4OOKA

Third metal bound m.tuberculosis methionine aminopeptidase
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
282
structure length
282
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 88
structure length 282
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4ookA01
2GU4A 2BHAA 2GG0A 2BHCA 2BN7A 4ZWOA 4FO8A 4S2TP 2GU7A 4RZZA 1QXZA 5CE6A 4S01A 5D6FA 1YW8A 4U71A 5JFRA 4FLLA 4U6JA 1PV9A 2G6PA 2B3HA 2GG5A 2NQ6A 2OKNA 3FM3A 2IW2A 3IU9A 5JHUA 4U70A 1W7VA 1KP0A 2BH3A 1WLRA 2ADUA 3CB5A 4IECA 4MATA 1BOAA 3RVAA 4FUKA 2GGCA 4PNCA 2V3XA 3CTZA 3CB6A 1YW7A 2BHBA 4IKRA 5FCFA 3MR1A 4EGEA 2V6CA 1YW9A 1JAWA 4ZWPA 3TB5A 3FMQA 2Q93A 3BITA 2B3KA 1R5HA 4QR8A 2P99A 4ZWUA 1KQ0A 4U6WA 4A6WA 4U76A 1C24A 1N51A 5E5BA 4U75A 2EVOA 2GG8A 2BWXA 3PKEA 5D6EA 5CDVA 1Y1NA 4IF7A 2Q8KA 2EA2A 5CNXA 3MATA 4JUQA 2GU5A 1WKMA 1XGSA 3TAVA 4U1BA 4OOKA 1XGOA 2BWVA 1YVMA 2BWSA 3L24A 4U69A 2V3ZA 4IKTA 2ZSGA 1WL6A 1C23A 1R5GA 4U73A 1KQ9A 2P9AA 1XGMA 4PV4A 2GGBA 2GZ5A 2P98A 1MATA 2EA4A 3PKDA 4FLIA 2EVMA 1WY2A 4IDYA 4S2RP 3S6BA 1C21A 4FO7A 1XGNA 1XNZA 1BN5A 2BWYA 2MATA 1B6AA 4B28A 4FKCA 4FLKA 2Q94A 5JI6A 3L7GA 4U6CA 3D27A 3IU8A 4A6VA 3IG4A 1CHMA 2OAZA 2B3LA 3PKCA 2GG9A 2GU6A 2V3YA 3Q6DA 1O0XA 2GG7A 3PKBA 1YJ3A 1WN1A 3BIQA 2NQ7A 2BB7A 2HOWA 2Q96A 4U6EA 5CDEA 4S00A 2BWWA 2GA2A 1WBQA 2BWUA 2GTXA 1B59A 1R58A 4ZNGA 5CLSA 4IPAA 5CDLA 1WL9A 2Q92A 1M35A 1QZYA 5CIKA 1C22A 4FLJA 4IKUA 4IU6A 2GG2A 4Z7MA 3RORA 2Q95A 2EVCA 4IKSA 3FMRA 4RZYA 2GG3A 1C27A 1W2MA 2BHDA 1QXWA 4HXXA 4R60A 1QXYA 4U6ZA 4KM3A 3IU7A 3PKAA 3MX6A 4RGZ1 5FCHA 2BWTA 1A16A 3BIPA 2DFIA
chains in the Genus database with same CATH superfamily
2GU4A 2BHAA 2GG0A 2BHCA 2BN7A 4ZWOA 4FO8A 4S2TP 2GU7A 4RZZA 1QXZA 5CE6A 4S01A 5D6FA 1YW8A 4U71A 5JFRA 4FLLA 4U6JA 1PV9A 2G6PA 2B3HA 2GG5A 2NQ6A 2OKNA 3FM3A 2IW2A 3IU9A 5JHUA 4U70A 1W7VA 1KP0A 2BH3A 1WLRA 2ADUA 3CB5A 4IECA 4MATA 1BOAA 3RVAA 4FUKA 2GGCA 4PNCA 2V3XA 3CTZA 3CB6A 1YW7A 2BHBA 4IKRA 5FCFA 3MR1A 4EGEA 2V6CA 1YW9A 1JAWA 4ZWPA 3TB5A 3FMQA 2Q93A 3BITA 2B3KA 1R5HA 4QR8A 2P99A 4ZWUA 1KQ0A 4U6WA 4A6WA 4U76A 1C24A 1N51A 5E5BA 4U75A 2EVOA 2GG8A 2BWXA 3PKEA 5D6EA 5CDVA 1Y1NA 4IF7A 2Q8KA 2EA2A 5CNXA 3MATA 4JUQA 2GU5A 1WKMA 1XGSA 3TAVA 4U1BA 4OOKA 1XGOA 2BWVA 1YVMA 2BWSA 3L24A 4U69A 2V3ZA 4IKTA 2ZSGA 1WL6A 1C23A 1R5GA 4U73A 1KQ9A 2P9AA 1XGMA 4PV4A 2GGBA 2GZ5A 2P98A 1MATA 2EA4A 3PKDA 4FLIA 2EVMA 1WY2A 4IDYA 4S2RP 3S6BA 1C21A 4FO7A 1XGNA 1XNZA 1BN5A 2BWYA 2MATA 1B6AA 4B28A 4FKCA 4FLKA 2Q94A 5JI6A 3L7GA 4U6CA 3D27A 3IU8A 4A6VA 3IG4A 1CHMA 2OAZA 2B3LA 3PKCA 2GG9A 2GU6A 2V3YA 3Q6DA 1O0XA 2GG7A 3PKBA 1YJ3A 1WN1A 3BIQA 2NQ7A 2BB7A 2HOWA 2Q96A 4U6EA 5CDEA 4S00A 2BWWA 2GA2A 1WBQA 2BWUA 2GTXA 1B59A 1R58A 4ZNGA 5CLSA 4IPAA 5CDLA 1WL9A 2Q92A 1M35A 1QZYA 5CIKA 1C22A 4FLJA 4IKUA 4IU6A 2GG2A 4Z7MA 3RORA 2Q95A 2EVCA 4IKSA 3FMRA 4RZYA 2GG3A 1C27A 1W2MA 2BHDA 1QXWA 4HXXA 4R60A 1QXYA 4U6ZA 4KM3A 3IU7A 3PKAA 3MX6A 4RGZ1 5FCHA 2BWTA 1A16A 3BIPA 2DFIA
chains in the Genus database with same CATH topology
2GU4A 2BHAA 2GG0A 2BHCA 2BN7A 4ZWOA 4FO8A 4S2TP 2GU7A 4RZZA 1QXZA 5CE6A 4S01A 5D6FA 1YW8A 4U71A 5JFRA 4FLLA 4U6JA 1PV9A 2G6PA 2B3HA 2GG5A 2NQ6A 2OKNA 3FM3A 2IW2A 3IU9A 5JHUA 4U70A 1W7VA 1KP0A 2BH3A 1WLRA 2ADUA 3CB5A 4IECA 4MATA 1BOAA 3RVAA 4FUKA 2GGCA 4PNCA 2V3XA 3CTZA 3CB6A 1YW7A 2BHBA 4IKRA 5FCFA 3MR1A 4EGEA 2V6CA 1YW9A 1JAWA 4ZWPA 3TB5A 3FMQA 2Q93A 3BITA 2B3KA 1R5HA 4QR8A 2P99A 4ZWUA 1KQ0A 4U6WA 4A6WA 4U76A 1C24A 1N51A 5E5BA 4U75A 2EVOA 2GG8A 2BWXA 3PKEA 5D6EA 5CDVA 1Y1NA 4IF7A 2Q8KA 2EA2A 5CNXA 3MATA 4JUQA 2GU5A 1WKMA 1XGSA 3TAVA 4U1BA 4OOKA 1XGOA 2BWVA 1YVMA 2BWSA 3L24A 4U69A 2V3ZA 4IKTA 2ZSGA 1WL6A 1C23A 1R5GA 4U73A 1KQ9A 2P9AA 1XGMA 4PV4A 2GGBA 2GZ5A 2P98A 1MATA 2EA4A 3PKDA 4FLIA 2EVMA 1WY2A 4IDYA 4S2RP 3S6BA 1C21A 4FO7A 1XGNA 1XNZA 1BN5A 2BWYA 2MATA 1B6AA 4B28A 4FKCA 4FLKA 2Q94A 5JI6A 3L7GA 4U6CA 3D27A 3IU8A 4A6VA 3IG4A 1CHMA 2OAZA 2B3LA 3PKCA 2GG9A 2GU6A 2V3YA 3Q6DA 1O0XA 2GG7A 3PKBA 1YJ3A 1WN1A 3BIQA 2NQ7A 2BB7A 2HOWA 2Q96A 4U6EA 5CDEA 4S00A 2BWWA 2GA2A 1WBQA 2BWUA 2GTXA 1B59A 1R58A 4ZNGA 5CLSA 4IPAA 5CDLA 1WL9A 2Q92A 1M35A 1QZYA 5CIKA 1C22A 4FLJA 4IKUA 4IU6A 2GG2A 4Z7MA 3RORA 2Q95A 2EVCA 4IKSA 3FMRA 4RZYA 2GG3A 1C27A 1W2MA 2BHDA 1QXWA 4HXXA 4R60A 1QXYA 4U6ZA 4KM3A 3IU7A 3PKAA 3MX6A 4RGZ1 5FCHA 2BWTA 1A16A 3BIPA 2DFIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GU4 A;  2BHA A;  2GG0 A;  2BHC A;  2BN7 A;  4ZWO A;  4FO8 A;  4S2T P;  2GU7 A;  4RZZ A;  1QXZ A;  5CE6 A;  4S01 A;  5D6F A;  1YW8 A;  4U71 A;  5JFR A;  4FLL A;  4U6J A;  1PV9 A;  2G6P A;  2B3H A;  2GG5 A;  2NQ6 A;  2OKN A;  3FM3 A;  2IW2 A;  3IU9 A;  5JHU A;  4U70 A;  1W7V A;  1KP0 A;  2BH3 A;  1WLR A;  2ADU A;  3CB5 A;  4IEC A;  4MAT A;  1BOA A;  3RVA A;  4FUK A;  2GGC A;  4PNC A;  2V3X A;  3CTZ A;  3CB6 A;  1YW7 A;  2BHB A;  4IKR A;  5FCF A;  3MR1 A;  4EGE A;  2V6C A;  1YW9 A;  1JAW A;  4ZWP A;  3TB5 A;  3FMQ A;  2Q93 A;  3BIT A;  2B3K A;  1R5H A;  4QR8 A;  2P99 A;  4ZWU A;  1KQ0 A;  4U6W A;  4A6W A;  4U76 A;  1C24 A;  1N51 A;  5E5B A;  4U75 A;  2EVO A;  2GG8 A;  2BWX A;  3PKE A;  5D6E A;  5CDV A;  1Y1N A;  4IF7 A;  2Q8K A;  2EA2 A;  5CNX A;  3MAT A;  4JUQ A;  2GU5 A;  1WKM A;  1XGS A;  3TAV A;  4U1B A;  4OOK A;  1XGO A;  2BWV A;  1YVM A;  2BWS A;  3L24 A;  4U69 A;  2V3Z A;  4IKT A;  2ZSG A;  1WL6 A;  1C23 A;  1R5G A;  4U73 A;  1KQ9 A;  2P9A A;  1XGM A;  4PV4 A;  2GGB A;  2GZ5 A;  2P98 A;  1MAT A;  2EA4 A;  3PKD A;  4FLI A;  2EVM A;  1WY2 A;  4IDY A;  4S2R P;  3S6B A;  1C21 A;  4FO7 A;  1XGN A;  1XNZ A;  1BN5 A;  2BWY A;  2MAT A;  1B6A A;  4B28 A;  4FKC A;  4FLK A;  2Q94 A;  5JI6 A;  3L7G A;  4U6C A;  3D27 A;  3IU8 A;  4A6V A;  3IG4 A;  1CHM A;  2OAZ A;  2B3L A;  3PKC A;  2GG9 A;  2GU6 A;  2V3Y A;  3Q6D A;  1O0X A;  2GG7 A;  3PKB A;  1YJ3 A;  1WN1 A;  3BIQ A;  2NQ7 A;  2BB7 A;  2HOW A;  2Q96 A;  4U6E A;  5CDE A;  4S00 A;  2BWW A;  2GA2 A;  1WBQ A;  2BWU A;  2GTX A;  1B59 A;  1R58 A;  4ZNG A;  5CLS A;  4IPA A;  5CDL A;  1WL9 A;  2Q92 A;  1M35 A;  1QZY A;  5CIK A;  1C22 A;  4FLJ A;  4IKU A;  4IU6 A;  2GG2 A;  4Z7M A;  3ROR A;  2Q95 A;  2EVC A;  4IKS A;  3FMR A;  4RZY A;  2GG3 A;  1C27 A;  1W2M A;  2BHD A;  1QXW A;  4HXX A;  4R60 A;  1QXY A;  4U6Z A;  4KM3 A;  3IU7 A;  3PKA A;  3MX6 A;  4RGZ 1;  5FCH A;  2BWT A;  1A16 A;  3BIP A;  2DFI A; 
#chains in the Genus database with same CATH topology
 2GU4 A;  2BHA A;  2GG0 A;  2BHC A;  2BN7 A;  4ZWO A;  4FO8 A;  4S2T P;  2GU7 A;  4RZZ A;  1QXZ A;  5CE6 A;  4S01 A;  5D6F A;  1YW8 A;  4U71 A;  5JFR A;  4FLL A;  4U6J A;  1PV9 A;  2G6P A;  2B3H A;  2GG5 A;  2NQ6 A;  2OKN A;  3FM3 A;  2IW2 A;  3IU9 A;  5JHU A;  4U70 A;  1W7V A;  1KP0 A;  2BH3 A;  1WLR A;  2ADU A;  3CB5 A;  4IEC A;  4MAT A;  1BOA A;  3RVA A;  4FUK A;  2GGC A;  4PNC A;  2V3X A;  3CTZ A;  3CB6 A;  1YW7 A;  2BHB A;  4IKR A;  5FCF A;  3MR1 A;  4EGE A;  2V6C A;  1YW9 A;  1JAW A;  4ZWP A;  3TB5 A;  3FMQ A;  2Q93 A;  3BIT A;  2B3K A;  1R5H A;  4QR8 A;  2P99 A;  4ZWU A;  1KQ0 A;  4U6W A;  4A6W A;  4U76 A;  1C24 A;  1N51 A;  5E5B A;  4U75 A;  2EVO A;  2GG8 A;  2BWX A;  3PKE A;  5D6E A;  5CDV A;  1Y1N A;  4IF7 A;  2Q8K A;  2EA2 A;  5CNX A;  3MAT A;  4JUQ A;  2GU5 A;  1WKM A;  1XGS A;  3TAV A;  4U1B A;  4OOK A;  1XGO A;  2BWV A;  1YVM A;  2BWS A;  3L24 A;  4U69 A;  2V3Z A;  4IKT A;  2ZSG A;  1WL6 A;  1C23 A;  1R5G A;  4U73 A;  1KQ9 A;  2P9A A;  1XGM A;  4PV4 A;  2GGB A;  2GZ5 A;  2P98 A;  1MAT A;  2EA4 A;  3PKD A;  4FLI A;  2EVM A;  1WY2 A;  4IDY A;  4S2R P;  3S6B A;  1C21 A;  4FO7 A;  1XGN A;  1XNZ A;  1BN5 A;  2BWY A;  2MAT A;  1B6A A;  4B28 A;  4FKC A;  4FLK A;  2Q94 A;  5JI6 A;  3L7G A;  4U6C A;  3D27 A;  3IU8 A;  4A6V A;  3IG4 A;  1CHM A;  2OAZ A;  2B3L A;  3PKC A;  2GG9 A;  2GU6 A;  2V3Y A;  3Q6D A;  1O0X A;  2GG7 A;  3PKB A;  1YJ3 A;  1WN1 A;  3BIQ A;  2NQ7 A;  2BB7 A;  2HOW A;  2Q96 A;  4U6E A;  5CDE A;  4S00 A;  2BWW A;  2GA2 A;  1WBQ A;  2BWU A;  2GTX A;  1B59 A;  1R58 A;  4ZNG A;  5CLS A;  4IPA A;  5CDL A;  1WL9 A;  2Q92 A;  1M35 A;  1QZY A;  5CIK A;  1C22 A;  4FLJ A;  4IKU A;  4IU6 A;  2GG2 A;  4Z7M A;  3ROR A;  2Q95 A;  2EVC A;  4IKS A;  3FMR A;  4RZY A;  2GG3 A;  1C27 A;  1W2M A;  2BHD A;  1QXW A;  4HXX A;  4R60 A;  1QXY A;  4U6Z A;  4KM3 A;  3IU7 A;  3PKA A;  3MX6 A;  4RGZ 1;  5FCH A;  2BWT A;  1A16 A;  3BIP A;  2DFI A; 
#chains in the Genus database with same CATH homology
 2GU4 A;  2BHA A;  2GG0 A;  2BHC A;  2BN7 A;  4ZWO A;  4FO8 A;  4S2T P;  2GU7 A;  4RZZ A;  1QXZ A;  5CE6 A;  4S01 A;  5D6F A;  1YW8 A;  4U71 A;  5JFR A;  4FLL A;  4U6J A;  1PV9 A;  2G6P A;  2B3H A;  2GG5 A;  2NQ6 A;  2OKN A;  3FM3 A;  2IW2 A;  3IU9 A;  5JHU A;  4U70 A;  1W7V A;  1KP0 A;  2BH3 A;  1WLR A;  2ADU A;  3CB5 A;  4IEC A;  4MAT A;  1BOA A;  3RVA A;  4FUK A;  2GGC A;  4PNC A;  2V3X A;  3CTZ A;  3CB6 A;  1YW7 A;  2BHB A;  4IKR A;  5FCF A;  3MR1 A;  4EGE A;  2V6C A;  1YW9 A;  1JAW A;  4ZWP A;  3TB5 A;  3FMQ A;  2Q93 A;  3BIT A;  2B3K A;  1R5H A;  4QR8 A;  2P99 A;  4ZWU A;  1KQ0 A;  4U6W A;  4A6W A;  4U76 A;  1C24 A;  1N51 A;  5E5B A;  4U75 A;  2EVO A;  2GG8 A;  2BWX A;  3PKE A;  5D6E A;  5CDV A;  1Y1N A;  4IF7 A;  2Q8K A;  2EA2 A;  5CNX A;  3MAT A;  4JUQ A;  2GU5 A;  1WKM A;  1XGS A;  3TAV A;  4U1B A;  4OOK A;  1XGO A;  2BWV A;  1YVM A;  2BWS A;  3L24 A;  4U69 A;  2V3Z A;  4IKT A;  2ZSG A;  1WL6 A;  1C23 A;  1R5G A;  4U73 A;  1KQ9 A;  2P9A A;  1XGM A;  4PV4 A;  2GGB A;  2GZ5 A;  2P98 A;  1MAT A;  2EA4 A;  3PKD A;  4FLI A;  2EVM A;  1WY2 A;  4IDY A;  4S2R P;  3S6B A;  1C21 A;  4FO7 A;  1XGN A;  1XNZ A;  1BN5 A;  2BWY A;  2MAT A;  1B6A A;  4B28 A;  4FKC A;  4FLK A;  2Q94 A;  5JI6 A;  3L7G A;  4U6C A;  3D27 A;  3IU8 A;  4A6V A;  3IG4 A;  1CHM A;  2OAZ A;  2B3L A;  3PKC A;  2GG9 A;  2GU6 A;  2V3Y A;  3Q6D A;  1O0X A;  2GG7 A;  3PKB A;  1YJ3 A;  1WN1 A;  3BIQ A;  2NQ7 A;  2BB7 A;  2HOW A;  2Q96 A;  4U6E A;  5CDE A;  4S00 A;  2BWW A;  2GA2 A;  1WBQ A;  2BWU A;  2GTX A;  1B59 A;  1R58 A;  4ZNG A;  5CLS A;  4IPA A;  5CDL A;  1WL9 A;  2Q92 A;  1M35 A;  1QZY A;  5CIK A;  1C22 A;  4FLJ A;  4IKU A;  4IU6 A;  2GG2 A;  4Z7M A;  3ROR A;  2Q95 A;  2EVC A;  4IKS A;  3FMR A;  4RZY A;  2GG3 A;  1C27 A;  1W2M A;  2BHD A;  1QXW A;  4HXX A;  4R60 A;  1QXY A;  4U6Z A;  4KM3 A;  3IU7 A;  3PKA A;  3MX6 A;  4RGZ 1;  5FCH A;  2BWT A;  1A16 A;  3BIP A;  2DFI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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