4JRAC

Crystal structure of the botulinum neurotoxin a receptor-binding domain in complex with the luminal domain of sv2c
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
85
structure length
83
Chain Sequence
ANFTITMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 20
structure length 83
sequence length 85
chains with identical sequence D
ec nomenclature
pdb deposition date 2013-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF13599 Pentapeptide_4 Pentapeptide repeats (9 copies)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.160.20.100 Mainly Beta 3 Solenoid Pectate Lyase C-like Pectate Lyase C-like 4jraC00
2F3LA 5JLVC 4JRAC 2BM6A 2BM5A 2J8IA 2G0YA 3N90A 2BM7A 2BM4A 2W7ZA 5JMCB
chains in the Genus database with same CATH superfamily
4XOPA 1RWRA 1OFLA 1LM1A 4YDTA 1EE6A 4OJOA 4XN0A 4Z03A 2VBEA 3GQ8A 4KH3A 4OM9A 2NTQA 2NSTA 1K4ZA 1XG2A 2VFPA 2X6YA 1O88A 4V02C 4XM3A 1QCXA 4XL9A 3N6ZA 4Z05A 3SUCA 2UVFA 3UW0A 1RU4A 1O8JA 2BM4A 4OJ5A 1BHEA 1EZGA 1OGOX 4XLFA 4OJPA 5AMVA 3LMWA 4XR6A 4XORA 1WXRA 2XC1A 3FY3A 2B0RA 4U4BA 2QX3A 4OZYA 4W8TA 1HG8A 3PETA 2BX6A 2VBKA 2X3HA 3NB2A 4YZXA 5C1CA 3RIQA 2XTWA 3EQOA 2INUA 1PE9A 1QRCA 2XT4A 4MR0A 4XLAA 4XOTA 3JX8A 1IB4A 1PXZA 2NZMA 3LJYA 1IA5A 2ODLA 4JRAC 2NSPA 2VFNA 3GQ9A 4YCQA 2NTBA 1EA0A 1O8IA 4YEJA 1KTWA 4PMHA 2X6XA 3SY2A 1OFMA 1JTAA 1X0CA 1IDKA 1O8DA 2VBMA 4OZZA 2UVEA 3EQNA 1KCDA 1QA2A 1TSPA 2EWEA 3H09A 3SQVA 1O8FA 1VBLA 5C1EA 2QXZA 3GQ7A 4HWVA 3VMWA 4YEIA 1QA1A 3NAWA 4YELA 5JMCB 3SYJA 1PLUA 2VFOA 1HF2A 1O8HA 2XTYA 2PYGA 3BH7B 3PSSA 4XKWA 3ZSCA 4NK6A 2O17A 2XTXA 1IDJA 3DU1X 4OPWA 2VFQA 4W8SA 3T9GA 2X6WA 1QA3A 5JLVC 4XN3A 2INVA 2O6WA 1GQ8A 3ML3A 3N90A 1CLWA 1CZFA 2BSPA 3PSZA 1DABA 1KCCA 3VMVA 2IQ7A 1LLWA 1O8KA 3LYCA 2O0WA 4YFOA 1K8FA 3B4NA 2W7ZA 1RMGA 5DNSA 1TYXA 2YUHA 3KRGA 2VJJA 4XLCA 1L1IA 1QQ1A 2NTPA 2O04A 2NT6A 4AVZA 1K5CA 3P4GA 2BM7A 4XKVA 3ZPPA 4Z06A 1QRBA 2QYUA 1DBOA 4OJ6A 1TYVA 1NHCA 3B90A 2BM5A 4W8RA 4XONA 2VFMA 2XT2A 2Z8GA 4YZAA 1KQ5A 2QZAA 4C2LA 4XMYA 1LLZA 2F3LA 2VJIA 2BM6A 4XLHA 4YZQA 4EW9A 2PECA 2X85A 3AK5A 3B8YA 3TH0A 3VSTA 4MXNA 4URRA 1WMRA 4U49A 2QY1A 4W8QA 1BN8A 1O8MA 1OFEA 3SZEA 3GQAA 2O0VA 4I84A 2O1DA 1DBGA 3GRHA 3BH6B 1JRGA 3VSVA 1OGMX 4OJLA 4YC5A 3JURA 4YZ0A 1QJVA 1TYUA 3WWGA 1O8LA 1H80A 1O8GA 2V5IA 1TYWA 1O8EA 2PYHA 1OFDA 2J8IA 2G0YA 4NK8A 2IOUG 4XNFA 4XLEA 4XQFA 2NT9A 1AIRA 1OOCA 2J8KA 3VSUA
chains in the Genus database with same CATH topology
2VFOA 3BH7B 1HF2A 3RIQA 4OJ6A 1TYVA 2BM5A 4OJOA 2VFMA 4KH3A 4OM9A 1KQ5A 2VFPA 1K4ZA 1QRCA 4V02C 4OPWA 2VFQA 3N6ZA 1QA3A 2F3LA 5JLVC 2BM6A 3JX8A 3LJYA 3ML3A 3N90A 3AK5A 2BM4A 1CLWA 4OJ5A 3TH0A 1DABA 4OJPA 4JRAC 3SZEA 2VFNA 3LYCA 1K8FA 1WXRA 2XC1A 3BH6B 2W7ZA 2B0RA 1TYXA 2YUHA 4OJLA 1QQ1A 1TSPA 1QA2A 3H09A 1TYUA 2V5IA 1TYWA 2J8IA 2G0YA 3P4GA 2IOUG 3PETA 2BM7A 1QA1A 2BX6A 1QRBA 5JMCB 3SYJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2F3L A;  5JLV C;  4JRA C;  2BM6 A;  2BM5 A;  2J8I A;  2G0Y A;  3N90 A;  2BM7 A;  2BM4 A;  2W7Z A;  5JMC B; 
#chains in the Genus database with same CATH topology
 4XOP A;  1RWR A;  1OFL A;  1LM1 A;  4YDT A;  1EE6 A;  4OJO A;  4XN0 A;  4Z03 A;  2VBE A;  3GQ8 A;  4KH3 A;  4OM9 A;  2NTQ A;  2NST A;  1K4Z A;  1XG2 A;  2VFP A;  2X6Y A;  1O88 A;  4V02 C;  4XM3 A;  1QCX A;  4XL9 A;  3N6Z A;  4Z05 A;  3SUC A;  2UVF A;  3UW0 A;  1RU4 A;  1O8J A;  2BM4 A;  4OJ5 A;  1BHE A;  1EZG A;  1OGO X;  4XLF A;  4OJP A;  5AMV A;  3LMW A;  4XR6 A;  4XOR A;  1WXR A;  2XC1 A;  3FY3 A;  2B0R A;  4U4B A;  2QX3 A;  4OZY A;  4W8T A;  1HG8 A;  3PET A;  2BX6 A;  2VBK A;  2X3H A;  3NB2 A;  4YZX A;  5C1C A;  3RIQ A;  2XTW A;  3EQO A;  2INU A;  1PE9 A;  1QRC A;  2XT4 A;  4MR0 A;  4XLA A;  4XOT A;  3JX8 A;  1IB4 A;  1PXZ A;  2NZM A;  3LJY A;  1IA5 A;  2ODL A;  4JRA C;  2NSP A;  2VFN A;  3GQ9 A;  4YCQ A;  2NTB A;  1EA0 A;  1O8I A;  4YEJ A;  1KTW A;  4PMH A;  2X6X A;  3SY2 A;  1OFM A;  1JTA A;  1X0C A;  1IDK A;  1O8D A;  2VBM A;  4OZZ A;  2UVE A;  3EQN A;  1KCD A;  1QA2 A;  1TSP A;  2EWE A;  3H09 A;  3SQV A;  1O8F A;  1VBL A;  5C1E A;  2QXZ A;  3GQ7 A;  4HWV A;  3VMW A;  4YEI A;  1QA1 A;  3NAW A;  4YEL A;  5JMC B;  3SYJ A;  1PLU A;  2VFO A;  1HF2 A;  1O8H A;  2XTY A;  2PYG A;  3BH7 B;  3PSS A;  4XKW A;  3ZSC A;  4NK6 A;  2O17 A;  2XTX A;  1IDJ A;  3DU1 X;  4OPW A;  2VFQ A;  4W8S A;  3T9G A;  2X6W A;  1QA3 A;  5JLV C;  4XN3 A;  2INV A;  2O6W A;  1GQ8 A;  3ML3 A;  3N90 A;  1CLW A;  1CZF A;  2BSP A;  3PSZ A;  1DAB A;  1KCC A;  3VMV A;  2IQ7 A;  1LLW A;  1O8K A;  3LYC A;  2O0W A;  4YFO A;  1K8F A;  3B4N A;  2W7Z A;  1RMG A;  5DNS A;  1TYX A;  2YUH A;  3KRG A;  2VJJ A;  4XLC A;  1L1I A;  1QQ1 A;  2NTP A;  2O04 A;  2NT6 A;  4AVZ A;  1K5C A;  3P4G A;  2BM7 A;  4XKV A;  3ZPP A;  4Z06 A;  1QRB A;  2QYU A;  1DBO A;  4OJ6 A;  1TYV A;  1NHC A;  3B90 A;  2BM5 A;  4W8R A;  4XON A;  2VFM A;  2XT2 A;  2Z8G A;  4YZA A;  1KQ5 A;  2QZA A;  4C2L A;  4XMY A;  1LLZ A;  2F3L A;  2VJI A;  2BM6 A;  4XLH A;  4YZQ A;  4EW9 A;  2PEC A;  2X85 A;  3AK5 A;  3B8Y A;  3TH0 A;  3VST A;  4MXN A;  4URR A;  1WMR A;  4U49 A;  2QY1 A;  4W8Q A;  1BN8 A;  1O8M A;  1OFE A;  3SZE A;  3GQA A;  2O0V A;  4I84 A;  2O1D A;  1DBG A;  3GRH A;  3BH6 B;  1JRG A;  3VSV A;  1OGM X;  4OJL A;  4YC5 A;  3JUR A;  4YZ0 A;  1QJV A;  1TYU A;  3WWG A;  1O8L A;  1H80 A;  1O8G A;  2V5I A;  1TYW A;  1O8E A;  2PYH A;  1OFD A;  2J8I A;  2G0Y A;  4NK8 A;  2IOU G;  4XNF A;  4XLE A;  4XQF A;  2NT9 A;  1AIR A;  1OOC A;  2J8K A;  3VSU A; 
#chains in the Genus database with same CATH homology
 2VFO A;  3BH7 B;  1HF2 A;  3RIQ A;  4OJ6 A;  1TYV A;  2BM5 A;  4OJO A;  2VFM A;  4KH3 A;  4OM9 A;  1KQ5 A;  2VFP A;  1K4Z A;  1QRC A;  4V02 C;  4OPW A;  2VFQ A;  3N6Z A;  1QA3 A;  2F3L A;  5JLV C;  2BM6 A;  3JX8 A;  3LJY A;  3ML3 A;  3N90 A;  3AK5 A;  2BM4 A;  1CLW A;  4OJ5 A;  3TH0 A;  1DAB A;  4OJP A;  4JRA C;  3SZE A;  2VFN A;  3LYC A;  1K8F A;  1WXR A;  2XC1 A;  3BH6 B;  2W7Z A;  2B0R A;  1TYX A;  2YUH A;  4OJL A;  1QQ1 A;  1TSP A;  1QA2 A;  3H09 A;  1TYU A;  2V5I A;  1TYW A;  2J8I A;  2G0Y A;  3P4G A;  2IOU G;  3PET A;  2BM7 A;  1QA1 A;  2BX6 A;  1QRB A;  5JMC B;  3SYJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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