4Q3SA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhpe
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
344
structure length
335
Chain Sequence
b'KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Arginase
publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
source organism Schistosoma mansoni
molecule tags Hydrolase/hydrolase inhibitor
total genus 127
structure length 335
sequence length 344
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3sA00
4MXRA 3LP4A 3SL1A 4Q3RA 1WVAA 2PHAA 1P8QA 3E8QA 1WOIA 3NIPA 4HXQA 4RHKA 1T4RA 3MFVA 1P8RA 1CEVA 3F80A 4CEVA 1WOHA 3THJA 1ZPEA 3NIQA 4MYLA 1P8PA 3SKKA 2EF5A 3E9BA 4FCKA 1T4SA 3E8ZA 4GSZA 4IU1A 4FCIA 4I06A 4RLAA 1HQGA 3THHA 4MYNA 1T4TA 2ZAVA 4Q3PA 4ITYA 4IU0A 4Q41A 1P8MA 4Q3TA 4IE3A 1GQ7A 3SL0A 1RLAA 1D3VA 4RHMA 4HWWA 4Q3UA 1HQFA 4MYKA 1PQ3A 1T4PA 1HQXA 4HZEA 3PZLA 4IE2A 1HQ5A 3MJLA 3LHLA 5HJAA 1P8OA 1ZPGA 4MYFA 5CEVA 1TA1A 3THEA 5RLAA 4RHLA 3GN0A 4Q3RC 4RHIA 4GWDA 1T5GA 4Q3QA 1P8SA 2AEBA 1TBLA 1TBJA 4IU5A 4IXVA 4Q3VA 1WOGA 1GQ6A 4GSMA 4IU4A 3E6KA 1HQHA 3TF3A 3E6VA 2PHOA 3DJ8A 1WVBA 4Q42A 4G3HA 4GSVA 3RLAA 4RHJA 1XFKA 2EIVA 4IE1A 4DZ4A 3KV2A 3TH7A 4GWCA 3SJTA 2RLAA 2CEVA 2A0MA 3CEVA 3MFWA 3LP7A 2EF4A 3MMRA 3M1RA 4Q3SA 4RHQA 2PLLA 3GMZA 4IXUA 1P8NA 3NIOA 1R1OA 4Q40A 1TBHA 1T5FA 5HJ9A
chains in the Genus database with same CATH superfamily
4MXRA 3LP4A 3SL1A 5A2SA 4Q3RA 5EFJD 1WVAA 2PHAA 1P8QA 4QA1A 5G13A 5D1CA 3E8QA 3F07A 3ZNRA 4ZURA 1WOIA 2GH6A 3EZTA 3NIPA 4HXQA 4RHKA 2VQMA 1T4RA 4QA3A 4ZUPA 3MFVA 3SFHA 1P8RA 1CEVA 5G10A 3F80A 3EZPA 5FCWA 5G1CA 1WOHA 4CEVA 3THJA 1ZPEA 3NIQA 3Q9FA 5DC7A 4MYLA 1P8PA 5EEKA 1ZZ1A 3SKKA 5G12A 4BZ8A 2EF5A 3E9BA 4FCKA 5BWZA 4A69A 1T4SA 5D1DA 5G3WA 2VCGA 3E8ZA 4GSZA 4IU1A 5G1AA 4LY1A 4RN1A 4FCIA 3F0RA 5DC5A 4RN2A 5LI3A 4I06A 4RLAA 1HQGA 3THHA 5EFNA 4MYNA 1T4TA 3MZ4A 5EFGA 4BZ7A 2ZAVA 4Q3PA 4ITYA 4IU0A 5G0YA 5EFHA 4Q41A 1W22A 1P8MA 1T67A 4Q3TA 4IE3A 5EENA 5DC6A 4CBYA 5EEIA 1GQ7A 5DC8A 4LXZA 3SL0A 4BZ5A 5THUA 1RLAA 3EW8A 1D3VA 4RHMA 4HWWA 4Q3UA 1HQFA 5G17A 3Q9BA 4MYKA 4RN0A 4QA5A 1PQ3A 1VKGA 1T4PA 3Q9CA 3Q9EA 1HQXA 2VQVA 5IWGA 4HZEA 5D1BA 3PZLA 4IE2A 1HQ5A 3MJLA 4CQFA 4ZUMA 5ICNB 2VQJA 5G0GA 3LHLA 5HJAA 2VQQA 4ZUOA 1P8OA 4ZUQA 5G11A 1ZPGA 4MYFA 5CEVA 1TA1A 3THEA 2VQWG 5RLAA 5G1BA 5THTA 4RHLA 5THSA 1C3PA 5EEMA 3GN0A 4ZUNA 4Q3RC 5G0IA 4RHIA 4GWDA 1T5GA 4Q3QA 1P8SA 5EF8A 2AEBA 1T64A 1TBLA 1TBJA 4IU5A 4IXVA 4Q3VA 4QA0A 1WOGA 1GQ6A 5IX0A 4GSMA 4IU4A 3E6KA 1HQHA 5THVA 3TF3A 3E6VA 2PHOA 3DJ8A 2V5WA 1C3SA 2V5XA 4QA2A 1ZZ0A 1T69A 1WVBA 4Q42A 4G3HA 5EFBD 4GSVA 5FUEA 3RLAA 3EWFA 4RHJA 1XFKA 2EIVA 3MZ7A 4IE1A 4DZ4A 5G0HA 2VQOA 1C3RA 3KV2A 5EEFA 1ZZ3A 4QA7A 3MZ6A 3TH7A 3F06A 4GWCA 4QA4A 2RLAA 3MZ3A 3SJTA 4BKXB 3RQDA 2CEVA 3ZNSA 4CBTA 2A0MA 4BZ6A 3CEVA 3MFWA 3LP7A 2EF4A 3MMRA 3MENA 3C0ZA 3M1RA 4Q3SA 4RHQA 5G0XA 3MAXA 2PLLA 3GMZA 4IXUA 1P8NA 5EF7A 5G0JA 4QA6A 5JI5A 5EFKB 3SFFA 4BZ9A 3NIOA 1R1OA 3C10A 4Q40A 1TBHA 1T5FA 3C0YA 5HJ9A
chains in the Genus database with same CATH topology
4MXRA 3LP4A 3SL1A 4Q3RA 1WVAA 2PHAA 1P8QA 3E8QA 1WOIA 3NIPA 4HXQA 4RHKA 1T4RA 3MFVA 1P8RA 1CEVA 3F80A 4CEVA 1WOHA 3THJA 1ZPEA 3NIQA 4MYLA 1P8PA 3SKKA 2EF5A 3E9BA 4FCKA 1T4SA 3E8ZA 4GSZA 4IU1A 4FCIA 4I06A 4RLAA 1HQGA 3THHA 4MYNA 1T4TA 2ZAVA 4Q3PA 4ITYA 4IU0A 4Q41A 1P8MA 4Q3TA 4IE3A 1GQ7A 3SL0A 1RLAA 1D3VA 4RHMA 4HWWA 4Q3UA 1HQFA 4MYKA 1PQ3A 1T4PA 1HQXA 4HZEA 3PZLA 4IE2A 1HQ5A 3MJLA 3LHLA 5HJAA 1P8OA 1ZPGA 4MYFA 5CEVA 1TA1A 3THEA 5RLAA 4RHLA 3GN0A 4Q3RC 4RHIA 4GWDA 1T5GA 4Q3QA 1P8SA 2AEBA 1TBLA 1TBJA 4IU5A 4IXVA 4Q3VA 1WOGA 1GQ6A 4GSMA 4IU4A 3E6KA 1HQHA 3TF3A 3E6VA 2PHOA 3DJ8A 1WVBA 4Q42A 4G3HA 4GSVA 3RLAA 4RHJA 1XFKA 2EIVA 4IE1A 4DZ4A 3KV2A 3TH7A 4GWCA 3SJTA 2RLAA 2CEVA 2A0MA 3CEVA 3MFWA 3LP7A 2EF4A 3MMRA 3M1RA 4Q3SA 4RHQA 2PLLA 3GMZA 4IXUA 1P8NA 3NIOA 1R1OA 4Q40A 1TBHA 1T5FA 5HJ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MXR A;  3LP4 A;  3SL1 A;  4Q3R A;  1WVA A;  2PHA A;  1P8Q A;  3E8Q A;  1WOI A;  3NIP A;  4HXQ A;  4RHK A;  1T4R A;  3MFV A;  1P8R A;  1CEV A;  3F80 A;  4CEV A;  1WOH A;  3THJ A;  1ZPE A;  3NIQ A;  4MYL A;  1P8P A;  3SKK A;  2EF5 A;  3E9B A;  4FCK A;  1T4S A;  3E8Z A;  4GSZ A;  4IU1 A;  4FCI A;  4I06 A;  4RLA A;  1HQG A;  3THH A;  4MYN A;  1T4T A;  2ZAV A;  4Q3P A;  4ITY A;  4IU0 A;  4Q41 A;  1P8M A;  4Q3T A;  4IE3 A;  1GQ7 A;  3SL0 A;  1RLA A;  1D3V A;  4RHM A;  4HWW A;  4Q3U A;  1HQF A;  4MYK A;  1PQ3 A;  1T4P A;  1HQX A;  4HZE A;  3PZL A;  4IE2 A;  1HQ5 A;  3MJL A;  3LHL A;  5HJA A;  1P8O A;  1ZPG A;  4MYF A;  5CEV A;  1TA1 A;  3THE A;  5RLA A;  4RHL A;  3GN0 A;  4Q3R C;  4RHI A;  4GWD A;  1T5G A;  4Q3Q A;  1P8S A;  2AEB A;  1TBL A;  1TBJ A;  4IU5 A;  4IXV A;  4Q3V A;  1WOG A;  1GQ6 A;  4GSM A;  4IU4 A;  3E6K A;  1HQH A;  3TF3 A;  3E6V A;  2PHO A;  3DJ8 A;  1WVB A;  4Q42 A;  4G3H A;  4GSV A;  3RLA A;  4RHJ A;  1XFK A;  2EIV A;  4IE1 A;  4DZ4 A;  3KV2 A;  3TH7 A;  4GWC A;  3SJT A;  2RLA A;  2CEV A;  2A0M A;  3CEV A;  3MFW A;  3LP7 A;  2EF4 A;  3MMR A;  3M1R A;  4Q3S A;  4RHQ A;  2PLL A;  3GMZ A;  4IXU A;  1P8N A;  3NIO A;  1R1O A;  4Q40 A;  1TBH A;  1T5F A;  5HJ9 A; 
#chains in the Genus database with same CATH topology
 4MXR A;  3LP4 A;  3SL1 A;  5A2S A;  4Q3R A;  5EFJ D;  1WVA A;  2PHA A;  1P8Q A;  4QA1 A;  5G13 A;  5D1C A;  3E8Q A;  3F07 A;  3ZNR A;  4ZUR A;  1WOI A;  2GH6 A;  3EZT A;  3NIP A;  4HXQ A;  4RHK A;  2VQM A;  1T4R A;  4QA3 A;  4ZUP A;  3MFV A;  3SFH A;  1P8R A;  1CEV A;  5G10 A;  3F80 A;  3EZP A;  5FCW A;  5G1C A;  1WOH A;  4CEV A;  3THJ A;  1ZPE A;  3NIQ A;  3Q9F A;  5DC7 A;  4MYL A;  1P8P A;  5EEK A;  1ZZ1 A;  3SKK A;  5G12 A;  4BZ8 A;  2EF5 A;  3E9B A;  4FCK A;  5BWZ A;  4A69 A;  1T4S A;  5D1D A;  5G3W A;  2VCG A;  3E8Z A;  4GSZ A;  4IU1 A;  5G1A A;  4LY1 A;  4RN1 A;  4FCI A;  3F0R A;  5DC5 A;  4RN2 A;  5LI3 A;  4I06 A;  4RLA A;  1HQG A;  3THH A;  5EFN A;  4MYN A;  1T4T A;  3MZ4 A;  5EFG A;  4BZ7 A;  2ZAV A;  4Q3P A;  4ITY A;  4IU0 A;  5G0Y A;  5EFH A;  4Q41 A;  1W22 A;  1P8M A;  1T67 A;  4Q3T A;  4IE3 A;  5EEN A;  5DC6 A;  4CBY A;  5EEI A;  1GQ7 A;  5DC8 A;  4LXZ A;  3SL0 A;  4BZ5 A;  5THU A;  1RLA A;  3EW8 A;  1D3V A;  4RHM A;  4HWW A;  4Q3U A;  1HQF A;  5G17 A;  3Q9B A;  4MYK A;  4RN0 A;  4QA5 A;  1PQ3 A;  1VKG A;  1T4P A;  3Q9C A;  3Q9E A;  1HQX A;  2VQV A;  5IWG A;  4HZE A;  5D1B A;  3PZL A;  4IE2 A;  1HQ5 A;  3MJL A;  4CQF A;  4ZUM A;  5ICN B;  2VQJ A;  5G0G A;  3LHL A;  5HJA A;  2VQQ A;  4ZUO A;  1P8O A;  4ZUQ A;  5G11 A;  1ZPG A;  4MYF A;  5CEV A;  1TA1 A;  3THE A;  2VQW G;  5RLA A;  5G1B A;  5THT A;  4RHL A;  5THS A;  1C3P A;  5EEM A;  3GN0 A;  4ZUN A;  4Q3R C;  5G0I A;  4RHI A;  4GWD A;  1T5G A;  4Q3Q A;  1P8S A;  5EF8 A;  2AEB A;  1T64 A;  1TBL A;  1TBJ A;  4IU5 A;  4IXV A;  4Q3V A;  4QA0 A;  1WOG A;  1GQ6 A;  5IX0 A;  4GSM A;  4IU4 A;  3E6K A;  1HQH A;  5THV A;  3TF3 A;  3E6V A;  2PHO A;  3DJ8 A;  2V5W A;  1C3S A;  2V5X A;  4QA2 A;  1ZZ0 A;  1T69 A;  1WVB A;  4Q42 A;  4G3H A;  5EFB D;  4GSV A;  5FUE A;  3RLA A;  3EWF A;  4RHJ A;  1XFK A;  2EIV A;  3MZ7 A;  4IE1 A;  4DZ4 A;  5G0H A;  2VQO A;  1C3R A;  3KV2 A;  5EEF A;  1ZZ3 A;  4QA7 A;  3MZ6 A;  3TH7 A;  3F06 A;  4GWC A;  4QA4 A;  2RLA A;  3MZ3 A;  3SJT A;  4BKX B;  3RQD A;  2CEV A;  3ZNS A;  4CBT A;  2A0M A;  4BZ6 A;  3CEV A;  3MFW A;  3LP7 A;  2EF4 A;  3MMR A;  3MEN A;  3C0Z A;  3M1R A;  4Q3S A;  4RHQ A;  5G0X A;  3MAX A;  2PLL A;  3GMZ A;  4IXU A;  1P8N A;  5EF7 A;  5G0J A;  4QA6 A;  5JI5 A;  5EFK B;  3SFF A;  4BZ9 A;  3NIO A;  1R1O A;  3C10 A;  4Q40 A;  1TBH A;  1T5F A;  3C0Y A;  5HJ9 A; 
#chains in the Genus database with same CATH homology
 4MXR A;  3LP4 A;  3SL1 A;  4Q3R A;  1WVA A;  2PHA A;  1P8Q A;  3E8Q A;  1WOI A;  3NIP A;  4HXQ A;  4RHK A;  1T4R A;  3MFV A;  1P8R A;  1CEV A;  3F80 A;  4CEV A;  1WOH A;  3THJ A;  1ZPE A;  3NIQ A;  4MYL A;  1P8P A;  3SKK A;  2EF5 A;  3E9B A;  4FCK A;  1T4S A;  3E8Z A;  4GSZ A;  4IU1 A;  4FCI A;  4I06 A;  4RLA A;  1HQG A;  3THH A;  4MYN A;  1T4T A;  2ZAV A;  4Q3P A;  4ITY A;  4IU0 A;  4Q41 A;  1P8M A;  4Q3T A;  4IE3 A;  1GQ7 A;  3SL0 A;  1RLA A;  1D3V A;  4RHM A;  4HWW A;  4Q3U A;  1HQF A;  4MYK A;  1PQ3 A;  1T4P A;  1HQX A;  4HZE A;  3PZL A;  4IE2 A;  1HQ5 A;  3MJL A;  3LHL A;  5HJA A;  1P8O A;  1ZPG A;  4MYF A;  5CEV A;  1TA1 A;  3THE A;  5RLA A;  4RHL A;  3GN0 A;  4Q3R C;  4RHI A;  4GWD A;  1T5G A;  4Q3Q A;  1P8S A;  2AEB A;  1TBL A;  1TBJ A;  4IU5 A;  4IXV A;  4Q3V A;  1WOG A;  1GQ6 A;  4GSM A;  4IU4 A;  3E6K A;  1HQH A;  3TF3 A;  3E6V A;  2PHO A;  3DJ8 A;  1WVB A;  4Q42 A;  4G3H A;  4GSV A;  3RLA A;  4RHJ A;  1XFK A;  2EIV A;  4IE1 A;  4DZ4 A;  3KV2 A;  3TH7 A;  4GWC A;  3SJT A;  2RLA A;  2CEV A;  2A0M A;  3CEV A;  3MFW A;  3LP7 A;  2EF4 A;  3MMR A;  3M1R A;  4Q3S A;  4RHQ A;  2PLL A;  3GMZ A;  4IXU A;  1P8N A;  3NIO A;  1R1O A;  4Q40 A;  1TBH A;  1T5F A;  5HJ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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