4PO2A

Crystal structure of the stress-inducible human heat shock protein hsp70 substrate-binding domain in complex with peptide substrate
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
228
structure length
228
Chain Sequence
ENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Chaperone
molecule keywords Heat shock 70 kDa protein 1A/1B
total genus 71
structure length 228
sequence length 228
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-02-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.10 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Substrate Binding Domain Of Dnak; Chain:A; Domain 2 4po2A02
2.60.34.10 Mainly Beta Sandwich Substrate Binding Domain Of DNAk; Chain A, domain 1 Substrate Binding Domain Of DNAk; Chain A, domain 1 4po2A01
4PO2A 2WINM 3OHXM 4R5LA 4EZQA 1YUWA 4H6IA 2QFFA 5TKYA 1U00A 5E84A 4EZWA 4EZPA 4R5KA 4E81A 4EZVA 4EZZA 4WV7A 2KHOA 4JNFA 3DPPA 3T4AG 1DKYA 3T46A 4EZSA 4F00A 3DOBA 7HSCA 4EZXA 1CKRA 4JN4A 3L3OM 3DQGA 3D2FA 4JWCA 4JNEA 4R5GA 4JWEA 3T48A 2OP6A 3C7NA 4EZRA 1Q5LA 4FL9A 1BPRA 4EZUA 4F01A 1DKXA 3DPQA 4EZYA 1DG4A 4R5IA 4JWIA 4EZNA 4WV5A 4HY9A 2QXLA 4EZTA 2V7YA 1DKZA 4R5JA 4B9QA 3H0XA 2BPRA 3N8EA 4JWDA 4H6HA 4HYBA 3C7NB 4EZOA 3D2EA 3T49A 3QNJA 3T47A 3DPOA
chains in the Genus database with same CATH superfamily
2ND1A 2YL9A 4AZHA 2WINM 3OHXM 4AZGA 3UITA 3D4ZA 2EX3B 4EZPA 4FZPA 4R5KA 1I4TA 2JNKA 2OZNB 3FD9A 4EZVA 4F00A 4D8JA 1SU7A 2OBMA 3T46A 2WYHA 1SU6A 3VKHA 1QX1A 4AZIA 2F7PA 3DX0A 2EWFA 3HAHA 3T48A 4JWEA 1HXKA 3EJSA 3C7NA 4NQIA 4EZRA 1CKRA 5FIGA 2OO2A 1GNTA 4UDXX 2RAKA 4IM0A 3BUDA 4NPHA 3BUQA 3VEBA 1OA0A 1ZYLA 2ALWA 4AZCB 2Z8YA 2F1AA 2YL5A 2BPRA 1TQTA 2Z0NA 1GNLA 4AZ5A 4H6HA 2C08A 2N3KA 2O0I1 2X3WA 4WPEA 3B52X 3QNJA 1LQ7A 3M3WA 4H8SA 3SBSA 5C5BA 1SU8A 1MJGA 2JNSA 3D50A 1YWMA 2LM0A 2X3XA 2YL6A 4EZQA 3RPMA 2QFFA 1E9VA 2QKWA 5E84A 4EZWA 3BUBA 1UPXA 3B53X 3DX2A 1R34A 3SOGA 3DOBA 1TQWA 3DPPA 3ACOA 1DKYA 4JNFA 3T4AG 4BNEA 1SUFA 4EZSA 3LLLA 3DYTA 2Q12A 4AVMA 2ELBA 4KIKB 3KAVA 3ER8C 2YI9A 3D2FA 3DX3A 3LVTA 2OP6A 3GI7A 4IM2A 3ZEFA 1Q5LA 3I39X 4HR1A 1BPRA 3EJRA 1DKXA 3EJUA 1X04A 1E1DA 2MI7A 2FYVA 3QA8A 2X3VA 3CKDA 2FICA 1R5EA 2YIAA 3A98A 3ERCC 2V7YA 2V0OA 1TQVA 3QE6A 1TQUA 1JQKA 3Q0KA 3D51A 4R5JA 1WDZA 4JWDA 3BUIA 2RAIA 3BLBA 2EFLA 1HTYA 3D2EA 2PY6A 3BVWA 4ILGA 3DPOA 2RT6A 2YKTA 3O3NB 4R5LA 2X5CA 4AZBA 1YUWA 3BVTA 2ND0A 3BVXA 3D52A 3VEAA 2GF4A 2YLLA 3DDFA 3CZNA 2ZXQA 3DX4A 4FZOA 4JL9A 4JLCA 4KIKA 2OBLA 1O7DB 2KHOA 3OWGA 4EZZA 2NCZA 4WV7A 2F7RA 2RAJA 1PS3A 4HR1B 7HSCA 4EZXA 2YIVX 4AZ7A 1DG4A 1E2UA 1I49A 2GAFD 4JWCA 4JNEA 3BVVA 4FL9A 4ILHB 1HWWA 2LXYA 4EZYA 4F01A 1QWNA 2YI8A 4FM3A 4JWIA 4R5IA 4FZSA 2YIBA 5C5BB 3F7WA 4MQDA 2EFKA 3HAIA 2Q13A 4WV5A 3CV5A 4I43A 1DKZA 1ZWWA 3EJQA 3QNIA 3ZEDA 3ER9B 3H0XA 2YL8A 2D1LA 2GA9D 3CVRA 3HAJA 2OW7A 3O3OB 1TQSA 3ABHA 3QWEA 1X03A 4IWOA 3C7NB 3CAZA 3O3MB 4M0MA 3EJPA 3SBTB 3LMFA 4PO2A 3KDRA 1I4DA 4UDYX 4DCNC 1I4LA 3D4YA 4G6QA 4H6IA 2Z0VA 5TKYA 3SYVA 4AZCA 1U00A 2F1BA 3CZSA 4AKVA 4E81A 2F7OA 3I04A 1OAOA 2PMRA 4AZ6A 4E3CA 4ATMA 4ILIA 3DDGA 2Z0OA 1W9MA 3EJTA 4IWQA 5KBPA 4IW0A 5FLEX 3I2WA 3RV1A 4JN4A 3L3OM 3DQGA 3I01A 2OW6A 4R5GA 1R33A 1O7DC 3RV0A 4I1QA 4DYLA 3DX1A 3B51X 3KAWA 4IM3A 3DPQA 4EZUA 1GN9A 4EZNA 3L3PA 2YLAA 3OK8A 2QXLA 4HY9A 4EZTA 3Q84A 3BVUA 3PLTA 4B9QA 4NSWA 3N8EA 3G9GA 1OA1A 2F18A 2D4CA 4WPCA 4HYBA 2WYIA 4IWPA 4EZOA 1URUA 2F7QA 1QWUA 3BUPA 1Y2OA 3T49A 3T47A
chains in the Genus database with same CATH topology
2ND1A 2WINM 3OHXM 3UITA 2EX3B 4EZPA 4R5KA 4EZVA 3FD9A 4D8JA 4F00A 1SU7A 2OBMA 3T46A 1SU6A 3VKHA 2EWFA 3T48A 4JWEA 1CKRA 3C7NA 4EZRA 5FIGA 1GNTA 4UDXX 4IM0A 4NPHA 3VEBA 1OA0A 1ZYLA 2Z8YA 2BPRA 1GNLA 4H6HA 2N3KA 3B52X 3QNJA 3SBSA 1SU8A 1MJGA 2JNSA 2LM0A 4EZQA 2QFFA 1E9VA 5E84A 4EZWA 1UPXA 3B53X 3DOBA 4JNFA 3DPPA 3T4AG 1DKYA 4EZSA 1SUFA 4KIKB 3KAVA 3ER8C 2YI9A 3D2FA 2OP6A 3ZEFA 3GI7A 4IM2A 1Q5LA 3I39X 4HR1A 1BPRA 1DKXA 1E1DA 3QA8A 2YIAA 3A98A 3ERCC 2V7YA 4R5JA 1JQKA 4JWDA 3D2EA 2PY6A 4ILGA 3DPOA 2RT6A 4R5LA 3O3NB 2X5CA 1YUWA 2ND0A 3VEAA 4JL9A 4JLCA 4KIKA 4EZZA 2OBLA 3OWGA 2KHOA 4WV7A 2NCZA 4HR1B 7HSCA 4EZXA 2YIVX 1E2UA 2GAFD 4JWCA 4JNEA 4FL9A 4ILHB 4F01A 4EZYA 2YI8A 4FM3A 4JWIA 4R5IA 2YIBA 3F7WA 4MQDA 4WV5A 1DKZA 3ZEDA 3ER9B 3H0XA 2GA9D 3O3OB 3C7NB 4IWOA 3O3MB 4M0MA 3SBTB 3LMFA 4PO2A 3KDRA 4UDYX 4G6QA 4H6IA 5TKYA 1U00A 4E81A 1DG4A 3I04A 1OAOA 4E3CA 4ILIA 1W9MA 4IWQA 4IW0A 5FLEX 3RV1A 4JN4A 3L3OM 3DQGA 3I01A 4R5GA 3RV0A 3B51X 3KAWA 4IM3A 3DPQA 4EZUA 1GN9A 4EZNA 2QXLA 4HY9A 4EZTA 4B9QA 3N8EA 1OA1A 4HYBA 4IWPA 4EZOA 3T49A 4I43A 3T47A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PO2 A;  2WIN M;  3OHX M;  4R5L A;  4EZQ A;  1YUW A;  4H6I A;  2QFF A;  5TKY A;  1U00 A;  5E84 A;  4EZW A;  4EZP A;  4R5K A;  4E81 A;  4EZV A;  4EZZ A;  4WV7 A;  2KHO A;  4JNF A;  3DPP A;  3T4A G;  1DKY A;  3T46 A;  4EZS A;  4F00 A;  3DOB A;  7HSC A;  4EZX A;  1CKR A;  4JN4 A;  3L3O M;  3DQG A;  3D2F A;  4JWC A;  4JNE A;  4R5G A;  4JWE A;  3T48 A;  2OP6 A;  3C7N A;  4EZR A;  1Q5L A;  4FL9 A;  1BPR A;  4EZU A;  4F01 A;  1DKX A;  3DPQ A;  4EZY A;  1DG4 A;  4R5I A;  4JWI A;  4EZN A;  4WV5 A;  4HY9 A;  2QXL A;  4EZT A;  2V7Y A;  1DKZ A;  4R5J A;  4B9Q A;  3H0X A;  2BPR A;  3N8E A;  4JWD A;  4H6H A;  4HYB A;  3C7N B;  4EZO A;  3D2E A;  3T49 A;  3QNJ A;  3T47 A;  3DPO A; 
#chains in the Genus database with same CATH topology
 2ND1 A;  2YL9 A;  4AZH A;  2WIN M;  3OHX M;  4AZG A;  3UIT A;  3D4Z A;  2EX3 B;  4EZP A;  4FZP A;  4R5K A;  1I4T A;  2JNK A;  2OZN B;  3FD9 A;  4EZV A;  4F00 A;  4D8J A;  1SU7 A;  2OBM A;  3T46 A;  2WYH A;  1SU6 A;  3VKH A;  1QX1 A;  4AZI A;  2F7P A;  3DX0 A;  2EWF A;  3HAH A;  3T48 A;  4JWE A;  1HXK A;  3EJS A;  3C7N A;  4NQI A;  4EZR A;  1CKR A;  5FIG A;  2OO2 A;  1GNT A;  4UDX X;  2RAK A;  4IM0 A;  3BUD A;  4NPH A;  3BUQ A;  3VEB A;  1OA0 A;  1ZYL A;  2ALW A;  4AZC B;  2Z8Y A;  2F1A A;  2YL5 A;  2BPR A;  1TQT A;  2Z0N A;  1GNL A;  4AZ5 A;  4H6H A;  2C08 A;  2N3K A;  2O0I 1;  2X3W A;  4WPE A;  3B52 X;  3QNJ A;  1LQ7 A;  3M3W A;  4H8S A;  3SBS A;  5C5B A;  1SU8 A;  1MJG A;  2JNS A;  3D50 A;  1YWM A;  2LM0 A;  2X3X A;  2YL6 A;  4EZQ A;  3RPM A;  2QFF A;  1E9V A;  2QKW A;  5E84 A;  4EZW A;  3BUB A;  1UPX A;  3B53 X;  3DX2 A;  1R34 A;  3SOG A;  3DOB A;  1TQW A;  3DPP A;  3ACO A;  1DKY A;  4JNF A;  3T4A G;  4BNE A;  1SUF A;  4EZS A;  3LLL A;  3DYT A;  2Q12 A;  4AVM A;  2ELB A;  4KIK B;  3KAV A;  3ER8 C;  2YI9 A;  3D2F A;  3DX3 A;  3LVT A;  2OP6 A;  3GI7 A;  4IM2 A;  3ZEF A;  1Q5L A;  3I39 X;  4HR1 A;  1BPR A;  3EJR A;  1DKX A;  3EJU A;  1X04 A;  1E1D A;  2MI7 A;  2FYV A;  3QA8 A;  2X3V A;  3CKD A;  2FIC A;  1R5E A;  2YIA A;  3A98 A;  3ERC C;  2V7Y A;  2V0O A;  1TQV A;  3QE6 A;  1TQU A;  1JQK A;  3Q0K A;  3D51 A;  4R5J A;  1WDZ A;  4JWD A;  3BUI A;  2RAI A;  3BLB A;  2EFL A;  1HTY A;  3D2E A;  2PY6 A;  3BVW A;  4ILG A;  3DPO A;  2RT6 A;  2YKT A;  3O3N B;  4R5L A;  2X5C A;  4AZB A;  1YUW A;  3BVT A;  2ND0 A;  3BVX A;  3D52 A;  3VEA A;  2GF4 A;  2YLL A;  3DDF A;  3CZN A;  2ZXQ A;  3DX4 A;  4FZO A;  4JL9 A;  4JLC A;  4KIK A;  2OBL A;  1O7D B;  2KHO A;  3OWG A;  4EZZ A;  2NCZ A;  4WV7 A;  2F7R A;  2RAJ A;  1PS3 A;  4HR1 B;  7HSC A;  4EZX A;  2YIV X;  4AZ7 A;  1DG4 A;  1E2U A;  1I49 A;  2GAF D;  4JWC A;  4JNE A;  3BVV A;  4FL9 A;  4ILH B;  1HWW A;  2LXY A;  4EZY A;  4F01 A;  1QWN A;  2YI8 A;  4FM3 A;  4JWI A;  4R5I A;  4FZS A;  2YIB A;  5C5B B;  3F7W A;  4MQD A;  2EFK A;  3HAI A;  2Q13 A;  4WV5 A;  3CV5 A;  4I43 A;  1DKZ A;  1ZWW A;  3EJQ A;  3QNI A;  3ZED A;  3ER9 B;  3H0X A;  2YL8 A;  2D1L A;  2GA9 D;  3CVR A;  3HAJ A;  2OW7 A;  3O3O B;  1TQS A;  3ABH A;  3QWE A;  1X03 A;  4IWO A;  3C7N B;  3CAZ A;  3O3M B;  4M0M A;  3EJP A;  3SBT B;  3LMF A;  4PO2 A;  3KDR A;  1I4D A;  4UDY X;  4DCN C;  1I4L A;  3D4Y A;  4G6Q A;  4H6I A;  2Z0V A;  5TKY A;  3SYV A;  4AZC A;  1U00 A;  2F1B A;  3CZS A;  4AKV A;  4E81 A;  2F7O A;  3I04 A;  1OAO A;  2PMR A;  4AZ6 A;  4E3C A;  4ATM A;  4ILI A;  3DDG A;  2Z0O A;  1W9M A;  3EJT A;  4IWQ A;  5KBP A;  4IW0 A;  5FLE X;  3I2W A;  3RV1 A;  4JN4 A;  3L3O M;  3DQG A;  3I01 A;  2OW6 A;  4R5G A;  1R33 A;  1O7D C;  3RV0 A;  4I1Q A;  4DYL A;  3DX1 A;  3B51 X;  3KAW A;  4IM3 A;  3DPQ A;  4EZU A;  1GN9 A;  4EZN A;  3L3P A;  2YLA A;  3OK8 A;  2QXL A;  4HY9 A;  4EZT A;  3Q84 A;  3BVU A;  3PLT A;  4B9Q A;  4NSW A;  3N8E A;  3G9G A;  1OA1 A;  2F18 A;  2D4C A;  4WPC A;  4HYB A;  2WYI A;  4IWP A;  4EZO A;  1URU A;  2F7Q A;  1QWU A;  3BUP A;  1Y2O A;  3T49 A;  3T47 A; 
#chains in the Genus database with same CATH homology
 2ND1 A;  2WIN M;  3OHX M;  3UIT A;  2EX3 B;  4EZP A;  4R5K A;  4EZV A;  3FD9 A;  4D8J A;  4F00 A;  1SU7 A;  2OBM A;  3T46 A;  1SU6 A;  3VKH A;  2EWF A;  3T48 A;  4JWE A;  1CKR A;  3C7N A;  4EZR A;  5FIG A;  1GNT A;  4UDX X;  4IM0 A;  4NPH A;  3VEB A;  1OA0 A;  1ZYL A;  2Z8Y A;  2BPR A;  1GNL A;  4H6H A;  2N3K A;  3B52 X;  3QNJ A;  3SBS A;  1SU8 A;  1MJG A;  2JNS A;  2LM0 A;  4EZQ A;  2QFF A;  1E9V A;  5E84 A;  4EZW A;  1UPX A;  3B53 X;  3DOB A;  4JNF A;  3DPP A;  3T4A G;  1DKY A;  4EZS A;  1SUF A;  4KIK B;  3KAV A;  3ER8 C;  2YI9 A;  3D2F A;  2OP6 A;  3ZEF A;  3GI7 A;  4IM2 A;  1Q5L A;  3I39 X;  4HR1 A;  1BPR A;  1DKX A;  1E1D A;  3QA8 A;  2YIA A;  3A98 A;  3ERC C;  2V7Y A;  4R5J A;  1JQK A;  4JWD A;  3D2E A;  2PY6 A;  4ILG A;  3DPO A;  2RT6 A;  4R5L A;  3O3N B;  2X5C A;  1YUW A;  2ND0 A;  3VEA A;  4JL9 A;  4JLC A;  4KIK A;  4EZZ A;  2OBL A;  3OWG A;  2KHO A;  4WV7 A;  2NCZ A;  4HR1 B;  7HSC A;  4EZX A;  2YIV X;  1E2U A;  2GAF D;  4JWC A;  4JNE A;  4FL9 A;  4ILH B;  4F01 A;  4EZY A;  2YI8 A;  4FM3 A;  4JWI A;  4R5I A;  2YIB A;  3F7W A;  4MQD A;  4WV5 A;  1DKZ A;  3ZED A;  3ER9 B;  3H0X A;  2GA9 D;  3O3O B;  3C7N B;  4IWO A;  3O3M B;  4M0M A;  3SBT B;  3LMF A;  4PO2 A;  3KDR A;  4UDY X;  4G6Q A;  4H6I A;  5TKY A;  1U00 A;  4E81 A;  1DG4 A;  3I04 A;  1OAO A;  4E3C A;  4ILI A;  1W9M A;  4IWQ A;  4IW0 A;  5FLE X;  3RV1 A;  4JN4 A;  3L3O M;  3DQG A;  3I01 A;  4R5G A;  3RV0 A;  3B51 X;  3KAW A;  4IM3 A;  3DPQ A;  4EZU A;  1GN9 A;  4EZN A;  2QXL A;  4HY9 A;  4EZT A;  4B9Q A;  3N8E A;  1OA1 A;  4HYB A;  4IWP A;  4EZO A;  3T49 A;  4I43 A;  3T47 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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