4Z7MA

Novel inhibitors of bacterial methionine aminopeptidase with broad-spectrum biochemical activity
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
261
structure length
261
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Methionine aminopeptidase
publication title Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity
rcsb
source organism Escherichia coli
total genus 83
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2015-04-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4z7mA00
1YW9A 5JFRA 1CHMA 1B6AA 2NQ6A 4RGZ1 2BB7A 5JI6A 1C24A 4IKTA 3PKBA 3IU9A 4PNCA 3PKDA 5CDEA 2Q96A 4S00A 4U69A 2NQ7A 4IU6A 4U73A 3BIQA 4U70A 1WL6A 3PKEA 1KQ9A 2GA2A 2B3LA 2V3YA 5FCFA 1MATA 2EVCA 2IW2A 3L7GA 3S6BA 2ZSGA 2BWSA 1WL9A 4FO8A 4S2RP 1YW7A 2BWYA 4U1BA 3TB5A 4S01A 1YW8A 2GGCA 3MATA 1JAWA 4ZWOA 5FCHA 2GU7A 2GZ5A 5CDVA 4RZYA 4FLIA 4MATA 2G6PA 1C23A 2GTXA 2OKNA 4IKUA 3IU8A 2V6CA 3CTZA 4U6WA 2B3KA 2Q95A 3PKAA 4IECA 3PKCA 1Y1NA 1C22A 1XGOA 4U6ZA 4U75A 5JHUA 3IG4A 4U76A 2BH3A 4Z7MA 4FLLA 1WY2A 2GU4A 5CLSA 4IF7A 1W7VA 1YVMA 2MATA 2V3ZA 2DFIA 2OAZA 4IPAA 1KP0A 4U6EA 4FO7A 2GG5A 3MX6A 2GU6A 4IDYA 3BITA 4KM3A 2GGBA 4FLKA 2BWXA 1B59A 3RORA 4S2TP 5CE6A 1R5HA 1M35A 4U6JA 1WKMA 1XNZA 1QXZA 1YJ3A 3IU7A 3RVAA 5CIKA 3CB6A 4ZWUA 4QR8A 1W2MA 2GG7A 3Q6DA 2EVOA 1WBQA 4A6WA 2BWVA 1C21A 2B3HA 2BN7A 4ZNGA 4U6CA 4ZWPA 1BN5A 5D6FA 4HXXA 2Q92A 1R58A 2GG0A 2GG2A 4RZZA 2GG8A 1XGMA 2BHAA 5D6EA 2EVMA 2HOWA 2GU5A 2EA4A 4PV4A 1O0XA 2Q8KA 3MR1A 4FKCA 4R60A 2BHBA 3FMQA 2GG3A 2BHDA 2GG9A 1N51A 1QXWA 2P99A 1QZYA 3FMRA 4EGEA 2EA2A 1R5GA 2V3XA 4JUQA 3L24A 2P9AA 4OOKA 2ADUA 2BWUA 4A6VA 2BWWA 4IKSA 1PV9A 1XGNA 1WN1A 2BWTA 1XGSA 2P98A 3TAVA 4B28A 2Q93A 3FM3A 1KQ0A 5CNXA 2Q94A 2BHCA 1QXYA 1A16A 4FUKA 5CDLA 3D27A 1C27A 3BIPA 4IKRA 1WLRA 3CB5A 5E5BA 1BOAA 4U71A 4FLJA
chains in the Genus database with same CATH superfamily
1YW9A 5JFRA 1CHMA 1B6AA 2NQ6A 4RGZ1 2BB7A 5JI6A 1C24A 4IKTA 3PKBA 3IU9A 4PNCA 3PKDA 5CDEA 2Q96A 4S00A 4U69A 2NQ7A 4IU6A 4U73A 3BIQA 4U70A 1WL6A 3PKEA 1KQ9A 2GA2A 2B3LA 2V3YA 5FCFA 1MATA 2EVCA 2IW2A 3L7GA 3S6BA 2ZSGA 2BWSA 1WL9A 4FO8A 4S2RP 1YW7A 2BWYA 4U1BA 3TB5A 4S01A 1YW8A 2GGCA 3MATA 1JAWA 4ZWOA 5FCHA 2GU7A 2GZ5A 5CDVA 4RZYA 4FLIA 4MATA 2G6PA 1C23A 2GTXA 2OKNA 4IKUA 3IU8A 2V6CA 3CTZA 4U6WA 2B3KA 2Q95A 3PKAA 4IECA 3PKCA 1Y1NA 1C22A 1XGOA 4U6ZA 4U75A 5JHUA 3IG4A 4U76A 2BH3A 4Z7MA 4FLLA 1WY2A 2GU4A 5CLSA 4IF7A 1W7VA 1YVMA 2MATA 2V3ZA 2DFIA 2OAZA 4IPAA 1KP0A 4U6EA 4FO7A 2GG5A 3MX6A 2GU6A 4IDYA 3BITA 4KM3A 2GGBA 4FLKA 2BWXA 1B59A 3RORA 4S2TP 5CE6A 1R5HA 1M35A 4U6JA 1WKMA 1XNZA 1QXZA 1YJ3A 3IU7A 3RVAA 5CIKA 3CB6A 4ZWUA 4QR8A 1W2MA 2GG7A 3Q6DA 2EVOA 1WBQA 4A6WA 2BWVA 1C21A 2B3HA 2BN7A 4ZNGA 4U6CA 4ZWPA 1BN5A 5D6FA 4HXXA 2Q92A 1R58A 2GG0A 2GG2A 4RZZA 2GG8A 1XGMA 2BHAA 5D6EA 2EVMA 2HOWA 2GU5A 2EA4A 4PV4A 1O0XA 2Q8KA 3MR1A 4FKCA 4R60A 2BHBA 3FMQA 2GG3A 2BHDA 2GG9A 1N51A 1QXWA 2P99A 1QZYA 3FMRA 4EGEA 2EA2A 1R5GA 2V3XA 4JUQA 3L24A 2P9AA 4OOKA 2ADUA 2BWUA 4A6VA 2BWWA 4IKSA 1PV9A 1XGNA 1WN1A 2BWTA 1XGSA 2P98A 3TAVA 4B28A 2Q93A 3FM3A 1KQ0A 5CNXA 2Q94A 2BHCA 1QXYA 1A16A 4FUKA 5CDLA 3D27A 1C27A 3BIPA 4IKRA 1WLRA 3CB5A 5E5BA 1BOAA 4U71A 4FLJA
chains in the Genus database with same CATH topology
1YW9A 5JFRA 1CHMA 1B6AA 2NQ6A 4RGZ1 2BB7A 5JI6A 1C24A 4IKTA 3PKBA 3IU9A 4PNCA 3PKDA 5CDEA 2Q96A 4S00A 4U69A 2NQ7A 4IU6A 4U73A 3BIQA 4U70A 1WL6A 3PKEA 1KQ9A 2GA2A 2B3LA 2V3YA 5FCFA 1MATA 2EVCA 2IW2A 3L7GA 3S6BA 2ZSGA 2BWSA 1WL9A 4FO8A 4S2RP 1YW7A 2BWYA 4U1BA 3TB5A 4S01A 1YW8A 2GGCA 3MATA 1JAWA 4ZWOA 5FCHA 2GU7A 2GZ5A 5CDVA 4RZYA 4FLIA 4MATA 2G6PA 1C23A 2GTXA 2OKNA 4IKUA 3IU8A 2V6CA 3CTZA 4U6WA 2B3KA 2Q95A 3PKAA 4IECA 3PKCA 1Y1NA 1C22A 1XGOA 4U6ZA 4U75A 5JHUA 3IG4A 4U76A 2BH3A 4Z7MA 4FLLA 1WY2A 2GU4A 5CLSA 4IF7A 1W7VA 1YVMA 2MATA 2V3ZA 2DFIA 2OAZA 4IPAA 1KP0A 4U6EA 4FO7A 2GG5A 3MX6A 2GU6A 4IDYA 3BITA 4KM3A 2GGBA 4FLKA 2BWXA 1B59A 3RORA 4S2TP 5CE6A 1R5HA 1M35A 4U6JA 1WKMA 1XNZA 1QXZA 1YJ3A 3IU7A 3RVAA 5CIKA 3CB6A 4ZWUA 4QR8A 1W2MA 2GG7A 3Q6DA 2EVOA 1WBQA 4A6WA 2BWVA 1C21A 2B3HA 2BN7A 4ZNGA 4U6CA 4ZWPA 1BN5A 5D6FA 4HXXA 2Q92A 1R58A 2GG0A 2GG2A 4RZZA 2GG8A 1XGMA 2BHAA 5D6EA 2EVMA 2HOWA 2GU5A 2EA4A 4PV4A 1O0XA 2Q8KA 3MR1A 4FKCA 4R60A 2BHBA 3FMQA 2GG3A 2BHDA 2GG9A 1N51A 1QXWA 2P99A 1QZYA 3FMRA 4EGEA 2EA2A 1R5GA 2V3XA 4JUQA 3L24A 2P9AA 4OOKA 2ADUA 2BWUA 4A6VA 2BWWA 4IKSA 1PV9A 1XGNA 1WN1A 2BWTA 1XGSA 2P98A 3TAVA 4B28A 2Q93A 3FM3A 1KQ0A 5CNXA 2Q94A 2BHCA 1QXYA 1A16A 4FUKA 5CDLA 3D27A 1C27A 3BIPA 4IKRA 1WLRA 3CB5A 5E5BA 1BOAA 4U71A 4FLJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YW9 A;  5JFR A;  1CHM A;  1B6A A;  2NQ6 A;  4RGZ 1;  2BB7 A;  5JI6 A;  1C24 A;  4IKT A;  3PKB A;  3IU9 A;  4PNC A;  3PKD A;  5CDE A;  2Q96 A;  4S00 A;  4U69 A;  2NQ7 A;  4IU6 A;  4U73 A;  3BIQ A;  4U70 A;  1WL6 A;  3PKE A;  1KQ9 A;  2GA2 A;  2B3L A;  2V3Y A;  5FCF A;  1MAT A;  2EVC A;  2IW2 A;  3L7G A;  3S6B A;  2ZSG A;  2BWS A;  1WL9 A;  4FO8 A;  4S2R P;  1YW7 A;  2BWY A;  4U1B A;  3TB5 A;  4S01 A;  1YW8 A;  2GGC A;  3MAT A;  1JAW A;  4ZWO A;  5FCH A;  2GU7 A;  2GZ5 A;  5CDV A;  4RZY A;  4FLI A;  4MAT A;  2G6P A;  1C23 A;  2GTX A;  2OKN A;  4IKU A;  3IU8 A;  2V6C A;  3CTZ A;  4U6W A;  2B3K A;  2Q95 A;  3PKA A;  4IEC A;  3PKC A;  1Y1N A;  1C22 A;  1XGO A;  4U6Z A;  4U75 A;  5JHU A;  3IG4 A;  4U76 A;  2BH3 A;  4Z7M A;  4FLL A;  1WY2 A;  2GU4 A;  5CLS A;  4IF7 A;  1W7V A;  1YVM A;  2MAT A;  2V3Z A;  2DFI A;  2OAZ A;  4IPA A;  1KP0 A;  4U6E A;  4FO7 A;  2GG5 A;  3MX6 A;  2GU6 A;  4IDY A;  3BIT A;  4KM3 A;  2GGB A;  4FLK A;  2BWX A;  1B59 A;  3ROR A;  4S2T P;  5CE6 A;  1R5H A;  1M35 A;  4U6J A;  1WKM A;  1XNZ A;  1QXZ A;  1YJ3 A;  3IU7 A;  3RVA A;  5CIK A;  3CB6 A;  4ZWU A;  4QR8 A;  1W2M A;  2GG7 A;  3Q6D A;  2EVO A;  1WBQ A;  4A6W A;  2BWV A;  1C21 A;  2B3H A;  2BN7 A;  4ZNG A;  4U6C A;  4ZWP A;  1BN5 A;  5D6F A;  4HXX A;  2Q92 A;  1R58 A;  2GG0 A;  2GG2 A;  4RZZ A;  2GG8 A;  1XGM A;  2BHA A;  5D6E A;  2EVM A;  2HOW A;  2GU5 A;  2EA4 A;  4PV4 A;  1O0X A;  2Q8K A;  3MR1 A;  4FKC A;  4R60 A;  2BHB A;  3FMQ A;  2GG3 A;  2BHD A;  2GG9 A;  1N51 A;  1QXW A;  2P99 A;  1QZY A;  3FMR A;  4EGE A;  2EA2 A;  1R5G A;  2V3X A;  4JUQ A;  3L24 A;  2P9A A;  4OOK A;  2ADU A;  2BWU A;  4A6V A;  2BWW A;  4IKS A;  1PV9 A;  1XGN A;  1WN1 A;  2BWT A;  1XGS A;  2P98 A;  3TAV A;  4B28 A;  2Q93 A;  3FM3 A;  1KQ0 A;  5CNX A;  2Q94 A;  2BHC A;  1QXY A;  1A16 A;  4FUK A;  5CDL A;  3D27 A;  1C27 A;  3BIP A;  4IKR A;  1WLR A;  3CB5 A;  5E5B A;  1BOA A;  4U71 A;  4FLJ A; 
#chains in the Genus database with same CATH topology
 1YW9 A;  5JFR A;  1CHM A;  1B6A A;  2NQ6 A;  4RGZ 1;  2BB7 A;  5JI6 A;  1C24 A;  4IKT A;  3PKB A;  3IU9 A;  4PNC A;  3PKD A;  5CDE A;  2Q96 A;  4S00 A;  4U69 A;  2NQ7 A;  4IU6 A;  4U73 A;  3BIQ A;  4U70 A;  1WL6 A;  3PKE A;  1KQ9 A;  2GA2 A;  2B3L A;  2V3Y A;  5FCF A;  1MAT A;  2EVC A;  2IW2 A;  3L7G A;  3S6B A;  2ZSG A;  2BWS A;  1WL9 A;  4FO8 A;  4S2R P;  1YW7 A;  2BWY A;  4U1B A;  3TB5 A;  4S01 A;  1YW8 A;  2GGC A;  3MAT A;  1JAW A;  4ZWO A;  5FCH A;  2GU7 A;  2GZ5 A;  5CDV A;  4RZY A;  4FLI A;  4MAT A;  2G6P A;  1C23 A;  2GTX A;  2OKN A;  4IKU A;  3IU8 A;  2V6C A;  3CTZ A;  4U6W A;  2B3K A;  2Q95 A;  3PKA A;  4IEC A;  3PKC A;  1Y1N A;  1C22 A;  1XGO A;  4U6Z A;  4U75 A;  5JHU A;  3IG4 A;  4U76 A;  2BH3 A;  4Z7M A;  4FLL A;  1WY2 A;  2GU4 A;  5CLS A;  4IF7 A;  1W7V A;  1YVM A;  2MAT A;  2V3Z A;  2DFI A;  2OAZ A;  4IPA A;  1KP0 A;  4U6E A;  4FO7 A;  2GG5 A;  3MX6 A;  2GU6 A;  4IDY A;  3BIT A;  4KM3 A;  2GGB A;  4FLK A;  2BWX A;  1B59 A;  3ROR A;  4S2T P;  5CE6 A;  1R5H A;  1M35 A;  4U6J A;  1WKM A;  1XNZ A;  1QXZ A;  1YJ3 A;  3IU7 A;  3RVA A;  5CIK A;  3CB6 A;  4ZWU A;  4QR8 A;  1W2M A;  2GG7 A;  3Q6D A;  2EVO A;  1WBQ A;  4A6W A;  2BWV A;  1C21 A;  2B3H A;  2BN7 A;  4ZNG A;  4U6C A;  4ZWP A;  1BN5 A;  5D6F A;  4HXX A;  2Q92 A;  1R58 A;  2GG0 A;  2GG2 A;  4RZZ A;  2GG8 A;  1XGM A;  2BHA A;  5D6E A;  2EVM A;  2HOW A;  2GU5 A;  2EA4 A;  4PV4 A;  1O0X A;  2Q8K A;  3MR1 A;  4FKC A;  4R60 A;  2BHB A;  3FMQ A;  2GG3 A;  2BHD A;  2GG9 A;  1N51 A;  1QXW A;  2P99 A;  1QZY A;  3FMR A;  4EGE A;  2EA2 A;  1R5G A;  2V3X A;  4JUQ A;  3L24 A;  2P9A A;  4OOK A;  2ADU A;  2BWU A;  4A6V A;  2BWW A;  4IKS A;  1PV9 A;  1XGN A;  1WN1 A;  2BWT A;  1XGS A;  2P98 A;  3TAV A;  4B28 A;  2Q93 A;  3FM3 A;  1KQ0 A;  5CNX A;  2Q94 A;  2BHC A;  1QXY A;  1A16 A;  4FUK A;  5CDL A;  3D27 A;  1C27 A;  3BIP A;  4IKR A;  1WLR A;  3CB5 A;  5E5B A;  1BOA A;  4U71 A;  4FLJ A; 
#chains in the Genus database with same CATH homology
 1YW9 A;  5JFR A;  1CHM A;  1B6A A;  2NQ6 A;  4RGZ 1;  2BB7 A;  5JI6 A;  1C24 A;  4IKT A;  3PKB A;  3IU9 A;  4PNC A;  3PKD A;  5CDE A;  2Q96 A;  4S00 A;  4U69 A;  2NQ7 A;  4IU6 A;  4U73 A;  3BIQ A;  4U70 A;  1WL6 A;  3PKE A;  1KQ9 A;  2GA2 A;  2B3L A;  2V3Y A;  5FCF A;  1MAT A;  2EVC A;  2IW2 A;  3L7G A;  3S6B A;  2ZSG A;  2BWS A;  1WL9 A;  4FO8 A;  4S2R P;  1YW7 A;  2BWY A;  4U1B A;  3TB5 A;  4S01 A;  1YW8 A;  2GGC A;  3MAT A;  1JAW A;  4ZWO A;  5FCH A;  2GU7 A;  2GZ5 A;  5CDV A;  4RZY A;  4FLI A;  4MAT A;  2G6P A;  1C23 A;  2GTX A;  2OKN A;  4IKU A;  3IU8 A;  2V6C A;  3CTZ A;  4U6W A;  2B3K A;  2Q95 A;  3PKA A;  4IEC A;  3PKC A;  1Y1N A;  1C22 A;  1XGO A;  4U6Z A;  4U75 A;  5JHU A;  3IG4 A;  4U76 A;  2BH3 A;  4Z7M A;  4FLL A;  1WY2 A;  2GU4 A;  5CLS A;  4IF7 A;  1W7V A;  1YVM A;  2MAT A;  2V3Z A;  2DFI A;  2OAZ A;  4IPA A;  1KP0 A;  4U6E A;  4FO7 A;  2GG5 A;  3MX6 A;  2GU6 A;  4IDY A;  3BIT A;  4KM3 A;  2GGB A;  4FLK A;  2BWX A;  1B59 A;  3ROR A;  4S2T P;  5CE6 A;  1R5H A;  1M35 A;  4U6J A;  1WKM A;  1XNZ A;  1QXZ A;  1YJ3 A;  3IU7 A;  3RVA A;  5CIK A;  3CB6 A;  4ZWU A;  4QR8 A;  1W2M A;  2GG7 A;  3Q6D A;  2EVO A;  1WBQ A;  4A6W A;  2BWV A;  1C21 A;  2B3H A;  2BN7 A;  4ZNG A;  4U6C A;  4ZWP A;  1BN5 A;  5D6F A;  4HXX A;  2Q92 A;  1R58 A;  2GG0 A;  2GG2 A;  4RZZ A;  2GG8 A;  1XGM A;  2BHA A;  5D6E A;  2EVM A;  2HOW A;  2GU5 A;  2EA4 A;  4PV4 A;  1O0X A;  2Q8K A;  3MR1 A;  4FKC A;  4R60 A;  2BHB A;  3FMQ A;  2GG3 A;  2BHD A;  2GG9 A;  1N51 A;  1QXW A;  2P99 A;  1QZY A;  3FMR A;  4EGE A;  2EA2 A;  1R5G A;  2V3X A;  4JUQ A;  3L24 A;  2P9A A;  4OOK A;  2ADU A;  2BWU A;  4A6V A;  2BWW A;  4IKS A;  1PV9 A;  1XGN A;  1WN1 A;  2BWT A;  1XGS A;  2P98 A;  3TAV A;  4B28 A;  2Q93 A;  3FM3 A;  1KQ0 A;  5CNX A;  2Q94 A;  2BHC A;  1QXY A;  1A16 A;  4FUK A;  5CDL A;  3D27 A;  1C27 A;  3BIP A;  4IKR A;  1WLR A;  3CB5 A;  5E5B A;  1BOA A;  4U71 A;  4FLJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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