4ZWPA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
438
structure length
422
Chain Sequence
KLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords OPAA organophosphate prolidase anhydrolase
total genus 148
structure length 422
sequence length 438
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwpA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwpA02
2DFIA 5CDLA 1KQ0A 5D6EA 1QXYA 2GTXA 2P99A 4RZZA 3MX6A 4FLLA 4ZWUA 5E5BA 2GU7A 4R60A 4S01A 3BIPA 3RVAA 2GU6A 5CE6A 1Y1NA 4FUKA 2Q94A 2Q92A 2Q95A 1XGNA 4U1BA 1N51A 1R5GA 2NQ6A 5CLSA 4U6ZA 4IU6A 3OOOA 4IKTA 3QOCA 2BWSA 4FO7A 1XGOA 4U6CA 2OAZA 2BB7A 1JAWA 2B3KA 3PKEA 4U6WA 1BN5A 1WL9A 2P98A 2EVOA 1WKMA 2BWWA 4IECA 3FM3A 4S2TP 4U6EA 4QR8A 2BHCA 1C22A 1BOAA 2GG2A 2GG0A 4IKSA 1WY2A 5JHUA 2B3LA 4JUQA 1MATA 5FCFA 4IF7A 2GG8A 3TB5A 2BN7A 3CB6A 4ZWPA 1YW7A 5CDEA 2GU5A 1WL6A 3BITA 3CB5A 4U71A 1YW8A 2BWTA 1YVMA 2NQ7A 1R5HA 3PKBA 1W7VA 1A16A 2BWXA 4U6JA 2GG9A 3MR1A 3PKAA 2G6PA 1WN1A 5E2CA 5CNXA 3IU7A 4FLKA 4HXXA 4U75A 1C27A 1CHMA 1WLRA 2ADUA 4FLIA 4ZNGA 2BHDA 1KQ9A 3IG4A 4FLJA 1YW9A 3IU8A 5D6FA 2Q8KA 2V3XA 2EA4A 4U76A 1C24A 1KP0A 2MATA 3S6BA 1QZYA 1XNZA 1C23A 4U70A 2GG3A 1QXZA 1PV9A 3MATA 2B3HA 1QXWA 4MATA 3PKDA 2IW2A 4A6VA 3FMQA 4ZWOA 3PN9A 2EVCA 2GA2A 2EA2A 3FMRA 4Z7MA 4EGEA 2GZ5A 4A6WA 4PV4A 2GU4A 2HOWA 5CIKA 1W2MA 4IKUA 4RGZ1 2BHAA 2EVMA 1B6AA 1R58A 3I7MA 4FO8A 5JFRA 3L7GA 1WBQA 2P9AA 4B28A 4IDYA 2V3YA 3D27A 3O5VA 1YJ3A 5JI6A 2Q96A 4OOKA 2BHBA 2OKNA 1XGSA 4RZYA 2GG5A 2GGCA 2GGBA 4FKCA 2BWVA 5CDVA 4KM3A 4U73A 2V3ZA 1XGMA 3Q6DA 3IU9A 4S2RP 4IKRA 1O0XA 2ZSGA 3IL0A 4S00A 1C21A 2Q93A 2BWUA 2GG7A 1M35A 3CTZA 3PKCA 3TAVA 2V6CA 5FCHA 2BWYA 3OVKA 3PEBA 4IPAA 2BH3A 3BIQA 4PNCA 4U69A 1B59A 3RORA 3L24A
chains in the Genus database with same CATH superfamily
2DFIA 5CDLA 1KQ0A 5D6EA 1QXYA 2GTXA 2P99A 4RZZA 3MX6A 4FLLA 4ZWUA 5E5BA 2GU7A 4R60A 4S01A 3BIPA 3RVAA 2GU6A 5CE6A 1Y1NA 4FUKA 2Q94A 2Q92A 2Q95A 1XGNA 4U1BA 1N51A 1R5GA 2NQ6A 5CLSA 4U6ZA 4IU6A 3OOOA 4IKTA 3QOCA 2BWSA 4FO7A 1XGOA 4U6CA 2OAZA 2BB7A 1JAWA 2B3KA 3PKEA 4U6WA 1BN5A 1WL9A 2P98A 2EVOA 1WKMA 2BWWA 4IECA 3FM3A 4S2TP 4U6EA 4QR8A 2BHCA 1C22A 1BOAA 2GG2A 2GG0A 4IKSA 1WY2A 5JHUA 2B3LA 4JUQA 1MATA 5FCFA 4IF7A 2GG8A 3TB5A 2BN7A 3CB6A 4ZWPA 1YW7A 5CDEA 2GU5A 1WL6A 3BITA 3CB5A 4U71A 1YW8A 2BWTA 1YVMA 2NQ7A 1R5HA 3PKBA 1W7VA 1A16A 2BWXA 4U6JA 2GG9A 3MR1A 3PKAA 2G6PA 1WN1A 5E2CA 5CNXA 3IU7A 4FLKA 4HXXA 4U75A 1C27A 1CHMA 1WLRA 2ADUA 4FLIA 4ZNGA 2BHDA 1KQ9A 3IG4A 4FLJA 1YW9A 3IU8A 5D6FA 2Q8KA 2V3XA 2EA4A 4U76A 1C24A 1KP0A 2MATA 3S6BA 1QZYA 1XNZA 1C23A 4U70A 2GG3A 1QXZA 1PV9A 3MATA 2B3HA 1QXWA 4MATA 3PKDA 2IW2A 4A6VA 3FMQA 4ZWOA 3PN9A 2EVCA 2GA2A 2EA2A 3FMRA 4Z7MA 4EGEA 2GZ5A 4A6WA 4PV4A 2GU4A 2HOWA 5CIKA 1W2MA 4IKUA 4RGZ1 2BHAA 2EVMA 1B6AA 1R58A 3I7MA 4FO8A 5JFRA 3L7GA 1WBQA 2P9AA 4B28A 4IDYA 2V3YA 3D27A 3O5VA 1YJ3A 5JI6A 2Q96A 4OOKA 2BHBA 2OKNA 1XGSA 4RZYA 2GG5A 2GGCA 2GGBA 4FKCA 2BWVA 5CDVA 4KM3A 4U73A 2V3ZA 1XGMA 3Q6DA 3IU9A 4S2RP 4IKRA 1O0XA 2ZSGA 3IL0A 4S00A 1C21A 2Q93A 2BWUA 2GG7A 1M35A 3CTZA 3PKCA 3TAVA 2V6CA 5FCHA 2BWYA 3OVKA 3PEBA 4IPAA 2BH3A 3BIQA 4PNCA 4U69A 1B59A 3RORA 3L24A
chains in the Genus database with same CATH topology
2DFIA 5CDLA 1KQ0A 5D6EA 1QXYA 2GTXA 2P99A 4RZZA 3MX6A 4FLLA 4ZWUA 5E5BA 2GU7A 4R60A 4S01A 3BIPA 3RVAA 2GU6A 5CE6A 1Y1NA 4FUKA 2Q94A 2Q92A 2Q95A 1XGNA 4U1BA 1N51A 1R5GA 2NQ6A 5CLSA 4U6ZA 4IU6A 3OOOA 4IKTA 3QOCA 2BWSA 4FO7A 1XGOA 4U6CA 2OAZA 2BB7A 1JAWA 2B3KA 3PKEA 4U6WA 1BN5A 1WL9A 2P98A 2EVOA 1WKMA 2BWWA 4IECA 3FM3A 4S2TP 4U6EA 4QR8A 2BHCA 1C22A 1BOAA 2GG2A 2GG0A 4IKSA 1WY2A 5JHUA 2B3LA 4JUQA 1MATA 5FCFA 4IF7A 2GG8A 3TB5A 2BN7A 3CB6A 4ZWPA 1YW7A 5CDEA 2GU5A 1WL6A 3BITA 3CB5A 4U71A 1YW8A 2BWTA 1YVMA 2NQ7A 1R5HA 3PKBA 1W7VA 1A16A 2BWXA 4U6JA 2GG9A 3MR1A 3PKAA 2G6PA 1WN1A 5E2CA 5CNXA 3IU7A 4FLKA 4HXXA 4U75A 1C27A 1CHMA 1WLRA 2ADUA 4FLIA 4ZNGA 2BHDA 1KQ9A 3IG4A 4FLJA 1YW9A 3IU8A 5D6FA 2Q8KA 2V3XA 2EA4A 4U76A 1C24A 1KP0A 2MATA 3S6BA 1QZYA 1XNZA 1C23A 4U70A 2GG3A 1QXZA 1PV9A 3MATA 2B3HA 1QXWA 4MATA 3PKDA 2IW2A 4A6VA 3FMQA 4ZWOA 3PN9A 2EVCA 2GA2A 2EA2A 3FMRA 4Z7MA 4EGEA 2GZ5A 4A6WA 4PV4A 2GU4A 2HOWA 5CIKA 1W2MA 4IKUA 4RGZ1 2BHAA 2EVMA 1B6AA 1R58A 3I7MA 4FO8A 5JFRA 3L7GA 1WBQA 2P9AA 4B28A 4IDYA 2V3YA 3D27A 3O5VA 1YJ3A 5JI6A 2Q96A 4OOKA 2BHBA 2OKNA 1XGSA 4RZYA 2GG5A 2GGCA 2GGBA 4FKCA 2BWVA 5CDVA 4KM3A 4U73A 2V3ZA 1XGMA 3Q6DA 3IU9A 4S2RP 4IKRA 1O0XA 2ZSGA 3IL0A 4S00A 1C21A 2Q93A 2BWUA 2GG7A 1M35A 3CTZA 3PKCA 3TAVA 2V6CA 5FCHA 2BWYA 3OVKA 3PEBA 4IPAA 2BH3A 3BIQA 4PNCA 4U69A 1B59A 3RORA 3L24A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DFI A;  5CDL A;  1KQ0 A;  5D6E A;  1QXY A;  2GTX A;  2P99 A;  4RZZ A;  3MX6 A;  4FLL A;  4ZWU A;  5E5B A;  2GU7 A;  4R60 A;  4S01 A;  3BIP A;  3RVA A;  2GU6 A;  5CE6 A;  1Y1N A;  4FUK A;  2Q94 A;  2Q92 A;  2Q95 A;  1XGN A;  4U1B A;  1N51 A;  1R5G A;  2NQ6 A;  5CLS A;  4U6Z A;  4IU6 A;  3OOO A;  4IKT A;  3QOC A;  2BWS A;  4FO7 A;  1XGO A;  4U6C A;  2OAZ A;  2BB7 A;  1JAW A;  2B3K A;  3PKE A;  4U6W A;  1BN5 A;  1WL9 A;  2P98 A;  2EVO A;  1WKM A;  2BWW A;  4IEC A;  3FM3 A;  4S2T P;  4U6E A;  4QR8 A;  2BHC A;  1C22 A;  1BOA A;  2GG2 A;  2GG0 A;  4IKS A;  1WY2 A;  5JHU A;  2B3L A;  4JUQ A;  1MAT A;  5FCF A;  4IF7 A;  2GG8 A;  3TB5 A;  2BN7 A;  3CB6 A;  4ZWP A;  1YW7 A;  5CDE A;  2GU5 A;  1WL6 A;  3BIT A;  3CB5 A;  4U71 A;  1YW8 A;  2BWT A;  1YVM A;  2NQ7 A;  1R5H A;  3PKB A;  1W7V A;  1A16 A;  2BWX A;  4U6J A;  2GG9 A;  3MR1 A;  3PKA A;  2G6P A;  1WN1 A;  5E2C A;  5CNX A;  3IU7 A;  4FLK A;  4HXX A;  4U75 A;  1C27 A;  1CHM A;  1WLR A;  2ADU A;  4FLI A;  4ZNG A;  2BHD A;  1KQ9 A;  3IG4 A;  4FLJ A;  1YW9 A;  3IU8 A;  5D6F A;  2Q8K A;  2V3X A;  2EA4 A;  4U76 A;  1C24 A;  1KP0 A;  2MAT A;  3S6B A;  1QZY A;  1XNZ A;  1C23 A;  4U70 A;  2GG3 A;  1QXZ A;  1PV9 A;  3MAT A;  2B3H A;  1QXW A;  4MAT A;  3PKD A;  2IW2 A;  4A6V A;  3FMQ A;  4ZWO A;  3PN9 A;  2EVC A;  2GA2 A;  2EA2 A;  3FMR A;  4Z7M A;  4EGE A;  2GZ5 A;  4A6W A;  4PV4 A;  2GU4 A;  2HOW A;  5CIK A;  1W2M A;  4IKU A;  4RGZ 1;  2BHA A;  2EVM A;  1B6A A;  1R58 A;  3I7M A;  4FO8 A;  5JFR A;  3L7G A;  1WBQ A;  2P9A A;  4B28 A;  4IDY A;  2V3Y A;  3D27 A;  3O5V A;  1YJ3 A;  5JI6 A;  2Q96 A;  4OOK A;  2BHB A;  2OKN A;  1XGS A;  4RZY A;  2GG5 A;  2GGC A;  2GGB A;  4FKC A;  2BWV A;  5CDV A;  4KM3 A;  4U73 A;  2V3Z A;  1XGM A;  3Q6D A;  3IU9 A;  4S2R P;  4IKR A;  1O0X A;  2ZSG A;  3IL0 A;  4S00 A;  1C21 A;  2Q93 A;  2BWU A;  2GG7 A;  1M35 A;  3CTZ A;  3PKC A;  3TAV A;  2V6C A;  5FCH A;  2BWY A;  3OVK A;  3PEB A;  4IPA A;  2BH3 A;  3BIQ A;  4PNC A;  4U69 A;  1B59 A;  3ROR A;  3L24 A; 
#chains in the Genus database with same CATH topology
 2DFI A;  5CDL A;  1KQ0 A;  5D6E A;  1QXY A;  2GTX A;  2P99 A;  4RZZ A;  3MX6 A;  4FLL A;  4ZWU A;  5E5B A;  2GU7 A;  4R60 A;  4S01 A;  3BIP A;  3RVA A;  2GU6 A;  5CE6 A;  1Y1N A;  4FUK A;  2Q94 A;  2Q92 A;  2Q95 A;  1XGN A;  4U1B A;  1N51 A;  1R5G A;  2NQ6 A;  5CLS A;  4U6Z A;  4IU6 A;  3OOO A;  4IKT A;  3QOC A;  2BWS A;  4FO7 A;  1XGO A;  4U6C A;  2OAZ A;  2BB7 A;  1JAW A;  2B3K A;  3PKE A;  4U6W A;  1BN5 A;  1WL9 A;  2P98 A;  2EVO A;  1WKM A;  2BWW A;  4IEC A;  3FM3 A;  4S2T P;  4U6E A;  4QR8 A;  2BHC A;  1C22 A;  1BOA A;  2GG2 A;  2GG0 A;  4IKS A;  1WY2 A;  5JHU A;  2B3L A;  4JUQ A;  1MAT A;  5FCF A;  4IF7 A;  2GG8 A;  3TB5 A;  2BN7 A;  3CB6 A;  4ZWP A;  1YW7 A;  5CDE A;  2GU5 A;  1WL6 A;  3BIT A;  3CB5 A;  4U71 A;  1YW8 A;  2BWT A;  1YVM A;  2NQ7 A;  1R5H A;  3PKB A;  1W7V A;  1A16 A;  2BWX A;  4U6J A;  2GG9 A;  3MR1 A;  3PKA A;  2G6P A;  1WN1 A;  5E2C A;  5CNX A;  3IU7 A;  4FLK A;  4HXX A;  4U75 A;  1C27 A;  1CHM A;  1WLR A;  2ADU A;  4FLI A;  4ZNG A;  2BHD A;  1KQ9 A;  3IG4 A;  4FLJ A;  1YW9 A;  3IU8 A;  5D6F A;  2Q8K A;  2V3X A;  2EA4 A;  4U76 A;  1C24 A;  1KP0 A;  2MAT A;  3S6B A;  1QZY A;  1XNZ A;  1C23 A;  4U70 A;  2GG3 A;  1QXZ A;  1PV9 A;  3MAT A;  2B3H A;  1QXW A;  4MAT A;  3PKD A;  2IW2 A;  4A6V A;  3FMQ A;  4ZWO A;  3PN9 A;  2EVC A;  2GA2 A;  2EA2 A;  3FMR A;  4Z7M A;  4EGE A;  2GZ5 A;  4A6W A;  4PV4 A;  2GU4 A;  2HOW A;  5CIK A;  1W2M A;  4IKU A;  4RGZ 1;  2BHA A;  2EVM A;  1B6A A;  1R58 A;  3I7M A;  4FO8 A;  5JFR A;  3L7G A;  1WBQ A;  2P9A A;  4B28 A;  4IDY A;  2V3Y A;  3D27 A;  3O5V A;  1YJ3 A;  5JI6 A;  2Q96 A;  4OOK A;  2BHB A;  2OKN A;  1XGS A;  4RZY A;  2GG5 A;  2GGC A;  2GGB A;  4FKC A;  2BWV A;  5CDV A;  4KM3 A;  4U73 A;  2V3Z A;  1XGM A;  3Q6D A;  3IU9 A;  4S2R P;  4IKR A;  1O0X A;  2ZSG A;  3IL0 A;  4S00 A;  1C21 A;  2Q93 A;  2BWU A;  2GG7 A;  1M35 A;  3CTZ A;  3PKC A;  3TAV A;  2V6C A;  5FCH A;  2BWY A;  3OVK A;  3PEB A;  4IPA A;  2BH3 A;  3BIQ A;  4PNC A;  4U69 A;  1B59 A;  3ROR A;  3L24 A; 
#chains in the Genus database with same CATH homology
 2DFI A;  5CDL A;  1KQ0 A;  5D6E A;  1QXY A;  2GTX A;  2P99 A;  4RZZ A;  3MX6 A;  4FLL A;  4ZWU A;  5E5B A;  2GU7 A;  4R60 A;  4S01 A;  3BIP A;  3RVA A;  2GU6 A;  5CE6 A;  1Y1N A;  4FUK A;  2Q94 A;  2Q92 A;  2Q95 A;  1XGN A;  4U1B A;  1N51 A;  1R5G A;  2NQ6 A;  5CLS A;  4U6Z A;  4IU6 A;  3OOO A;  4IKT A;  3QOC A;  2BWS A;  4FO7 A;  1XGO A;  4U6C A;  2OAZ A;  2BB7 A;  1JAW A;  2B3K A;  3PKE A;  4U6W A;  1BN5 A;  1WL9 A;  2P98 A;  2EVO A;  1WKM A;  2BWW A;  4IEC A;  3FM3 A;  4S2T P;  4U6E A;  4QR8 A;  2BHC A;  1C22 A;  1BOA A;  2GG2 A;  2GG0 A;  4IKS A;  1WY2 A;  5JHU A;  2B3L A;  4JUQ A;  1MAT A;  5FCF A;  4IF7 A;  2GG8 A;  3TB5 A;  2BN7 A;  3CB6 A;  4ZWP A;  1YW7 A;  5CDE A;  2GU5 A;  1WL6 A;  3BIT A;  3CB5 A;  4U71 A;  1YW8 A;  2BWT A;  1YVM A;  2NQ7 A;  1R5H A;  3PKB A;  1W7V A;  1A16 A;  2BWX A;  4U6J A;  2GG9 A;  3MR1 A;  3PKA A;  2G6P A;  1WN1 A;  5E2C A;  5CNX A;  3IU7 A;  4FLK A;  4HXX A;  4U75 A;  1C27 A;  1CHM A;  1WLR A;  2ADU A;  4FLI A;  4ZNG A;  2BHD A;  1KQ9 A;  3IG4 A;  4FLJ A;  1YW9 A;  3IU8 A;  5D6F A;  2Q8K A;  2V3X A;  2EA4 A;  4U76 A;  1C24 A;  1KP0 A;  2MAT A;  3S6B A;  1QZY A;  1XNZ A;  1C23 A;  4U70 A;  2GG3 A;  1QXZ A;  1PV9 A;  3MAT A;  2B3H A;  1QXW A;  4MAT A;  3PKD A;  2IW2 A;  4A6V A;  3FMQ A;  4ZWO A;  3PN9 A;  2EVC A;  2GA2 A;  2EA2 A;  3FMR A;  4Z7M A;  4EGE A;  2GZ5 A;  4A6W A;  4PV4 A;  2GU4 A;  2HOW A;  5CIK A;  1W2M A;  4IKU A;  4RGZ 1;  2BHA A;  2EVM A;  1B6A A;  1R58 A;  3I7M A;  4FO8 A;  5JFR A;  3L7G A;  1WBQ A;  2P9A A;  4B28 A;  4IDY A;  2V3Y A;  3D27 A;  3O5V A;  1YJ3 A;  5JI6 A;  2Q96 A;  4OOK A;  2BHB A;  2OKN A;  1XGS A;  4RZY A;  2GG5 A;  2GGC A;  2GGB A;  4FKC A;  2BWV A;  5CDV A;  4KM3 A;  4U73 A;  2V3Z A;  1XGM A;  3Q6D A;  3IU9 A;  4S2R P;  4IKR A;  1O0X A;  2ZSG A;  3IL0 A;  4S00 A;  1C21 A;  2Q93 A;  2BWU A;  2GG7 A;  1M35 A;  3CTZ A;  3PKC A;  3TAV A;  2V6C A;  5FCH A;  2BWY A;  3OVK A;  3PEB A;  4IPA A;  2BH3 A;  3BIQ A;  4PNC A;  4U69 A;  1B59 A;  3ROR A;  3L24 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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