4M5XA

Crystal structure of the usp7/hausp catalytic domain
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
346
structure length
339
Chain Sequence
KHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
total genus 108
structure length 339
sequence length 346
chains with identical sequence B
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2013-08-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00443 UCH Ubiquitin carboxyl-terminal hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.210.10 Mainly Beta Single Sheet ubp-family deubiquitinating enzyme fold ubp-family deubiquitinating enzyme superfamily 4m5xA02
4M5XA 1NB8A 1NBFA 2F1ZA 4M5WA
chains in the Genus database with same CATH superfamily
3HRZC 4M5XA 3HS0C 1NBFA 1NB8A 2F1ZA 4M5WA 3FRPB
chains in the Genus database with same CATH topology
4M5XA 1NB8A 1NBFA 2F1ZA 4M5WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4M5X A;  1NB8 A;  1NBF A;  2F1Z A;  4M5W A; 
#chains in the Genus database with same CATH topology
 3HRZ C;  4M5X A;  3HS0 C;  1NBF A;  1NB8 A;  2F1Z A;  4M5W A;  3FRP B; 
#chains in the Genus database with same CATH homology
 4M5X A;  1NB8 A;  1NBF A;  2F1Z A;  4M5W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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