4U75A

Hsmetap (f309m) in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u75A00
4IECA 1WY2A 1R58A 2ZSGA 4A6WA 5FCHA 1KQ9A 2GG9A 1KQ0A 2B3HA 1QXWA 2OAZA 2BB7A 4RGZ1 2Q94A 1C23A 2P99A 4IF7A 4IKUA 1XGNA 4IDYA 2GZ5A 4FO8A 1XGOA 2GG7A 2GG8A 5CDEA 1C27A 3IU7A 5CIKA 5CDLA 4IU6A 5CLSA 4U70A 4FLLA 1YW8A 4U71A 3PKBA 2P98A 1W2MA 5CNXA 1C21A 2BWXA 3PKDA 1N51A 4U6JA 3S6BA 1BOAA 2BWVA 2GTXA 1O0XA 2BHCA 1QXYA 4ZWUA 2BHBA 1XNZA 1MATA 1C24A 4S2RP 2BHAA 4EGEA 4FKCA 3FMQA 4S2TP 2EVMA 1QXZA 4MATA 4Z7MA 4QR8A 2GGCA 1B6AA 2NQ6A 4KM3A 2GG2A 4PNCA 4ZWOA 2BHDA 2V3YA 3Q6DA 2BH3A 2GU4A 3IG4A 4U76A 4PV4A 4U6EA 4S01A 2NQ7A 2P9AA 1A16A 1XGMA 2MATA 3MR1A 1W7VA 1KP0A 2DFIA 1JAWA 3IU9A 2G6PA 3D27A 2Q96A 1YW7A 3PKCA 1YJ3A 4FLKA 3RORA 2Q8KA 4A6VA 2BN7A 2Q92A 3BIQA 4IKRA 4FLJA 3BIPA 4FLIA 4U73A 4FO7A 4B28A 4RZZA 4U1BA 1B59A 3PKAA 4IKTA 1XGSA 4IPAA 3MATA 1QZYA 1M35A 1PV9A 2OKNA 1WN1A 2GG0A 2GU5A 4S00A 2Q93A 2B3KA 2V6CA 2GG3A 5CDVA 4JUQA 1WKMA 3FM3A 4U75A 4IKSA 4ZWPA 4HXXA 4U69A 5FCFA 2GU6A 5D6EA 2GU7A 3L24A 3RVAA 2BWSA 1BN5A 4U6ZA 1WBQA 1CHMA 2B3LA 2BWTA 1Y1NA 1YW9A 4FUKA 3BITA 3CTZA 4RZYA 5E5BA 2BWWA 5D6FA 2V3XA 3TAVA 2EA4A 2V3ZA 2GA2A 2HOWA 1WL9A 2EVCA 1WL6A 4U6CA 1WLRA 2BWUA 3IU8A 3CB5A 1YVMA 2EA2A 3FMRA 5CE6A 2EVOA 1R5HA 2Q95A 5JI6A 4U6WA 2GG5A 1C22A 2ADUA 3MX6A 3TB5A 2BWYA 3PKEA 5JFRA 3L7GA 4R60A 3CB6A 4ZNGA 1R5GA 2GGBA 4OOKA 5JHUA 2IW2A
chains in the Genus database with same CATH superfamily
4IECA 1WY2A 1R58A 2ZSGA 4A6WA 5FCHA 1KQ9A 2GG9A 1KQ0A 2B3HA 1QXWA 2OAZA 2BB7A 4RGZ1 2Q94A 1C23A 2P99A 4IF7A 4IKUA 1XGNA 4IDYA 2GZ5A 4FO8A 1XGOA 2GG7A 2GG8A 5CDEA 1C27A 3IU7A 5CIKA 5CDLA 4IU6A 5CLSA 4U70A 4FLLA 1YW8A 4U71A 3PKBA 2P98A 1W2MA 5CNXA 1C21A 2BWXA 3PKDA 1N51A 4U6JA 3S6BA 1BOAA 2BWVA 2GTXA 1O0XA 2BHCA 1QXYA 4ZWUA 2BHBA 1XNZA 1MATA 1C24A 4S2RP 2BHAA 4EGEA 4FKCA 3FMQA 4S2TP 2EVMA 1QXZA 4MATA 4Z7MA 4QR8A 2GGCA 1B6AA 2NQ6A 4KM3A 2GG2A 4PNCA 4ZWOA 2BHDA 2V3YA 3Q6DA 2BH3A 2GU4A 3IG4A 4U76A 4PV4A 4U6EA 4S01A 2NQ7A 2P9AA 1A16A 1XGMA 2MATA 3MR1A 1W7VA 1KP0A 2DFIA 1JAWA 3IU9A 2G6PA 3D27A 2Q96A 1YW7A 3PKCA 1YJ3A 4FLKA 3RORA 2Q8KA 4A6VA 2BN7A 2Q92A 3BIQA 4IKRA 4FLJA 3BIPA 4FLIA 4U73A 4FO7A 4B28A 4RZZA 4U1BA 1B59A 3PKAA 4IKTA 1XGSA 4IPAA 3MATA 1QZYA 1M35A 1PV9A 2OKNA 1WN1A 2GG0A 2GU5A 4S00A 2Q93A 2B3KA 2V6CA 2GG3A 5CDVA 4JUQA 1WKMA 3FM3A 4U75A 4IKSA 4ZWPA 4HXXA 4U69A 5FCFA 2GU6A 5D6EA 2GU7A 3L24A 3RVAA 2BWSA 1BN5A 4U6ZA 1WBQA 1CHMA 2B3LA 2BWTA 1Y1NA 1YW9A 4FUKA 3BITA 3CTZA 4RZYA 5E5BA 2BWWA 5D6FA 2V3XA 3TAVA 2EA4A 2V3ZA 2GA2A 2HOWA 1WL9A 2EVCA 1WL6A 4U6CA 1WLRA 2BWUA 3IU8A 3CB5A 1YVMA 2EA2A 3FMRA 5CE6A 2EVOA 1R5HA 2Q95A 5JI6A 4U6WA 2GG5A 1C22A 2ADUA 3MX6A 3TB5A 2BWYA 3PKEA 5JFRA 3L7GA 4R60A 3CB6A 4ZNGA 1R5GA 2GGBA 4OOKA 5JHUA 2IW2A
chains in the Genus database with same CATH topology
4IECA 1WY2A 1R58A 2ZSGA 4A6WA 5FCHA 1KQ9A 2GG9A 1KQ0A 2B3HA 1QXWA 2OAZA 2BB7A 4RGZ1 2Q94A 1C23A 2P99A 4IF7A 4IKUA 1XGNA 4IDYA 2GZ5A 4FO8A 1XGOA 2GG7A 2GG8A 5CDEA 1C27A 3IU7A 5CIKA 5CDLA 4IU6A 5CLSA 4U70A 4FLLA 1YW8A 4U71A 3PKBA 2P98A 1W2MA 5CNXA 1C21A 2BWXA 3PKDA 1N51A 4U6JA 3S6BA 1BOAA 2BWVA 2GTXA 1O0XA 2BHCA 1QXYA 4ZWUA 2BHBA 1XNZA 1MATA 1C24A 4S2RP 2BHAA 4EGEA 4FKCA 3FMQA 4S2TP 2EVMA 1QXZA 4MATA 4Z7MA 4QR8A 2GGCA 1B6AA 2NQ6A 4KM3A 2GG2A 4PNCA 4ZWOA 2BHDA 2V3YA 3Q6DA 2BH3A 2GU4A 3IG4A 4U76A 4PV4A 4U6EA 4S01A 2NQ7A 2P9AA 1A16A 1XGMA 2MATA 3MR1A 1W7VA 1KP0A 2DFIA 1JAWA 3IU9A 2G6PA 3D27A 2Q96A 1YW7A 3PKCA 1YJ3A 4FLKA 3RORA 2Q8KA 4A6VA 2BN7A 2Q92A 3BIQA 4IKRA 4FLJA 3BIPA 4FLIA 4U73A 4FO7A 4B28A 4RZZA 4U1BA 1B59A 3PKAA 4IKTA 1XGSA 4IPAA 3MATA 1QZYA 1M35A 1PV9A 2OKNA 1WN1A 2GG0A 2GU5A 4S00A 2Q93A 2B3KA 2V6CA 2GG3A 5CDVA 4JUQA 1WKMA 3FM3A 4U75A 4IKSA 4ZWPA 4HXXA 4U69A 5FCFA 2GU6A 5D6EA 2GU7A 3L24A 3RVAA 2BWSA 1BN5A 4U6ZA 1WBQA 1CHMA 2B3LA 2BWTA 1Y1NA 1YW9A 4FUKA 3BITA 3CTZA 4RZYA 5E5BA 2BWWA 5D6FA 2V3XA 3TAVA 2EA4A 2V3ZA 2GA2A 2HOWA 1WL9A 2EVCA 1WL6A 4U6CA 1WLRA 2BWUA 3IU8A 3CB5A 1YVMA 2EA2A 3FMRA 5CE6A 2EVOA 1R5HA 2Q95A 5JI6A 4U6WA 2GG5A 1C22A 2ADUA 3MX6A 3TB5A 2BWYA 3PKEA 5JFRA 3L7GA 4R60A 3CB6A 4ZNGA 1R5GA 2GGBA 4OOKA 5JHUA 2IW2A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4IEC A;  1WY2 A;  1R58 A;  2ZSG A;  4A6W A;  5FCH A;  1KQ9 A;  2GG9 A;  1KQ0 A;  2B3H A;  1QXW A;  2OAZ A;  2BB7 A;  4RGZ 1;  2Q94 A;  1C23 A;  2P99 A;  4IF7 A;  4IKU A;  1XGN A;  4IDY A;  2GZ5 A;  4FO8 A;  1XGO A;  2GG7 A;  2GG8 A;  5CDE A;  1C27 A;  3IU7 A;  5CIK A;  5CDL A;  4IU6 A;  5CLS A;  4U70 A;  4FLL A;  1YW8 A;  4U71 A;  3PKB A;  2P98 A;  1W2M A;  5CNX A;  1C21 A;  2BWX A;  3PKD A;  1N51 A;  4U6J A;  3S6B A;  1BOA A;  2BWV A;  2GTX A;  1O0X A;  2BHC A;  1QXY A;  4ZWU A;  2BHB A;  1XNZ A;  1MAT A;  1C24 A;  4S2R P;  2BHA A;  4EGE A;  4FKC A;  3FMQ A;  4S2T P;  2EVM A;  1QXZ A;  4MAT A;  4Z7M A;  4QR8 A;  2GGC A;  1B6A A;  2NQ6 A;  4KM3 A;  2GG2 A;  4PNC A;  4ZWO A;  2BHD A;  2V3Y A;  3Q6D A;  2BH3 A;  2GU4 A;  3IG4 A;  4U76 A;  4PV4 A;  4U6E A;  4S01 A;  2NQ7 A;  2P9A A;  1A16 A;  1XGM A;  2MAT A;  3MR1 A;  1W7V A;  1KP0 A;  2DFI A;  1JAW A;  3IU9 A;  2G6P A;  3D27 A;  2Q96 A;  1YW7 A;  3PKC A;  1YJ3 A;  4FLK A;  3ROR A;  2Q8K A;  4A6V A;  2BN7 A;  2Q92 A;  3BIQ A;  4IKR A;  4FLJ A;  3BIP A;  4FLI A;  4U73 A;  4FO7 A;  4B28 A;  4RZZ A;  4U1B A;  1B59 A;  3PKA A;  4IKT A;  1XGS A;  4IPA A;  3MAT A;  1QZY A;  1M35 A;  1PV9 A;  2OKN A;  1WN1 A;  2GG0 A;  2GU5 A;  4S00 A;  2Q93 A;  2B3K A;  2V6C A;  2GG3 A;  5CDV A;  4JUQ A;  1WKM A;  3FM3 A;  4U75 A;  4IKS A;  4ZWP A;  4HXX A;  4U69 A;  5FCF A;  2GU6 A;  5D6E A;  2GU7 A;  3L24 A;  3RVA A;  2BWS A;  1BN5 A;  4U6Z A;  1WBQ A;  1CHM A;  2B3L A;  2BWT A;  1Y1N A;  1YW9 A;  4FUK A;  3BIT A;  3CTZ A;  4RZY A;  5E5B A;  2BWW A;  5D6F A;  2V3X A;  3TAV A;  2EA4 A;  2V3Z A;  2GA2 A;  2HOW A;  1WL9 A;  2EVC A;  1WL6 A;  4U6C A;  1WLR A;  2BWU A;  3IU8 A;  3CB5 A;  1YVM A;  2EA2 A;  3FMR A;  5CE6 A;  2EVO A;  1R5H A;  2Q95 A;  5JI6 A;  4U6W A;  2GG5 A;  1C22 A;  2ADU A;  3MX6 A;  3TB5 A;  2BWY A;  3PKE A;  5JFR A;  3L7G A;  4R60 A;  3CB6 A;  4ZNG A;  1R5G A;  2GGB A;  4OOK A;  5JHU A;  2IW2 A; 
#chains in the Genus database with same CATH topology
 4IEC A;  1WY2 A;  1R58 A;  2ZSG A;  4A6W A;  5FCH A;  1KQ9 A;  2GG9 A;  1KQ0 A;  2B3H A;  1QXW A;  2OAZ A;  2BB7 A;  4RGZ 1;  2Q94 A;  1C23 A;  2P99 A;  4IF7 A;  4IKU A;  1XGN A;  4IDY A;  2GZ5 A;  4FO8 A;  1XGO A;  2GG7 A;  2GG8 A;  5CDE A;  1C27 A;  3IU7 A;  5CIK A;  5CDL A;  4IU6 A;  5CLS A;  4U70 A;  4FLL A;  1YW8 A;  4U71 A;  3PKB A;  2P98 A;  1W2M A;  5CNX A;  1C21 A;  2BWX A;  3PKD A;  1N51 A;  4U6J A;  3S6B A;  1BOA A;  2BWV A;  2GTX A;  1O0X A;  2BHC A;  1QXY A;  4ZWU A;  2BHB A;  1XNZ A;  1MAT A;  1C24 A;  4S2R P;  2BHA A;  4EGE A;  4FKC A;  3FMQ A;  4S2T P;  2EVM A;  1QXZ A;  4MAT A;  4Z7M A;  4QR8 A;  2GGC A;  1B6A A;  2NQ6 A;  4KM3 A;  2GG2 A;  4PNC A;  4ZWO A;  2BHD A;  2V3Y A;  3Q6D A;  2BH3 A;  2GU4 A;  3IG4 A;  4U76 A;  4PV4 A;  4U6E A;  4S01 A;  2NQ7 A;  2P9A A;  1A16 A;  1XGM A;  2MAT A;  3MR1 A;  1W7V A;  1KP0 A;  2DFI A;  1JAW A;  3IU9 A;  2G6P A;  3D27 A;  2Q96 A;  1YW7 A;  3PKC A;  1YJ3 A;  4FLK A;  3ROR A;  2Q8K A;  4A6V A;  2BN7 A;  2Q92 A;  3BIQ A;  4IKR A;  4FLJ A;  3BIP A;  4FLI A;  4U73 A;  4FO7 A;  4B28 A;  4RZZ A;  4U1B A;  1B59 A;  3PKA A;  4IKT A;  1XGS A;  4IPA A;  3MAT A;  1QZY A;  1M35 A;  1PV9 A;  2OKN A;  1WN1 A;  2GG0 A;  2GU5 A;  4S00 A;  2Q93 A;  2B3K A;  2V6C A;  2GG3 A;  5CDV A;  4JUQ A;  1WKM A;  3FM3 A;  4U75 A;  4IKS A;  4ZWP A;  4HXX A;  4U69 A;  5FCF A;  2GU6 A;  5D6E A;  2GU7 A;  3L24 A;  3RVA A;  2BWS A;  1BN5 A;  4U6Z A;  1WBQ A;  1CHM A;  2B3L A;  2BWT A;  1Y1N A;  1YW9 A;  4FUK A;  3BIT A;  3CTZ A;  4RZY A;  5E5B A;  2BWW A;  5D6F A;  2V3X A;  3TAV A;  2EA4 A;  2V3Z A;  2GA2 A;  2HOW A;  1WL9 A;  2EVC A;  1WL6 A;  4U6C A;  1WLR A;  2BWU A;  3IU8 A;  3CB5 A;  1YVM A;  2EA2 A;  3FMR A;  5CE6 A;  2EVO A;  1R5H A;  2Q95 A;  5JI6 A;  4U6W A;  2GG5 A;  1C22 A;  2ADU A;  3MX6 A;  3TB5 A;  2BWY A;  3PKE A;  5JFR A;  3L7G A;  4R60 A;  3CB6 A;  4ZNG A;  1R5G A;  2GGB A;  4OOK A;  5JHU A;  2IW2 A; 
#chains in the Genus database with same CATH homology
 4IEC A;  1WY2 A;  1R58 A;  2ZSG A;  4A6W A;  5FCH A;  1KQ9 A;  2GG9 A;  1KQ0 A;  2B3H A;  1QXW A;  2OAZ A;  2BB7 A;  4RGZ 1;  2Q94 A;  1C23 A;  2P99 A;  4IF7 A;  4IKU A;  1XGN A;  4IDY A;  2GZ5 A;  4FO8 A;  1XGO A;  2GG7 A;  2GG8 A;  5CDE A;  1C27 A;  3IU7 A;  5CIK A;  5CDL A;  4IU6 A;  5CLS A;  4U70 A;  4FLL A;  1YW8 A;  4U71 A;  3PKB A;  2P98 A;  1W2M A;  5CNX A;  1C21 A;  2BWX A;  3PKD A;  1N51 A;  4U6J A;  3S6B A;  1BOA A;  2BWV A;  2GTX A;  1O0X A;  2BHC A;  1QXY A;  4ZWU A;  2BHB A;  1XNZ A;  1MAT A;  1C24 A;  4S2R P;  2BHA A;  4EGE A;  4FKC A;  3FMQ A;  4S2T P;  2EVM A;  1QXZ A;  4MAT A;  4Z7M A;  4QR8 A;  2GGC A;  1B6A A;  2NQ6 A;  4KM3 A;  2GG2 A;  4PNC A;  4ZWO A;  2BHD A;  2V3Y A;  3Q6D A;  2BH3 A;  2GU4 A;  3IG4 A;  4U76 A;  4PV4 A;  4U6E A;  4S01 A;  2NQ7 A;  2P9A A;  1A16 A;  1XGM A;  2MAT A;  3MR1 A;  1W7V A;  1KP0 A;  2DFI A;  1JAW A;  3IU9 A;  2G6P A;  3D27 A;  2Q96 A;  1YW7 A;  3PKC A;  1YJ3 A;  4FLK A;  3ROR A;  2Q8K A;  4A6V A;  2BN7 A;  2Q92 A;  3BIQ A;  4IKR A;  4FLJ A;  3BIP A;  4FLI A;  4U73 A;  4FO7 A;  4B28 A;  4RZZ A;  4U1B A;  1B59 A;  3PKA A;  4IKT A;  1XGS A;  4IPA A;  3MAT A;  1QZY A;  1M35 A;  1PV9 A;  2OKN A;  1WN1 A;  2GG0 A;  2GU5 A;  4S00 A;  2Q93 A;  2B3K A;  2V6C A;  2GG3 A;  5CDV A;  4JUQ A;  1WKM A;  3FM3 A;  4U75 A;  4IKS A;  4ZWP A;  4HXX A;  4U69 A;  5FCF A;  2GU6 A;  5D6E A;  2GU7 A;  3L24 A;  3RVA A;  2BWS A;  1BN5 A;  4U6Z A;  1WBQ A;  1CHM A;  2B3L A;  2BWT A;  1Y1N A;  1YW9 A;  4FUK A;  3BIT A;  3CTZ A;  4RZY A;  5E5B A;  2BWW A;  5D6F A;  2V3X A;  3TAV A;  2EA4 A;  2V3Z A;  2GA2 A;  2HOW A;  1WL9 A;  2EVC A;  1WL6 A;  4U6C A;  1WLR A;  2BWU A;  3IU8 A;  3CB5 A;  1YVM A;  2EA2 A;  3FMR A;  5CE6 A;  2EVO A;  1R5H A;  2Q95 A;  5JI6 A;  4U6W A;  2GG5 A;  1C22 A;  2ADU A;  3MX6 A;  3TB5 A;  2BWY A;  3PKE A;  5JFR A;  3L7G A;  4R60 A;  3CB6 A;  4ZNG A;  1R5G A;  2GGB A;  4OOK A;  5JHU A;  2IW2 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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