  1C09 A;  4AR5 A;  1E8J A;  4ZN1 B;  1IU5 A;  4POF A;  1VZH A;  1DVB A;  1NXG A;  1SMW A;  2KKD A;  4JAD A;  4AHX A;  5K2M E;  4WFN 1;  1BE7 A;  3WWL A;  4AHZ A;  1S2Z A;  3PKI A;  1QCV A;  1IRN A;  2VL6 A;  3KYU A;  2V0F A;  2CR8 A;  1VZG A;  2PSM C;  4YWM A;  1OWC A;  4POG A;  5MFZ A;  1YK5 A;  2HR5 A;  4AR3 A;  3B08 B;  1RDV A;  3LPE B;  3ZG6 A;  4AI3 A;  3MPS A;  1T9P A;  1BQ9 A;  4B8C D;  2A68 D;  1NXE A;  1JYB A;  4TPU A;  1B2O A;  4ZN3 B;  1FHH A;  2J9U B;  2NYD A;  1YV1 A;  1BRF A;  3QQC E;  1LKO A;  2Z3Q B;  4AR4 A;  4AI2 A;  3PIP 1;  1LKM A;  1YUX A;  5IY0 A;  2V0E A;  4E6Y A;  3A44 A;  4JAF A;  3VPB E;  1VZI A;  5H1S c;  2CKC A;  2JI3 A;  2PPT A;  1SMM A;  1B2J A;  2K2D A;  2M6O A;  2XJS A;  2A6E D;  3RZT A;  1Z92 B;  1R0G A;  3KYW A;  5AI2 A;  5AN9 H;  1RYQ A;  4JAE A;  1ZRP A;  2AYJ A;  2XJT A;  3J7Y 1;  1BFY A;  3WWN B;  1T9Q A;  4YWL A;  4AR6 A;  2L0Z A;  1R0I A;  4AHW A;  3B0A B;  3NFP I;  2O5J D;  4AI1 A;  2PVX A;  4V19 6;  1YUZ A;  5AI3 A;  1DX8 A;  1RDG A;  1RWD A;  2A6H D;  5RXN A;  3KYV A;  2ERJ A;  3MSU A;  2JI2 A;  4K9F A;  5GAE c;  1ODH A;  3PIO 1;  4XXB B;  5JVG 1;  1WJV A;  3QVD A;  1NNQ A;  5JVH 1;  3KYY A;  8RXN A;  5DM6 1;  1IW7 D;  3PZA A;  3K35 A;  2B5I D;  2H12 A;  1YK4 A;  6RXN A;  3PWF A;  5MFP A;  4UY8 1;  2CKA A;  5GAD c;  1BQ8 A;  1CAA A;  1QYB A;  4LHL A;  4RXN A;  2A69 D;  1IU6 A;  2ERS A;  1RB9 A;  2M4V A;  2XJU A;  2RDV A;  5EIO C;  2DSX A;  4JAG A;  4G6B A;  2GMG A;  3IU3 I;  2MS3 A;  1R0F A;  4U67 1;  1FHM A;  3PKJ A;  2Z3R B;  5MF6 A;  4AHY A;  1T9O A;  1IRO A;  1S30 A;  2JI1 A;  2XJV A;  2LCQ A;  5GAH c;  3LNL A;  1OWB A;  1H7V A;  4LHN A;  2V3B B;  4AI0 A;  2M4Y A;  1LTL A;  2XJP A;  1R0H A;  1B71 A;  2BE5 D;  2PYA A;  7RXN A;  3J7Z 1;  4ME3 A;  2PVE A;  4TVM A;  3RYG A;  2C6B A;  4XGH A;  1S24 A;  2XJQ A;  1R0J A;  4GS7 D;  3KYX A;  5EIN C;  2C6A A;  5MGN A;  5GAG c;  2KN9 A;  1CAD A;  1SMU A;  2XJR A;  1RYT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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