4ZWOA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
sequence length
439
structure length
425
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords organophosphate anhydrolase/prolidase
total genus 158
structure length 425
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwoA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwoA02
2V3ZA 2P9AA 3PKDA 4A6VA 1C22A 5CE6A 2EA2A 4IU6A 4U70A 4IF7A 4IKUA 5CDLA 2NQ7A 4U73A 2Q94A 4JUQA 1C27A 1M35A 1YJ3A 4KM3A 2GU5A 5FCFA 3S6BA 5CNXA 1WL6A 2EVOA 3IU8A 4R60A 5D6FA 3Q6DA 1R5GA 5JI6A 1QXYA 4S2RP 2BWXA 3O5VA 2Q95A 4IDYA 2MATA 3FM3A 4U6EA 4IKSA 2GGCA 1R5HA 1XGMA 3PKEA 3L7GA 3PKCA 1B59A 1C21A 1BOAA 4U6JA 1W7VA 1JAWA 2V6CA 2IW2A 1WLRA 2V3XA 4RZZA 1C24A 2BB7A 3D27A 3PEBA 4ZWUA 2EVMA 2BWUA 2ADUA 5CIKA 2Q93A 3IL0A 2BWWA 3RORA 5JHUA 5FCHA 3MX6A 4RZYA 2BWVA 4PV4A 2BHCA 3PN9A 2GTXA 1CHMA 3FMRA 4FLJA 4FO8A 2B3KA 2OKNA 4U76A 3MR1A 2P98A 2NQ6A 3TB5A 2BWTA 1YW7A 3I7MA 3OOOA 2BH3A 3IG4A 2GGBA 2OAZA 3MATA 2BHAA 5CLSA 1BN5A 1A16A 3RVAA 4HXXA 2Q92A 3IU9A 1O0XA 2HOWA 4FLKA 2GU4A 3FMQA 2GA2A 2Q96A 1YW9A 2V3YA 3CB5A 1C23A 3IU7A 3L24A 3QOCA 4QR8A 1WL9A 4U6WA 4Z7MA 1WKMA 4ZWPA 4B28A 4S00A 1XGSA 4EGEA 1MATA 4OOKA 4U1BA 2B3HA 2GG3A 3PKAA 2ZSGA 4RGZ1 2Q8KA 4ZWOA 4U6CA 1YW8A 5JFRA 1KP0A 2GG0A 2BHDA 2EA4A 2G6PA 4IKRA 1Y1NA 2GG7A 1PV9A 2B3LA 2DFIA 2GZ5A 2GG2A 4IECA 2BWYA 3OVKA 1N51A 1XGNA 2GU7A 4S2TP 3BIPA 5E2CA 1QXWA 4FUKA 1YVMA 1XGOA 1XNZA 4FLIA 4U69A 5E5BA 4IKTA 1QXZA 1WN1A 2BN7A 1KQ0A 3CB6A 4S01A 2GG9A 2P99A 4MATA 1QZYA 4IPAA 3PKBA 4U6ZA 3TAVA 3CTZA 4ZNGA 5CDEA 1R58A 2BHBA 2GG5A 1W2MA 4PNCA 4FKCA 2EVCA 4U75A 3BITA 4FLLA 1WBQA 1WY2A 5CDVA 1KQ9A 3BIQA 2GG8A 5D6EA 4U71A 4A6WA 2GU6A 2BWSA 4FO7A 1B6AA
chains in the Genus database with same CATH superfamily
2V3ZA 2P9AA 3PKDA 4A6VA 1C22A 5CE6A 2EA2A 4IU6A 4U70A 4IF7A 4IKUA 5CDLA 2NQ7A 4U73A 2Q94A 4JUQA 1C27A 1M35A 1YJ3A 4KM3A 2GU5A 5FCFA 3S6BA 5CNXA 1WL6A 2EVOA 3IU8A 4R60A 5D6FA 3Q6DA 1R5GA 5JI6A 1QXYA 4S2RP 2BWXA 3O5VA 2Q95A 4IDYA 2MATA 3FM3A 4U6EA 4IKSA 2GGCA 1R5HA 1XGMA 3PKEA 3L7GA 3PKCA 1B59A 1C21A 1BOAA 4U6JA 1W7VA 1JAWA 2V6CA 2IW2A 1WLRA 2V3XA 4RZZA 1C24A 2BB7A 3D27A 3PEBA 4ZWUA 2EVMA 2BWUA 2ADUA 5CIKA 2Q93A 3IL0A 2BWWA 3RORA 5JHUA 5FCHA 3MX6A 4RZYA 2BWVA 4PV4A 2BHCA 3PN9A 2GTXA 1CHMA 3FMRA 4FLJA 4FO8A 2B3KA 2OKNA 4U76A 3MR1A 2P98A 2NQ6A 3TB5A 2BWTA 1YW7A 3I7MA 3OOOA 2BH3A 3IG4A 2GGBA 2OAZA 3MATA 2BHAA 5CLSA 1BN5A 1A16A 3RVAA 4HXXA 2Q92A 3IU9A 1O0XA 2HOWA 4FLKA 2GU4A 3FMQA 2GA2A 2Q96A 1YW9A 2V3YA 3CB5A 1C23A 3IU7A 3L24A 3QOCA 4QR8A 1WL9A 4U6WA 4Z7MA 1WKMA 4ZWPA 4B28A 4S00A 1XGSA 4EGEA 1MATA 4OOKA 4U1BA 2B3HA 2GG3A 3PKAA 2ZSGA 4RGZ1 2Q8KA 4ZWOA 4U6CA 1YW8A 5JFRA 1KP0A 2GG0A 2BHDA 2EA4A 2G6PA 4IKRA 1Y1NA 2GG7A 1PV9A 2B3LA 2DFIA 2GZ5A 2GG2A 4IECA 2BWYA 3OVKA 1N51A 1XGNA 2GU7A 4S2TP 3BIPA 5E2CA 1QXWA 4FUKA 1YVMA 1XGOA 1XNZA 4FLIA 4U69A 5E5BA 4IKTA 1QXZA 1WN1A 2BN7A 1KQ0A 3CB6A 4S01A 2GG9A 2P99A 4MATA 1QZYA 4IPAA 3PKBA 4U6ZA 3TAVA 3CTZA 4ZNGA 5CDEA 1R58A 2BHBA 2GG5A 1W2MA 4PNCA 4FKCA 2EVCA 4U75A 3BITA 4FLLA 1WBQA 1WY2A 5CDVA 1KQ9A 3BIQA 2GG8A 5D6EA 4U71A 4A6WA 2GU6A 2BWSA 4FO7A 1B6AA
chains in the Genus database with same CATH topology
2V3ZA 2P9AA 3PKDA 4A6VA 1C22A 5CE6A 2EA2A 4IU6A 4U70A 4IF7A 4IKUA 5CDLA 2NQ7A 4U73A 2Q94A 4JUQA 1C27A 1M35A 1YJ3A 4KM3A 2GU5A 5FCFA 3S6BA 5CNXA 1WL6A 2EVOA 3IU8A 4R60A 5D6FA 3Q6DA 1R5GA 5JI6A 1QXYA 4S2RP 2BWXA 3O5VA 2Q95A 4IDYA 2MATA 3FM3A 4U6EA 4IKSA 2GGCA 1R5HA 1XGMA 3PKEA 3L7GA 3PKCA 1B59A 1C21A 1BOAA 4U6JA 1W7VA 1JAWA 2V6CA 2IW2A 1WLRA 2V3XA 4RZZA 1C24A 2BB7A 3D27A 3PEBA 4ZWUA 2EVMA 2BWUA 2ADUA 5CIKA 2Q93A 3IL0A 2BWWA 3RORA 5JHUA 5FCHA 3MX6A 4RZYA 2BWVA 4PV4A 2BHCA 3PN9A 2GTXA 1CHMA 3FMRA 4FLJA 4FO8A 2B3KA 2OKNA 4U76A 3MR1A 2P98A 2NQ6A 3TB5A 2BWTA 1YW7A 3I7MA 3OOOA 2BH3A 3IG4A 2GGBA 2OAZA 3MATA 2BHAA 5CLSA 1BN5A 1A16A 3RVAA 4HXXA 2Q92A 3IU9A 1O0XA 2HOWA 4FLKA 2GU4A 3FMQA 2GA2A 2Q96A 1YW9A 2V3YA 3CB5A 1C23A 3IU7A 3L24A 3QOCA 4QR8A 1WL9A 4U6WA 4Z7MA 1WKMA 4ZWPA 4B28A 4S00A 1XGSA 4EGEA 1MATA 4OOKA 4U1BA 2B3HA 2GG3A 3PKAA 2ZSGA 4RGZ1 2Q8KA 4ZWOA 4U6CA 1YW8A 5JFRA 1KP0A 2GG0A 2BHDA 2EA4A 2G6PA 4IKRA 1Y1NA 2GG7A 1PV9A 2B3LA 2DFIA 2GZ5A 2GG2A 4IECA 2BWYA 3OVKA 1N51A 1XGNA 2GU7A 4S2TP 3BIPA 5E2CA 1QXWA 4FUKA 1YVMA 1XGOA 1XNZA 4FLIA 4U69A 5E5BA 4IKTA 1QXZA 1WN1A 2BN7A 1KQ0A 3CB6A 4S01A 2GG9A 2P99A 4MATA 1QZYA 4IPAA 3PKBA 4U6ZA 3TAVA 3CTZA 4ZNGA 5CDEA 1R58A 2BHBA 2GG5A 1W2MA 4PNCA 4FKCA 2EVCA 4U75A 3BITA 4FLLA 1WBQA 1WY2A 5CDVA 1KQ9A 3BIQA 2GG8A 5D6EA 4U71A 4A6WA 2GU6A 2BWSA 4FO7A 1B6AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V3Z A;  2P9A A;  3PKD A;  4A6V A;  1C22 A;  5CE6 A;  2EA2 A;  4IU6 A;  4U70 A;  4IF7 A;  4IKU A;  5CDL A;  2NQ7 A;  4U73 A;  2Q94 A;  4JUQ A;  1C27 A;  1M35 A;  1YJ3 A;  4KM3 A;  2GU5 A;  5FCF A;  3S6B A;  5CNX A;  1WL6 A;  2EVO A;  3IU8 A;  4R60 A;  5D6F A;  3Q6D A;  1R5G A;  5JI6 A;  1QXY A;  4S2R P;  2BWX A;  3O5V A;  2Q95 A;  4IDY A;  2MAT A;  3FM3 A;  4U6E A;  4IKS A;  2GGC A;  1R5H A;  1XGM A;  3PKE A;  3L7G A;  3PKC A;  1B59 A;  1C21 A;  1BOA A;  4U6J A;  1W7V A;  1JAW A;  2V6C A;  2IW2 A;  1WLR A;  2V3X A;  4RZZ A;  1C24 A;  2BB7 A;  3D27 A;  3PEB A;  4ZWU A;  2EVM A;  2BWU A;  2ADU A;  5CIK A;  2Q93 A;  3IL0 A;  2BWW A;  3ROR A;  5JHU A;  5FCH A;  3MX6 A;  4RZY A;  2BWV A;  4PV4 A;  2BHC A;  3PN9 A;  2GTX A;  1CHM A;  3FMR A;  4FLJ A;  4FO8 A;  2B3K A;  2OKN A;  4U76 A;  3MR1 A;  2P98 A;  2NQ6 A;  3TB5 A;  2BWT A;  1YW7 A;  3I7M A;  3OOO A;  2BH3 A;  3IG4 A;  2GGB A;  2OAZ A;  3MAT A;  2BHA A;  5CLS A;  1BN5 A;  1A16 A;  3RVA A;  4HXX A;  2Q92 A;  3IU9 A;  1O0X A;  2HOW A;  4FLK A;  2GU4 A;  3FMQ A;  2GA2 A;  2Q96 A;  1YW9 A;  2V3Y A;  3CB5 A;  1C23 A;  3IU7 A;  3L24 A;  3QOC A;  4QR8 A;  1WL9 A;  4U6W A;  4Z7M A;  1WKM A;  4ZWP A;  4B28 A;  4S00 A;  1XGS A;  4EGE A;  1MAT A;  4OOK A;  4U1B A;  2B3H A;  2GG3 A;  3PKA A;  2ZSG A;  4RGZ 1;  2Q8K A;  4ZWO A;  4U6C A;  1YW8 A;  5JFR A;  1KP0 A;  2GG0 A;  2BHD A;  2EA4 A;  2G6P A;  4IKR A;  1Y1N A;  2GG7 A;  1PV9 A;  2B3L A;  2DFI A;  2GZ5 A;  2GG2 A;  4IEC A;  2BWY A;  3OVK A;  1N51 A;  1XGN A;  2GU7 A;  4S2T P;  3BIP A;  5E2C A;  1QXW A;  4FUK A;  1YVM A;  1XGO A;  1XNZ A;  4FLI A;  4U69 A;  5E5B A;  4IKT A;  1QXZ A;  1WN1 A;  2BN7 A;  1KQ0 A;  3CB6 A;  4S01 A;  2GG9 A;  2P99 A;  4MAT A;  1QZY A;  4IPA A;  3PKB A;  4U6Z A;  3TAV A;  3CTZ A;  4ZNG A;  5CDE A;  1R58 A;  2BHB A;  2GG5 A;  1W2M A;  4PNC A;  4FKC A;  2EVC A;  4U75 A;  3BIT A;  4FLL A;  1WBQ A;  1WY2 A;  5CDV A;  1KQ9 A;  3BIQ A;  2GG8 A;  5D6E A;  4U71 A;  4A6W A;  2GU6 A;  2BWS A;  4FO7 A;  1B6A A; 
#chains in the Genus database with same CATH topology
 2V3Z A;  2P9A A;  3PKD A;  4A6V A;  1C22 A;  5CE6 A;  2EA2 A;  4IU6 A;  4U70 A;  4IF7 A;  4IKU A;  5CDL A;  2NQ7 A;  4U73 A;  2Q94 A;  4JUQ A;  1C27 A;  1M35 A;  1YJ3 A;  4KM3 A;  2GU5 A;  5FCF A;  3S6B A;  5CNX A;  1WL6 A;  2EVO A;  3IU8 A;  4R60 A;  5D6F A;  3Q6D A;  1R5G A;  5JI6 A;  1QXY A;  4S2R P;  2BWX A;  3O5V A;  2Q95 A;  4IDY A;  2MAT A;  3FM3 A;  4U6E A;  4IKS A;  2GGC A;  1R5H A;  1XGM A;  3PKE A;  3L7G A;  3PKC A;  1B59 A;  1C21 A;  1BOA A;  4U6J A;  1W7V A;  1JAW A;  2V6C A;  2IW2 A;  1WLR A;  2V3X A;  4RZZ A;  1C24 A;  2BB7 A;  3D27 A;  3PEB A;  4ZWU A;  2EVM A;  2BWU A;  2ADU A;  5CIK A;  2Q93 A;  3IL0 A;  2BWW A;  3ROR A;  5JHU A;  5FCH A;  3MX6 A;  4RZY A;  2BWV A;  4PV4 A;  2BHC A;  3PN9 A;  2GTX A;  1CHM A;  3FMR A;  4FLJ A;  4FO8 A;  2B3K A;  2OKN A;  4U76 A;  3MR1 A;  2P98 A;  2NQ6 A;  3TB5 A;  2BWT A;  1YW7 A;  3I7M A;  3OOO A;  2BH3 A;  3IG4 A;  2GGB A;  2OAZ A;  3MAT A;  2BHA A;  5CLS A;  1BN5 A;  1A16 A;  3RVA A;  4HXX A;  2Q92 A;  3IU9 A;  1O0X A;  2HOW A;  4FLK A;  2GU4 A;  3FMQ A;  2GA2 A;  2Q96 A;  1YW9 A;  2V3Y A;  3CB5 A;  1C23 A;  3IU7 A;  3L24 A;  3QOC A;  4QR8 A;  1WL9 A;  4U6W A;  4Z7M A;  1WKM A;  4ZWP A;  4B28 A;  4S00 A;  1XGS A;  4EGE A;  1MAT A;  4OOK A;  4U1B A;  2B3H A;  2GG3 A;  3PKA A;  2ZSG A;  4RGZ 1;  2Q8K A;  4ZWO A;  4U6C A;  1YW8 A;  5JFR A;  1KP0 A;  2GG0 A;  2BHD A;  2EA4 A;  2G6P A;  4IKR A;  1Y1N A;  2GG7 A;  1PV9 A;  2B3L A;  2DFI A;  2GZ5 A;  2GG2 A;  4IEC A;  2BWY A;  3OVK A;  1N51 A;  1XGN A;  2GU7 A;  4S2T P;  3BIP A;  5E2C A;  1QXW A;  4FUK A;  1YVM A;  1XGO A;  1XNZ A;  4FLI A;  4U69 A;  5E5B A;  4IKT A;  1QXZ A;  1WN1 A;  2BN7 A;  1KQ0 A;  3CB6 A;  4S01 A;  2GG9 A;  2P99 A;  4MAT A;  1QZY A;  4IPA A;  3PKB A;  4U6Z A;  3TAV A;  3CTZ A;  4ZNG A;  5CDE A;  1R58 A;  2BHB A;  2GG5 A;  1W2M A;  4PNC A;  4FKC A;  2EVC A;  4U75 A;  3BIT A;  4FLL A;  1WBQ A;  1WY2 A;  5CDV A;  1KQ9 A;  3BIQ A;  2GG8 A;  5D6E A;  4U71 A;  4A6W A;  2GU6 A;  2BWS A;  4FO7 A;  1B6A A; 
#chains in the Genus database with same CATH homology
 2V3Z A;  2P9A A;  3PKD A;  4A6V A;  1C22 A;  5CE6 A;  2EA2 A;  4IU6 A;  4U70 A;  4IF7 A;  4IKU A;  5CDL A;  2NQ7 A;  4U73 A;  2Q94 A;  4JUQ A;  1C27 A;  1M35 A;  1YJ3 A;  4KM3 A;  2GU5 A;  5FCF A;  3S6B A;  5CNX A;  1WL6 A;  2EVO A;  3IU8 A;  4R60 A;  5D6F A;  3Q6D A;  1R5G A;  5JI6 A;  1QXY A;  4S2R P;  2BWX A;  3O5V A;  2Q95 A;  4IDY A;  2MAT A;  3FM3 A;  4U6E A;  4IKS A;  2GGC A;  1R5H A;  1XGM A;  3PKE A;  3L7G A;  3PKC A;  1B59 A;  1C21 A;  1BOA A;  4U6J A;  1W7V A;  1JAW A;  2V6C A;  2IW2 A;  1WLR A;  2V3X A;  4RZZ A;  1C24 A;  2BB7 A;  3D27 A;  3PEB A;  4ZWU A;  2EVM A;  2BWU A;  2ADU A;  5CIK A;  2Q93 A;  3IL0 A;  2BWW A;  3ROR A;  5JHU A;  5FCH A;  3MX6 A;  4RZY A;  2BWV A;  4PV4 A;  2BHC A;  3PN9 A;  2GTX A;  1CHM A;  3FMR A;  4FLJ A;  4FO8 A;  2B3K A;  2OKN A;  4U76 A;  3MR1 A;  2P98 A;  2NQ6 A;  3TB5 A;  2BWT A;  1YW7 A;  3I7M A;  3OOO A;  2BH3 A;  3IG4 A;  2GGB A;  2OAZ A;  3MAT A;  2BHA A;  5CLS A;  1BN5 A;  1A16 A;  3RVA A;  4HXX A;  2Q92 A;  3IU9 A;  1O0X A;  2HOW A;  4FLK A;  2GU4 A;  3FMQ A;  2GA2 A;  2Q96 A;  1YW9 A;  2V3Y A;  3CB5 A;  1C23 A;  3IU7 A;  3L24 A;  3QOC A;  4QR8 A;  1WL9 A;  4U6W A;  4Z7M A;  1WKM A;  4ZWP A;  4B28 A;  4S00 A;  1XGS A;  4EGE A;  1MAT A;  4OOK A;  4U1B A;  2B3H A;  2GG3 A;  3PKA A;  2ZSG A;  4RGZ 1;  2Q8K A;  4ZWO A;  4U6C A;  1YW8 A;  5JFR A;  1KP0 A;  2GG0 A;  2BHD A;  2EA4 A;  2G6P A;  4IKR A;  1Y1N A;  2GG7 A;  1PV9 A;  2B3L A;  2DFI A;  2GZ5 A;  2GG2 A;  4IEC A;  2BWY A;  3OVK A;  1N51 A;  1XGN A;  2GU7 A;  4S2T P;  3BIP A;  5E2C A;  1QXW A;  4FUK A;  1YVM A;  1XGO A;  1XNZ A;  4FLI A;  4U69 A;  5E5B A;  4IKT A;  1QXZ A;  1WN1 A;  2BN7 A;  1KQ0 A;  3CB6 A;  4S01 A;  2GG9 A;  2P99 A;  4MAT A;  1QZY A;  4IPA A;  3PKB A;  4U6Z A;  3TAV A;  3CTZ A;  4ZNG A;  5CDE A;  1R58 A;  2BHB A;  2GG5 A;  1W2M A;  4PNC A;  4FKC A;  2EVC A;  4U75 A;  3BIT A;  4FLL A;  1WBQ A;  1WY2 A;  5CDV A;  1KQ9 A;  3BIQ A;  2GG8 A;  5D6E A;  4U71 A;  4A6W A;  2GU6 A;  2BWS A;  4FO7 A;  1B6A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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