4ITYA

Crystal structure of leishmania mexicana arginase
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
310
structure length
310
Chain Sequence
b'KKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISVGCAIARCMMGETLLYT'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Arginase
publication title Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
pubmed doi rcsb
source organism Leishmania mexicana
molecule tags Hydrolase
total genus 111
structure length 310
sequence length 310
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ityA00
3E6VA 4GSZA 4DZ4A 5CEVA 4IXUA 2ZAVA 4RHLA 1ZPEA 3LHLA 3E6KA 4GWCA 3F80A 1T4SA 1T5FA 4HXQA 3SKKA 1P8NA 1RLAA 3MMRA 4IU1A 3GMZA 3NIPA 1HQFA 3NIOA 3DJ8A 3TH7A 1P8RA 4Q42A 4Q3PA 4ITYA 4GSMA 4IXVA 4HZEA 4IU0A 5RLAA 4CEVA 1GQ7A 4GWDA 2PHAA 1T4RA 4G3HA 5HJ9A 3LP7A 1P8OA 4Q3UA 4RHKA 3RLAA 3THJA 4RLAA 2PLLA 1TBHA 1GQ6A 1CEVA 1T4TA 3TF3A 4MYNA 1P8QA 4Q40A 3E9BA 4Q3QA 4MXRA 1D3VA 1HQHA 4HWWA 5HJAA 4FCIA 4Q3RA 4MYKA 1TBJA 4RHMA 4MYLA 4RHQA 3THEA 1PQ3A 3SL1A 3MJLA 1HQ5A 4Q3VA 1TBLA 2EIVA 2AEBA 4MYFA 4Q41A 1T5GA 4FCKA 1P8SA 1T4PA 4IU5A 1WVAA 2CEVA 4IE3A 3MFWA 2EF4A 3GN0A 1WVBA 3SL0A 1P8MA 4Q3TA 3E8ZA 4IE1A 2A0MA 3MFVA 4IE2A 3THHA 3M1RA 1P8PA 2EF5A 1TA1A 4GSVA 1XFKA 3KV2A 1HQXA 1WOHA 2PHOA 4RHIA 1ZPGA 3LP4A 4RHJA 1WOGA 3SJTA 4Q3SA 1WOIA 4Q3RC 4IU4A 3E8QA 4I06A 3NIQA 3PZLA 1HQGA 3CEVA 2RLAA 1R1OA
chains in the Genus database with same CATH superfamily
3ZNSA 3E6VA 4GSZA 5EEFA 4QA0A 4BKXB 1C3RA 5G0JA 5G3WA 4QA4A 5G0IA 4DZ4A 5CEVA 3EW8A 4QA3A 2VQWG 5IWGA 4ZUMA 4IXUA 1T67A 2ZAVA 4QA5A 1ZPEA 4RHLA 3LHLA 5D1CA 3E6KA 4ZUNA 5THTA 4GWCA 5THSA 3F80A 1T4SA 5G10A 5IX0A 1T5FA 4HXQA 5LI3A 3SKKA 1P8NA 1RLAA 3MMRA 3ZNRA 4IU1A 3EZPA 3GMZA 3NIPA 1HQFA 2VQOA 3NIOA 3DJ8A 5G0HA 3TH7A 4LXZA 1P8RA 4QA2A 4Q42A 4Q3PA 3MZ3A 4ITYA 4GSMA 5G1AA 3C0ZA 4IXVA 5G1BA 4HZEA 4IU0A 5RLAA 4CEVA 3Q9CA 4QA7A 5EEMA 4ZUOA 1GQ7A 4GWDA 5EFGA 5G17A 2PHAA 5EEKA 1T4RA 5EENA 4G3HA 5HJ9A 3LP7A 5EFNA 5EFJD 1P8OA 4Q3UA 4BZ9A 4RHKA 3MZ7A 3F0RA 3RLAA 3THJA 3EZTA 4BZ8A 4CBYA 3F06A 5G12A 4RLAA 2PLLA 3C0YA 1TBHA 1ZZ0A 4RN1A 5EFKB 3Q9FA 4RN2A 4CBTA 1GQ6A 5EF7A 1CEVA 3MZ4A 3F07A 1T4TA 4A69A 3TF3A 4MYNA 1C3PA 3Q9BA 5G1CA 1P8QA 4Q40A 3E9BA 4Q3QA 4RN0A 4MXRA 2VQVA 1ZZ3A 3C10A 1D3VA 1HQHA 4HWWA 5DC5A 5BWZA 5HJAA 4FCIA 4Q3RA 4MYKA 1TBJA 5A2SA 4RHMA 4MYLA 4RHQA 3THEA 1PQ3A 3SL1A 3MJLA 5G13A 1HQ5A 2VQJA 4Q3VA 3MAXA 1TBLA 2EIVA 2AEBA 4MYFA 5EF8A 4Q41A 3MZ6A 1T69A 1T5GA 5G0GA 3SFFA 4FCKA 1P8SA 1T4PA 4IU5A 1WVAA 2CEVA 4IE3A 4ZURA 3MFWA 3RQDA 5ICNB 2EF4A 5EEIA 3SFHA 3GN0A 1WVBA 1ZZ1A 3SL0A 1C3SA 5FUEA 5THVA 1P8MA 5EFHA 4Q3TA 3E8ZA 4IE1A 2A0MA 3MFVA 2VCGA 4IE2A 5DC6A 3THHA 4LY1A 3M1RA 1P8PA 3MENA 4QA6A 2GH6A 2EF5A 3EWFA 5G0XA 1TA1A 5DC7A 4GSVA 5DC8A 1XFKA 5G0YA 5FCWA 3KV2A 4ZUPA 1T64A 4BZ6A 5JI5A 1HQXA 4ZUQA 1WOHA 2PHOA 5EFBD 5G11A 4RHIA 1ZPGA 2V5XA 3LP4A 4RHJA 1WOGA 1W22A 4QA1A 3SJTA 4CQFA 4Q3SA 2VQQA 4BZ7A 1VKGA 1WOIA 3Q9EA 4Q3RC 4IU4A 3E8QA 2VQMA 4I06A 3NIQA 3PZLA 1HQGA 5D1BA 5D1DA 2V5WA 3CEVA 4BZ5A 5THUA 2RLAA 1R1OA
chains in the Genus database with same CATH topology
3E6VA 4GSZA 4DZ4A 5CEVA 4IXUA 2ZAVA 4RHLA 1ZPEA 3LHLA 3E6KA 4GWCA 3F80A 1T4SA 1T5FA 4HXQA 3SKKA 1P8NA 1RLAA 3MMRA 4IU1A 3GMZA 3NIPA 1HQFA 3NIOA 3DJ8A 3TH7A 1P8RA 4Q42A 4Q3PA 4ITYA 4GSMA 4IXVA 4HZEA 4IU0A 5RLAA 4CEVA 1GQ7A 4GWDA 2PHAA 1T4RA 4G3HA 5HJ9A 3LP7A 1P8OA 4Q3UA 4RHKA 3RLAA 3THJA 4RLAA 2PLLA 1TBHA 1GQ6A 1CEVA 1T4TA 3TF3A 4MYNA 1P8QA 4Q40A 3E9BA 4Q3QA 4MXRA 1D3VA 1HQHA 4HWWA 5HJAA 4FCIA 4Q3RA 4MYKA 1TBJA 4RHMA 4MYLA 4RHQA 3THEA 1PQ3A 3SL1A 3MJLA 1HQ5A 4Q3VA 1TBLA 2EIVA 2AEBA 4MYFA 4Q41A 1T5GA 4FCKA 1P8SA 1T4PA 4IU5A 1WVAA 2CEVA 4IE3A 3MFWA 2EF4A 3GN0A 1WVBA 3SL0A 1P8MA 4Q3TA 3E8ZA 4IE1A 2A0MA 3MFVA 4IE2A 3THHA 3M1RA 1P8PA 2EF5A 1TA1A 4GSVA 1XFKA 3KV2A 1HQXA 1WOHA 2PHOA 4RHIA 1ZPGA 3LP4A 4RHJA 1WOGA 3SJTA 4Q3SA 1WOIA 4Q3RC 4IU4A 3E8QA 4I06A 3NIQA 3PZLA 1HQGA 3CEVA 2RLAA 1R1OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E6V A;  4GSZ A;  4DZ4 A;  5CEV A;  4IXU A;  2ZAV A;  4RHL A;  1ZPE A;  3LHL A;  3E6K A;  4GWC A;  3F80 A;  1T4S A;  1T5F A;  4HXQ A;  3SKK A;  1P8N A;  1RLA A;  3MMR A;  4IU1 A;  3GMZ A;  3NIP A;  1HQF A;  3NIO A;  3DJ8 A;  3TH7 A;  1P8R A;  4Q42 A;  4Q3P A;  4ITY A;  4GSM A;  4IXV A;  4HZE A;  4IU0 A;  5RLA A;  4CEV A;  1GQ7 A;  4GWD A;  2PHA A;  1T4R A;  4G3H A;  5HJ9 A;  3LP7 A;  1P8O A;  4Q3U A;  4RHK A;  3RLA A;  3THJ A;  4RLA A;  2PLL A;  1TBH A;  1GQ6 A;  1CEV A;  1T4T A;  3TF3 A;  4MYN A;  1P8Q A;  4Q40 A;  3E9B A;  4Q3Q A;  4MXR A;  1D3V A;  1HQH A;  4HWW A;  5HJA A;  4FCI A;  4Q3R A;  4MYK A;  1TBJ A;  4RHM A;  4MYL A;  4RHQ A;  3THE A;  1PQ3 A;  3SL1 A;  3MJL A;  1HQ5 A;  4Q3V A;  1TBL A;  2EIV A;  2AEB A;  4MYF A;  4Q41 A;  1T5G A;  4FCK A;  1P8S A;  1T4P A;  4IU5 A;  1WVA A;  2CEV A;  4IE3 A;  3MFW A;  2EF4 A;  3GN0 A;  1WVB A;  3SL0 A;  1P8M A;  4Q3T A;  3E8Z A;  4IE1 A;  2A0M A;  3MFV A;  4IE2 A;  3THH A;  3M1R A;  1P8P A;  2EF5 A;  1TA1 A;  4GSV A;  1XFK A;  3KV2 A;  1HQX A;  1WOH A;  2PHO A;  4RHI A;  1ZPG A;  3LP4 A;  4RHJ A;  1WOG A;  3SJT A;  4Q3S A;  1WOI A;  4Q3R C;  4IU4 A;  3E8Q A;  4I06 A;  3NIQ A;  3PZL A;  1HQG A;  3CEV A;  2RLA A;  1R1O A; 
#chains in the Genus database with same CATH topology
 3ZNS A;  3E6V A;  4GSZ A;  5EEF A;  4QA0 A;  4BKX B;  1C3R A;  5G0J A;  5G3W A;  4QA4 A;  5G0I A;  4DZ4 A;  5CEV A;  3EW8 A;  4QA3 A;  2VQW G;  5IWG A;  4ZUM A;  4IXU A;  1T67 A;  2ZAV A;  4QA5 A;  1ZPE A;  4RHL A;  3LHL A;  5D1C A;  3E6K A;  4ZUN A;  5THT A;  4GWC A;  5THS A;  3F80 A;  1T4S A;  5G10 A;  5IX0 A;  1T5F A;  4HXQ A;  5LI3 A;  3SKK A;  1P8N A;  1RLA A;  3MMR A;  3ZNR A;  4IU1 A;  3EZP A;  3GMZ A;  3NIP A;  1HQF A;  2VQO A;  3NIO A;  3DJ8 A;  5G0H A;  3TH7 A;  4LXZ A;  1P8R A;  4QA2 A;  4Q42 A;  4Q3P A;  3MZ3 A;  4ITY A;  4GSM A;  5G1A A;  3C0Z A;  4IXV A;  5G1B A;  4HZE A;  4IU0 A;  5RLA A;  4CEV A;  3Q9C A;  4QA7 A;  5EEM A;  4ZUO A;  1GQ7 A;  4GWD A;  5EFG A;  5G17 A;  2PHA A;  5EEK A;  1T4R A;  5EEN A;  4G3H A;  5HJ9 A;  3LP7 A;  5EFN A;  5EFJ D;  1P8O A;  4Q3U A;  4BZ9 A;  4RHK A;  3MZ7 A;  3F0R A;  3RLA A;  3THJ A;  3EZT A;  4BZ8 A;  4CBY A;  3F06 A;  5G12 A;  4RLA A;  2PLL A;  3C0Y A;  1TBH A;  1ZZ0 A;  4RN1 A;  5EFK B;  3Q9F A;  4RN2 A;  4CBT A;  1GQ6 A;  5EF7 A;  1CEV A;  3MZ4 A;  3F07 A;  1T4T A;  4A69 A;  3TF3 A;  4MYN A;  1C3P A;  3Q9B A;  5G1C A;  1P8Q A;  4Q40 A;  3E9B A;  4Q3Q A;  4RN0 A;  4MXR A;  2VQV A;  1ZZ3 A;  3C10 A;  1D3V A;  1HQH A;  4HWW A;  5DC5 A;  5BWZ A;  5HJA A;  4FCI A;  4Q3R A;  4MYK A;  1TBJ A;  5A2S A;  4RHM A;  4MYL A;  4RHQ A;  3THE A;  1PQ3 A;  3SL1 A;  3MJL A;  5G13 A;  1HQ5 A;  2VQJ A;  4Q3V A;  3MAX A;  1TBL A;  2EIV A;  2AEB A;  4MYF A;  5EF8 A;  4Q41 A;  3MZ6 A;  1T69 A;  1T5G A;  5G0G A;  3SFF A;  4FCK A;  1P8S A;  1T4P A;  4IU5 A;  1WVA A;  2CEV A;  4IE3 A;  4ZUR A;  3MFW A;  3RQD A;  5ICN B;  2EF4 A;  5EEI A;  3SFH A;  3GN0 A;  1WVB A;  1ZZ1 A;  3SL0 A;  1C3S A;  5FUE A;  5THV A;  1P8M A;  5EFH A;  4Q3T A;  3E8Z A;  4IE1 A;  2A0M A;  3MFV A;  2VCG A;  4IE2 A;  5DC6 A;  3THH A;  4LY1 A;  3M1R A;  1P8P A;  3MEN A;  4QA6 A;  2GH6 A;  2EF5 A;  3EWF A;  5G0X A;  1TA1 A;  5DC7 A;  4GSV A;  5DC8 A;  1XFK A;  5G0Y A;  5FCW A;  3KV2 A;  4ZUP A;  1T64 A;  4BZ6 A;  5JI5 A;  1HQX A;  4ZUQ A;  1WOH A;  2PHO A;  5EFB D;  5G11 A;  4RHI A;  1ZPG A;  2V5X A;  3LP4 A;  4RHJ A;  1WOG A;  1W22 A;  4QA1 A;  3SJT A;  4CQF A;  4Q3S A;  2VQQ A;  4BZ7 A;  1VKG A;  1WOI A;  3Q9E A;  4Q3R C;  4IU4 A;  3E8Q A;  2VQM A;  4I06 A;  3NIQ A;  3PZL A;  1HQG A;  5D1B A;  5D1D A;  2V5W A;  3CEV A;  4BZ5 A;  5THU A;  2RLA A;  1R1O A; 
#chains in the Genus database with same CATH homology
 3E6V A;  4GSZ A;  4DZ4 A;  5CEV A;  4IXU A;  2ZAV A;  4RHL A;  1ZPE A;  3LHL A;  3E6K A;  4GWC A;  3F80 A;  1T4S A;  1T5F A;  4HXQ A;  3SKK A;  1P8N A;  1RLA A;  3MMR A;  4IU1 A;  3GMZ A;  3NIP A;  1HQF A;  3NIO A;  3DJ8 A;  3TH7 A;  1P8R A;  4Q42 A;  4Q3P A;  4ITY A;  4GSM A;  4IXV A;  4HZE A;  4IU0 A;  5RLA A;  4CEV A;  1GQ7 A;  4GWD A;  2PHA A;  1T4R A;  4G3H A;  5HJ9 A;  3LP7 A;  1P8O A;  4Q3U A;  4RHK A;  3RLA A;  3THJ A;  4RLA A;  2PLL A;  1TBH A;  1GQ6 A;  1CEV A;  1T4T A;  3TF3 A;  4MYN A;  1P8Q A;  4Q40 A;  3E9B A;  4Q3Q A;  4MXR A;  1D3V A;  1HQH A;  4HWW A;  5HJA A;  4FCI A;  4Q3R A;  4MYK A;  1TBJ A;  4RHM A;  4MYL A;  4RHQ A;  3THE A;  1PQ3 A;  3SL1 A;  3MJL A;  1HQ5 A;  4Q3V A;  1TBL A;  2EIV A;  2AEB A;  4MYF A;  4Q41 A;  1T5G A;  4FCK A;  1P8S A;  1T4P A;  4IU5 A;  1WVA A;  2CEV A;  4IE3 A;  3MFW A;  2EF4 A;  3GN0 A;  1WVB A;  3SL0 A;  1P8M A;  4Q3T A;  3E8Z A;  4IE1 A;  2A0M A;  3MFV A;  4IE2 A;  3THH A;  3M1R A;  1P8P A;  2EF5 A;  1TA1 A;  4GSV A;  1XFK A;  3KV2 A;  1HQX A;  1WOH A;  2PHO A;  4RHI A;  1ZPG A;  3LP4 A;  4RHJ A;  1WOG A;  3SJT A;  4Q3S A;  1WOI A;  4Q3R C;  4IU4 A;  3E8Q A;  4I06 A;  3NIQ A;  3PZL A;  1HQG A;  3CEV A;  2RLA A;  1R1O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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