4RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE
total genus 108
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4rlaA00
1P8QA 4CEVA 3THEA 4RHJA 1HQFA 2EIVA 4MYNA 4MYKA 3DJ8A 3CEVA 3LP7A 1HQXA 2EF5A 3E6VA 3THJA 3KV2A 4GSVA 1P8OA 3F80A 3NIPA 1WVBA 4HXQA 3SL1A 4RLAA 3E9BA 1T4TA 1R1OA 3MJLA 4IE1A 2PHAA 1WOIA 4Q3QA 4IU1A 1RLAA 1TA1A 4Q40A 1P8NA 1XFKA 4Q3UA 1HQHA 1T4SA 4MXRA 4RHMA 4IU4A 4I06A 4Q3VA 4RHQA 4MYFA 4Q3SA 4Q3TA 3PZLA 4Q3RA 4RHIA 3E6KA 3E8QA 5HJAA 1P8SA 1TBLA 4GWCA 1T5GA 2AEBA 1P8RA 3THHA 1D3VA 1HQ5A 4IU0A 4Q42A 3NIOA 4Q3PA 4RHLA 1GQ6A 4GSMA 3TF3A 3NIQA 4DZ4A 2CEVA 3MFVA 3M1RA 2A0MA 2EF4A 1PQ3A 5RLAA 4HWWA 1T4RA 4Q3RC 1P8MA 4FCKA 2PHOA 2PLLA 1T5FA 1TBJA 3SKKA 3TH7A 1WOHA 4G3HA 1P8PA 3LP4A 3LHLA 3RLAA 3SL0A 4FCIA 1HQGA 4ITYA 2ZAVA 3GN0A 3E8ZA 1ZPEA 1ZPGA 1T4PA 1TBHA 4HZEA 5CEVA 4Q41A 4GSZA 3MFWA 4IE3A 4IU5A 4IXUA 1WOGA 4MYLA 3SJTA 4IE2A 2RLAA 4RHKA 4IXVA 4GWDA 3GMZA 5HJ9A 1WVAA 3MMRA 1CEVA 1GQ7A
chains in the Genus database with same CATH superfamily
5EFGA 5EFBD 4BZ6A 3SFHA 5EEMA 4CQFA 1P8QA 4CEVA 3THEA 4RHJA 1HQFA 2EIVA 2GH6A 4MYNA 4MYKA 5D1BA 3DJ8A 5G0JA 4BZ7A 3SFFA 3CEVA 3LP7A 5EF8A 5EEKA 1HQXA 2EF5A 3F06A 5IWGA 3E6VA 5ICNB 3THJA 4RN1A 3KV2A 4CBTA 4GSVA 1P8OA 3F80A 3NIPA 1WVBA 4QA6A 5EF7A 4HXQA 5EFJD 5A2SA 1ZZ0A 3EWFA 5EEIA 5G3WA 3SL1A 3EZPA 2VQVA 4RLAA 3E9BA 1T4TA 1R1OA 4LXZA 5BWZA 1ZZ1A 3MJLA 2PHAA 1WOIA 4IE1A 4Q3QA 5DC8A 4BKXB 4ZUMA 5EFHA 3F07A 4IU1A 5JI5A 5G12A 1RLAA 4ZUQA 1TA1A 4RN2A 4Q40A 1C3SA 1P8NA 1XFKA 2VQQA 5G10A 3C0ZA 4Q3UA 5IX0A 1HQHA 1T4SA 4LY1A 1T64A 4MXRA 5G0IA 5DC6A 4RHMA 4IU4A 4I06A 3C10A 4Q3VA 4RHQA 4MYFA 4Q3SA 5THTA 3ZNRA 4Q3TA 4RN0A 3PZLA 4Q3RA 5THUA 4RHIA 3ZNSA 3E6KA 5EENA 5G17A 3E8QA 5HJAA 3EZTA 1P8SA 1TBLA 1T67A 3Q9BA 4ZURA 1ZZ3A 5LI3A 4GWCA 1T5GA 3EW8A 1C3RA 2AEBA 1P8RA 3THHA 1D3VA 1HQ5A 3F0RA 4IU0A 3NIOA 4Q3PA 4Q42A 2VQMA 4RHLA 5THVA 1GQ6A 4GSMA 4ZUOA 5G1AA 3TF3A 5EEFA 4QA3A 3NIQA 5G13A 2VQJA 5G0XA 4DZ4A 2CEVA 3MFVA 3M1RA 5G1CA 2A0MA 2EF4A 5DC5A 4ZUNA 4QA1A 1PQ3A 4QA4A 5D1DA 5RLAA 4HWWA 4BZ8A 1T4RA 3Q9EA 4Q3RC 1T69A 5EFKB 5G0GA 5G1BA 1P8MA 3MZ7A 5G0YA 4FCKA 4QA2A 3MZ3A 3C0YA 2PHOA 2PLLA 1T5FA 1TBJA 3MZ4A 3SKKA 3TH7A 1WOHA 4G3HA 1P8PA 4CBYA 3LP4A 3LHLA 3RLAA 3SL0A 2V5WA 1HQGA 4FCIA 4ITYA 2ZAVA 3GN0A 3E8ZA 5G0HA 1ZPEA 5EFNA 1ZPGA 1W22A 1TBHA 2VQWG 5DC7A 4HZEA 3MMRA 5CEVA 5FUEA 4Q41A 3RQDA 4GSZA 3MFWA 4IE3A 4IU5A 5THSA 4IXUA 1WOGA 4MYLA 4QA5A 1C3PA 3SJTA 4ZUPA 4A69A 4IE2A 5D1CA 2RLAA 3Q9FA 4QA0A 3MZ6A 4RHKA 4IXVA 5FCWA 4BZ5A 3MENA 4GWDA 4QA7A 1VKGA 3GMZA 5HJ9A 4BZ9A 2VCGA 3MAXA 1WVAA 5G11A 2VQOA 3Q9CA 2V5XA 1T4PA 1CEVA 1GQ7A
chains in the Genus database with same CATH topology
1P8QA 4CEVA 3THEA 4RHJA 1HQFA 2EIVA 4MYNA 4MYKA 3DJ8A 3CEVA 3LP7A 1HQXA 2EF5A 3E6VA 3THJA 3KV2A 4GSVA 1P8OA 3F80A 3NIPA 1WVBA 4HXQA 3SL1A 4RLAA 3E9BA 1T4TA 1R1OA 3MJLA 4IE1A 2PHAA 1WOIA 4Q3QA 4IU1A 1RLAA 1TA1A 4Q40A 1P8NA 1XFKA 4Q3UA 1HQHA 1T4SA 4MXRA 4RHMA 4IU4A 4I06A 4Q3VA 4RHQA 4MYFA 4Q3SA 4Q3TA 3PZLA 4Q3RA 4RHIA 3E6KA 3E8QA 5HJAA 1P8SA 1TBLA 4GWCA 1T5GA 2AEBA 1P8RA 3THHA 1D3VA 1HQ5A 4IU0A 4Q42A 3NIOA 4Q3PA 4RHLA 1GQ6A 4GSMA 3TF3A 3NIQA 4DZ4A 2CEVA 3MFVA 3M1RA 2A0MA 2EF4A 1PQ3A 5RLAA 4HWWA 1T4RA 4Q3RC 1P8MA 4FCKA 2PHOA 2PLLA 1T5FA 1TBJA 3SKKA 3TH7A 1WOHA 4G3HA 1P8PA 3LP4A 3LHLA 3RLAA 3SL0A 4FCIA 1HQGA 4ITYA 2ZAVA 3GN0A 3E8ZA 1ZPEA 1ZPGA 1T4PA 1TBHA 4HZEA 5CEVA 4Q41A 4GSZA 3MFWA 4IE3A 4IU5A 4IXUA 1WOGA 4MYLA 3SJTA 4IE2A 2RLAA 4RHKA 4IXVA 4GWDA 3GMZA 5HJ9A 1WVAA 3MMRA 1CEVA 1GQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P8Q A;  4CEV A;  3THE A;  4RHJ A;  1HQF A;  2EIV A;  4MYN A;  4MYK A;  3DJ8 A;  3CEV A;  3LP7 A;  1HQX A;  2EF5 A;  3E6V A;  3THJ A;  3KV2 A;  4GSV A;  1P8O A;  3F80 A;  3NIP A;  1WVB A;  4HXQ A;  3SL1 A;  4RLA A;  3E9B A;  1T4T A;  1R1O A;  3MJL A;  4IE1 A;  2PHA A;  1WOI A;  4Q3Q A;  4IU1 A;  1RLA A;  1TA1 A;  4Q40 A;  1P8N A;  1XFK A;  4Q3U A;  1HQH A;  1T4S A;  4MXR A;  4RHM A;  4IU4 A;  4I06 A;  4Q3V A;  4RHQ A;  4MYF A;  4Q3S A;  4Q3T A;  3PZL A;  4Q3R A;  4RHI A;  3E6K A;  3E8Q A;  5HJA A;  1P8S A;  1TBL A;  4GWC A;  1T5G A;  2AEB A;  1P8R A;  3THH A;  1D3V A;  1HQ5 A;  4IU0 A;  4Q42 A;  3NIO A;  4Q3P A;  4RHL A;  1GQ6 A;  4GSM A;  3TF3 A;  3NIQ A;  4DZ4 A;  2CEV A;  3MFV A;  3M1R A;  2A0M A;  2EF4 A;  1PQ3 A;  5RLA A;  4HWW A;  1T4R A;  4Q3R C;  1P8M A;  4FCK A;  2PHO A;  2PLL A;  1T5F A;  1TBJ A;  3SKK A;  3TH7 A;  1WOH A;  4G3H A;  1P8P A;  3LP4 A;  3LHL A;  3RLA A;  3SL0 A;  4FCI A;  1HQG A;  4ITY A;  2ZAV A;  3GN0 A;  3E8Z A;  1ZPE A;  1ZPG A;  1T4P A;  1TBH A;  4HZE A;  5CEV A;  4Q41 A;  4GSZ A;  3MFW A;  4IE3 A;  4IU5 A;  4IXU A;  1WOG A;  4MYL A;  3SJT A;  4IE2 A;  2RLA A;  4RHK A;  4IXV A;  4GWD A;  3GMZ A;  5HJ9 A;  1WVA A;  3MMR A;  1CEV A;  1GQ7 A; 
#chains in the Genus database with same CATH topology
 5EFG A;  5EFB D;  4BZ6 A;  3SFH A;  5EEM A;  4CQF A;  1P8Q A;  4CEV A;  3THE A;  4RHJ A;  1HQF A;  2EIV A;  2GH6 A;  4MYN A;  4MYK A;  5D1B A;  3DJ8 A;  5G0J A;  4BZ7 A;  3SFF A;  3CEV A;  3LP7 A;  5EF8 A;  5EEK A;  1HQX A;  2EF5 A;  3F06 A;  5IWG A;  3E6V A;  5ICN B;  3THJ A;  4RN1 A;  3KV2 A;  4CBT A;  4GSV A;  1P8O A;  3F80 A;  3NIP A;  1WVB A;  4QA6 A;  5EF7 A;  4HXQ A;  5EFJ D;  5A2S A;  1ZZ0 A;  3EWF A;  5EEI A;  5G3W A;  3SL1 A;  3EZP A;  2VQV A;  4RLA A;  3E9B A;  1T4T A;  1R1O A;  4LXZ A;  5BWZ A;  1ZZ1 A;  3MJL A;  2PHA A;  1WOI A;  4IE1 A;  4Q3Q A;  5DC8 A;  4BKX B;  4ZUM A;  5EFH A;  3F07 A;  4IU1 A;  5JI5 A;  5G12 A;  1RLA A;  4ZUQ A;  1TA1 A;  4RN2 A;  4Q40 A;  1C3S A;  1P8N A;  1XFK A;  2VQQ A;  5G10 A;  3C0Z A;  4Q3U A;  5IX0 A;  1HQH A;  1T4S A;  4LY1 A;  1T64 A;  4MXR A;  5G0I A;  5DC6 A;  4RHM A;  4IU4 A;  4I06 A;  3C10 A;  4Q3V A;  4RHQ A;  4MYF A;  4Q3S A;  5THT A;  3ZNR A;  4Q3T A;  4RN0 A;  3PZL A;  4Q3R A;  5THU A;  4RHI A;  3ZNS A;  3E6K A;  5EEN A;  5G17 A;  3E8Q A;  5HJA A;  3EZT A;  1P8S A;  1TBL A;  1T67 A;  3Q9B A;  4ZUR A;  1ZZ3 A;  5LI3 A;  4GWC A;  1T5G A;  3EW8 A;  1C3R A;  2AEB A;  1P8R A;  3THH A;  1D3V A;  1HQ5 A;  3F0R A;  4IU0 A;  3NIO A;  4Q3P A;  4Q42 A;  2VQM A;  4RHL A;  5THV A;  1GQ6 A;  4GSM A;  4ZUO A;  5G1A A;  3TF3 A;  5EEF A;  4QA3 A;  3NIQ A;  5G13 A;  2VQJ A;  5G0X A;  4DZ4 A;  2CEV A;  3MFV A;  3M1R A;  5G1C A;  2A0M A;  2EF4 A;  5DC5 A;  4ZUN A;  4QA1 A;  1PQ3 A;  4QA4 A;  5D1D A;  5RLA A;  4HWW A;  4BZ8 A;  1T4R A;  3Q9E A;  4Q3R C;  1T69 A;  5EFK B;  5G0G A;  5G1B A;  1P8M A;  3MZ7 A;  5G0Y A;  4FCK A;  4QA2 A;  3MZ3 A;  3C0Y A;  2PHO A;  2PLL A;  1T5F A;  1TBJ A;  3MZ4 A;  3SKK A;  3TH7 A;  1WOH A;  4G3H A;  1P8P A;  4CBY A;  3LP4 A;  3LHL A;  3RLA A;  3SL0 A;  2V5W A;  1HQG A;  4FCI A;  4ITY A;  2ZAV A;  3GN0 A;  3E8Z A;  5G0H A;  1ZPE A;  5EFN A;  1ZPG A;  1W22 A;  1TBH A;  2VQW G;  5DC7 A;  4HZE A;  3MMR A;  5CEV A;  5FUE A;  4Q41 A;  3RQD A;  4GSZ A;  3MFW A;  4IE3 A;  4IU5 A;  5THS A;  4IXU A;  1WOG A;  4MYL A;  4QA5 A;  1C3P A;  3SJT A;  4ZUP A;  4A69 A;  4IE2 A;  5D1C A;  2RLA A;  3Q9F A;  4QA0 A;  3MZ6 A;  4RHK A;  4IXV A;  5FCW A;  4BZ5 A;  3MEN A;  4GWD A;  4QA7 A;  1VKG A;  3GMZ A;  5HJ9 A;  4BZ9 A;  2VCG A;  3MAX A;  1WVA A;  5G11 A;  2VQO A;  3Q9C A;  2V5X A;  1T4P A;  1CEV A;  1GQ7 A; 
#chains in the Genus database with same CATH homology
 1P8Q A;  4CEV A;  3THE A;  4RHJ A;  1HQF A;  2EIV A;  4MYN A;  4MYK A;  3DJ8 A;  3CEV A;  3LP7 A;  1HQX A;  2EF5 A;  3E6V A;  3THJ A;  3KV2 A;  4GSV A;  1P8O A;  3F80 A;  3NIP A;  1WVB A;  4HXQ A;  3SL1 A;  4RLA A;  3E9B A;  1T4T A;  1R1O A;  3MJL A;  4IE1 A;  2PHA A;  1WOI A;  4Q3Q A;  4IU1 A;  1RLA A;  1TA1 A;  4Q40 A;  1P8N A;  1XFK A;  4Q3U A;  1HQH A;  1T4S A;  4MXR A;  4RHM A;  4IU4 A;  4I06 A;  4Q3V A;  4RHQ A;  4MYF A;  4Q3S A;  4Q3T A;  3PZL A;  4Q3R A;  4RHI A;  3E6K A;  3E8Q A;  5HJA A;  1P8S A;  1TBL A;  4GWC A;  1T5G A;  2AEB A;  1P8R A;  3THH A;  1D3V A;  1HQ5 A;  4IU0 A;  4Q42 A;  3NIO A;  4Q3P A;  4RHL A;  1GQ6 A;  4GSM A;  3TF3 A;  3NIQ A;  4DZ4 A;  2CEV A;  3MFV A;  3M1R A;  2A0M A;  2EF4 A;  1PQ3 A;  5RLA A;  4HWW A;  1T4R A;  4Q3R C;  1P8M A;  4FCK A;  2PHO A;  2PLL A;  1T5F A;  1TBJ A;  3SKK A;  3TH7 A;  1WOH A;  4G3H A;  1P8P A;  3LP4 A;  3LHL A;  3RLA A;  3SL0 A;  4FCI A;  1HQG A;  4ITY A;  2ZAV A;  3GN0 A;  3E8Z A;  1ZPE A;  1ZPG A;  1T4P A;  1TBH A;  4HZE A;  5CEV A;  4Q41 A;  4GSZ A;  3MFW A;  4IE3 A;  4IU5 A;  4IXU A;  1WOG A;  4MYL A;  3SJT A;  4IE2 A;  2RLA A;  4RHK A;  4IXV A;  4GWD A;  3GMZ A;  5HJ9 A;  1WVA A;  3MMR A;  1CEV A;  1GQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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