4XXBB

Crystal structure of human mdm2-rpl11
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
42
structure length
42
Chain Sequence
EDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation
pubmed doi rcsb
molecule tags Rna binding protein/metal binding protein
source organism Homo sapiens
molecule keywords 60S ribosomal protein L11
total genus 3
structure length 42
sequence length 42
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2015-01-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00641 zf-RanBP Zn-finger in Ran binding protein and others
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.140 Mainly Beta Single Sheet Rubrerythrin, domain 2 Rubrerythrin, domain 2 4xxbB00
2C6AA 2J9UB 3B08B 4XXBB 3B0AB 2C6BA 2PPTA 3P2AA
chains in the Genus database with same CATH superfamily
2M4YA 4POFA 4AI1A 4XXBB 3PKIA 2QL0A 4QIWP 1LKMA 2MS3A 1VZHA 1WCML 3GTKL 2APOB 2CKAA 3MSUA 1BQ9A 5AI3A 4JADA 3M3YL 2XJSA 4POGA 4AHWA 5IYDL 4A3EL 2PMZP 3JR7A 2A6ED 3K35A 2RDVA 4ME3A 1VZGA 4A3BL 2H12A 3GTLL 1IRNA 1IU6A 1TWFL 2V0FA 3GTML 1T9PA 2PPTA 2A68D 3S16L 4V196 3S14L 2AUSB 1VZIA 3VPBE 3RZOL 2NVQL 1SMMA 3B08B 2O5JD 3PO3L 3S2DL 3H97A 2NVYL 2GMGA 2V0EA 3LNLA 2JI3A 4A93L 5DM61 1QQTA 1TWHL 1ODHA 3HJWB 4AYBP 3S17L 1SMWA 1BE7A 1I50L 5H1Sc 3S2HL 1PFUA 2BE5D 5EIOC 1RYQA 2R7ZL 3GTPL 5RXNA 1QYBA 4A3DL 3CQZL 4BXXL 3FKIL 5C3EL 1NXGA 5MFZA 5IY0A 2NVTL 1JYBA 4TVMA 1R0JA 5M3FL 2R93L 3S1QL 1OWBA 2PYAA 1H7VA 4C2M1 2C6AA 5IP7L 2R92L 2VL6A 1RB9A 5DM71 2VUML 1IROA 3LWRB 4Y7NL 3M4OL 3J7Y1 2XJUA 3PIP1 3I4NL 2JA5L 2WAQP 4B8CD 1B2OA 2RFKB 1Y1VL 4JAGA 1NXEA 1C09A 1Z92B 1R0HA 5M5XL 1F4LA 1B2JA 4C3HL 1RWDA 2JA7L 1R9TL 3A44A 3HOZL 2NVXL 1T9OA 5MGNA 3HOYL 3PL5A 2AQCA 5M5YL 1P7PA 2XJRA 3H3VM 2ERJA 5M5WL 3PWFA 4AI0A 3LWVB 3HOVL 4AR5A 3H9CA 2CKCA 1Y1WL 1QCVA 2XJTA 4AR4A 5FLML 3IU3I 3PZAA 3PKJA 5C4JL 2E2HL 3H99A 4LHNA 4A3JL 2KN9A 2CR8A 2YU9L 4BY7L 5C4XL 2WB1P 3GTJL 1FHHA 1IU5A 3MPSA 1R0GA 3J7Z1 1YK5A 1YK4A 1R0IA 5IYBL 3B0AB 3P8BA 4YWMA 3S15L 1DVBA 1BFYA 5C44L 1RDVA 1LKOA 2ZIXA 4A3CL 3LPEB 5MFPA 4TPUA 3HAXC 2PSMC 3HOUL 3S1NL 4X6AL 3P2AA 1RDGA 1BQ8A 3PIO1 3LWQB 3HOXL 5K2ME 2PVXA 4XGHA 3HJYB 2A69D 3WWLA 1OWCA 5JVG1 2JI1A 8RXNA 2B63L 4ZN1B 5AI2A 4AR6A 2EY4E 1I6HL 4A3GL 3KYUA 2C6BA 4A3IL 2M6PA 4JAFA 1PFWA 3KYYA 4ZN3B 4BBSL 1TWAL 3I4ML 4G6BA 1PFYA 5GADc 5M3ML 2JA8L 4RXNA 2PVEA 5GAGc 4AI3A 3S1RL 4A3FL 3WWNB 4YWLA 3RZDL 1CAAA 1LTLA 2A6HD 3H9BA 2M6OA 1S30A 1ZRPA 1R0FA 4E6YA 3QVDA 1FHMA 1WJVA 2AYJA 5MLC3 4UY81 4C3IL 4AHXA 4U671 1RYTA 5EINC 2E2JL 5IP9L 4BBRL 2Y0SP 4BY1L 3QQCE 5JVH1 3GTOL 1LKPA 2L0ZA 2M4VA 4C3JL 2B5ID 2K2DA 4AHZA 7RXNA 2HR5A 4AHYA 1K83L 1VCXA 2LCQA 4A3ML 3PO2L 3HOWL 2Z3RB 1PFVA 4AI2A 5MF6A 4Y52L 1CADA 5IYCL 4JAEA 3LWOB 3NFPI 3FDJA 2Z3QB 1E8JA 1YV1A 1YUXA 5AN9H 3ZG6A 2XJQA 1S2ZA 3RYGA 3K7AL 1T9QA 3KYWA 1TWGL 1SMUA 4K9FA 3KYXA 5GAHc 3MQKB 3GTGL 2KKDA 1S24A 4AR3A 4WFN1 5GAEc 1B71A 3RZTA 3HKZP 1IW7D 2JA6L 2JI2A 1PZXA 4A3KL 4LHLA 6RXNA 4A3LL 2DSXA 2J9UB 1B13A 3RZ6A 1I3QL 1YUZA 1TWCL 2NYDA 4GS7D 3SS2A 5FJ8L 1DX8A 3S1ML 1NNQA 3GTQL 2E2IL 3H0GL 3KYVA 2XJPA 2V3BB 2XJVA 2HVYC 3LWPB 2ERSA 1SFOL 1BRFA
chains in the Genus database with same CATH topology
1YK4A 1R0IA 1WJVA 2AYJA 5MLC3 2M4YA 4UY81 1NXGA 4POFA 3B0AB 5MFZA 3P8BA 5IY0A 1JYBA 4TVMA 4AI1A 4AHXA 4YWMA 4U671 1DVBA 1BFYA 4XXBB 1R0JA 3PKIA 1RYTA 2QL0A 5EINC 1OWBA 2PYAA 1RDVA 1LKOA 1H7VA 2C6AA 2ZIXA 1LKMA 2MS3A 1VZHA 3LPEB 3QQCE 5MFPA 5JVH1 2VL6A 2CKAA 3MSUA 1BQ9A 5AI3A 4JADA 1LKPA 4TPUA 2L0ZA 1RB9A 2PSMC 5DM71 2XJSA 2M4VA 2B5ID 3P2AA 1RDGA 4POGA 4AHWA 1BQ8A 3PIO1 1IROA 2K2DA 4AHZA 5K2ME 7RXNA 2PVXA 2HR5A 4XGHA 4AHYA 2A69D 1VCXA 2A6ED 2LCQA 3J7Y1 3K35A 2XJUA 3WWLA 1OWCA 3PIP1 2RDVA 4ME3A 1VZGA 2Z3RB 4AI2A 5MF6A 4B8CD 1B2OA 2H12A 1CADA 5JVG1 4JAGA 2JI1A 1IRNA 8RXNA 1NXEA 1C09A 4ZN1B 1IU6A 4JAEA 1Z92B 1R0HA 3NFPI 2V0FA 2Z3QB 5AI2A 4AR6A 1E8JA 1B2JA 1YV1A 1YUXA 1T9PA 1RWDA 5AN9H 2PPTA 3ZG6A 2XJQA 2A68D 1S2ZA 3RYGA 3KYUA 3A44A 1T9QA 4V196 2C6BA 1T9OA 3KYWA 5MGNA 1SMUA 4K9FA 3KYXA 2M6PA 2XJRA 4JAFA 5GAHc 2ERJA 1VZIA 3KYYA 3PWFA 2KKDA 1S24A 3VPBE 1SMMA 4AI0A 4ZN3B 4AR3A 4WFN1 5GAEc 4AR5A 1B71A 2CKCA 3RZTA 3B08B 2O5JD 1IW7D 1QCVA 4G6BA 2JI2A 2XJTA 4AR4A 2GMGA 4LHLA 5GADc 6RXNA 3IU3I 3PZAA 4RXNA 2PVEA 5GAGc 2V0EA 4AI3A 2DSXA 2J9UB 1B13A 3RZ6A 3PKJA 1YUZA 3WWNB 4YWLA 3LNLA 2NYDA 4GS7D 3SS2A 2JI3A 1CAAA 1LTLA 1DX8A 5DM61 2A6HD 4LHNA 1ODHA 2KN9A 1NNQA 2CR8A 1SMWA 2M6OA 1BE7A 1S30A 1ZRPA 5H1Sc 1R0FA 3KYVA 2BE5D 2XJPA 4E6YA 3QVDA 2V3BB 2XJVA 5EIOC 1RYQA 1FHHA 5RXNA 1IU5A 3MPSA 1FHMA 1R0GA 3J7Z1 2ERSA 1YK5A 1QYBA 1BRFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C6A A;  2J9U B;  3B08 B;  4XXB B;  3B0A B;  2C6B A;  2PPT A;  3P2A A; 
#chains in the Genus database with same CATH topology
 2M4Y A;  4POF A;  4AI1 A;  4XXB B;  3PKI A;  2QL0 A;  4QIW P;  1LKM A;  2MS3 A;  1VZH A;  1WCM L;  3GTK L;  2APO B;  2CKA A;  3MSU A;  1BQ9 A;  5AI3 A;  4JAD A;  3M3Y L;  2XJS A;  4POG A;  4AHW A;  5IYD L;  4A3E L;  2PMZ P;  3JR7 A;  2A6E D;  3K35 A;  2RDV A;  4ME3 A;  1VZG A;  4A3B L;  2H12 A;  3GTL L;  1IRN A;  1IU6 A;  1TWF L;  2V0F A;  3GTM L;  1T9P A;  2PPT A;  2A68 D;  3S16 L;  4V19 6;  3S14 L;  2AUS B;  1VZI A;  3VPB E;  3RZO L;  2NVQ L;  1SMM A;  3B08 B;  2O5J D;  3PO3 L;  3S2D L;  3H97 A;  2NVY L;  2GMG A;  2V0E A;  3LNL A;  2JI3 A;  4A93 L;  5DM6 1;  1QQT A;  1TWH L;  1ODH A;  3HJW B;  4AYB P;  3S17 L;  1SMW A;  1BE7 A;  1I50 L;  5H1S c;  3S2H L;  1PFU A;  2BE5 D;  5EIO C;  1RYQ A;  2R7Z L;  3GTP L;  5RXN A;  1QYB A;  4A3D L;  3CQZ L;  4BXX L;  3FKI L;  5C3E L;  1NXG A;  5MFZ A;  5IY0 A;  2NVT L;  1JYB A;  4TVM A;  1R0J A;  5M3F L;  2R93 L;  3S1Q L;  1OWB A;  2PYA A;  1H7V A;  4C2M 1;  2C6A A;  5IP7 L;  2R92 L;  2VL6 A;  1RB9 A;  5DM7 1;  2VUM L;  1IRO A;  3LWR B;  4Y7N L;  3M4O L;  3J7Y 1;  2XJU A;  3PIP 1;  3I4N L;  2JA5 L;  2WAQ P;  4B8C D;  1B2O A;  2RFK B;  1Y1V L;  4JAG A;  1NXE A;  1C09 A;  1Z92 B;  1R0H A;  5M5X L;  1F4L A;  1B2J A;  4C3H L;  1RWD A;  2JA7 L;  1R9T L;  3A44 A;  3HOZ L;  2NVX L;  1T9O A;  5MGN A;  3HOY L;  3PL5 A;  2AQC A;  5M5Y L;  1P7P A;  2XJR A;  3H3V M;  2ERJ A;  5M5W L;  3PWF A;  4AI0 A;  3LWV B;  3HOV L;  4AR5 A;  3H9C A;  2CKC A;  1Y1W L;  1QCV A;  2XJT A;  4AR4 A;  5FLM L;  3IU3 I;  3PZA A;  3PKJ A;  5C4J L;  2E2H L;  3H99 A;  4LHN A;  4A3J L;  2KN9 A;  2CR8 A;  2YU9 L;  4BY7 L;  5C4X L;  2WB1 P;  3GTJ L;  1FHH A;  1IU5 A;  3MPS A;  1R0G A;  3J7Z 1;  1YK5 A;  1YK4 A;  1R0I A;  5IYB L;  3B0A B;  3P8B A;  4YWM A;  3S15 L;  1DVB A;  1BFY A;  5C44 L;  1RDV A;  1LKO A;  2ZIX A;  4A3C L;  3LPE B;  5MFP A;  4TPU A;  3HAX C;  2PSM C;  3HOU L;  3S1N L;  4X6A L;  3P2A A;  1RDG A;  1BQ8 A;  3PIO 1;  3LWQ B;  3HOX L;  5K2M E;  2PVX A;  4XGH A;  3HJY B;  2A69 D;  3WWL A;  1OWC A;  5JVG 1;  2JI1 A;  8RXN A;  2B63 L;  4ZN1 B;  5AI2 A;  4AR6 A;  2EY4 E;  1I6H L;  4A3G L;  3KYU A;  2C6B A;  4A3I L;  2M6P A;  4JAF A;  1PFW A;  3KYY A;  4ZN3 B;  4BBS L;  1TWA L;  3I4M L;  4G6B A;  1PFY A;  5GAD c;  5M3M L;  2JA8 L;  4RXN A;  2PVE A;  5GAG c;  4AI3 A;  3S1R L;  4A3F L;  3WWN B;  4YWL A;  3RZD L;  1CAA A;  1LTL A;  2A6H D;  3H9B A;  2M6O A;  1S30 A;  1ZRP A;  1R0F A;  4E6Y A;  3QVD A;  1FHM A;  1WJV A;  2AYJ A;  5MLC 3;  4UY8 1;  4C3I L;  4AHX A;  4U67 1;  1RYT A;  5EIN C;  2E2J L;  5IP9 L;  4BBR L;  2Y0S P;  4BY1 L;  3QQC E;  5JVH 1;  3GTO L;  1LKP A;  2L0Z A;  2M4V A;  4C3J L;  2B5I D;  2K2D A;  4AHZ A;  7RXN A;  2HR5 A;  4AHY A;  1K83 L;  1VCX A;  2LCQ A;  4A3M L;  3PO2 L;  3HOW L;  2Z3R B;  1PFV A;  4AI2 A;  5MF6 A;  4Y52 L;  1CAD A;  5IYC L;  4JAE A;  3LWO B;  3NFP I;  3FDJ A;  2Z3Q B;  1E8J A;  1YV1 A;  1YUX A;  5AN9 H;  3ZG6 A;  2XJQ A;  1S2Z A;  3RYG A;  3K7A L;  1T9Q A;  3KYW A;  1TWG L;  1SMU A;  4K9F A;  3KYX A;  5GAH c;  3MQK B;  3GTG L;  2KKD A;  1S24 A;  4AR3 A;  4WFN 1;  5GAE c;  1B71 A;  3RZT A;  3HKZ P;  1IW7 D;  2JA6 L;  2JI2 A;  1PZX A;  4A3K L;  4LHL A;  6RXN A;  4A3L L;  2DSX A;  2J9U B;  1B13 A;  3RZ6 A;  1I3Q L;  1YUZ A;  1TWC L;  2NYD A;  4GS7 D;  3SS2 A;  5FJ8 L;  1DX8 A;  3S1M L;  1NNQ A;  3GTQ L;  2E2I L;  3H0G L;  3KYV A;  2XJP A;  2V3B B;  2XJV A;  2HVY C;  3LWP B;  2ERS A;  1SFO L;  1BRF A; 
#chains in the Genus database with same CATH homology
 1YK4 A;  1R0I A;  1WJV A;  2AYJ A;  5MLC 3;  2M4Y A;  4UY8 1;  1NXG A;  4POF A;  3B0A B;  5MFZ A;  3P8B A;  5IY0 A;  1JYB A;  4TVM A;  4AI1 A;  4AHX A;  4YWM A;  4U67 1;  1DVB A;  1BFY A;  4XXB B;  1R0J A;  3PKI A;  1RYT A;  2QL0 A;  5EIN C;  1OWB A;  2PYA A;  1RDV A;  1LKO A;  1H7V A;  2C6A A;  2ZIX A;  1LKM A;  2MS3 A;  1VZH A;  3LPE B;  3QQC E;  5MFP A;  5JVH 1;  2VL6 A;  2CKA A;  3MSU A;  1BQ9 A;  5AI3 A;  4JAD A;  1LKP A;  4TPU A;  2L0Z A;  1RB9 A;  2PSM C;  5DM7 1;  2XJS A;  2M4V A;  2B5I D;  3P2A A;  1RDG A;  4POG A;  4AHW A;  1BQ8 A;  3PIO 1;  1IRO A;  2K2D A;  4AHZ A;  5K2M E;  7RXN A;  2PVX A;  2HR5 A;  4XGH A;  4AHY A;  2A69 D;  1VCX A;  2A6E D;  2LCQ A;  3J7Y 1;  3K35 A;  2XJU A;  3WWL A;  1OWC A;  3PIP 1;  2RDV A;  4ME3 A;  1VZG A;  2Z3R B;  4AI2 A;  5MF6 A;  4B8C D;  1B2O A;  2H12 A;  1CAD A;  5JVG 1;  4JAG A;  2JI1 A;  1IRN A;  8RXN A;  1NXE A;  1C09 A;  4ZN1 B;  1IU6 A;  4JAE A;  1Z92 B;  1R0H A;  3NFP I;  2V0F A;  2Z3Q B;  5AI2 A;  4AR6 A;  1E8J A;  1B2J A;  1YV1 A;  1YUX A;  1T9P A;  1RWD A;  5AN9 H;  2PPT A;  3ZG6 A;  2XJQ A;  2A68 D;  1S2Z A;  3RYG A;  3KYU A;  3A44 A;  1T9Q A;  4V19 6;  2C6B A;  1T9O A;  3KYW A;  5MGN A;  1SMU A;  4K9F A;  3KYX A;  2M6P A;  2XJR A;  4JAF A;  5GAH c;  2ERJ A;  1VZI A;  3KYY A;  3PWF A;  2KKD A;  1S24 A;  3VPB E;  1SMM A;  4AI0 A;  4ZN3 B;  4AR3 A;  4WFN 1;  5GAE c;  4AR5 A;  1B71 A;  2CKC A;  3RZT A;  3B08 B;  2O5J D;  1IW7 D;  1QCV A;  4G6B A;  2JI2 A;  2XJT A;  4AR4 A;  2GMG A;  4LHL A;  5GAD c;  6RXN A;  3IU3 I;  3PZA A;  4RXN A;  2PVE A;  5GAG c;  2V0E A;  4AI3 A;  2DSX A;  2J9U B;  1B13 A;  3RZ6 A;  3PKJ A;  1YUZ A;  3WWN B;  4YWL A;  3LNL A;  2NYD A;  4GS7 D;  3SS2 A;  2JI3 A;  1CAA A;  1LTL A;  1DX8 A;  5DM6 1;  2A6H D;  4LHN A;  1ODH A;  2KN9 A;  1NNQ A;  2CR8 A;  1SMW A;  2M6O A;  1BE7 A;  1S30 A;  1ZRP A;  5H1S c;  1R0F A;  3KYV A;  2BE5 D;  2XJP A;  4E6Y A;  3QVD A;  2V3B B;  2XJV A;  5EIO C;  1RYQ A;  1FHH A;  5RXN A;  1IU5 A;  3MPS A;  1FHM A;  1R0G A;  3J7Z 1;  2ERS A;  1YK5 A;  1QYB A;  1BRF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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