4IKUA

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4ikuA00
2OAZA 4IPAA 1WL6A 4PV4A 3MATA 4IKTA 4RGZ1 5E5BA 3TAVA 2P9AA 4U6WA 3CB5A 2GTXA 2GG3A 4ZWOA 1MATA 2EVMA 3PKBA 1WKMA 4U75A 4U76A 3BIPA 3IU7A 1KP0A 2GU4A 2Q8KA 1C24A 4R60A 1C22A 1YW7A 1B59A 2V3YA 2GG5A 1XGSA 1Y1NA 4IDYA 5CLSA 4B28A 1A16A 1WY2A 4IKRA 4Z7MA 3PKAA 2DFIA 4RZYA 5FCHA 1R58A 2GG7A 3BIQA 4IU6A 1O0XA 5JFRA 2GG2A 2EVOA 2Q96A 2V3XA 2BWWA 4HXXA 2BN7A 2GGBA 4IKSA 4U69A 5D6EA 3PKEA 3L7GA 1QXWA 1WLRA 1QXZA 2MATA 3PKCA 5CDVA 4RZZA 2Q95A 2GU7A 2V3ZA 2EA2A 2V6CA 4PNCA 2GU5A 1JAWA 1BN5A 3Q6DA 4U6ZA 2BWUA 1C21A 5JHUA 5CIKA 1XNZA 2BWYA 1W7VA 2NQ6A 2OKNA 4MATA 5JI6A 3BITA 4FO8A 2Q94A 4S00A 4OOKA 4U6CA 1PV9A 3FMRA 4U70A 2BWVA 4FLLA 1WN1A 3CB6A 4QR8A 2GG8A 4IKUA 1YVMA 5CE6A 1C23A 3IU9A 4A6VA 4IF7A 2ZSGA 2IW2A 4JUQA 2B3HA 2BHDA 2NQ7A 4U73A 1KQ9A 1N51A 2GU6A 3PKDA 2BWTA 4S01A 1R5GA 1WBQA 4U6EA 3CTZA 5FCFA 5CDEA 4A6WA 4KM3A 3TB5A 2EVCA 4ZWPA 2P98A 3RVAA 1R5HA 2GG0A 3RORA 3IG4A 3FM3A 1YW8A 2BHBA 2GG9A 3L24A 4FLJA 4FUKA 4ZWUA 1QZYA 2GGCA 2BWSA 4FLKA 2Q92A 2B3KA 4U6JA 5D6FA 2Q93A 4FLIA 4U1BA 2BHAA 4ZNGA 3IU8A 1BOAA 1XGNA 1KQ0A 2BB7A 2EA4A 1QXYA 3S6BA 4EGEA 2BWXA 5CDLA 4S2RP 3MR1A 2ADUA 4IECA 1CHMA 4U71A 1WL9A 5CNXA 1YJ3A 4FO7A 3FMQA 2GZ5A 2BHCA 2HOWA 4S2TP 1M35A 1XGMA 4FKCA 1YW9A 1B6AA 3MX6A 1C27A 1XGOA 2GA2A 2B3LA 2BH3A 3D27A 2P99A 2G6PA 1W2MA
chains in the Genus database with same CATH superfamily
2OAZA 4IPAA 1WL6A 4PV4A 3MATA 4IKTA 4RGZ1 5E5BA 3TAVA 2P9AA 4U6WA 3CB5A 2GTXA 2GG3A 4ZWOA 1MATA 2EVMA 3PKBA 1WKMA 4U75A 4U76A 3BIPA 3IU7A 1KP0A 2GU4A 2Q8KA 1C24A 4R60A 1C22A 1YW7A 1B59A 2V3YA 2GG5A 1XGSA 1Y1NA 4IDYA 5CLSA 4B28A 1A16A 1WY2A 4IKRA 4Z7MA 3PKAA 2DFIA 4RZYA 5FCHA 1R58A 2GG7A 3BIQA 4IU6A 1O0XA 5JFRA 2GG2A 2EVOA 2Q96A 2V3XA 2BWWA 4HXXA 2BN7A 2GGBA 4IKSA 4U69A 5D6EA 3PKEA 3L7GA 1QXWA 1WLRA 1QXZA 2MATA 3PKCA 5CDVA 4RZZA 2Q95A 2GU7A 2V3ZA 2EA2A 2V6CA 4PNCA 2GU5A 1JAWA 1BN5A 3Q6DA 4U6ZA 2BWUA 1C21A 5JHUA 5CIKA 1XNZA 2BWYA 1W7VA 2NQ6A 2OKNA 4MATA 5JI6A 3BITA 4FO8A 2Q94A 4S00A 4OOKA 4U6CA 1PV9A 3FMRA 4U70A 2BWVA 4FLLA 1WN1A 3CB6A 4QR8A 2GG8A 4IKUA 1YVMA 5CE6A 1C23A 3IU9A 4A6VA 4IF7A 2ZSGA 2IW2A 4JUQA 2B3HA 2BHDA 2NQ7A 4U73A 1KQ9A 1N51A 2GU6A 3PKDA 2BWTA 4S01A 1R5GA 1WBQA 4U6EA 3CTZA 5FCFA 5CDEA 4A6WA 4KM3A 3TB5A 2EVCA 4ZWPA 2P98A 3RVAA 1R5HA 2GG0A 3RORA 3IG4A 3FM3A 1YW8A 2BHBA 2GG9A 3L24A 4FLJA 4FUKA 4ZWUA 1QZYA 2GGCA 2BWSA 4FLKA 2Q92A 2B3KA 4U6JA 5D6FA 2Q93A 4FLIA 4U1BA 2BHAA 4ZNGA 3IU8A 1BOAA 1XGNA 1KQ0A 2BB7A 2EA4A 1QXYA 3S6BA 4EGEA 2BWXA 5CDLA 4S2RP 3MR1A 2ADUA 4IECA 1CHMA 4U71A 1WL9A 5CNXA 1YJ3A 4FO7A 3FMQA 2GZ5A 2BHCA 2HOWA 4S2TP 1M35A 1XGMA 4FKCA 1YW9A 1B6AA 3MX6A 1C27A 1XGOA 2GA2A 2B3LA 2BH3A 3D27A 2P99A 2G6PA 1W2MA
chains in the Genus database with same CATH topology
2OAZA 4IPAA 1WL6A 4PV4A 3MATA 4IKTA 4RGZ1 5E5BA 3TAVA 2P9AA 4U6WA 3CB5A 2GTXA 2GG3A 4ZWOA 1MATA 2EVMA 3PKBA 1WKMA 4U75A 4U76A 3BIPA 3IU7A 1KP0A 2GU4A 2Q8KA 1C24A 4R60A 1C22A 1YW7A 1B59A 2V3YA 2GG5A 1XGSA 1Y1NA 4IDYA 5CLSA 4B28A 1A16A 1WY2A 4IKRA 4Z7MA 3PKAA 2DFIA 4RZYA 5FCHA 1R58A 2GG7A 3BIQA 4IU6A 1O0XA 5JFRA 2GG2A 2EVOA 2Q96A 2V3XA 2BWWA 4HXXA 2BN7A 2GGBA 4IKSA 4U69A 5D6EA 3PKEA 3L7GA 1QXWA 1WLRA 1QXZA 2MATA 3PKCA 5CDVA 4RZZA 2Q95A 2GU7A 2V3ZA 2EA2A 2V6CA 4PNCA 2GU5A 1JAWA 1BN5A 3Q6DA 4U6ZA 2BWUA 1C21A 5JHUA 5CIKA 1XNZA 2BWYA 1W7VA 2NQ6A 2OKNA 4MATA 5JI6A 3BITA 4FO8A 2Q94A 4S00A 4OOKA 4U6CA 1PV9A 3FMRA 4U70A 2BWVA 4FLLA 1WN1A 3CB6A 4QR8A 2GG8A 4IKUA 1YVMA 5CE6A 1C23A 3IU9A 4A6VA 4IF7A 2ZSGA 2IW2A 4JUQA 2B3HA 2BHDA 2NQ7A 4U73A 1KQ9A 1N51A 2GU6A 3PKDA 2BWTA 4S01A 1R5GA 1WBQA 4U6EA 3CTZA 5FCFA 5CDEA 4A6WA 4KM3A 3TB5A 2EVCA 4ZWPA 2P98A 3RVAA 1R5HA 2GG0A 3RORA 3IG4A 3FM3A 1YW8A 2BHBA 2GG9A 3L24A 4FLJA 4FUKA 4ZWUA 1QZYA 2GGCA 2BWSA 4FLKA 2Q92A 2B3KA 4U6JA 5D6FA 2Q93A 4FLIA 4U1BA 2BHAA 4ZNGA 3IU8A 1BOAA 1XGNA 1KQ0A 2BB7A 2EA4A 1QXYA 3S6BA 4EGEA 2BWXA 5CDLA 4S2RP 3MR1A 2ADUA 4IECA 1CHMA 4U71A 1WL9A 5CNXA 1YJ3A 4FO7A 3FMQA 2GZ5A 2BHCA 2HOWA 4S2TP 1M35A 1XGMA 4FKCA 1YW9A 1B6AA 3MX6A 1C27A 1XGOA 2GA2A 2B3LA 2BH3A 3D27A 2P99A 2G6PA 1W2MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OAZ A;  4IPA A;  1WL6 A;  4PV4 A;  3MAT A;  4IKT A;  4RGZ 1;  5E5B A;  3TAV A;  2P9A A;  4U6W A;  3CB5 A;  2GTX A;  2GG3 A;  4ZWO A;  1MAT A;  2EVM A;  3PKB A;  1WKM A;  4U75 A;  4U76 A;  3BIP A;  3IU7 A;  1KP0 A;  2GU4 A;  2Q8K A;  1C24 A;  4R60 A;  1C22 A;  1YW7 A;  1B59 A;  2V3Y A;  2GG5 A;  1XGS A;  1Y1N A;  4IDY A;  5CLS A;  4B28 A;  1A16 A;  1WY2 A;  4IKR A;  4Z7M A;  3PKA A;  2DFI A;  4RZY A;  5FCH A;  1R58 A;  2GG7 A;  3BIQ A;  4IU6 A;  1O0X A;  5JFR A;  2GG2 A;  2EVO A;  2Q96 A;  2V3X A;  2BWW A;  4HXX A;  2BN7 A;  2GGB A;  4IKS A;  4U69 A;  5D6E A;  3PKE A;  3L7G A;  1QXW A;  1WLR A;  1QXZ A;  2MAT A;  3PKC A;  5CDV A;  4RZZ A;  2Q95 A;  2GU7 A;  2V3Z A;  2EA2 A;  2V6C A;  4PNC A;  2GU5 A;  1JAW A;  1BN5 A;  3Q6D A;  4U6Z A;  2BWU A;  1C21 A;  5JHU A;  5CIK A;  1XNZ A;  2BWY A;  1W7V A;  2NQ6 A;  2OKN A;  4MAT A;  5JI6 A;  3BIT A;  4FO8 A;  2Q94 A;  4S00 A;  4OOK A;  4U6C A;  1PV9 A;  3FMR A;  4U70 A;  2BWV A;  4FLL A;  1WN1 A;  3CB6 A;  4QR8 A;  2GG8 A;  4IKU A;  1YVM A;  5CE6 A;  1C23 A;  3IU9 A;  4A6V A;  4IF7 A;  2ZSG A;  2IW2 A;  4JUQ A;  2B3H A;  2BHD A;  2NQ7 A;  4U73 A;  1KQ9 A;  1N51 A;  2GU6 A;  3PKD A;  2BWT A;  4S01 A;  1R5G A;  1WBQ A;  4U6E A;  3CTZ A;  5FCF A;  5CDE A;  4A6W A;  4KM3 A;  3TB5 A;  2EVC A;  4ZWP A;  2P98 A;  3RVA A;  1R5H A;  2GG0 A;  3ROR A;  3IG4 A;  3FM3 A;  1YW8 A;  2BHB A;  2GG9 A;  3L24 A;  4FLJ A;  4FUK A;  4ZWU A;  1QZY A;  2GGC A;  2BWS A;  4FLK A;  2Q92 A;  2B3K A;  4U6J A;  5D6F A;  2Q93 A;  4FLI A;  4U1B A;  2BHA A;  4ZNG A;  3IU8 A;  1BOA A;  1XGN A;  1KQ0 A;  2BB7 A;  2EA4 A;  1QXY A;  3S6B A;  4EGE A;  2BWX A;  5CDL A;  4S2R P;  3MR1 A;  2ADU A;  4IEC A;  1CHM A;  4U71 A;  1WL9 A;  5CNX A;  1YJ3 A;  4FO7 A;  3FMQ A;  2GZ5 A;  2BHC A;  2HOW A;  4S2T P;  1M35 A;  1XGM A;  4FKC A;  1YW9 A;  1B6A A;  3MX6 A;  1C27 A;  1XGO A;  2GA2 A;  2B3L A;  2BH3 A;  3D27 A;  2P99 A;  2G6P A;  1W2M A; 
#chains in the Genus database with same CATH topology
 2OAZ A;  4IPA A;  1WL6 A;  4PV4 A;  3MAT A;  4IKT A;  4RGZ 1;  5E5B A;  3TAV A;  2P9A A;  4U6W A;  3CB5 A;  2GTX A;  2GG3 A;  4ZWO A;  1MAT A;  2EVM A;  3PKB A;  1WKM A;  4U75 A;  4U76 A;  3BIP A;  3IU7 A;  1KP0 A;  2GU4 A;  2Q8K A;  1C24 A;  4R60 A;  1C22 A;  1YW7 A;  1B59 A;  2V3Y A;  2GG5 A;  1XGS A;  1Y1N A;  4IDY A;  5CLS A;  4B28 A;  1A16 A;  1WY2 A;  4IKR A;  4Z7M A;  3PKA A;  2DFI A;  4RZY A;  5FCH A;  1R58 A;  2GG7 A;  3BIQ A;  4IU6 A;  1O0X A;  5JFR A;  2GG2 A;  2EVO A;  2Q96 A;  2V3X A;  2BWW A;  4HXX A;  2BN7 A;  2GGB A;  4IKS A;  4U69 A;  5D6E A;  3PKE A;  3L7G A;  1QXW A;  1WLR A;  1QXZ A;  2MAT A;  3PKC A;  5CDV A;  4RZZ A;  2Q95 A;  2GU7 A;  2V3Z A;  2EA2 A;  2V6C A;  4PNC A;  2GU5 A;  1JAW A;  1BN5 A;  3Q6D A;  4U6Z A;  2BWU A;  1C21 A;  5JHU A;  5CIK A;  1XNZ A;  2BWY A;  1W7V A;  2NQ6 A;  2OKN A;  4MAT A;  5JI6 A;  3BIT A;  4FO8 A;  2Q94 A;  4S00 A;  4OOK A;  4U6C A;  1PV9 A;  3FMR A;  4U70 A;  2BWV A;  4FLL A;  1WN1 A;  3CB6 A;  4QR8 A;  2GG8 A;  4IKU A;  1YVM A;  5CE6 A;  1C23 A;  3IU9 A;  4A6V A;  4IF7 A;  2ZSG A;  2IW2 A;  4JUQ A;  2B3H A;  2BHD A;  2NQ7 A;  4U73 A;  1KQ9 A;  1N51 A;  2GU6 A;  3PKD A;  2BWT A;  4S01 A;  1R5G A;  1WBQ A;  4U6E A;  3CTZ A;  5FCF A;  5CDE A;  4A6W A;  4KM3 A;  3TB5 A;  2EVC A;  4ZWP A;  2P98 A;  3RVA A;  1R5H A;  2GG0 A;  3ROR A;  3IG4 A;  3FM3 A;  1YW8 A;  2BHB A;  2GG9 A;  3L24 A;  4FLJ A;  4FUK A;  4ZWU A;  1QZY A;  2GGC A;  2BWS A;  4FLK A;  2Q92 A;  2B3K A;  4U6J A;  5D6F A;  2Q93 A;  4FLI A;  4U1B A;  2BHA A;  4ZNG A;  3IU8 A;  1BOA A;  1XGN A;  1KQ0 A;  2BB7 A;  2EA4 A;  1QXY A;  3S6B A;  4EGE A;  2BWX A;  5CDL A;  4S2R P;  3MR1 A;  2ADU A;  4IEC A;  1CHM A;  4U71 A;  1WL9 A;  5CNX A;  1YJ3 A;  4FO7 A;  3FMQ A;  2GZ5 A;  2BHC A;  2HOW A;  4S2T P;  1M35 A;  1XGM A;  4FKC A;  1YW9 A;  1B6A A;  3MX6 A;  1C27 A;  1XGO A;  2GA2 A;  2B3L A;  2BH3 A;  3D27 A;  2P99 A;  2G6P A;  1W2M A; 
#chains in the Genus database with same CATH homology
 2OAZ A;  4IPA A;  1WL6 A;  4PV4 A;  3MAT A;  4IKT A;  4RGZ 1;  5E5B A;  3TAV A;  2P9A A;  4U6W A;  3CB5 A;  2GTX A;  2GG3 A;  4ZWO A;  1MAT A;  2EVM A;  3PKB A;  1WKM A;  4U75 A;  4U76 A;  3BIP A;  3IU7 A;  1KP0 A;  2GU4 A;  2Q8K A;  1C24 A;  4R60 A;  1C22 A;  1YW7 A;  1B59 A;  2V3Y A;  2GG5 A;  1XGS A;  1Y1N A;  4IDY A;  5CLS A;  4B28 A;  1A16 A;  1WY2 A;  4IKR A;  4Z7M A;  3PKA A;  2DFI A;  4RZY A;  5FCH A;  1R58 A;  2GG7 A;  3BIQ A;  4IU6 A;  1O0X A;  5JFR A;  2GG2 A;  2EVO A;  2Q96 A;  2V3X A;  2BWW A;  4HXX A;  2BN7 A;  2GGB A;  4IKS A;  4U69 A;  5D6E A;  3PKE A;  3L7G A;  1QXW A;  1WLR A;  1QXZ A;  2MAT A;  3PKC A;  5CDV A;  4RZZ A;  2Q95 A;  2GU7 A;  2V3Z A;  2EA2 A;  2V6C A;  4PNC A;  2GU5 A;  1JAW A;  1BN5 A;  3Q6D A;  4U6Z A;  2BWU A;  1C21 A;  5JHU A;  5CIK A;  1XNZ A;  2BWY A;  1W7V A;  2NQ6 A;  2OKN A;  4MAT A;  5JI6 A;  3BIT A;  4FO8 A;  2Q94 A;  4S00 A;  4OOK A;  4U6C A;  1PV9 A;  3FMR A;  4U70 A;  2BWV A;  4FLL A;  1WN1 A;  3CB6 A;  4QR8 A;  2GG8 A;  4IKU A;  1YVM A;  5CE6 A;  1C23 A;  3IU9 A;  4A6V A;  4IF7 A;  2ZSG A;  2IW2 A;  4JUQ A;  2B3H A;  2BHD A;  2NQ7 A;  4U73 A;  1KQ9 A;  1N51 A;  2GU6 A;  3PKD A;  2BWT A;  4S01 A;  1R5G A;  1WBQ A;  4U6E A;  3CTZ A;  5FCF A;  5CDE A;  4A6W A;  4KM3 A;  3TB5 A;  2EVC A;  4ZWP A;  2P98 A;  3RVA A;  1R5H A;  2GG0 A;  3ROR A;  3IG4 A;  3FM3 A;  1YW8 A;  2BHB A;  2GG9 A;  3L24 A;  4FLJ A;  4FUK A;  4ZWU A;  1QZY A;  2GGC A;  2BWS A;  4FLK A;  2Q92 A;  2B3K A;  4U6J A;  5D6F A;  2Q93 A;  4FLI A;  4U1B A;  2BHA A;  4ZNG A;  3IU8 A;  1BOA A;  1XGN A;  1KQ0 A;  2BB7 A;  2EA4 A;  1QXY A;  3S6B A;  4EGE A;  2BWX A;  5CDL A;  4S2R P;  3MR1 A;  2ADU A;  4IEC A;  1CHM A;  4U71 A;  1WL9 A;  5CNX A;  1YJ3 A;  4FO7 A;  3FMQ A;  2GZ5 A;  2BHC A;  2HOW A;  4S2T P;  1M35 A;  1XGM A;  4FKC A;  1YW9 A;  1B6A A;  3MX6 A;  1C27 A;  1XGO A;  2GA2 A;  2B3L A;  2BH3 A;  3D27 A;  2P99 A;  2G6P A;  1W2M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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