5A38A

Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
223
structure length
223
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ALPHA-ACTININ-2
publication title Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Actin-binding protein
total genus 86
structure length 223
sequence length 223
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a38A02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a38A01
1AA2A 1QAGA 1PXYA 5A37A 1TJTA 2D87A 3HOCA 3KMUB 1WJOA 2VZGB 1MB8A 3HOPA 2QJXA 4Q59A 1SH6A 1WYOA 3F7PA 2D88A 2K2RA 4EDMA 3CO1A 1WKUA 2K3SA 5A38A 5L0OA 2D86A 1PA7A 1V5KA 2VZIB 2D85A 1SH5A 3KMWB 4EDNA 3KY9A 1WYLA 2YRNA 3JALM 3FERA 2VZCA 5BVRA 4TXIA 3HORA 2QJZA 2E9KA 2WFNA 2RR8A 1WYRA 4Q57B 2WA6A 3I6XA 1WYNA 1WYMA 1VKAA 1UJOA 3REPB 1BHDA 2VZDA 1WIXA 2L3GA 2EE7A 2WA5A 3JARM 1BKRA 4TXKA 1WYPA 1AOAA 2DK9A 1DXXA 4EDLA 1P5SA 5J8EA 1UEGA 2EYIA 5A4BA 2JV9A 2D89A 2EYNA 3JAKM 2R0OA 1RT8A 2R8UA 2WA7A 4B7LA 4Q58A 1P2XA 1H67A 1WYQA 5A36A
chains in the Genus database with same CATH superfamily
1AA2A 2VE7A 1QAGA 1PXYA 2WDTA 1TJTA 5A37A 2D87A 3HOCA 3KMUB 1WJOA 2VZGB 1MB8A 3HOPA 2QJXA 5FMTA 4Q59A 1SH6A 1WYOA 3F7PA 2D88A 2K2RA 4EDMA 3CO1A 1WKUA 2IGPA 2K3SA 5A38A 5L0OA 2D86A 1PA7A 2HL9A 1V5KA 2VZIB 2D85A 1SH5A 3KMWB 4EDNA 3KY9A 1WYLA 2YRNA 3JALM 4LVPA 2WE6A 3FERA 2VZCA 5BVRA 4TXIA 3HORA 3EAYA 5FMUA 2QJZA 2E9KA 2WFNA 2RR8A 1WYRA 4Q57B 2WA6A 3I6XA 1WYNA 1WYMA 1VKAA 1UJOA 3REPB 1BHDA 2VZDA 1WIXA 2L3GA 2EE7A 2WA5A 3JARM 1BKRA 4TXKA 1WYPA 1AOAA 2DK9A 1DXXA 4EDLA 1P5SA 5J8EA 1UEGA 2EYIA 5A4BA 2JV9A 2VE7C 2D89A 2EQOA 4LVRA 2EYNA 2HKPA 3JAKM 3VP7A 2R0OA 1RT8A 2R8UA 1EUVA 2WA7A 2HL8A 4B7LA 4DDPA 4Q58A 1P2XA 1H67A 1WYQA 5A36A
chains in the Genus database with same CATH topology
1AA2A 1QAGA 1PXYA 5A37A 1TJTA 2D87A 3HOCA 3KMUB 1WJOA 2VZGB 1MB8A 3HOPA 2QJXA 4Q59A 1SH6A 1WYOA 3F7PA 2D88A 2K2RA 4EDMA 3CO1A 1WKUA 2K3SA 5A38A 5L0OA 2D86A 1PA7A 1V5KA 2VZIB 2D85A 1SH5A 3KMWB 4EDNA 3KY9A 1WYLA 2YRNA 3JALM 3FERA 2VZCA 5BVRA 4TXIA 3HORA 2QJZA 2E9KA 2WFNA 2RR8A 1WYRA 4Q57B 2WA6A 3I6XA 1WYNA 1WYMA 1VKAA 1UJOA 3REPB 1BHDA 2VZDA 1WIXA 2L3GA 2EE7A 2WA5A 3JARM 1BKRA 4TXKA 1WYPA 1AOAA 2DK9A 1DXXA 4EDLA 1P5SA 5J8EA 1UEGA 2EYIA 5A4BA 2JV9A 2D89A 2EYNA 3JAKM 2R0OA 1RT8A 2R8UA 2WA7A 4B7LA 4Q58A 1P2XA 1H67A 1WYQA 5A36A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AA2 A;  1QAG A;  1PXY A;  5A37 A;  1TJT A;  2D87 A;  3HOC A;  3KMU B;  1WJO A;  2VZG B;  1MB8 A;  3HOP A;  2QJX A;  4Q59 A;  1SH6 A;  1WYO A;  3F7P A;  2D88 A;  2K2R A;  4EDM A;  3CO1 A;  1WKU A;  2K3S A;  5A38 A;  5L0O A;  2D86 A;  1PA7 A;  1V5K A;  2VZI B;  2D85 A;  1SH5 A;  3KMW B;  4EDN A;  3KY9 A;  1WYL A;  2YRN A;  3JAL M;  3FER A;  2VZC A;  5BVR A;  4TXI A;  3HOR A;  2QJZ A;  2E9K A;  2WFN A;  2RR8 A;  1WYR A;  4Q57 B;  2WA6 A;  3I6X A;  1WYN A;  1WYM A;  1VKA A;  1UJO A;  3REP B;  1BHD A;  2VZD A;  1WIX A;  2L3G A;  2EE7 A;  2WA5 A;  3JAR M;  1BKR A;  4TXK A;  1WYP A;  1AOA A;  2DK9 A;  1DXX A;  4EDL A;  1P5S A;  5J8E A;  1UEG A;  2EYI A;  5A4B A;  2JV9 A;  2D89 A;  2EYN A;  3JAK M;  2R0O A;  1RT8 A;  2R8U A;  2WA7 A;  4B7L A;  4Q58 A;  1P2X A;  1H67 A;  1WYQ A;  5A36 A; 
#chains in the Genus database with same CATH topology
 1AA2 A;  2VE7 A;  1QAG A;  1PXY A;  2WDT A;  1TJT A;  5A37 A;  2D87 A;  3HOC A;  3KMU B;  1WJO A;  2VZG B;  1MB8 A;  3HOP A;  2QJX A;  5FMT A;  4Q59 A;  1SH6 A;  1WYO A;  3F7P A;  2D88 A;  2K2R A;  4EDM A;  3CO1 A;  1WKU A;  2IGP A;  2K3S A;  5A38 A;  5L0O A;  2D86 A;  1PA7 A;  2HL9 A;  1V5K A;  2VZI B;  2D85 A;  1SH5 A;  3KMW B;  4EDN A;  3KY9 A;  1WYL A;  2YRN A;  3JAL M;  4LVP A;  2WE6 A;  3FER A;  2VZC A;  5BVR A;  4TXI A;  3HOR A;  3EAY A;  5FMU A;  2QJZ A;  2E9K A;  2WFN A;  2RR8 A;  1WYR A;  4Q57 B;  2WA6 A;  3I6X A;  1WYN A;  1WYM A;  1VKA A;  1UJO A;  3REP B;  1BHD A;  2VZD A;  1WIX A;  2L3G A;  2EE7 A;  2WA5 A;  3JAR M;  1BKR A;  4TXK A;  1WYP A;  1AOA A;  2DK9 A;  1DXX A;  4EDL A;  1P5S A;  5J8E A;  1UEG A;  2EYI A;  5A4B A;  2JV9 A;  2VE7 C;  2D89 A;  2EQO A;  4LVR A;  2EYN A;  2HKP A;  3JAK M;  3VP7 A;  2R0O A;  1RT8 A;  2R8U A;  1EUV A;  2WA7 A;  2HL8 A;  4B7L A;  4DDP A;  4Q58 A;  1P2X A;  1H67 A;  1WYQ A;  5A36 A; 
#chains in the Genus database with same CATH homology
 1AA2 A;  1QAG A;  1PXY A;  5A37 A;  1TJT A;  2D87 A;  3HOC A;  3KMU B;  1WJO A;  2VZG B;  1MB8 A;  3HOP A;  2QJX A;  4Q59 A;  1SH6 A;  1WYO A;  3F7P A;  2D88 A;  2K2R A;  4EDM A;  3CO1 A;  1WKU A;  2K3S A;  5A38 A;  5L0O A;  2D86 A;  1PA7 A;  1V5K A;  2VZI B;  2D85 A;  1SH5 A;  3KMW B;  4EDN A;  3KY9 A;  1WYL A;  2YRN A;  3JAL M;  3FER A;  2VZC A;  5BVR A;  4TXI A;  3HOR A;  2QJZ A;  2E9K A;  2WFN A;  2RR8 A;  1WYR A;  4Q57 B;  2WA6 A;  3I6X A;  1WYN A;  1WYM A;  1VKA A;  1UJO A;  3REP B;  1BHD A;  2VZD A;  1WIX A;  2L3G A;  2EE7 A;  2WA5 A;  3JAR M;  1BKR A;  4TXK A;  1WYP A;  1AOA A;  2DK9 A;  1DXX A;  4EDL A;  1P5S A;  5J8E A;  1UEG A;  2EYI A;  5A4B A;  2JV9 A;  2D89 A;  2EYN A;  3JAK M;  2R0O A;  1RT8 A;  2R8U A;  2WA7 A;  4B7L A;  4Q58 A;  1P2X A;  1H67 A;  1WYQ A;  5A36 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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