4M8DA

Crystal structure of an isatin hydrolase bound to product analogue thioisatinate
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
262
structure length
262
Chain Sequence
MSAQSALSGLGAKLLSGEVEVVDCTGVLGPNTPILQLPPDFAKNTPKVEIHKISEYDSDGPFFAWNWMVLGEHSGTHFDAPHHWITGKDYSDGFTDTLDVQRLIAPVNVIDCSKESAADPDFLLTADLIKAWEAEHGEIGAGEWVVMRTDWDKRAGDEAAFLNADETGPHSPGPTPDAIEYLLSKKIVGWGSQCIGTDAGQAGGMEPPFPAHNLLHRDNCFGLASLANLDKLPAKGAILIAAPLKIERGTGSPIRALALVPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A proton wire and water channel revealed in the crystal structure of isatin hydrolase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Labrenzia aggregata
molecule keywords Putative uncharacterized protein
total genus 78
structure length 262
sequence length 262
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L
ec nomenclature ec 3.5.2.20: Isatin hydrolase.
pdb deposition date 2013-08-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04199 Cyclase Putative cyclase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.30.50 Alpha Beta 3-Layer(bba) Sandwich Glucose Oxidase; domain 1 Putative cyclase 4m8dA00
2B0AA 4J0NA 4COBA 4M8DA 3KRVA 4CO9A 4COGA 1R61A 4CZ1A
chains in the Genus database with same CATH superfamily
1C30B 3SJGA 4NGRA 3KASA 4M8DA 4TJXA 5F1YA 4YN3A 2X0SA 3TLCA 4P4FA 3BHXA 3EZAA 1EZAA 4C99A 4C84A 4C85A 1WVMA 1XF1A 4P44A 1NBWA 4C9EA 4MCQA 3SJFA 3IIBA 3TLYA 2E28A 2JBJA 3EZBA 3G23A 3T5MA 2C6PA 2YJTA 3TLAA 3VTAA 1CS0B 1C3OB 4C9VA 4CO9A 4NGQA 5JVLA 4OC3A 2XEFA 1VBGA 2EK8A 3FEDA 2DIKA 2XEIA 4OC0A 2XEJA 2PVVA 4MCSA 3SJXA 3D7GA 3C8OA 1DE4C 3TYXA 1JDBC 4MJXA 4TJVA 4E94A 2GP4A 4NGNA 1GGOA 4C9UA 4OMEA 4CZ1A 5D29A 2PCNA 4CDKA 3IWWA 4C9AA 3RBUA 1T36B 2EZAA 3T07A 3ICUA 3D7DA 4OC2A 4C8TA 4P4DA 3EZEA 4W9YA 4P45A 2HROA 3BI1A 3D7HA 4JYWA 4C86A 1R61A 4NGPA 1KBLA 5ELYA 4J0NA 1VBHA 2PVWA 2R82A 4NGSA 5F9MA 3SR3A 4NGTA 4INJA 2OOTA 5IB9A 1ZRSA 5FD8A 2CIJA 1Q5XA 3S9MA 3EIFA 4C8CA 1DIKA 1J3LA 3I6SA 2D0PA 2OLSA 4CDJA 1KEEB 2C5QA 3K4IA 4E5SA 1A9XB 1V6CA 3D7FA 2OR4A 4IIXA 3T05A 3I74A 3U1BA 1VI4A 1KC7A 3TLGA 4NGMA 3TLZA 4P4JA 4C8PA 3S9NA 4EYSA 4OC4A 1JDEA 5F5XA 3BI0A 5F09A 4JVOA 2MP0A 1BXRB 2YJVA 3T0TA 4OC1A 4MCPA 2EZCA 4C8FA 3TLEA 1CX8A 1M6VB 1Z8LA 3KRVA 2HI6A 2D0OA 1CE8B 3NOJA 4MI1A 4P4IA 3TLBA 3S9LA 3FEEA 2XEGA 1NXJA 4C8AA 1ZYMA 3FECA 5JYBA 4H1HA 4MCRA 4IIYA 2HWGA 3TLGB 4KNGE 4COBA 4P4BA 3SJEA 2JBKA 2EK9A 4JZ0A 1ZL0A 4P4EA 4TWEA 2C6CA 4C8UA 4OC5A 3K9TA 5IR2A 1Y9ZA 2EZBA 4X3RA 1EZBA 4LQGA 2AUMA 4COGA 5K99A 2AUNA 3GJZA 2B0AA 3BXMA 2C6GA 4C9RA 3FF3A 2FM4A
chains in the Genus database with same CATH topology
2B0AA 4J0NA 4COBA 4M8DA 3KRVA 4CO9A 4COGA 1R61A 4CZ1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B0A A;  4J0N A;  4COB A;  4M8D A;  3KRV A;  4CO9 A;  4COG A;  1R61 A;  4CZ1 A; 
#chains in the Genus database with same CATH topology
 1C30 B;  3SJG A;  4NGR A;  3KAS A;  4M8D A;  4TJX A;  5F1Y A;  4YN3 A;  2X0S A;  3TLC A;  4P4F A;  3BHX A;  3EZA A;  1EZA A;  4C99 A;  4C84 A;  4C85 A;  1WVM A;  1XF1 A;  4P44 A;  1NBW A;  4C9E A;  4MCQ A;  3SJF A;  3IIB A;  3TLY A;  2E28 A;  2JBJ A;  3EZB A;  3G23 A;  3T5M A;  2C6P A;  2YJT A;  3TLA A;  3VTA A;  1CS0 B;  1C3O B;  4C9V A;  4CO9 A;  4NGQ A;  5JVL A;  4OC3 A;  2XEF A;  1VBG A;  2EK8 A;  3FED A;  2DIK A;  2XEI A;  4OC0 A;  2XEJ A;  2PVV A;  4MCS A;  3SJX A;  3D7G A;  3C8O A;  1DE4 C;  3TYX A;  1JDB C;  4MJX A;  4TJV A;  4E94 A;  2GP4 A;  4NGN A;  1GGO A;  4C9U A;  4OME A;  4CZ1 A;  5D29 A;  2PCN A;  4CDK A;  3IWW A;  4C9A A;  3RBU A;  1T36 B;  2EZA A;  3T07 A;  3ICU A;  3D7D A;  4OC2 A;  4C8T A;  4P4D A;  3EZE A;  4W9Y A;  4P45 A;  2HRO A;  3BI1 A;  3D7H A;  4JYW A;  4C86 A;  1R61 A;  4NGP A;  1KBL A;  5ELY A;  4J0N A;  1VBH A;  2PVW A;  2R82 A;  4NGS A;  5F9M A;  3SR3 A;  4NGT A;  4INJ A;  2OOT A;  5IB9 A;  1ZRS A;  5FD8 A;  2CIJ A;  1Q5X A;  3S9M A;  3EIF A;  4C8C A;  1DIK A;  1J3L A;  3I6S A;  2D0P A;  2OLS A;  4CDJ A;  1KEE B;  2C5Q A;  3K4I A;  4E5S A;  1A9X B;  1V6C A;  3D7F A;  2OR4 A;  4IIX A;  3T05 A;  3I74 A;  3U1B A;  1VI4 A;  1KC7 A;  3TLG A;  4NGM A;  3TLZ A;  4P4J A;  4C8P A;  3S9N A;  4EYS A;  4OC4 A;  1JDE A;  5F5X A;  3BI0 A;  5F09 A;  4JVO A;  2MP0 A;  1BXR B;  2YJV A;  3T0T A;  4OC1 A;  4MCP A;  2EZC A;  4C8F A;  3TLE A;  1CX8 A;  1M6V B;  1Z8L A;  3KRV A;  2HI6 A;  2D0O A;  1CE8 B;  3NOJ A;  4MI1 A;  4P4I A;  3TLB A;  3S9L A;  3FEE A;  2XEG A;  1NXJ A;  4C8A A;  1ZYM A;  3FEC A;  5JYB A;  4H1H A;  4MCR A;  4IIY A;  2HWG A;  3TLG B;  4KNG E;  4COB A;  4P4B A;  3SJE A;  2JBK A;  2EK9 A;  4JZ0 A;  1ZL0 A;  4P4E A;  4TWE A;  2C6C A;  4C8U A;  4OC5 A;  3K9T A;  5IR2 A;  1Y9Z A;  2EZB A;  4X3R A;  1EZB A;  4LQG A;  2AUM A;  4COG A;  5K99 A;  2AUN A;  3GJZ A;  2B0A A;  3BXM A;  2C6G A;  4C9R A;  3FF3 A;  2FM4 A; 
#chains in the Genus database with same CATH homology
 2B0A A;  4J0N A;  4COB A;  4M8D A;  3KRV A;  4CO9 A;  4COG A;  1R61 A;  4CZ1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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