5A38A

Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
Total Genus 86
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
223
structure length
223
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Actin-binding protein
molecule keywords ALPHA-ACTININ-2
publication title Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
pubmed doi rcsb
source organism Homo sapiens
total genus 86
structure length 223
sequence length 223
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a38A02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a38A01
1AA2A 2WA6A 3HOCA 4EDMA 1WYLA 4B7LA 1QAGA 2QJXA 2RR8A 3REPB 1AOAA 1BHDA 3JAKM 3HOPA 5A38A 3I6XA 1UEGA 2D87A 3CO1A 5A4BA 2D86A 3KY9A 1WYMA 3KMWB 1WIXA 4TXKA 2L3GA 1SH5A 2VZDA 2K2RA 3F7PA 2WA7A 2WFNA 1TJTA 2EYIA 4TXIA 1UJOA 1PXYA 1P2XA 1H67A 1BKRA 1WYQA 1MB8A 2D89A 5L0OA 2JV9A 1WJOA 4Q59A 1VKAA 2DK9A 1RT8A 2EYNA 3JARM 1DXXA 4Q58A 2WA5A 1V5KA 1PA7A 2R8UA 1WYOA 3FERA 1WYRA 3JALM 1SH6A 5J8EA 2E9KA 2EE7A 2VZGB 5A37A 2D85A 1WYPA 3HORA 5BVRA 2K3SA 1WYNA 5A36A 2VZIB 3KMUB 1WKUA 2D88A 4Q57B 4EDNA 2R0OA 2QJZA 2VZCA 2YRNA 4EDLA 1P5SA
chains in the Genus database with same CATH superfamily
1AA2A 2WA6A 3HOCA 4EDMA 1WYLA 4B7LA 1QAGA 2QJXA 2RR8A 3REPB 1AOAA 1BHDA 3JAKM 3HOPA 5A38A 3I6XA 1UEGA 4LVPA 1EUVA 2D87A 3CO1A 5A4BA 2D86A 3KY9A 1WYMA 3KMWB 1WIXA 4TXKA 2L3GA 1SH5A 2WDTA 2VZDA 3EAYA 2K2RA 3F7PA 2WA7A 2WFNA 1TJTA 2EYIA 4TXIA 1UJOA 1PXYA 1P2XA 2HL9A 5FMUA 1H67A 1BKRA 1WYQA 1MB8A 5FMTA 2D89A 5L0OA 2JV9A 1WJOA 4Q59A 1VKAA 2DK9A 1RT8A 2EYNA 2VE7A 3JARM 1DXXA 4Q58A 2WA5A 2IGPA 1V5KA 1PA7A 2R8UA 1WYOA 3FERA 1WYRA 3JALM 1SH6A 5J8EA 2E9KA 2EE7A 2VZGB 2HL8A 5A37A 2D85A 1WYPA 2EQOA 3HORA 5BVRA 2K3SA 1WYNA 3VP7A 5A36A 2WE6A 2VE7C 4DDPA 2VZIB 3KMUB 1WKUA 2D88A 4Q57B 4EDNA 2R0OA 2QJZA 2VZCA 2YRNA 2HKPA 4EDLA 1P5SA 4LVRA
chains in the Genus database with same CATH topology
1AA2A 2WA6A 3HOCA 4EDMA 1WYLA 4B7LA 1QAGA 2QJXA 2RR8A 3REPB 1AOAA 1BHDA 3JAKM 3HOPA 5A38A 3I6XA 1UEGA 2D87A 3CO1A 5A4BA 2D86A 3KY9A 1WYMA 3KMWB 1WIXA 4TXKA 2L3GA 1SH5A 2VZDA 2K2RA 3F7PA 2WA7A 2WFNA 1TJTA 2EYIA 4TXIA 1UJOA 1PXYA 1P2XA 1H67A 1BKRA 1WYQA 1MB8A 2D89A 5L0OA 2JV9A 1WJOA 4Q59A 1VKAA 2DK9A 1RT8A 2EYNA 3JARM 1DXXA 4Q58A 2WA5A 1V5KA 1PA7A 2R8UA 1WYOA 3FERA 1WYRA 3JALM 1SH6A 5J8EA 2E9KA 2EE7A 2VZGB 5A37A 2D85A 1WYPA 3HORA 5BVRA 2K3SA 1WYNA 5A36A 2VZIB 3KMUB 1WKUA 2D88A 4Q57B 4EDNA 2R0OA 2QJZA 2VZCA 2YRNA 4EDLA 1P5SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AA2 A;  2WA6 A;  3HOC A;  4EDM A;  1WYL A;  4B7L A;  1QAG A;  2QJX A;  2RR8 A;  3REP B;  1AOA A;  1BHD A;  3JAK M;  3HOP A;  5A38 A;  3I6X A;  1UEG A;  2D87 A;  3CO1 A;  5A4B A;  2D86 A;  3KY9 A;  1WYM A;  3KMW B;  1WIX A;  4TXK A;  2L3G A;  1SH5 A;  2VZD A;  2K2R A;  3F7P A;  2WA7 A;  2WFN A;  1TJT A;  2EYI A;  4TXI A;  1UJO A;  1PXY A;  1P2X A;  1H67 A;  1BKR A;  1WYQ A;  1MB8 A;  2D89 A;  5L0O A;  2JV9 A;  1WJO A;  4Q59 A;  1VKA A;  2DK9 A;  1RT8 A;  2EYN A;  3JAR M;  1DXX A;  4Q58 A;  2WA5 A;  1V5K A;  1PA7 A;  2R8U A;  1WYO A;  3FER A;  1WYR A;  3JAL M;  1SH6 A;  5J8E A;  2E9K A;  2EE7 A;  2VZG B;  5A37 A;  2D85 A;  1WYP A;  3HOR A;  5BVR A;  2K3S A;  1WYN A;  5A36 A;  2VZI B;  3KMU B;  1WKU A;  2D88 A;  4Q57 B;  4EDN A;  2R0O A;  2QJZ A;  2VZC A;  2YRN A;  4EDL A;  1P5S A; 
#chains in the Genus database with same CATH topology
 1AA2 A;  2WA6 A;  3HOC A;  4EDM A;  1WYL A;  4B7L A;  1QAG A;  2QJX A;  2RR8 A;  3REP B;  1AOA A;  1BHD A;  3JAK M;  3HOP A;  5A38 A;  3I6X A;  1UEG A;  4LVP A;  1EUV A;  2D87 A;  3CO1 A;  5A4B A;  2D86 A;  3KY9 A;  1WYM A;  3KMW B;  1WIX A;  4TXK A;  2L3G A;  1SH5 A;  2WDT A;  2VZD A;  3EAY A;  2K2R A;  3F7P A;  2WA7 A;  2WFN A;  1TJT A;  2EYI A;  4TXI A;  1UJO A;  1PXY A;  1P2X A;  2HL9 A;  5FMU A;  1H67 A;  1BKR A;  1WYQ A;  1MB8 A;  5FMT A;  2D89 A;  5L0O A;  2JV9 A;  1WJO A;  4Q59 A;  1VKA A;  2DK9 A;  1RT8 A;  2EYN A;  2VE7 A;  3JAR M;  1DXX A;  4Q58 A;  2WA5 A;  2IGP A;  1V5K A;  1PA7 A;  2R8U A;  1WYO A;  3FER A;  1WYR A;  3JAL M;  1SH6 A;  5J8E A;  2E9K A;  2EE7 A;  2VZG B;  2HL8 A;  5A37 A;  2D85 A;  1WYP A;  2EQO A;  3HOR A;  5BVR A;  2K3S A;  1WYN A;  3VP7 A;  5A36 A;  2WE6 A;  2VE7 C;  4DDP A;  2VZI B;  3KMU B;  1WKU A;  2D88 A;  4Q57 B;  4EDN A;  2R0O A;  2QJZ A;  2VZC A;  2YRN A;  2HKP A;  4EDL A;  1P5S A;  4LVR A; 
#chains in the Genus database with same CATH homology
 1AA2 A;  2WA6 A;  3HOC A;  4EDM A;  1WYL A;  4B7L A;  1QAG A;  2QJX A;  2RR8 A;  3REP B;  1AOA A;  1BHD A;  3JAK M;  3HOP A;  5A38 A;  3I6X A;  1UEG A;  2D87 A;  3CO1 A;  5A4B A;  2D86 A;  3KY9 A;  1WYM A;  3KMW B;  1WIX A;  4TXK A;  2L3G A;  1SH5 A;  2VZD A;  2K2R A;  3F7P A;  2WA7 A;  2WFN A;  1TJT A;  2EYI A;  4TXI A;  1UJO A;  1PXY A;  1P2X A;  1H67 A;  1BKR A;  1WYQ A;  1MB8 A;  2D89 A;  5L0O A;  2JV9 A;  1WJO A;  4Q59 A;  1VKA A;  2DK9 A;  1RT8 A;  2EYN A;  3JAR M;  1DXX A;  4Q58 A;  2WA5 A;  1V5K A;  1PA7 A;  2R8U A;  1WYO A;  3FER A;  1WYR A;  3JAL M;  1SH6 A;  5J8E A;  2E9K A;  2EE7 A;  2VZG B;  5A37 A;  2D85 A;  1WYP A;  3HOR A;  5BVR A;  2K3S A;  1WYN A;  5A36 A;  2VZI B;  3KMU B;  1WKU A;  2D88 A;  4Q57 B;  4EDN A;  2R0O A;  2QJZ A;  2VZC A;  2YRN A;  4EDL A;  1P5S A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...