4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
1B6AA 4ZWPA 1KQ9A 1YW7A 4S2RP 3D27A 3S6BA 4ZWUA 3MR1A 2EA4A 3IU7A 3BIQA 2BN7A 3RVAA 4RZZA 5CDEA 1W7VA 2V3YA 1MATA 2BHCA 2P9AA 1XGSA 1YW8A 1N51A 5CIKA 2BB7A 4IKTA 2EVCA 1JAWA 2GTXA 2GA2A 1QXWA 2BWWA 1YVMA 3PKDA 2MATA 3MATA 4U6EA 1WBQA 3CB5A 4FLKA 4KM3A 4U76A 5CDVA 3FM3A 4U6ZA 1C23A 4IDYA 2GG0A 2Q96A 2Q8KA 2OKNA 2V6CA 5FCHA 2Q95A 2GU7A 4PNCA 1CHMA 3CTZA 4U75A 2GU5A 1O0XA 2P99A 5CDLA 4QR8A 1WY2A 2BWVA 1R58A 1WKMA 4ZNGA 1B59A 4A6VA 5CLSA 1W2MA 2BWUA 5CE6A 3PKEA 2P98A 4IKRA 2BWSA 2BWTA 4U69A 2GU4A 1R5HA 4EGEA 2ZSGA 5CNXA 1A16A 1M35A 4IKUA 2ADUA 4FO7A 4OOKA 4U70A 3IG4A 5JHUA 1XNZA 3TB5A 1QZYA 2V3ZA 2DFIA 2BHDA 2BHBA 4IPAA 4Z7MA 1YW9A 1C24A 4FO8A 1BN5A 3BITA 5E5BA 2Q93A 4IECA 3PKAA 2G6PA 2GGBA 3CB6A 2GG5A 4RGZ1 2BH3A 2BWXA 3RORA 5JI6A 2V3XA 2GG8A 1C22A 2EVOA 4U6JA 4A6WA 2GG3A 4U73A 1C21A 2IW2A 3TAVA 1XGMA 2B3KA 5FCFA 3PKCA 2Q92A 1WN1A 2GG7A 2GG9A 4R60A 2GZ5A 4JUQA 1XGOA 4HXXA 1KQ0A 1R5GA 4RZYA 5JFRA 1QXZA 4IKSA 1WLRA 4ZWOA 1BOAA 3Q6DA 4U1BA 3FMQA 1PV9A 4U71A 3L24A 3MX6A 2OAZA 4B28A 2NQ7A 3FMRA 3L7GA 3IU8A 2BHAA 5D6FA 4FLJA 2GG2A 5D6EA 2GU6A 4S01A 3IU9A 4IF7A 1QXYA 2BWYA 4FLLA 1WL6A 4PV4A 2Q94A 1XGNA 4IU6A 1KP0A 2B3LA 2B3HA 2GGCA 4U6CA 2EVMA 2EA2A 1Y1NA 4FUKA 4U6WA 2HOWA 1WL9A 3BIPA 2NQ6A 1C27A 3PKBA 4S2TP 1YJ3A 4FKCA 4S00A 4FLIA 4MATA
chains in the Genus database with same CATH superfamily
1B6AA 4ZWPA 1KQ9A 1YW7A 4S2RP 3D27A 3S6BA 4ZWUA 3MR1A 2EA4A 3IU7A 3BIQA 2BN7A 3RVAA 4RZZA 5CDEA 1W7VA 2V3YA 1MATA 2BHCA 2P9AA 1XGSA 1YW8A 1N51A 5CIKA 2BB7A 4IKTA 2EVCA 1JAWA 2GTXA 2GA2A 1QXWA 2BWWA 1YVMA 3PKDA 2MATA 3MATA 4U6EA 1WBQA 3CB5A 4FLKA 4KM3A 4U76A 5CDVA 3FM3A 4U6ZA 1C23A 4IDYA 2GG0A 2Q96A 2Q8KA 2OKNA 2V6CA 5FCHA 2Q95A 2GU7A 4PNCA 1CHMA 3CTZA 4U75A 2GU5A 1O0XA 2P99A 5CDLA 4QR8A 1WY2A 2BWVA 1R58A 1WKMA 4ZNGA 1B59A 4A6VA 5CLSA 1W2MA 2BWUA 5CE6A 3PKEA 2P98A 4IKRA 2BWSA 2BWTA 4U69A 2GU4A 1R5HA 4EGEA 2ZSGA 5CNXA 1A16A 1M35A 4IKUA 2ADUA 4FO7A 4OOKA 4U70A 3IG4A 5JHUA 1XNZA 3TB5A 1QZYA 2V3ZA 2DFIA 2BHDA 2BHBA 4IPAA 4Z7MA 1YW9A 1C24A 4FO8A 1BN5A 3BITA 5E5BA 2Q93A 4IECA 3PKAA 2G6PA 2GGBA 3CB6A 2GG5A 4RGZ1 2BH3A 2BWXA 3RORA 5JI6A 2V3XA 2GG8A 1C22A 2EVOA 4U6JA 4A6WA 2GG3A 4U73A 1C21A 2IW2A 3TAVA 1XGMA 2B3KA 5FCFA 3PKCA 2Q92A 1WN1A 2GG7A 2GG9A 4R60A 2GZ5A 4JUQA 1XGOA 4HXXA 1KQ0A 1R5GA 4RZYA 5JFRA 1QXZA 4IKSA 1WLRA 4ZWOA 1BOAA 3Q6DA 4U1BA 3FMQA 1PV9A 4U71A 3L24A 3MX6A 2OAZA 4B28A 2NQ7A 3FMRA 3L7GA 3IU8A 2BHAA 5D6FA 4FLJA 2GG2A 5D6EA 2GU6A 4S01A 3IU9A 4IF7A 1QXYA 2BWYA 4FLLA 1WL6A 4PV4A 2Q94A 1XGNA 4IU6A 1KP0A 2B3LA 2B3HA 2GGCA 4U6CA 2EVMA 2EA2A 1Y1NA 4FUKA 4U6WA 2HOWA 1WL9A 3BIPA 2NQ6A 1C27A 3PKBA 4S2TP 1YJ3A 4FKCA 4S00A 4FLIA 4MATA
chains in the Genus database with same CATH topology
1B6AA 4ZWPA 1KQ9A 1YW7A 4S2RP 3D27A 3S6BA 4ZWUA 3MR1A 2EA4A 3IU7A 3BIQA 2BN7A 3RVAA 4RZZA 5CDEA 1W7VA 2V3YA 1MATA 2BHCA 2P9AA 1XGSA 1YW8A 1N51A 5CIKA 2BB7A 4IKTA 2EVCA 1JAWA 2GTXA 2GA2A 1QXWA 2BWWA 1YVMA 3PKDA 2MATA 3MATA 4U6EA 1WBQA 3CB5A 4FLKA 4KM3A 4U76A 5CDVA 3FM3A 4U6ZA 1C23A 4IDYA 2GG0A 2Q96A 2Q8KA 2OKNA 2V6CA 5FCHA 2Q95A 2GU7A 4PNCA 1CHMA 3CTZA 4U75A 2GU5A 1O0XA 2P99A 5CDLA 4QR8A 1WY2A 2BWVA 1R58A 1WKMA 4ZNGA 1B59A 4A6VA 5CLSA 1W2MA 2BWUA 5CE6A 3PKEA 2P98A 4IKRA 2BWSA 2BWTA 4U69A 2GU4A 1R5HA 4EGEA 2ZSGA 5CNXA 1A16A 1M35A 4IKUA 2ADUA 4FO7A 4OOKA 4U70A 3IG4A 5JHUA 1XNZA 3TB5A 1QZYA 2V3ZA 2DFIA 2BHDA 2BHBA 4IPAA 4Z7MA 1YW9A 1C24A 4FO8A 1BN5A 3BITA 5E5BA 2Q93A 4IECA 3PKAA 2G6PA 2GGBA 3CB6A 2GG5A 4RGZ1 2BH3A 2BWXA 3RORA 5JI6A 2V3XA 2GG8A 1C22A 2EVOA 4U6JA 4A6WA 2GG3A 4U73A 1C21A 2IW2A 3TAVA 1XGMA 2B3KA 5FCFA 3PKCA 2Q92A 1WN1A 2GG7A 2GG9A 4R60A 2GZ5A 4JUQA 1XGOA 4HXXA 1KQ0A 1R5GA 4RZYA 5JFRA 1QXZA 4IKSA 1WLRA 4ZWOA 1BOAA 3Q6DA 4U1BA 3FMQA 1PV9A 4U71A 3L24A 3MX6A 2OAZA 4B28A 2NQ7A 3FMRA 3L7GA 3IU8A 2BHAA 5D6FA 4FLJA 2GG2A 5D6EA 2GU6A 4S01A 3IU9A 4IF7A 1QXYA 2BWYA 4FLLA 1WL6A 4PV4A 2Q94A 1XGNA 4IU6A 1KP0A 2B3LA 2B3HA 2GGCA 4U6CA 2EVMA 2EA2A 1Y1NA 4FUKA 4U6WA 2HOWA 1WL9A 3BIPA 2NQ6A 1C27A 3PKBA 4S2TP 1YJ3A 4FKCA 4S00A 4FLIA 4MATA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1B6A A;  4ZWP A;  1KQ9 A;  1YW7 A;  4S2R P;  3D27 A;  3S6B A;  4ZWU A;  3MR1 A;  2EA4 A;  3IU7 A;  3BIQ A;  2BN7 A;  3RVA A;  4RZZ A;  5CDE A;  1W7V A;  2V3Y A;  1MAT A;  2BHC A;  2P9A A;  1XGS A;  1YW8 A;  1N51 A;  5CIK A;  2BB7 A;  4IKT A;  2EVC A;  1JAW A;  2GTX A;  2GA2 A;  1QXW A;  2BWW A;  1YVM A;  3PKD A;  2MAT A;  3MAT A;  4U6E A;  1WBQ A;  3CB5 A;  4FLK A;  4KM3 A;  4U76 A;  5CDV A;  3FM3 A;  4U6Z A;  1C23 A;  4IDY A;  2GG0 A;  2Q96 A;  2Q8K A;  2OKN A;  2V6C A;  5FCH A;  2Q95 A;  2GU7 A;  4PNC A;  1CHM A;  3CTZ A;  4U75 A;  2GU5 A;  1O0X A;  2P99 A;  5CDL A;  4QR8 A;  1WY2 A;  2BWV A;  1R58 A;  1WKM A;  4ZNG A;  1B59 A;  4A6V A;  5CLS A;  1W2M A;  2BWU A;  5CE6 A;  3PKE A;  2P98 A;  4IKR A;  2BWS A;  2BWT A;  4U69 A;  2GU4 A;  1R5H A;  4EGE A;  2ZSG A;  5CNX A;  1A16 A;  1M35 A;  4IKU A;  2ADU A;  4FO7 A;  4OOK A;  4U70 A;  3IG4 A;  5JHU A;  1XNZ A;  3TB5 A;  1QZY A;  2V3Z A;  2DFI A;  2BHD A;  2BHB A;  4IPA A;  4Z7M A;  1YW9 A;  1C24 A;  4FO8 A;  1BN5 A;  3BIT A;  5E5B A;  2Q93 A;  4IEC A;  3PKA A;  2G6P A;  2GGB A;  3CB6 A;  2GG5 A;  4RGZ 1;  2BH3 A;  2BWX A;  3ROR A;  5JI6 A;  2V3X A;  2GG8 A;  1C22 A;  2EVO A;  4U6J A;  4A6W A;  2GG3 A;  4U73 A;  1C21 A;  2IW2 A;  3TAV A;  1XGM A;  2B3K A;  5FCF A;  3PKC A;  2Q92 A;  1WN1 A;  2GG7 A;  2GG9 A;  4R60 A;  2GZ5 A;  4JUQ A;  1XGO A;  4HXX A;  1KQ0 A;  1R5G A;  4RZY A;  5JFR A;  1QXZ A;  4IKS A;  1WLR A;  4ZWO A;  1BOA A;  3Q6D A;  4U1B A;  3FMQ A;  1PV9 A;  4U71 A;  3L24 A;  3MX6 A;  2OAZ A;  4B28 A;  2NQ7 A;  3FMR A;  3L7G A;  3IU8 A;  2BHA A;  5D6F A;  4FLJ A;  2GG2 A;  5D6E A;  2GU6 A;  4S01 A;  3IU9 A;  4IF7 A;  1QXY A;  2BWY A;  4FLL A;  1WL6 A;  4PV4 A;  2Q94 A;  1XGN A;  4IU6 A;  1KP0 A;  2B3L A;  2B3H A;  2GGC A;  4U6C A;  2EVM A;  2EA2 A;  1Y1N A;  4FUK A;  4U6W A;  2HOW A;  1WL9 A;  3BIP A;  2NQ6 A;  1C27 A;  3PKB A;  4S2T P;  1YJ3 A;  4FKC A;  4S00 A;  4FLI A;  4MAT A; 
#chains in the Genus database with same CATH topology
 1B6A A;  4ZWP A;  1KQ9 A;  1YW7 A;  4S2R P;  3D27 A;  3S6B A;  4ZWU A;  3MR1 A;  2EA4 A;  3IU7 A;  3BIQ A;  2BN7 A;  3RVA A;  4RZZ A;  5CDE A;  1W7V A;  2V3Y A;  1MAT A;  2BHC A;  2P9A A;  1XGS A;  1YW8 A;  1N51 A;  5CIK A;  2BB7 A;  4IKT A;  2EVC A;  1JAW A;  2GTX A;  2GA2 A;  1QXW A;  2BWW A;  1YVM A;  3PKD A;  2MAT A;  3MAT A;  4U6E A;  1WBQ A;  3CB5 A;  4FLK A;  4KM3 A;  4U76 A;  5CDV A;  3FM3 A;  4U6Z A;  1C23 A;  4IDY A;  2GG0 A;  2Q96 A;  2Q8K A;  2OKN A;  2V6C A;  5FCH A;  2Q95 A;  2GU7 A;  4PNC A;  1CHM A;  3CTZ A;  4U75 A;  2GU5 A;  1O0X A;  2P99 A;  5CDL A;  4QR8 A;  1WY2 A;  2BWV A;  1R58 A;  1WKM A;  4ZNG A;  1B59 A;  4A6V A;  5CLS A;  1W2M A;  2BWU A;  5CE6 A;  3PKE A;  2P98 A;  4IKR A;  2BWS A;  2BWT A;  4U69 A;  2GU4 A;  1R5H A;  4EGE A;  2ZSG A;  5CNX A;  1A16 A;  1M35 A;  4IKU A;  2ADU A;  4FO7 A;  4OOK A;  4U70 A;  3IG4 A;  5JHU A;  1XNZ A;  3TB5 A;  1QZY A;  2V3Z A;  2DFI A;  2BHD A;  2BHB A;  4IPA A;  4Z7M A;  1YW9 A;  1C24 A;  4FO8 A;  1BN5 A;  3BIT A;  5E5B A;  2Q93 A;  4IEC A;  3PKA A;  2G6P A;  2GGB A;  3CB6 A;  2GG5 A;  4RGZ 1;  2BH3 A;  2BWX A;  3ROR A;  5JI6 A;  2V3X A;  2GG8 A;  1C22 A;  2EVO A;  4U6J A;  4A6W A;  2GG3 A;  4U73 A;  1C21 A;  2IW2 A;  3TAV A;  1XGM A;  2B3K A;  5FCF A;  3PKC A;  2Q92 A;  1WN1 A;  2GG7 A;  2GG9 A;  4R60 A;  2GZ5 A;  4JUQ A;  1XGO A;  4HXX A;  1KQ0 A;  1R5G A;  4RZY A;  5JFR A;  1QXZ A;  4IKS A;  1WLR A;  4ZWO A;  1BOA A;  3Q6D A;  4U1B A;  3FMQ A;  1PV9 A;  4U71 A;  3L24 A;  3MX6 A;  2OAZ A;  4B28 A;  2NQ7 A;  3FMR A;  3L7G A;  3IU8 A;  2BHA A;  5D6F A;  4FLJ A;  2GG2 A;  5D6E A;  2GU6 A;  4S01 A;  3IU9 A;  4IF7 A;  1QXY A;  2BWY A;  4FLL A;  1WL6 A;  4PV4 A;  2Q94 A;  1XGN A;  4IU6 A;  1KP0 A;  2B3L A;  2B3H A;  2GGC A;  4U6C A;  2EVM A;  2EA2 A;  1Y1N A;  4FUK A;  4U6W A;  2HOW A;  1WL9 A;  3BIP A;  2NQ6 A;  1C27 A;  3PKB A;  4S2T P;  1YJ3 A;  4FKC A;  4S00 A;  4FLI A;  4MAT A; 
#chains in the Genus database with same CATH homology
 1B6A A;  4ZWP A;  1KQ9 A;  1YW7 A;  4S2R P;  3D27 A;  3S6B A;  4ZWU A;  3MR1 A;  2EA4 A;  3IU7 A;  3BIQ A;  2BN7 A;  3RVA A;  4RZZ A;  5CDE A;  1W7V A;  2V3Y A;  1MAT A;  2BHC A;  2P9A A;  1XGS A;  1YW8 A;  1N51 A;  5CIK A;  2BB7 A;  4IKT A;  2EVC A;  1JAW A;  2GTX A;  2GA2 A;  1QXW A;  2BWW A;  1YVM A;  3PKD A;  2MAT A;  3MAT A;  4U6E A;  1WBQ A;  3CB5 A;  4FLK A;  4KM3 A;  4U76 A;  5CDV A;  3FM3 A;  4U6Z A;  1C23 A;  4IDY A;  2GG0 A;  2Q96 A;  2Q8K A;  2OKN A;  2V6C A;  5FCH A;  2Q95 A;  2GU7 A;  4PNC A;  1CHM A;  3CTZ A;  4U75 A;  2GU5 A;  1O0X A;  2P99 A;  5CDL A;  4QR8 A;  1WY2 A;  2BWV A;  1R58 A;  1WKM A;  4ZNG A;  1B59 A;  4A6V A;  5CLS A;  1W2M A;  2BWU A;  5CE6 A;  3PKE A;  2P98 A;  4IKR A;  2BWS A;  2BWT A;  4U69 A;  2GU4 A;  1R5H A;  4EGE A;  2ZSG A;  5CNX A;  1A16 A;  1M35 A;  4IKU A;  2ADU A;  4FO7 A;  4OOK A;  4U70 A;  3IG4 A;  5JHU A;  1XNZ A;  3TB5 A;  1QZY A;  2V3Z A;  2DFI A;  2BHD A;  2BHB A;  4IPA A;  4Z7M A;  1YW9 A;  1C24 A;  4FO8 A;  1BN5 A;  3BIT A;  5E5B A;  2Q93 A;  4IEC A;  3PKA A;  2G6P A;  2GGB A;  3CB6 A;  2GG5 A;  4RGZ 1;  2BH3 A;  2BWX A;  3ROR A;  5JI6 A;  2V3X A;  2GG8 A;  1C22 A;  2EVO A;  4U6J A;  4A6W A;  2GG3 A;  4U73 A;  1C21 A;  2IW2 A;  3TAV A;  1XGM A;  2B3K A;  5FCF A;  3PKC A;  2Q92 A;  1WN1 A;  2GG7 A;  2GG9 A;  4R60 A;  2GZ5 A;  4JUQ A;  1XGO A;  4HXX A;  1KQ0 A;  1R5G A;  4RZY A;  5JFR A;  1QXZ A;  4IKS A;  1WLR A;  4ZWO A;  1BOA A;  3Q6D A;  4U1B A;  3FMQ A;  1PV9 A;  4U71 A;  3L24 A;  3MX6 A;  2OAZ A;  4B28 A;  2NQ7 A;  3FMR A;  3L7G A;  3IU8 A;  2BHA A;  5D6F A;  4FLJ A;  2GG2 A;  5D6E A;  2GU6 A;  4S01 A;  3IU9 A;  4IF7 A;  1QXY A;  2BWY A;  4FLL A;  1WL6 A;  4PV4 A;  2Q94 A;  1XGN A;  4IU6 A;  1KP0 A;  2B3L A;  2B3H A;  2GGC A;  4U6C A;  2EVM A;  2EA2 A;  1Y1N A;  4FUK A;  4U6W A;  2HOW A;  1WL9 A;  3BIP A;  2NQ6 A;  1C27 A;  3PKB A;  4S2T P;  1YJ3 A;  4FKC A;  4S00 A;  4FLI A;  4MAT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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