4IKRA

Crystal structure of type 1 human methionine aminopeptidase in complex with 2-(4-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)piperazin-1-yl)ethanol
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4ikrA00
1WL9A 3BIPA 5JFRA 4FLKA 1JAWA 3MR1A 5FCHA 2ZSGA 2BN7A 3S6BA 4QR8A 4B28A 3TB5A 4RGZ1 1C24A 2OAZA 4U71A 4IKUA 1YW9A 3PKEA 4U6ZA 4PNCA 2BWXA 4EGEA 1WL6A 3CTZA 3CB5A 1PV9A 4R60A 4S00A 4U6JA 2Q96A 1B6AA 2GTXA 3MATA 4U70A 4ZWOA 2MATA 2BHAA 2G6PA 4FLIA 4MATA 1R58A 2B3HA 2BHCA 4A6VA 4RZYA 4Z7MA 2OKNA 2GGCA 4ZWPA 5E5BA 2DFIA 2Q92A 2GU6A 1QZYA 2GG0A 5D6EA 5CDEA 3L7GA 1N51A 5CDLA 2V6CA 1W7VA 1XNZA 4IKSA 4RZZA 3L24A 4IPAA 4IU6A 4FLLA 4U73A 5D6FA 5CDVA 3D27A 3FMQA 4S01A 2V3XA 4IECA 3PKCA 1R5GA 2BWTA 1R5HA 4U69A 1Y1NA 1XGNA 2GG8A 4IKTA 4A6WA 1WLRA 3TAVA 3RORA 2EVMA 4FUKA 4U6WA 2NQ6A 4U76A 2NQ7A 2IW2A 2P98A 2BHBA 2V3YA 3IG4A 4U6EA 2BHDA 1C21A 1KP0A 1XGOA 4KM3A 5JHUA 5CLSA 4FLJA 2GZ5A 1BN5A 1WBQA 1O0XA 1M35A 2P9AA 3IU7A 2BWYA 2GG5A 1YW8A 2BWSA 2GGBA 1CHMA 2BWWA 1YVMA 3MX6A 3IU8A 5CNXA 3Q6DA 4FO8A 1XGSA 2GU7A 4U6CA 2P99A 2GU4A 1QXYA 2GG9A 3BIQA 1BOAA 4OOKA 4S2RP 5CE6A 1B59A 5JI6A 3FMRA 2B3KA 1QXZA 4FO7A 4U75A 4ZNGA 3CB6A 1A16A 5CIKA 2GG7A 1C27A 5FCFA 1WN1A 2Q8KA 1KQ9A 4IDYA 1QXWA 2HOWA 2GA2A 1C23A 3PKAA 4JUQA 4S2TP 3PKBA 2B3LA 1YW7A 2EA4A 2Q95A 4IF7A 3PKDA 4HXXA 4IKRA 1WKMA 2EVCA 1C22A 1KQ0A 1YJ3A 1XGMA 2GG3A 2EA2A 4PV4A 3FM3A 2GG2A 2BB7A 3BITA 2ADUA 2Q93A 3IU9A 3RVAA 4ZWUA 4FKCA 1MATA 4U1BA 2GU5A 1W2MA 2BH3A 2BWUA 2V3ZA 2BWVA 2EVOA 1WY2A 2Q94A
chains in the Genus database with same CATH superfamily
1WL9A 3BIPA 5JFRA 4FLKA 1JAWA 3MR1A 5FCHA 2ZSGA 2BN7A 3S6BA 4QR8A 4B28A 3TB5A 4RGZ1 1C24A 2OAZA 4U71A 4IKUA 1YW9A 3PKEA 4U6ZA 4PNCA 2BWXA 4EGEA 1WL6A 3CTZA 3CB5A 1PV9A 4R60A 4S00A 4U6JA 2Q96A 1B6AA 2GTXA 3MATA 4U70A 4ZWOA 2MATA 2BHAA 2G6PA 4FLIA 4MATA 1R58A 2B3HA 2BHCA 4A6VA 4RZYA 4Z7MA 2OKNA 2GGCA 4ZWPA 5E5BA 2DFIA 2Q92A 2GU6A 1QZYA 2GG0A 5D6EA 5CDEA 3L7GA 1N51A 5CDLA 2V6CA 1W7VA 1XNZA 4IKSA 4RZZA 3L24A 4IPAA 4IU6A 4FLLA 4U73A 5D6FA 5CDVA 3D27A 3FMQA 4S01A 2V3XA 4IECA 3PKCA 1R5GA 2BWTA 1R5HA 4U69A 1Y1NA 1XGNA 2GG8A 4IKTA 4A6WA 1WLRA 3TAVA 3RORA 2EVMA 4FUKA 4U6WA 2NQ6A 4U76A 2NQ7A 2IW2A 2P98A 2BHBA 2V3YA 3IG4A 4U6EA 2BHDA 1C21A 1KP0A 1XGOA 4KM3A 5JHUA 5CLSA 4FLJA 2GZ5A 1BN5A 1WBQA 1O0XA 1M35A 2P9AA 3IU7A 2BWYA 2GG5A 1YW8A 2BWSA 2GGBA 1CHMA 2BWWA 1YVMA 3MX6A 3IU8A 5CNXA 3Q6DA 4FO8A 1XGSA 2GU7A 4U6CA 2P99A 2GU4A 1QXYA 2GG9A 3BIQA 1BOAA 4OOKA 4S2RP 5CE6A 1B59A 5JI6A 3FMRA 2B3KA 1QXZA 4FO7A 4U75A 4ZNGA 3CB6A 1A16A 5CIKA 2GG7A 1C27A 5FCFA 1WN1A 2Q8KA 1KQ9A 4IDYA 1QXWA 2HOWA 2GA2A 1C23A 3PKAA 4JUQA 4S2TP 3PKBA 2B3LA 1YW7A 2EA4A 2Q95A 4IF7A 3PKDA 4HXXA 4IKRA 1WKMA 2EVCA 1C22A 1KQ0A 1YJ3A 1XGMA 2GG3A 2EA2A 4PV4A 3FM3A 2GG2A 2BB7A 3BITA 2ADUA 2Q93A 3IU9A 3RVAA 4ZWUA 4FKCA 1MATA 4U1BA 2GU5A 1W2MA 2BH3A 2BWUA 2V3ZA 2BWVA 2EVOA 1WY2A 2Q94A
chains in the Genus database with same CATH topology
1WL9A 3BIPA 5JFRA 4FLKA 1JAWA 3MR1A 5FCHA 2ZSGA 2BN7A 3S6BA 4QR8A 4B28A 3TB5A 4RGZ1 1C24A 2OAZA 4U71A 4IKUA 1YW9A 3PKEA 4U6ZA 4PNCA 2BWXA 4EGEA 1WL6A 3CTZA 3CB5A 1PV9A 4R60A 4S00A 4U6JA 2Q96A 1B6AA 2GTXA 3MATA 4U70A 4ZWOA 2MATA 2BHAA 2G6PA 4FLIA 4MATA 1R58A 2B3HA 2BHCA 4A6VA 4RZYA 4Z7MA 2OKNA 2GGCA 4ZWPA 5E5BA 2DFIA 2Q92A 2GU6A 1QZYA 2GG0A 5D6EA 5CDEA 3L7GA 1N51A 5CDLA 2V6CA 1W7VA 1XNZA 4IKSA 4RZZA 3L24A 4IPAA 4IU6A 4FLLA 4U73A 5D6FA 5CDVA 3D27A 3FMQA 4S01A 2V3XA 4IECA 3PKCA 1R5GA 2BWTA 1R5HA 4U69A 1Y1NA 1XGNA 2GG8A 4IKTA 4A6WA 1WLRA 3TAVA 3RORA 2EVMA 4FUKA 4U6WA 2NQ6A 4U76A 2NQ7A 2IW2A 2P98A 2BHBA 2V3YA 3IG4A 4U6EA 2BHDA 1C21A 1KP0A 1XGOA 4KM3A 5JHUA 5CLSA 4FLJA 2GZ5A 1BN5A 1WBQA 1O0XA 1M35A 2P9AA 3IU7A 2BWYA 2GG5A 1YW8A 2BWSA 2GGBA 1CHMA 2BWWA 1YVMA 3MX6A 3IU8A 5CNXA 3Q6DA 4FO8A 1XGSA 2GU7A 4U6CA 2P99A 2GU4A 1QXYA 2GG9A 3BIQA 1BOAA 4OOKA 4S2RP 5CE6A 1B59A 5JI6A 3FMRA 2B3KA 1QXZA 4FO7A 4U75A 4ZNGA 3CB6A 1A16A 5CIKA 2GG7A 1C27A 5FCFA 1WN1A 2Q8KA 1KQ9A 4IDYA 1QXWA 2HOWA 2GA2A 1C23A 3PKAA 4JUQA 4S2TP 3PKBA 2B3LA 1YW7A 2EA4A 2Q95A 4IF7A 3PKDA 4HXXA 4IKRA 1WKMA 2EVCA 1C22A 1KQ0A 1YJ3A 1XGMA 2GG3A 2EA2A 4PV4A 3FM3A 2GG2A 2BB7A 3BITA 2ADUA 2Q93A 3IU9A 3RVAA 4ZWUA 4FKCA 1MATA 4U1BA 2GU5A 1W2MA 2BH3A 2BWUA 2V3ZA 2BWVA 2EVOA 1WY2A 2Q94A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WL9 A;  3BIP A;  5JFR A;  4FLK A;  1JAW A;  3MR1 A;  5FCH A;  2ZSG A;  2BN7 A;  3S6B A;  4QR8 A;  4B28 A;  3TB5 A;  4RGZ 1;  1C24 A;  2OAZ A;  4U71 A;  4IKU A;  1YW9 A;  3PKE A;  4U6Z A;  4PNC A;  2BWX A;  4EGE A;  1WL6 A;  3CTZ A;  3CB5 A;  1PV9 A;  4R60 A;  4S00 A;  4U6J A;  2Q96 A;  1B6A A;  2GTX A;  3MAT A;  4U70 A;  4ZWO A;  2MAT A;  2BHA A;  2G6P A;  4FLI A;  4MAT A;  1R58 A;  2B3H A;  2BHC A;  4A6V A;  4RZY A;  4Z7M A;  2OKN A;  2GGC A;  4ZWP A;  5E5B A;  2DFI A;  2Q92 A;  2GU6 A;  1QZY A;  2GG0 A;  5D6E A;  5CDE A;  3L7G A;  1N51 A;  5CDL A;  2V6C A;  1W7V A;  1XNZ A;  4IKS A;  4RZZ A;  3L24 A;  4IPA A;  4IU6 A;  4FLL A;  4U73 A;  5D6F A;  5CDV A;  3D27 A;  3FMQ A;  4S01 A;  2V3X A;  4IEC A;  3PKC A;  1R5G A;  2BWT A;  1R5H A;  4U69 A;  1Y1N A;  1XGN A;  2GG8 A;  4IKT A;  4A6W A;  1WLR A;  3TAV A;  3ROR A;  2EVM A;  4FUK A;  4U6W A;  2NQ6 A;  4U76 A;  2NQ7 A;  2IW2 A;  2P98 A;  2BHB A;  2V3Y A;  3IG4 A;  4U6E A;  2BHD A;  1C21 A;  1KP0 A;  1XGO A;  4KM3 A;  5JHU A;  5CLS A;  4FLJ A;  2GZ5 A;  1BN5 A;  1WBQ A;  1O0X A;  1M35 A;  2P9A A;  3IU7 A;  2BWY A;  2GG5 A;  1YW8 A;  2BWS A;  2GGB A;  1CHM A;  2BWW A;  1YVM A;  3MX6 A;  3IU8 A;  5CNX A;  3Q6D A;  4FO8 A;  1XGS A;  2GU7 A;  4U6C A;  2P99 A;  2GU4 A;  1QXY A;  2GG9 A;  3BIQ A;  1BOA A;  4OOK A;  4S2R P;  5CE6 A;  1B59 A;  5JI6 A;  3FMR A;  2B3K A;  1QXZ A;  4FO7 A;  4U75 A;  4ZNG A;  3CB6 A;  1A16 A;  5CIK A;  2GG7 A;  1C27 A;  5FCF A;  1WN1 A;  2Q8K A;  1KQ9 A;  4IDY A;  1QXW A;  2HOW A;  2GA2 A;  1C23 A;  3PKA A;  4JUQ A;  4S2T P;  3PKB A;  2B3L A;  1YW7 A;  2EA4 A;  2Q95 A;  4IF7 A;  3PKD A;  4HXX A;  4IKR A;  1WKM A;  2EVC A;  1C22 A;  1KQ0 A;  1YJ3 A;  1XGM A;  2GG3 A;  2EA2 A;  4PV4 A;  3FM3 A;  2GG2 A;  2BB7 A;  3BIT A;  2ADU A;  2Q93 A;  3IU9 A;  3RVA A;  4ZWU A;  4FKC A;  1MAT A;  4U1B A;  2GU5 A;  1W2M A;  2BH3 A;  2BWU A;  2V3Z A;  2BWV A;  2EVO A;  1WY2 A;  2Q94 A; 
#chains in the Genus database with same CATH topology
 1WL9 A;  3BIP A;  5JFR A;  4FLK A;  1JAW A;  3MR1 A;  5FCH A;  2ZSG A;  2BN7 A;  3S6B A;  4QR8 A;  4B28 A;  3TB5 A;  4RGZ 1;  1C24 A;  2OAZ A;  4U71 A;  4IKU A;  1YW9 A;  3PKE A;  4U6Z A;  4PNC A;  2BWX A;  4EGE A;  1WL6 A;  3CTZ A;  3CB5 A;  1PV9 A;  4R60 A;  4S00 A;  4U6J A;  2Q96 A;  1B6A A;  2GTX A;  3MAT A;  4U70 A;  4ZWO A;  2MAT A;  2BHA A;  2G6P A;  4FLI A;  4MAT A;  1R58 A;  2B3H A;  2BHC A;  4A6V A;  4RZY A;  4Z7M A;  2OKN A;  2GGC A;  4ZWP A;  5E5B A;  2DFI A;  2Q92 A;  2GU6 A;  1QZY A;  2GG0 A;  5D6E A;  5CDE A;  3L7G A;  1N51 A;  5CDL A;  2V6C A;  1W7V A;  1XNZ A;  4IKS A;  4RZZ A;  3L24 A;  4IPA A;  4IU6 A;  4FLL A;  4U73 A;  5D6F A;  5CDV A;  3D27 A;  3FMQ A;  4S01 A;  2V3X A;  4IEC A;  3PKC A;  1R5G A;  2BWT A;  1R5H A;  4U69 A;  1Y1N A;  1XGN A;  2GG8 A;  4IKT A;  4A6W A;  1WLR A;  3TAV A;  3ROR A;  2EVM A;  4FUK A;  4U6W A;  2NQ6 A;  4U76 A;  2NQ7 A;  2IW2 A;  2P98 A;  2BHB A;  2V3Y A;  3IG4 A;  4U6E A;  2BHD A;  1C21 A;  1KP0 A;  1XGO A;  4KM3 A;  5JHU A;  5CLS A;  4FLJ A;  2GZ5 A;  1BN5 A;  1WBQ A;  1O0X A;  1M35 A;  2P9A A;  3IU7 A;  2BWY A;  2GG5 A;  1YW8 A;  2BWS A;  2GGB A;  1CHM A;  2BWW A;  1YVM A;  3MX6 A;  3IU8 A;  5CNX A;  3Q6D A;  4FO8 A;  1XGS A;  2GU7 A;  4U6C A;  2P99 A;  2GU4 A;  1QXY A;  2GG9 A;  3BIQ A;  1BOA A;  4OOK A;  4S2R P;  5CE6 A;  1B59 A;  5JI6 A;  3FMR A;  2B3K A;  1QXZ A;  4FO7 A;  4U75 A;  4ZNG A;  3CB6 A;  1A16 A;  5CIK A;  2GG7 A;  1C27 A;  5FCF A;  1WN1 A;  2Q8K A;  1KQ9 A;  4IDY A;  1QXW A;  2HOW A;  2GA2 A;  1C23 A;  3PKA A;  4JUQ A;  4S2T P;  3PKB A;  2B3L A;  1YW7 A;  2EA4 A;  2Q95 A;  4IF7 A;  3PKD A;  4HXX A;  4IKR A;  1WKM A;  2EVC A;  1C22 A;  1KQ0 A;  1YJ3 A;  1XGM A;  2GG3 A;  2EA2 A;  4PV4 A;  3FM3 A;  2GG2 A;  2BB7 A;  3BIT A;  2ADU A;  2Q93 A;  3IU9 A;  3RVA A;  4ZWU A;  4FKC A;  1MAT A;  4U1B A;  2GU5 A;  1W2M A;  2BH3 A;  2BWU A;  2V3Z A;  2BWV A;  2EVO A;  1WY2 A;  2Q94 A; 
#chains in the Genus database with same CATH homology
 1WL9 A;  3BIP A;  5JFR A;  4FLK A;  1JAW A;  3MR1 A;  5FCH A;  2ZSG A;  2BN7 A;  3S6B A;  4QR8 A;  4B28 A;  3TB5 A;  4RGZ 1;  1C24 A;  2OAZ A;  4U71 A;  4IKU A;  1YW9 A;  3PKE A;  4U6Z A;  4PNC A;  2BWX A;  4EGE A;  1WL6 A;  3CTZ A;  3CB5 A;  1PV9 A;  4R60 A;  4S00 A;  4U6J A;  2Q96 A;  1B6A A;  2GTX A;  3MAT A;  4U70 A;  4ZWO A;  2MAT A;  2BHA A;  2G6P A;  4FLI A;  4MAT A;  1R58 A;  2B3H A;  2BHC A;  4A6V A;  4RZY A;  4Z7M A;  2OKN A;  2GGC A;  4ZWP A;  5E5B A;  2DFI A;  2Q92 A;  2GU6 A;  1QZY A;  2GG0 A;  5D6E A;  5CDE A;  3L7G A;  1N51 A;  5CDL A;  2V6C A;  1W7V A;  1XNZ A;  4IKS A;  4RZZ A;  3L24 A;  4IPA A;  4IU6 A;  4FLL A;  4U73 A;  5D6F A;  5CDV A;  3D27 A;  3FMQ A;  4S01 A;  2V3X A;  4IEC A;  3PKC A;  1R5G A;  2BWT A;  1R5H A;  4U69 A;  1Y1N A;  1XGN A;  2GG8 A;  4IKT A;  4A6W A;  1WLR A;  3TAV A;  3ROR A;  2EVM A;  4FUK A;  4U6W A;  2NQ6 A;  4U76 A;  2NQ7 A;  2IW2 A;  2P98 A;  2BHB A;  2V3Y A;  3IG4 A;  4U6E A;  2BHD A;  1C21 A;  1KP0 A;  1XGO A;  4KM3 A;  5JHU A;  5CLS A;  4FLJ A;  2GZ5 A;  1BN5 A;  1WBQ A;  1O0X A;  1M35 A;  2P9A A;  3IU7 A;  2BWY A;  2GG5 A;  1YW8 A;  2BWS A;  2GGB A;  1CHM A;  2BWW A;  1YVM A;  3MX6 A;  3IU8 A;  5CNX A;  3Q6D A;  4FO8 A;  1XGS A;  2GU7 A;  4U6C A;  2P99 A;  2GU4 A;  1QXY A;  2GG9 A;  3BIQ A;  1BOA A;  4OOK A;  4S2R P;  5CE6 A;  1B59 A;  5JI6 A;  3FMR A;  2B3K A;  1QXZ A;  4FO7 A;  4U75 A;  4ZNG A;  3CB6 A;  1A16 A;  5CIK A;  2GG7 A;  1C27 A;  5FCF A;  1WN1 A;  2Q8K A;  1KQ9 A;  4IDY A;  1QXW A;  2HOW A;  2GA2 A;  1C23 A;  3PKA A;  4JUQ A;  4S2T P;  3PKB A;  2B3L A;  1YW7 A;  2EA4 A;  2Q95 A;  4IF7 A;  3PKD A;  4HXX A;  4IKR A;  1WKM A;  2EVC A;  1C22 A;  1KQ0 A;  1YJ3 A;  1XGM A;  2GG3 A;  2EA2 A;  4PV4 A;  3FM3 A;  2GG2 A;  2BB7 A;  3BIT A;  2ADU A;  2Q93 A;  3IU9 A;  3RVA A;  4ZWU A;  4FKC A;  1MAT A;  4U1B A;  2GU5 A;  1W2M A;  2BH3 A;  2BWU A;  2V3Z A;  2BWV A;  2EVO A;  1WY2 A;  2Q94 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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