4IU6A

Human methionine aminopeptidase in complex with fz1: pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Methionine aminopeptidase 1
publication title Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2013-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF15801 zf-C6H2 zf-MYND-like zinc finger, mRNA-binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4iu6A00
2GGCA 1B6AA 3PKEA 3MR1A 3IU9A 4S00A 4U75A 2BWTA 1BOAA 2GG2A 3BITA 2BWXA 4U76A 2EVOA 4IDYA 4PNCA 2GG3A 3PKBA 4U6EA 2V6CA 4IKTA 1WN1A 3FM3A 4U69A 2GZ5A 4MATA 1M35A 4FLLA 3RORA 3PKDA 4RZYA 4S2TP 4RZZA 4ZNGA 5CLSA 5CDEA 1CHMA 4IKUA 5D6FA 1XGOA 4FO8A 2BB7A 4U6CA 1YJ3A 4JUQA 4U6WA 5JHUA 3D27A 2Q92A 2EA4A 1C21A 4R60A 4ZWOA 2BH3A 1N51A 1O0XA 1PV9A 2G6PA 4U73A 2GG5A 5CNXA 2GTXA 4FLIA 5FCFA 5CDLA 2GGBA 4S01A 3MATA 2B3HA 1KQ9A 2B3KA 1R58A 2V3YA 4IECA 2BWVA 5CE6A 4KM3A 2OKNA 2B3LA 3FMQA 1C24A 5D6EA 4B28A 4IF7A 4FO7A 1WL9A 1Y1NA 4IPAA 1QXYA 2GG7A 2Q95A 3Q6DA 2GG9A 2DFIA 2BWSA 2GG8A 4RGZ1 4S2RP 2NQ6A 4U6JA 2BHAA 3L7GA 1C23A 2Q94A 3CB5A 2HOWA 4A6WA 1YW8A 2P9AA 1JAWA 2OAZA 2Q8KA 3IU8A 2EA2A 3BIPA 3BIQA 1W7VA 3CB6A 1XGSA 4U1BA 2BHCA 2GG0A 1YVMA 1WL6A 1WBQA 1BN5A 4FKCA 1R5GA 4HXXA 2ADUA 2NQ7A 2P99A 2BHBA 2EVCA 3PKAA 1YW9A 2MATA 2P98A 4OOKA 1C27A 1A16A 3MX6A 1XGMA 4FUKA 4IKSA 2Q93A 1WLRA 4U6ZA 1MATA 4Z7MA 1YW7A 1QXWA 3L24A 3TAVA 4A6VA 1R5HA 4U70A 1XGNA 3S6BA 2EVMA 2ZSGA 1W2MA 5CDVA 2GU7A 4QR8A 3IU7A 3TB5A 4U71A 1KP0A 2GA2A 2Q96A 4IU6A 4ZWPA 2V3XA 3CTZA 4FLKA 4EGEA 4FLJA 1QZYA 3IG4A 5FCHA 3PKCA 2GU4A 1XNZA 3RVAA 4ZWUA 2GU5A 3FMRA 1WY2A 2GU6A 5JFRA 2BWUA 2BHDA 1WKMA 2BWWA 2IW2A 4IKRA 4PV4A 5JI6A 2BWYA 5CIKA 1QXZA 2V3ZA 5E5BA 1KQ0A 1C22A 2BN7A 1B59A
chains in the Genus database with same CATH superfamily
2GGCA 1B6AA 3PKEA 3MR1A 3IU9A 4S00A 4U75A 2BWTA 1BOAA 2GG2A 3BITA 2BWXA 4U76A 2EVOA 4IDYA 4PNCA 2GG3A 3PKBA 4U6EA 2V6CA 4IKTA 1WN1A 3FM3A 4U69A 2GZ5A 4MATA 1M35A 4FLLA 3RORA 3PKDA 4RZYA 4S2TP 4RZZA 4ZNGA 5CLSA 5CDEA 1CHMA 4IKUA 5D6FA 1XGOA 4FO8A 2BB7A 4U6CA 1YJ3A 4JUQA 4U6WA 5JHUA 3D27A 2Q92A 2EA4A 1C21A 4R60A 4ZWOA 2BH3A 1N51A 1O0XA 1PV9A 2G6PA 4U73A 2GG5A 5CNXA 2GTXA 4FLIA 5FCFA 5CDLA 2GGBA 4S01A 3MATA 2B3HA 1KQ9A 2B3KA 1R58A 2V3YA 4IECA 2BWVA 5CE6A 4KM3A 2OKNA 2B3LA 3FMQA 1C24A 5D6EA 4B28A 4IF7A 4FO7A 1WL9A 1Y1NA 4IPAA 1QXYA 2GG7A 2Q95A 3Q6DA 2GG9A 2DFIA 2BWSA 2GG8A 4RGZ1 4S2RP 2NQ6A 4U6JA 2BHAA 3L7GA 1C23A 2Q94A 3CB5A 2HOWA 4A6WA 1YW8A 2P9AA 1JAWA 2OAZA 2Q8KA 3IU8A 2EA2A 3BIPA 3BIQA 1W7VA 3CB6A 1XGSA 4U1BA 2BHCA 2GG0A 1YVMA 1WL6A 1WBQA 1BN5A 4FKCA 1R5GA 4HXXA 2ADUA 2NQ7A 2P99A 2BHBA 2EVCA 3PKAA 1YW9A 2MATA 2P98A 4OOKA 1C27A 1A16A 3MX6A 1XGMA 4FUKA 4IKSA 2Q93A 1WLRA 4U6ZA 1MATA 4Z7MA 1YW7A 1QXWA 3L24A 3TAVA 4A6VA 1R5HA 4U70A 1XGNA 3S6BA 2EVMA 2ZSGA 1W2MA 5CDVA 2GU7A 4QR8A 3IU7A 3TB5A 4U71A 1KP0A 2GA2A 2Q96A 4IU6A 4ZWPA 2V3XA 3CTZA 4FLKA 4EGEA 4FLJA 1QZYA 3IG4A 5FCHA 3PKCA 2GU4A 1XNZA 3RVAA 4ZWUA 2GU5A 3FMRA 1WY2A 2GU6A 5JFRA 2BWUA 2BHDA 1WKMA 2BWWA 2IW2A 4IKRA 4PV4A 5JI6A 2BWYA 5CIKA 1QXZA 2V3ZA 5E5BA 1KQ0A 1C22A 2BN7A 1B59A
chains in the Genus database with same CATH topology
2GGCA 1B6AA 3PKEA 3MR1A 3IU9A 4S00A 4U75A 2BWTA 1BOAA 2GG2A 3BITA 2BWXA 4U76A 2EVOA 4IDYA 4PNCA 2GG3A 3PKBA 4U6EA 2V6CA 4IKTA 1WN1A 3FM3A 4U69A 2GZ5A 4MATA 1M35A 4FLLA 3RORA 3PKDA 4RZYA 4S2TP 4RZZA 4ZNGA 5CLSA 5CDEA 1CHMA 4IKUA 5D6FA 1XGOA 4FO8A 2BB7A 4U6CA 1YJ3A 4JUQA 4U6WA 5JHUA 3D27A 2Q92A 2EA4A 1C21A 4R60A 4ZWOA 2BH3A 1N51A 1O0XA 1PV9A 2G6PA 4U73A 2GG5A 5CNXA 2GTXA 4FLIA 5FCFA 5CDLA 2GGBA 4S01A 3MATA 2B3HA 1KQ9A 2B3KA 1R58A 2V3YA 4IECA 2BWVA 5CE6A 4KM3A 2OKNA 2B3LA 3FMQA 1C24A 5D6EA 4B28A 4IF7A 4FO7A 1WL9A 1Y1NA 4IPAA 1QXYA 2GG7A 2Q95A 3Q6DA 2GG9A 2DFIA 2BWSA 2GG8A 4RGZ1 4S2RP 2NQ6A 4U6JA 2BHAA 3L7GA 1C23A 2Q94A 3CB5A 2HOWA 4A6WA 1YW8A 2P9AA 1JAWA 2OAZA 2Q8KA 3IU8A 2EA2A 3BIPA 3BIQA 1W7VA 3CB6A 1XGSA 4U1BA 2BHCA 2GG0A 1YVMA 1WL6A 1WBQA 1BN5A 4FKCA 1R5GA 4HXXA 2ADUA 2NQ7A 2P99A 2BHBA 2EVCA 3PKAA 1YW9A 2MATA 2P98A 4OOKA 1C27A 1A16A 3MX6A 1XGMA 4FUKA 4IKSA 2Q93A 1WLRA 4U6ZA 1MATA 4Z7MA 1YW7A 1QXWA 3L24A 3TAVA 4A6VA 1R5HA 4U70A 1XGNA 3S6BA 2EVMA 2ZSGA 1W2MA 5CDVA 2GU7A 4QR8A 3IU7A 3TB5A 4U71A 1KP0A 2GA2A 2Q96A 4IU6A 4ZWPA 2V3XA 3CTZA 4FLKA 4EGEA 4FLJA 1QZYA 3IG4A 5FCHA 3PKCA 2GU4A 1XNZA 3RVAA 4ZWUA 2GU5A 3FMRA 1WY2A 2GU6A 5JFRA 2BWUA 2BHDA 1WKMA 2BWWA 2IW2A 4IKRA 4PV4A 5JI6A 2BWYA 5CIKA 1QXZA 2V3ZA 5E5BA 1KQ0A 1C22A 2BN7A 1B59A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GGC A;  1B6A A;  3PKE A;  3MR1 A;  3IU9 A;  4S00 A;  4U75 A;  2BWT A;  1BOA A;  2GG2 A;  3BIT A;  2BWX A;  4U76 A;  2EVO A;  4IDY A;  4PNC A;  2GG3 A;  3PKB A;  4U6E A;  2V6C A;  4IKT A;  1WN1 A;  3FM3 A;  4U69 A;  2GZ5 A;  4MAT A;  1M35 A;  4FLL A;  3ROR A;  3PKD A;  4RZY A;  4S2T P;  4RZZ A;  4ZNG A;  5CLS A;  5CDE A;  1CHM A;  4IKU A;  5D6F A;  1XGO A;  4FO8 A;  2BB7 A;  4U6C A;  1YJ3 A;  4JUQ A;  4U6W A;  5JHU A;  3D27 A;  2Q92 A;  2EA4 A;  1C21 A;  4R60 A;  4ZWO A;  2BH3 A;  1N51 A;  1O0X A;  1PV9 A;  2G6P A;  4U73 A;  2GG5 A;  5CNX A;  2GTX A;  4FLI A;  5FCF A;  5CDL A;  2GGB A;  4S01 A;  3MAT A;  2B3H A;  1KQ9 A;  2B3K A;  1R58 A;  2V3Y A;  4IEC A;  2BWV A;  5CE6 A;  4KM3 A;  2OKN A;  2B3L A;  3FMQ A;  1C24 A;  5D6E A;  4B28 A;  4IF7 A;  4FO7 A;  1WL9 A;  1Y1N A;  4IPA A;  1QXY A;  2GG7 A;  2Q95 A;  3Q6D A;  2GG9 A;  2DFI A;  2BWS A;  2GG8 A;  4RGZ 1;  4S2R P;  2NQ6 A;  4U6J A;  2BHA A;  3L7G A;  1C23 A;  2Q94 A;  3CB5 A;  2HOW A;  4A6W A;  1YW8 A;  2P9A A;  1JAW A;  2OAZ A;  2Q8K A;  3IU8 A;  2EA2 A;  3BIP A;  3BIQ A;  1W7V A;  3CB6 A;  1XGS A;  4U1B A;  2BHC A;  2GG0 A;  1YVM A;  1WL6 A;  1WBQ A;  1BN5 A;  4FKC A;  1R5G A;  4HXX A;  2ADU A;  2NQ7 A;  2P99 A;  2BHB A;  2EVC A;  3PKA A;  1YW9 A;  2MAT A;  2P98 A;  4OOK A;  1C27 A;  1A16 A;  3MX6 A;  1XGM A;  4FUK A;  4IKS A;  2Q93 A;  1WLR A;  4U6Z A;  1MAT A;  4Z7M A;  1YW7 A;  1QXW A;  3L24 A;  3TAV A;  4A6V A;  1R5H A;  4U70 A;  1XGN A;  3S6B A;  2EVM A;  2ZSG A;  1W2M A;  5CDV A;  2GU7 A;  4QR8 A;  3IU7 A;  3TB5 A;  4U71 A;  1KP0 A;  2GA2 A;  2Q96 A;  4IU6 A;  4ZWP A;  2V3X A;  3CTZ A;  4FLK A;  4EGE A;  4FLJ A;  1QZY A;  3IG4 A;  5FCH A;  3PKC A;  2GU4 A;  1XNZ A;  3RVA A;  4ZWU A;  2GU5 A;  3FMR A;  1WY2 A;  2GU6 A;  5JFR A;  2BWU A;  2BHD A;  1WKM A;  2BWW A;  2IW2 A;  4IKR A;  4PV4 A;  5JI6 A;  2BWY A;  5CIK A;  1QXZ A;  2V3Z A;  5E5B A;  1KQ0 A;  1C22 A;  2BN7 A;  1B59 A; 
#chains in the Genus database with same CATH topology
 2GGC A;  1B6A A;  3PKE A;  3MR1 A;  3IU9 A;  4S00 A;  4U75 A;  2BWT A;  1BOA A;  2GG2 A;  3BIT A;  2BWX A;  4U76 A;  2EVO A;  4IDY A;  4PNC A;  2GG3 A;  3PKB A;  4U6E A;  2V6C A;  4IKT A;  1WN1 A;  3FM3 A;  4U69 A;  2GZ5 A;  4MAT A;  1M35 A;  4FLL A;  3ROR A;  3PKD A;  4RZY A;  4S2T P;  4RZZ A;  4ZNG A;  5CLS A;  5CDE A;  1CHM A;  4IKU A;  5D6F A;  1XGO A;  4FO8 A;  2BB7 A;  4U6C A;  1YJ3 A;  4JUQ A;  4U6W A;  5JHU A;  3D27 A;  2Q92 A;  2EA4 A;  1C21 A;  4R60 A;  4ZWO A;  2BH3 A;  1N51 A;  1O0X A;  1PV9 A;  2G6P A;  4U73 A;  2GG5 A;  5CNX A;  2GTX A;  4FLI A;  5FCF A;  5CDL A;  2GGB A;  4S01 A;  3MAT A;  2B3H A;  1KQ9 A;  2B3K A;  1R58 A;  2V3Y A;  4IEC A;  2BWV A;  5CE6 A;  4KM3 A;  2OKN A;  2B3L A;  3FMQ A;  1C24 A;  5D6E A;  4B28 A;  4IF7 A;  4FO7 A;  1WL9 A;  1Y1N A;  4IPA A;  1QXY A;  2GG7 A;  2Q95 A;  3Q6D A;  2GG9 A;  2DFI A;  2BWS A;  2GG8 A;  4RGZ 1;  4S2R P;  2NQ6 A;  4U6J A;  2BHA A;  3L7G A;  1C23 A;  2Q94 A;  3CB5 A;  2HOW A;  4A6W A;  1YW8 A;  2P9A A;  1JAW A;  2OAZ A;  2Q8K A;  3IU8 A;  2EA2 A;  3BIP A;  3BIQ A;  1W7V A;  3CB6 A;  1XGS A;  4U1B A;  2BHC A;  2GG0 A;  1YVM A;  1WL6 A;  1WBQ A;  1BN5 A;  4FKC A;  1R5G A;  4HXX A;  2ADU A;  2NQ7 A;  2P99 A;  2BHB A;  2EVC A;  3PKA A;  1YW9 A;  2MAT A;  2P98 A;  4OOK A;  1C27 A;  1A16 A;  3MX6 A;  1XGM A;  4FUK A;  4IKS A;  2Q93 A;  1WLR A;  4U6Z A;  1MAT A;  4Z7M A;  1YW7 A;  1QXW A;  3L24 A;  3TAV A;  4A6V A;  1R5H A;  4U70 A;  1XGN A;  3S6B A;  2EVM A;  2ZSG A;  1W2M A;  5CDV A;  2GU7 A;  4QR8 A;  3IU7 A;  3TB5 A;  4U71 A;  1KP0 A;  2GA2 A;  2Q96 A;  4IU6 A;  4ZWP A;  2V3X A;  3CTZ A;  4FLK A;  4EGE A;  4FLJ A;  1QZY A;  3IG4 A;  5FCH A;  3PKC A;  2GU4 A;  1XNZ A;  3RVA A;  4ZWU A;  2GU5 A;  3FMR A;  1WY2 A;  2GU6 A;  5JFR A;  2BWU A;  2BHD A;  1WKM A;  2BWW A;  2IW2 A;  4IKR A;  4PV4 A;  5JI6 A;  2BWY A;  5CIK A;  1QXZ A;  2V3Z A;  5E5B A;  1KQ0 A;  1C22 A;  2BN7 A;  1B59 A; 
#chains in the Genus database with same CATH homology
 2GGC A;  1B6A A;  3PKE A;  3MR1 A;  3IU9 A;  4S00 A;  4U75 A;  2BWT A;  1BOA A;  2GG2 A;  3BIT A;  2BWX A;  4U76 A;  2EVO A;  4IDY A;  4PNC A;  2GG3 A;  3PKB A;  4U6E A;  2V6C A;  4IKT A;  1WN1 A;  3FM3 A;  4U69 A;  2GZ5 A;  4MAT A;  1M35 A;  4FLL A;  3ROR A;  3PKD A;  4RZY A;  4S2T P;  4RZZ A;  4ZNG A;  5CLS A;  5CDE A;  1CHM A;  4IKU A;  5D6F A;  1XGO A;  4FO8 A;  2BB7 A;  4U6C A;  1YJ3 A;  4JUQ A;  4U6W A;  5JHU A;  3D27 A;  2Q92 A;  2EA4 A;  1C21 A;  4R60 A;  4ZWO A;  2BH3 A;  1N51 A;  1O0X A;  1PV9 A;  2G6P A;  4U73 A;  2GG5 A;  5CNX A;  2GTX A;  4FLI A;  5FCF A;  5CDL A;  2GGB A;  4S01 A;  3MAT A;  2B3H A;  1KQ9 A;  2B3K A;  1R58 A;  2V3Y A;  4IEC A;  2BWV A;  5CE6 A;  4KM3 A;  2OKN A;  2B3L A;  3FMQ A;  1C24 A;  5D6E A;  4B28 A;  4IF7 A;  4FO7 A;  1WL9 A;  1Y1N A;  4IPA A;  1QXY A;  2GG7 A;  2Q95 A;  3Q6D A;  2GG9 A;  2DFI A;  2BWS A;  2GG8 A;  4RGZ 1;  4S2R P;  2NQ6 A;  4U6J A;  2BHA A;  3L7G A;  1C23 A;  2Q94 A;  3CB5 A;  2HOW A;  4A6W A;  1YW8 A;  2P9A A;  1JAW A;  2OAZ A;  2Q8K A;  3IU8 A;  2EA2 A;  3BIP A;  3BIQ A;  1W7V A;  3CB6 A;  1XGS A;  4U1B A;  2BHC A;  2GG0 A;  1YVM A;  1WL6 A;  1WBQ A;  1BN5 A;  4FKC A;  1R5G A;  4HXX A;  2ADU A;  2NQ7 A;  2P99 A;  2BHB A;  2EVC A;  3PKA A;  1YW9 A;  2MAT A;  2P98 A;  4OOK A;  1C27 A;  1A16 A;  3MX6 A;  1XGM A;  4FUK A;  4IKS A;  2Q93 A;  1WLR A;  4U6Z A;  1MAT A;  4Z7M A;  1YW7 A;  1QXW A;  3L24 A;  3TAV A;  4A6V A;  1R5H A;  4U70 A;  1XGN A;  3S6B A;  2EVM A;  2ZSG A;  1W2M A;  5CDV A;  2GU7 A;  4QR8 A;  3IU7 A;  3TB5 A;  4U71 A;  1KP0 A;  2GA2 A;  2Q96 A;  4IU6 A;  4ZWP A;  2V3X A;  3CTZ A;  4FLK A;  4EGE A;  4FLJ A;  1QZY A;  3IG4 A;  5FCH A;  3PKC A;  2GU4 A;  1XNZ A;  3RVA A;  4ZWU A;  2GU5 A;  3FMR A;  1WY2 A;  2GU6 A;  5JFR A;  2BWU A;  2BHD A;  1WKM A;  2BWW A;  2IW2 A;  4IKR A;  4PV4 A;  5JI6 A;  2BWY A;  5CIK A;  1QXZ A;  2V3Z A;  5E5B A;  1KQ0 A;  1C22 A;  2BN7 A;  1B59 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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