4YR1A

Crystal structure of e. coli alkaline phosphatase d101a/d153a in complex with inorganic phosphate
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
443
structure length
443
Chain Sequence
b'NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTASAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQAATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLKSA'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Extensive site-directed mutagenesis reveals interconnected functional units in the Alkaline Phosphatase active site.
pubmed doi rcsb
source organism Escherichia coli (strain k12)
molecule tags Hydrolase
total genus 155
structure length 443
sequence length 443
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4yr1A00
2ZKTA 3KD8A 1AJBA 2IUCB 5AJ9A 5IJQA 4YR1A 1ELXA 4MIVA 2W5SA 5TJ3A 2X98A 3M8ZA 3M8WA 4LR8A 1Y6VA 1ELYA 3WAXA 4LRDA 3T01A 4B56A 4ZG7A 2GSNA 5GRRA 1FSUA 3DPCA 1URAA 1KH9A 4QAXA 5L0KA 1K7HA 1URBA 3UN5A 3UNYA 3SZZA 5INHA 2QZUA 2W5XA 1KHNA 4KAVA 1AUKA 4ZG9A 2G9YA 4N7TA 3WAYA 1P49A 4UORA 3T00A 4GTYA 5C66A 4GTWA 1EW8A 4MY4A 2GSOA 4LRAA 4KAYA 4LRBA 4KJGA 4MHXA 1ALIA 3NKPA 4UPLA 1ANIA 3WAVA 2W5QA 4UPKA 5GOVA 4NWXA 5L0BA 5K4PA 1HDHA 4CXSA 5DLWA 3NKNA 1AJDA 1KHLA 1E1ZP 2W5TA 1N2KA 4KM4A 5KXAA 1N2LA 1ANJA 4FDIA 4UPHA 4FDJA 3MK1A 5LIAA 4LR9A 3UN3A 2ANHA 3OT9A 1ALKA 1Y7AA 2XR9A 3CMRA 3WAWA 3TG0A 4GTZA 4ZGAA 5DLVA 2W8DA 3IGZB 4LREA 4TN0A 3E2DA 1SHNA 3BDGA 5L0EA 3A52A 1ZEBA 3NKRA 2D1GA 3T02A 5DLTA 1ZEFA 2GLQA 2XRGA 3B5QA 1EQJA 5LRNA 5LQQA 2W5VA 3WBHA 1EW2A 2W8SA 1O99A 5IJSA 2RH6A 4LRFA 4ZG6A 3IDDA 1E33P 3LXQA 4CXKA 1KHKA 5LRMA 1ED9A 1HQAA 5EGEA 5HRTA 3TWZA 4CYSA 3NVLA 4UOOA 1EI6A 1E3CP 1ZEDA 3BDGB 3NKOA 4UOPA 1ELZA 2GA3A 1ALJA 4CXUA 3SZYA 2IUCA 4LR2A 3ED4A 3M8YA 2IFYA 1E2SP 2GSUA 1SHQA 1B8JA 2W5WA 3Q3QA 3NKMA 3BDFA 4GTXA 4LR7A 3BDHA 1KHJA 2VQRA 4KJDA 1AJAA 5EGHA 4CYRA 4UPIA 3NKQA 3MK0A 4NWJA 3IGYB 3TX0A 1EW9A 1KH4A 1O98A 1AJCA 1EJJA 4LRCA 1ALHA 1KH5A 2W5RA 1HJKA 3DYCA 3MK2A 3M7VA 4LQYA 1KH7A 1ED8A 3UO0A 3UN2A
chains in the Genus database with same CATH superfamily
2ZKTA 3KD8A 1AJBA 2IUCB 5AJ9A 5IJQA 4YR1A 1ELXA 4MIVA 2W5SA 5TJ3A 2X98A 3M8ZA 3M8WA 4LR8A 1Y6VA 1ELYA 3WAXA 4LRDA 3T01A 4B56A 4ZG7A 2GSNA 5GRRA 1FSUA 3DPCA 1URAA 1KH9A 4QAXA 5L0KA 1K7HA 1URBA 3UN5A 3UNYA 3SZZA 5INHA 2QZUA 2W5XA 1KHNA 4KAVA 1AUKA 4ZG9A 2G9YA 4N7TA 3WAYA 1P49A 4UORA 3T00A 4GTYA 5C66A 4GTWA 1EW8A 4MY4A 2GSOA 4LRAA 4KAYA 4LRBA 4KJGA 4MHXA 1ALIA 3NKPA 4UPLA 1ANIA 3WAVA 2W5QA 4UPKA 5GOVA 4NWXA 5L0BA 5K4PA 1HDHA 4CXSA 5DLWA 3NKNA 1AJDA 1KHLA 1E1ZP 2W5TA 1N2KA 4KM4A 5KXAA 1N2LA 1ANJA 4FDIA 4UPHA 4FDJA 3MK1A 5LIAA 4LR9A 3UN3A 2ANHA 3OT9A 1ALKA 1Y7AA 2XR9A 3CMRA 3WAWA 3TG0A 4GTZA 4ZGAA 5DLVA 2W8DA 3IGZB 4LREA 4TN0A 3E2DA 1SHNA 3BDGA 5L0EA 3A52A 1ZEBA 3NKRA 2D1GA 3T02A 5DLTA 1ZEFA 2GLQA 2XRGA 3B5QA 1EQJA 5LRNA 5LQQA 2W5VA 3WBHA 1EW2A 2W8SA 1O99A 5IJSA 2RH6A 4LRFA 4ZG6A 3IDDA 1E33P 3LXQA 4CXKA 1KHKA 5LRMA 1ED9A 1HQAA 5EGEA 5HRTA 3TWZA 4CYSA 3NVLA 4UOOA 1EI6A 1E3CP 1ZEDA 3BDGB 3NKOA 4UOPA 1ELZA 2GA3A 1ALJA 4CXUA 3SZYA 2IUCA 4LR2A 3ED4A 3M8YA 2IFYA 1E2SP 2GSUA 1SHQA 1B8JA 2W5WA 3Q3QA 3NKMA 3BDFA 4GTXA 4LR7A 3BDHA 1KHJA 2VQRA 4KJDA 1AJAA 5EGHA 4CYRA 4UPIA 3NKQA 3MK0A 4NWJA 3IGYB 3TX0A 1EW9A 1KH4A 1O98A 1AJCA 1EJJA 4LRCA 1ALHA 1KH5A 2W5RA 1HJKA 3DYCA 3MK2A 3M7VA 4LQYA 1KH7A 1ED8A 3UO0A 3UN2A
chains in the Genus database with same CATH topology
2ZKTA 3KD8A 1AJBA 2IUCB 5AJ9A 5IJQA 4YR1A 1ELXA 4MIVA 2W5SA 5TJ3A 2X98A 3M8ZA 3M8WA 4LR8A 1Y6VA 1ELYA 3WAXA 4LRDA 3T01A 4B56A 4ZG7A 2GSNA 5GRRA 1FSUA 3DPCA 1URAA 1KH9A 4QAXA 5L0KA 1K7HA 1URBA 3UN5A 3UNYA 3SZZA 5INHA 2QZUA 2W5XA 1KHNA 4KAVA 1AUKA 4ZG9A 2G9YA 4N7TA 3WAYA 1P49A 4UORA 3T00A 4GTYA 5C66A 4GTWA 1EW8A 4MY4A 2GSOA 4LRAA 4KAYA 4LRBA 4KJGA 4MHXA 1ALIA 3NKPA 4UPLA 1ANIA 3WAVA 2W5QA 4UPKA 5GOVA 4NWXA 5L0BA 5K4PA 1HDHA 4CXSA 5DLWA 3NKNA 1AJDA 1KHLA 1E1ZP 2W5TA 1N2KA 4KM4A 5KXAA 1N2LA 1ANJA 4FDIA 4UPHA 4FDJA 3MK1A 5LIAA 4LR9A 3UN3A 2ANHA 3OT9A 1ALKA 1Y7AA 2XR9A 3CMRA 3WAWA 3TG0A 4GTZA 4ZGAA 5DLVA 2W8DA 3IGZB 4LREA 4TN0A 3E2DA 1SHNA 3BDGA 5L0EA 3A52A 1ZEBA 3NKRA 2D1GA 3T02A 5DLTA 1ZEFA 2GLQA 2XRGA 3B5QA 1EQJA 5LRNA 5LQQA 2W5VA 3WBHA 1EW2A 2W8SA 1O99A 5IJSA 2RH6A 4LRFA 4ZG6A 3IDDA 1E33P 3LXQA 4CXKA 1KHKA 5LRMA 1ED9A 1HQAA 5EGEA 5HRTA 3TWZA 4CYSA 3NVLA 4UOOA 1EI6A 1E3CP 1ZEDA 3BDGB 3NKOA 4UOPA 1ELZA 2GA3A 1ALJA 4CXUA 3SZYA 2IUCA 4LR2A 3ED4A 3M8YA 2IFYA 1E2SP 2GSUA 1SHQA 1B8JA 2W5WA 3Q3QA 3NKMA 3BDFA 4GTXA 4LR7A 3BDHA 1KHJA 2VQRA 4KJDA 1AJAA 5EGHA 4CYRA 4UPIA 3NKQA 3MK0A 4NWJA 3IGYB 3TX0A 1EW9A 1KH4A 1O98A 1AJCA 1EJJA 4LRCA 1ALHA 1KH5A 2W5RA 1HJKA 3DYCA 3MK2A 3M7VA 4LQYA 1KH7A 1ED8A 3UO0A 3UN2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZKT A;  3KD8 A;  1AJB A;  2IUC B;  5AJ9 A;  5IJQ A;  4YR1 A;  1ELX A;  4MIV A;  2W5S A;  5TJ3 A;  2X98 A;  3M8Z A;  3M8W A;  4LR8 A;  1Y6V A;  1ELY A;  3WAX A;  4LRD A;  3T01 A;  4B56 A;  4ZG7 A;  2GSN A;  5GRR A;  1FSU A;  3DPC A;  1URA A;  1KH9 A;  4QAX A;  5L0K A;  1K7H A;  1URB A;  3UN5 A;  3UNY A;  3SZZ A;  5INH A;  2QZU A;  2W5X A;  1KHN A;  4KAV A;  1AUK A;  4ZG9 A;  2G9Y A;  4N7T A;  3WAY A;  1P49 A;  4UOR A;  3T00 A;  4GTY A;  5C66 A;  4GTW A;  1EW8 A;  4MY4 A;  2GSO A;  4LRA A;  4KAY A;  4LRB A;  4KJG A;  4MHX A;  1ALI A;  3NKP A;  4UPL A;  1ANI A;  3WAV A;  2W5Q A;  4UPK A;  5GOV A;  4NWX A;  5L0B A;  5K4P A;  1HDH A;  4CXS A;  5DLW A;  3NKN A;  1AJD A;  1KHL A;  1E1Z P;  2W5T A;  1N2K A;  4KM4 A;  5KXA A;  1N2L A;  1ANJ A;  4FDI A;  4UPH A;  4FDJ A;  3MK1 A;  5LIA A;  4LR9 A;  3UN3 A;  2ANH A;  3OT9 A;  1ALK A;  1Y7A A;  2XR9 A;  3CMR A;  3WAW A;  3TG0 A;  4GTZ A;  4ZGA A;  5DLV A;  2W8D A;  3IGZ B;  4LRE A;  4TN0 A;  3E2D A;  1SHN A;  3BDG A;  5L0E A;  3A52 A;  1ZEB A;  3NKR A;  2D1G A;  3T02 A;  5DLT A;  1ZEF A;  2GLQ A;  2XRG A;  3B5Q A;  1EQJ A;  5LRN A;  5LQQ A;  2W5V A;  3WBH A;  1EW2 A;  2W8S A;  1O99 A;  5IJS A;  2RH6 A;  4LRF A;  4ZG6 A;  3IDD A;  1E33 P;  3LXQ A;  4CXK A;  1KHK A;  5LRM A;  1ED9 A;  1HQA A;  5EGE A;  5HRT A;  3TWZ A;  4CYS A;  3NVL A;  4UOO A;  1EI6 A;  1E3C P;  1ZED A;  3BDG B;  3NKO A;  4UOP A;  1ELZ A;  2GA3 A;  1ALJ A;  4CXU A;  3SZY A;  2IUC A;  4LR2 A;  3ED4 A;  3M8Y A;  2IFY A;  1E2S P;  2GSU A;  1SHQ A;  1B8J A;  2W5W A;  3Q3Q A;  3NKM A;  3BDF A;  4GTX A;  4LR7 A;  3BDH A;  1KHJ A;  2VQR A;  4KJD A;  1AJA A;  5EGH A;  4CYR A;  4UPI A;  3NKQ A;  3MK0 A;  4NWJ A;  3IGY B;  3TX0 A;  1EW9 A;  1KH4 A;  1O98 A;  1AJC A;  1EJJ A;  4LRC A;  1ALH A;  1KH5 A;  2W5R A;  1HJK A;  3DYC A;  3MK2 A;  3M7V A;  4LQY A;  1KH7 A;  1ED8 A;  3UO0 A;  3UN2 A; 
#chains in the Genus database with same CATH topology
 2ZKT A;  3KD8 A;  1AJB A;  2IUC B;  5AJ9 A;  5IJQ A;  4YR1 A;  1ELX A;  4MIV A;  2W5S A;  5TJ3 A;  2X98 A;  3M8Z A;  3M8W A;  4LR8 A;  1Y6V A;  1ELY A;  3WAX A;  4LRD A;  3T01 A;  4B56 A;  4ZG7 A;  2GSN A;  5GRR A;  1FSU A;  3DPC A;  1URA A;  1KH9 A;  4QAX A;  5L0K A;  1K7H A;  1URB A;  3UN5 A;  3UNY A;  3SZZ A;  5INH A;  2QZU A;  2W5X A;  1KHN A;  4KAV A;  1AUK A;  4ZG9 A;  2G9Y A;  4N7T A;  3WAY A;  1P49 A;  4UOR A;  3T00 A;  4GTY A;  5C66 A;  4GTW A;  1EW8 A;  4MY4 A;  2GSO A;  4LRA A;  4KAY A;  4LRB A;  4KJG A;  4MHX A;  1ALI A;  3NKP A;  4UPL A;  1ANI A;  3WAV A;  2W5Q A;  4UPK A;  5GOV A;  4NWX A;  5L0B A;  5K4P A;  1HDH A;  4CXS A;  5DLW A;  3NKN A;  1AJD A;  1KHL A;  1E1Z P;  2W5T A;  1N2K A;  4KM4 A;  5KXA A;  1N2L A;  1ANJ A;  4FDI A;  4UPH A;  4FDJ A;  3MK1 A;  5LIA A;  4LR9 A;  3UN3 A;  2ANH A;  3OT9 A;  1ALK A;  1Y7A A;  2XR9 A;  3CMR A;  3WAW A;  3TG0 A;  4GTZ A;  4ZGA A;  5DLV A;  2W8D A;  3IGZ B;  4LRE A;  4TN0 A;  3E2D A;  1SHN A;  3BDG A;  5L0E A;  3A52 A;  1ZEB A;  3NKR A;  2D1G A;  3T02 A;  5DLT A;  1ZEF A;  2GLQ A;  2XRG A;  3B5Q A;  1EQJ A;  5LRN A;  5LQQ A;  2W5V A;  3WBH A;  1EW2 A;  2W8S A;  1O99 A;  5IJS A;  2RH6 A;  4LRF A;  4ZG6 A;  3IDD A;  1E33 P;  3LXQ A;  4CXK A;  1KHK A;  5LRM A;  1ED9 A;  1HQA A;  5EGE A;  5HRT A;  3TWZ A;  4CYS A;  3NVL A;  4UOO A;  1EI6 A;  1E3C P;  1ZED A;  3BDG B;  3NKO A;  4UOP A;  1ELZ A;  2GA3 A;  1ALJ A;  4CXU A;  3SZY A;  2IUC A;  4LR2 A;  3ED4 A;  3M8Y A;  2IFY A;  1E2S P;  2GSU A;  1SHQ A;  1B8J A;  2W5W A;  3Q3Q A;  3NKM A;  3BDF A;  4GTX A;  4LR7 A;  3BDH A;  1KHJ A;  2VQR A;  4KJD A;  1AJA A;  5EGH A;  4CYR A;  4UPI A;  3NKQ A;  3MK0 A;  4NWJ A;  3IGY B;  3TX0 A;  1EW9 A;  1KH4 A;  1O98 A;  1AJC A;  1EJJ A;  4LRC A;  1ALH A;  1KH5 A;  2W5R A;  1HJK A;  3DYC A;  3MK2 A;  3M7V A;  4LQY A;  1KH7 A;  1ED8 A;  3UO0 A;  3UN2 A; 
#chains in the Genus database with same CATH homology
 2ZKT A;  3KD8 A;  1AJB A;  2IUC B;  5AJ9 A;  5IJQ A;  4YR1 A;  1ELX A;  4MIV A;  2W5S A;  5TJ3 A;  2X98 A;  3M8Z A;  3M8W A;  4LR8 A;  1Y6V A;  1ELY A;  3WAX A;  4LRD A;  3T01 A;  4B56 A;  4ZG7 A;  2GSN A;  5GRR A;  1FSU A;  3DPC A;  1URA A;  1KH9 A;  4QAX A;  5L0K A;  1K7H A;  1URB A;  3UN5 A;  3UNY A;  3SZZ A;  5INH A;  2QZU A;  2W5X A;  1KHN A;  4KAV A;  1AUK A;  4ZG9 A;  2G9Y A;  4N7T A;  3WAY A;  1P49 A;  4UOR A;  3T00 A;  4GTY A;  5C66 A;  4GTW A;  1EW8 A;  4MY4 A;  2GSO A;  4LRA A;  4KAY A;  4LRB A;  4KJG A;  4MHX A;  1ALI A;  3NKP A;  4UPL A;  1ANI A;  3WAV A;  2W5Q A;  4UPK A;  5GOV A;  4NWX A;  5L0B A;  5K4P A;  1HDH A;  4CXS A;  5DLW A;  3NKN A;  1AJD A;  1KHL A;  1E1Z P;  2W5T A;  1N2K A;  4KM4 A;  5KXA A;  1N2L A;  1ANJ A;  4FDI A;  4UPH A;  4FDJ A;  3MK1 A;  5LIA A;  4LR9 A;  3UN3 A;  2ANH A;  3OT9 A;  1ALK A;  1Y7A A;  2XR9 A;  3CMR A;  3WAW A;  3TG0 A;  4GTZ A;  4ZGA A;  5DLV A;  2W8D A;  3IGZ B;  4LRE A;  4TN0 A;  3E2D A;  1SHN A;  3BDG A;  5L0E A;  3A52 A;  1ZEB A;  3NKR A;  2D1G A;  3T02 A;  5DLT A;  1ZEF A;  2GLQ A;  2XRG A;  3B5Q A;  1EQJ A;  5LRN A;  5LQQ A;  2W5V A;  3WBH A;  1EW2 A;  2W8S A;  1O99 A;  5IJS A;  2RH6 A;  4LRF A;  4ZG6 A;  3IDD A;  1E33 P;  3LXQ A;  4CXK A;  1KHK A;  5LRM A;  1ED9 A;  1HQA A;  5EGE A;  5HRT A;  3TWZ A;  4CYS A;  3NVL A;  4UOO A;  1EI6 A;  1E3C P;  1ZED A;  3BDG B;  3NKO A;  4UOP A;  1ELZ A;  2GA3 A;  1ALJ A;  4CXU A;  3SZY A;  2IUC A;  4LR2 A;  3ED4 A;  3M8Y A;  2IFY A;  1E2S P;  2GSU A;  1SHQ A;  1B8J A;  2W5W A;  3Q3Q A;  3NKM A;  3BDF A;  4GTX A;  4LR7 A;  3BDH A;  1KHJ A;  2VQR A;  4KJD A;  1AJA A;  5EGH A;  4CYR A;  4UPI A;  3NKQ A;  3MK0 A;  4NWJ A;  3IGY B;  3TX0 A;  1EW9 A;  1KH4 A;  1O98 A;  1AJC A;  1EJJ A;  4LRC A;  1ALH A;  1KH5 A;  2W5R A;  1HJK A;  3DYC A;  3MK2 A;  3M7V A;  4LQY A;  1KH7 A;  1ED8 A;  3UO0 A;  3UN2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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