4U71A

Hsmetap(f309m) in complex with 1- amino(cyclohexyl)methy)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u71A00
1C24A 2V3XA 1WL9A 4R60A 4IECA 4U69A 3MX6A 3BIPA 4RZZA 4IDYA 2BWVA 5CNXA 1PV9A 2B3KA 4IF7A 1YVMA 3RVAA 4FKCA 5JI6A 3PKDA 4FLKA 1QZYA 2V6CA 2V3YA 2HOWA 3CB5A 2BWUA 1MATA 1C21A 3BIQA 3PKCA 4S2TP 4EGEA 4IKRA 1XNZA 2P99A 1QXZA 1QXYA 2B3HA 2GG7A 2GG5A 2IW2A 4FUKA 5FCFA 1XGSA 2GTXA 2MATA 2DFIA 2BWYA 3MATA 4Z7MA 4A6VA 3PKAA 4ZWOA 2OAZA 2GU4A 2GU6A 4U70A 1XGMA 2NQ6A 2BB7A 1WL6A 1WLRA 2B3LA 2EVMA 4RGZ1 2GU7A 4U71A 1C22A 1WKMA 2GG9A 1KP0A 2Q94A 1R58A 2GGBA 2GGCA 4IKSA 1CHMA 2BHBA 4A6WA 4IU6A 2GA2A 2Q92A 3D27A 5CE6A 1R5HA 2BHCA 2OKNA 4U6EA 3IU7A 3BITA 3S6BA 4FO8A 1KQ9A 4IKTA 2EVCA 4MATA 3IU8A 3FM3A 2GZ5A 4U6JA 1B6AA 1YW8A 5CLSA 2P9AA 3L7GA 4ZWPA 2Q8KA 4PV4A 1N51A 1A16A 1BOAA 1WBQA 1C23A 2GG2A 4KM3A 1C27A 3CB6A 3TAVA 2Q96A 2ZSGA 2EVOA 4PNCA 4U75A 2EA4A 2BWTA 3TB5A 5CDLA 2BHDA 3PKEA 2EA2A 2BN7A 4IPAA 4JUQA 4S00A 1O0XA 2Q93A 4U76A 4ZWUA 2Q95A 2BH3A 3L24A 5JFRA 3Q6DA 1JAWA 5D6FA 1XGNA 2P98A 1W2MA 2BWXA 4U6WA 5E5BA 2GG8A 2BHAA 4U73A 3CTZA 2GG0A 1WN1A 3IU9A 4RZYA 1M35A 4FLIA 4FLJA 5JHUA 2GU5A 4B28A 3FMRA 4OOKA 2V3ZA 5CDEA 5FCHA 1W7VA 4U1BA 4S01A 1KQ0A 5D6EA 4QR8A 2BWSA 4S2RP 4HXXA 1YJ3A 4ZNGA 1B59A 1Y1NA 3FMQA 1XGOA 4FO7A 2G6PA 5CIKA 2GG3A 1QXWA 2BWWA 3IG4A 4U6CA 1WY2A 4IKUA 5CDVA 2NQ7A 3RORA 2ADUA 4FLLA 3PKBA 1BN5A 3MR1A 4U6ZA 1YW7A 1YW9A 1R5GA
chains in the Genus database with same CATH superfamily
1C24A 2V3XA 1WL9A 4R60A 4IECA 4U69A 3MX6A 3BIPA 4RZZA 4IDYA 2BWVA 5CNXA 1PV9A 2B3KA 4IF7A 1YVMA 3RVAA 4FKCA 5JI6A 3PKDA 4FLKA 1QZYA 2V6CA 2V3YA 2HOWA 3CB5A 2BWUA 1MATA 1C21A 3BIQA 3PKCA 4S2TP 4EGEA 4IKRA 1XNZA 2P99A 1QXZA 1QXYA 2B3HA 2GG7A 2GG5A 2IW2A 4FUKA 5FCFA 1XGSA 2GTXA 2MATA 2DFIA 2BWYA 3MATA 4Z7MA 4A6VA 3PKAA 4ZWOA 2OAZA 2GU4A 2GU6A 4U70A 1XGMA 2NQ6A 2BB7A 1WL6A 1WLRA 2B3LA 2EVMA 4RGZ1 2GU7A 4U71A 1C22A 1WKMA 2GG9A 1KP0A 2Q94A 1R58A 2GGBA 2GGCA 4IKSA 1CHMA 2BHBA 4A6WA 4IU6A 2GA2A 2Q92A 3D27A 5CE6A 1R5HA 2BHCA 2OKNA 4U6EA 3IU7A 3BITA 3S6BA 4FO8A 1KQ9A 4IKTA 2EVCA 4MATA 3IU8A 3FM3A 2GZ5A 4U6JA 1B6AA 1YW8A 5CLSA 2P9AA 3L7GA 4ZWPA 2Q8KA 4PV4A 1N51A 1A16A 1BOAA 1WBQA 1C23A 2GG2A 4KM3A 1C27A 3CB6A 3TAVA 2Q96A 2ZSGA 2EVOA 4PNCA 4U75A 2EA4A 2BWTA 3TB5A 5CDLA 2BHDA 3PKEA 2EA2A 2BN7A 4IPAA 4JUQA 4S00A 1O0XA 2Q93A 4U76A 4ZWUA 2Q95A 2BH3A 3L24A 5JFRA 3Q6DA 1JAWA 5D6FA 1XGNA 2P98A 1W2MA 2BWXA 4U6WA 5E5BA 2GG8A 2BHAA 4U73A 3CTZA 2GG0A 1WN1A 3IU9A 4RZYA 1M35A 4FLIA 4FLJA 5JHUA 2GU5A 4B28A 3FMRA 4OOKA 2V3ZA 5CDEA 5FCHA 1W7VA 4U1BA 4S01A 1KQ0A 5D6EA 4QR8A 2BWSA 4S2RP 4HXXA 1YJ3A 4ZNGA 1B59A 1Y1NA 3FMQA 1XGOA 4FO7A 2G6PA 5CIKA 2GG3A 1QXWA 2BWWA 3IG4A 4U6CA 1WY2A 4IKUA 5CDVA 2NQ7A 3RORA 2ADUA 4FLLA 3PKBA 1BN5A 3MR1A 4U6ZA 1YW7A 1YW9A 1R5GA
chains in the Genus database with same CATH topology
1C24A 2V3XA 1WL9A 4R60A 4IECA 4U69A 3MX6A 3BIPA 4RZZA 4IDYA 2BWVA 5CNXA 1PV9A 2B3KA 4IF7A 1YVMA 3RVAA 4FKCA 5JI6A 3PKDA 4FLKA 1QZYA 2V6CA 2V3YA 2HOWA 3CB5A 2BWUA 1MATA 1C21A 3BIQA 3PKCA 4S2TP 4EGEA 4IKRA 1XNZA 2P99A 1QXZA 1QXYA 2B3HA 2GG7A 2GG5A 2IW2A 4FUKA 5FCFA 1XGSA 2GTXA 2MATA 2DFIA 2BWYA 3MATA 4Z7MA 4A6VA 3PKAA 4ZWOA 2OAZA 2GU4A 2GU6A 4U70A 1XGMA 2NQ6A 2BB7A 1WL6A 1WLRA 2B3LA 2EVMA 4RGZ1 2GU7A 4U71A 1C22A 1WKMA 2GG9A 1KP0A 2Q94A 1R58A 2GGBA 2GGCA 4IKSA 1CHMA 2BHBA 4A6WA 4IU6A 2GA2A 2Q92A 3D27A 5CE6A 1R5HA 2BHCA 2OKNA 4U6EA 3IU7A 3BITA 3S6BA 4FO8A 1KQ9A 4IKTA 2EVCA 4MATA 3IU8A 3FM3A 2GZ5A 4U6JA 1B6AA 1YW8A 5CLSA 2P9AA 3L7GA 4ZWPA 2Q8KA 4PV4A 1N51A 1A16A 1BOAA 1WBQA 1C23A 2GG2A 4KM3A 1C27A 3CB6A 3TAVA 2Q96A 2ZSGA 2EVOA 4PNCA 4U75A 2EA4A 2BWTA 3TB5A 5CDLA 2BHDA 3PKEA 2EA2A 2BN7A 4IPAA 4JUQA 4S00A 1O0XA 2Q93A 4U76A 4ZWUA 2Q95A 2BH3A 3L24A 5JFRA 3Q6DA 1JAWA 5D6FA 1XGNA 2P98A 1W2MA 2BWXA 4U6WA 5E5BA 2GG8A 2BHAA 4U73A 3CTZA 2GG0A 1WN1A 3IU9A 4RZYA 1M35A 4FLIA 4FLJA 5JHUA 2GU5A 4B28A 3FMRA 4OOKA 2V3ZA 5CDEA 5FCHA 1W7VA 4U1BA 4S01A 1KQ0A 5D6EA 4QR8A 2BWSA 4S2RP 4HXXA 1YJ3A 4ZNGA 1B59A 1Y1NA 3FMQA 1XGOA 4FO7A 2G6PA 5CIKA 2GG3A 1QXWA 2BWWA 3IG4A 4U6CA 1WY2A 4IKUA 5CDVA 2NQ7A 3RORA 2ADUA 4FLLA 3PKBA 1BN5A 3MR1A 4U6ZA 1YW7A 1YW9A 1R5GA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1C24 A;  2V3X A;  1WL9 A;  4R60 A;  4IEC A;  4U69 A;  3MX6 A;  3BIP A;  4RZZ A;  4IDY A;  2BWV A;  5CNX A;  1PV9 A;  2B3K A;  4IF7 A;  1YVM A;  3RVA A;  4FKC A;  5JI6 A;  3PKD A;  4FLK A;  1QZY A;  2V6C A;  2V3Y A;  2HOW A;  3CB5 A;  2BWU A;  1MAT A;  1C21 A;  3BIQ A;  3PKC A;  4S2T P;  4EGE A;  4IKR A;  1XNZ A;  2P99 A;  1QXZ A;  1QXY A;  2B3H A;  2GG7 A;  2GG5 A;  2IW2 A;  4FUK A;  5FCF A;  1XGS A;  2GTX A;  2MAT A;  2DFI A;  2BWY A;  3MAT A;  4Z7M A;  4A6V A;  3PKA A;  4ZWO A;  2OAZ A;  2GU4 A;  2GU6 A;  4U70 A;  1XGM A;  2NQ6 A;  2BB7 A;  1WL6 A;  1WLR A;  2B3L A;  2EVM A;  4RGZ 1;  2GU7 A;  4U71 A;  1C22 A;  1WKM A;  2GG9 A;  1KP0 A;  2Q94 A;  1R58 A;  2GGB A;  2GGC A;  4IKS A;  1CHM A;  2BHB A;  4A6W A;  4IU6 A;  2GA2 A;  2Q92 A;  3D27 A;  5CE6 A;  1R5H A;  2BHC A;  2OKN A;  4U6E A;  3IU7 A;  3BIT A;  3S6B A;  4FO8 A;  1KQ9 A;  4IKT A;  2EVC A;  4MAT A;  3IU8 A;  3FM3 A;  2GZ5 A;  4U6J A;  1B6A A;  1YW8 A;  5CLS A;  2P9A A;  3L7G A;  4ZWP A;  2Q8K A;  4PV4 A;  1N51 A;  1A16 A;  1BOA A;  1WBQ A;  1C23 A;  2GG2 A;  4KM3 A;  1C27 A;  3CB6 A;  3TAV A;  2Q96 A;  2ZSG A;  2EVO A;  4PNC A;  4U75 A;  2EA4 A;  2BWT A;  3TB5 A;  5CDL A;  2BHD A;  3PKE A;  2EA2 A;  2BN7 A;  4IPA A;  4JUQ A;  4S00 A;  1O0X A;  2Q93 A;  4U76 A;  4ZWU A;  2Q95 A;  2BH3 A;  3L24 A;  5JFR A;  3Q6D A;  1JAW A;  5D6F A;  1XGN A;  2P98 A;  1W2M A;  2BWX A;  4U6W A;  5E5B A;  2GG8 A;  2BHA A;  4U73 A;  3CTZ A;  2GG0 A;  1WN1 A;  3IU9 A;  4RZY A;  1M35 A;  4FLI A;  4FLJ A;  5JHU A;  2GU5 A;  4B28 A;  3FMR A;  4OOK A;  2V3Z A;  5CDE A;  5FCH A;  1W7V A;  4U1B A;  4S01 A;  1KQ0 A;  5D6E A;  4QR8 A;  2BWS A;  4S2R P;  4HXX A;  1YJ3 A;  4ZNG A;  1B59 A;  1Y1N A;  3FMQ A;  1XGO A;  4FO7 A;  2G6P A;  5CIK A;  2GG3 A;  1QXW A;  2BWW A;  3IG4 A;  4U6C A;  1WY2 A;  4IKU A;  5CDV A;  2NQ7 A;  3ROR A;  2ADU A;  4FLL A;  3PKB A;  1BN5 A;  3MR1 A;  4U6Z A;  1YW7 A;  1YW9 A;  1R5G A; 
#chains in the Genus database with same CATH topology
 1C24 A;  2V3X A;  1WL9 A;  4R60 A;  4IEC A;  4U69 A;  3MX6 A;  3BIP A;  4RZZ A;  4IDY A;  2BWV A;  5CNX A;  1PV9 A;  2B3K A;  4IF7 A;  1YVM A;  3RVA A;  4FKC A;  5JI6 A;  3PKD A;  4FLK A;  1QZY A;  2V6C A;  2V3Y A;  2HOW A;  3CB5 A;  2BWU A;  1MAT A;  1C21 A;  3BIQ A;  3PKC A;  4S2T P;  4EGE A;  4IKR A;  1XNZ A;  2P99 A;  1QXZ A;  1QXY A;  2B3H A;  2GG7 A;  2GG5 A;  2IW2 A;  4FUK A;  5FCF A;  1XGS A;  2GTX A;  2MAT A;  2DFI A;  2BWY A;  3MAT A;  4Z7M A;  4A6V A;  3PKA A;  4ZWO A;  2OAZ A;  2GU4 A;  2GU6 A;  4U70 A;  1XGM A;  2NQ6 A;  2BB7 A;  1WL6 A;  1WLR A;  2B3L A;  2EVM A;  4RGZ 1;  2GU7 A;  4U71 A;  1C22 A;  1WKM A;  2GG9 A;  1KP0 A;  2Q94 A;  1R58 A;  2GGB A;  2GGC A;  4IKS A;  1CHM A;  2BHB A;  4A6W A;  4IU6 A;  2GA2 A;  2Q92 A;  3D27 A;  5CE6 A;  1R5H A;  2BHC A;  2OKN A;  4U6E A;  3IU7 A;  3BIT A;  3S6B A;  4FO8 A;  1KQ9 A;  4IKT A;  2EVC A;  4MAT A;  3IU8 A;  3FM3 A;  2GZ5 A;  4U6J A;  1B6A A;  1YW8 A;  5CLS A;  2P9A A;  3L7G A;  4ZWP A;  2Q8K A;  4PV4 A;  1N51 A;  1A16 A;  1BOA A;  1WBQ A;  1C23 A;  2GG2 A;  4KM3 A;  1C27 A;  3CB6 A;  3TAV A;  2Q96 A;  2ZSG A;  2EVO A;  4PNC A;  4U75 A;  2EA4 A;  2BWT A;  3TB5 A;  5CDL A;  2BHD A;  3PKE A;  2EA2 A;  2BN7 A;  4IPA A;  4JUQ A;  4S00 A;  1O0X A;  2Q93 A;  4U76 A;  4ZWU A;  2Q95 A;  2BH3 A;  3L24 A;  5JFR A;  3Q6D A;  1JAW A;  5D6F A;  1XGN A;  2P98 A;  1W2M A;  2BWX A;  4U6W A;  5E5B A;  2GG8 A;  2BHA A;  4U73 A;  3CTZ A;  2GG0 A;  1WN1 A;  3IU9 A;  4RZY A;  1M35 A;  4FLI A;  4FLJ A;  5JHU A;  2GU5 A;  4B28 A;  3FMR A;  4OOK A;  2V3Z A;  5CDE A;  5FCH A;  1W7V A;  4U1B A;  4S01 A;  1KQ0 A;  5D6E A;  4QR8 A;  2BWS A;  4S2R P;  4HXX A;  1YJ3 A;  4ZNG A;  1B59 A;  1Y1N A;  3FMQ A;  1XGO A;  4FO7 A;  2G6P A;  5CIK A;  2GG3 A;  1QXW A;  2BWW A;  3IG4 A;  4U6C A;  1WY2 A;  4IKU A;  5CDV A;  2NQ7 A;  3ROR A;  2ADU A;  4FLL A;  3PKB A;  1BN5 A;  3MR1 A;  4U6Z A;  1YW7 A;  1YW9 A;  1R5G A; 
#chains in the Genus database with same CATH homology
 1C24 A;  2V3X A;  1WL9 A;  4R60 A;  4IEC A;  4U69 A;  3MX6 A;  3BIP A;  4RZZ A;  4IDY A;  2BWV A;  5CNX A;  1PV9 A;  2B3K A;  4IF7 A;  1YVM A;  3RVA A;  4FKC A;  5JI6 A;  3PKD A;  4FLK A;  1QZY A;  2V6C A;  2V3Y A;  2HOW A;  3CB5 A;  2BWU A;  1MAT A;  1C21 A;  3BIQ A;  3PKC A;  4S2T P;  4EGE A;  4IKR A;  1XNZ A;  2P99 A;  1QXZ A;  1QXY A;  2B3H A;  2GG7 A;  2GG5 A;  2IW2 A;  4FUK A;  5FCF A;  1XGS A;  2GTX A;  2MAT A;  2DFI A;  2BWY A;  3MAT A;  4Z7M A;  4A6V A;  3PKA A;  4ZWO A;  2OAZ A;  2GU4 A;  2GU6 A;  4U70 A;  1XGM A;  2NQ6 A;  2BB7 A;  1WL6 A;  1WLR A;  2B3L A;  2EVM A;  4RGZ 1;  2GU7 A;  4U71 A;  1C22 A;  1WKM A;  2GG9 A;  1KP0 A;  2Q94 A;  1R58 A;  2GGB A;  2GGC A;  4IKS A;  1CHM A;  2BHB A;  4A6W A;  4IU6 A;  2GA2 A;  2Q92 A;  3D27 A;  5CE6 A;  1R5H A;  2BHC A;  2OKN A;  4U6E A;  3IU7 A;  3BIT A;  3S6B A;  4FO8 A;  1KQ9 A;  4IKT A;  2EVC A;  4MAT A;  3IU8 A;  3FM3 A;  2GZ5 A;  4U6J A;  1B6A A;  1YW8 A;  5CLS A;  2P9A A;  3L7G A;  4ZWP A;  2Q8K A;  4PV4 A;  1N51 A;  1A16 A;  1BOA A;  1WBQ A;  1C23 A;  2GG2 A;  4KM3 A;  1C27 A;  3CB6 A;  3TAV A;  2Q96 A;  2ZSG A;  2EVO A;  4PNC A;  4U75 A;  2EA4 A;  2BWT A;  3TB5 A;  5CDL A;  2BHD A;  3PKE A;  2EA2 A;  2BN7 A;  4IPA A;  4JUQ A;  4S00 A;  1O0X A;  2Q93 A;  4U76 A;  4ZWU A;  2Q95 A;  2BH3 A;  3L24 A;  5JFR A;  3Q6D A;  1JAW A;  5D6F A;  1XGN A;  2P98 A;  1W2M A;  2BWX A;  4U6W A;  5E5B A;  2GG8 A;  2BHA A;  4U73 A;  3CTZ A;  2GG0 A;  1WN1 A;  3IU9 A;  4RZY A;  1M35 A;  4FLI A;  4FLJ A;  5JHU A;  2GU5 A;  4B28 A;  3FMR A;  4OOK A;  2V3Z A;  5CDE A;  5FCH A;  1W7V A;  4U1B A;  4S01 A;  1KQ0 A;  5D6E A;  4QR8 A;  2BWS A;  4S2R P;  4HXX A;  1YJ3 A;  4ZNG A;  1B59 A;  1Y1N A;  3FMQ A;  1XGO A;  4FO7 A;  2G6P A;  5CIK A;  2GG3 A;  1QXW A;  2BWW A;  3IG4 A;  4U6C A;  1WY2 A;  4IKU A;  5CDV A;  2NQ7 A;  3ROR A;  2ADU A;  4FLL A;  3PKB A;  1BN5 A;  3MR1 A;  4U6Z A;  1YW7 A;  1YW9 A;  1R5G A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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