5A38A

Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
223
structure length
223
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
pubmed doi rcsb
molecule tags Actin-binding protein
source organism Homo sapiens
molecule keywords ALPHA-ACTININ-2
total genus 86
structure length 223
sequence length 223
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a38A02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a38A01
4TXIA 1WIXA 3HOCA 1VKAA 3HORA 2L3GA 1BKRA 1P2XA 5J8EA 5L0OA 3F7PA 5A37A 1RT8A 3JARM 2RR8A 2VZCA 2R8UA 2D88A 2WA5A 1DXXA 1WYPA 3JAKM 2EYIA 3KY9A 4EDNA 2EE7A 1H67A 3KMWB 5A36A 1WYMA 1BHDA 1AA2A 1WYLA 3FERA 1WYNA 4EDMA 2VZDA 4EDLA 2D86A 2R0OA 3CO1A 3HOPA 2D85A 5A38A 2E9KA 2YRNA 4TXKA 2WA6A 4Q57B 2DK9A 2QJXA 5A4BA 2JV9A 2WFNA 3I6XA 2VZIB 1V5KA 2D89A 1TJTA 2K2RA 2EYNA 4Q58A 1AOAA 2D87A 5BVRA 1PXYA 1MB8A 1P5SA 1UEGA 1SH5A 1PA7A 2VZGB 2K3SA 3KMUB 1WYQA 2WA7A 1WYOA 1WKUA 2QJZA 1WYRA 4B7LA 3JALM 4Q59A 1QAGA 1UJOA 1WJOA 3REPB 1SH6A
chains in the Genus database with same CATH superfamily
4TXIA 1WIXA 3HOCA 1VKAA 3HORA 2L3GA 1BKRA 2HKPA 1P2XA 5J8EA 5L0OA 3F7PA 5A37A 1RT8A 3JARM 2RR8A 2VZCA 4LVPA 2VE7C 2R8UA 2D88A 2WA5A 1EUVA 1DXXA 1WYPA 3VP7A 3JAKM 2EYIA 3KY9A 4EDNA 2EE7A 1H67A 2IGPA 3KMWB 5A36A 1WYMA 1BHDA 1AA2A 1WYLA 3FERA 1WYNA 4EDMA 2VZDA 4EDLA 2D86A 2HL8A 2R0OA 3CO1A 3HOPA 3EAYA 2D85A 5A38A 4DDPA 2E9KA 2YRNA 4TXKA 2WA6A 4Q57B 5FMUA 2DK9A 2QJXA 5A4BA 2JV9A 2WFNA 3I6XA 2VZIB 2WDTA 1V5KA 4LVRA 2D89A 1TJTA 2K2RA 2EYNA 4Q58A 1AOAA 2VE7A 2D87A 5BVRA 1PXYA 1MB8A 1P5SA 1UEGA 1SH5A 5FMTA 1PA7A 2EQOA 2VZGB 2K3SA 3KMUB 1WYQA 2WA7A 1WYOA 1WKUA 2QJZA 1WYRA 4B7LA 2HL9A 3JALM 4Q59A 1QAGA 1UJOA 1WJOA 2WE6A 3REPB 1SH6A
chains in the Genus database with same CATH topology
4TXIA 1WIXA 3HOCA 1VKAA 3HORA 2L3GA 1BKRA 1P2XA 5J8EA 5L0OA 3F7PA 5A37A 1RT8A 3JARM 2RR8A 2VZCA 2R8UA 2D88A 2WA5A 1DXXA 1WYPA 3JAKM 2EYIA 3KY9A 4EDNA 2EE7A 1H67A 3KMWB 5A36A 1WYMA 1BHDA 1AA2A 1WYLA 3FERA 1WYNA 4EDMA 2VZDA 4EDLA 2D86A 2R0OA 3CO1A 3HOPA 2D85A 5A38A 2E9KA 2YRNA 4TXKA 2WA6A 4Q57B 2DK9A 2QJXA 5A4BA 2JV9A 2WFNA 3I6XA 2VZIB 1V5KA 2D89A 1TJTA 2K2RA 2EYNA 4Q58A 1AOAA 2D87A 5BVRA 1PXYA 1MB8A 1P5SA 1UEGA 1SH5A 1PA7A 2VZGB 2K3SA 3KMUB 1WYQA 2WA7A 1WYOA 1WKUA 2QJZA 1WYRA 4B7LA 3JALM 4Q59A 1QAGA 1UJOA 1WJOA 3REPB 1SH6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TXI A;  1WIX A;  3HOC A;  1VKA A;  3HOR A;  2L3G A;  1BKR A;  1P2X A;  5J8E A;  5L0O A;  3F7P A;  5A37 A;  1RT8 A;  3JAR M;  2RR8 A;  2VZC A;  2R8U A;  2D88 A;  2WA5 A;  1DXX A;  1WYP A;  3JAK M;  2EYI A;  3KY9 A;  4EDN A;  2EE7 A;  1H67 A;  3KMW B;  5A36 A;  1WYM A;  1BHD A;  1AA2 A;  1WYL A;  3FER A;  1WYN A;  4EDM A;  2VZD A;  4EDL A;  2D86 A;  2R0O A;  3CO1 A;  3HOP A;  2D85 A;  5A38 A;  2E9K A;  2YRN A;  4TXK A;  2WA6 A;  4Q57 B;  2DK9 A;  2QJX A;  5A4B A;  2JV9 A;  2WFN A;  3I6X A;  2VZI B;  1V5K A;  2D89 A;  1TJT A;  2K2R A;  2EYN A;  4Q58 A;  1AOA A;  2D87 A;  5BVR A;  1PXY A;  1MB8 A;  1P5S A;  1UEG A;  1SH5 A;  1PA7 A;  2VZG B;  2K3S A;  3KMU B;  1WYQ A;  2WA7 A;  1WYO A;  1WKU A;  2QJZ A;  1WYR A;  4B7L A;  3JAL M;  4Q59 A;  1QAG A;  1UJO A;  1WJO A;  3REP B;  1SH6 A; 
#chains in the Genus database with same CATH topology
 4TXI A;  1WIX A;  3HOC A;  1VKA A;  3HOR A;  2L3G A;  1BKR A;  2HKP A;  1P2X A;  5J8E A;  5L0O A;  3F7P A;  5A37 A;  1RT8 A;  3JAR M;  2RR8 A;  2VZC A;  4LVP A;  2VE7 C;  2R8U A;  2D88 A;  2WA5 A;  1EUV A;  1DXX A;  1WYP A;  3VP7 A;  3JAK M;  2EYI A;  3KY9 A;  4EDN A;  2EE7 A;  1H67 A;  2IGP A;  3KMW B;  5A36 A;  1WYM A;  1BHD A;  1AA2 A;  1WYL A;  3FER A;  1WYN A;  4EDM A;  2VZD A;  4EDL A;  2D86 A;  2HL8 A;  2R0O A;  3CO1 A;  3HOP A;  3EAY A;  2D85 A;  5A38 A;  4DDP A;  2E9K A;  2YRN A;  4TXK A;  2WA6 A;  4Q57 B;  5FMU A;  2DK9 A;  2QJX A;  5A4B A;  2JV9 A;  2WFN A;  3I6X A;  2VZI B;  2WDT A;  1V5K A;  4LVR A;  2D89 A;  1TJT A;  2K2R A;  2EYN A;  4Q58 A;  1AOA A;  2VE7 A;  2D87 A;  5BVR A;  1PXY A;  1MB8 A;  1P5S A;  1UEG A;  1SH5 A;  5FMT A;  1PA7 A;  2EQO A;  2VZG B;  2K3S A;  3KMU B;  1WYQ A;  2WA7 A;  1WYO A;  1WKU A;  2QJZ A;  1WYR A;  4B7L A;  2HL9 A;  3JAL M;  4Q59 A;  1QAG A;  1UJO A;  1WJO A;  2WE6 A;  3REP B;  1SH6 A; 
#chains in the Genus database with same CATH homology
 4TXI A;  1WIX A;  3HOC A;  1VKA A;  3HOR A;  2L3G A;  1BKR A;  1P2X A;  5J8E A;  5L0O A;  3F7P A;  5A37 A;  1RT8 A;  3JAR M;  2RR8 A;  2VZC A;  2R8U A;  2D88 A;  2WA5 A;  1DXX A;  1WYP A;  3JAK M;  2EYI A;  3KY9 A;  4EDN A;  2EE7 A;  1H67 A;  3KMW B;  5A36 A;  1WYM A;  1BHD A;  1AA2 A;  1WYL A;  3FER A;  1WYN A;  4EDM A;  2VZD A;  4EDL A;  2D86 A;  2R0O A;  3CO1 A;  3HOP A;  2D85 A;  5A38 A;  2E9K A;  2YRN A;  4TXK A;  2WA6 A;  4Q57 B;  2DK9 A;  2QJX A;  5A4B A;  2JV9 A;  2WFN A;  3I6X A;  2VZI B;  1V5K A;  2D89 A;  1TJT A;  2K2R A;  2EYN A;  4Q58 A;  1AOA A;  2D87 A;  5BVR A;  1PXY A;  1MB8 A;  1P5S A;  1UEG A;  1SH5 A;  1PA7 A;  2VZG B;  2K3S A;  3KMU B;  1WYQ A;  2WA7 A;  1WYO A;  1WKU A;  2QJZ A;  1WYR A;  4B7L A;  3JAL M;  4Q59 A;  1QAG A;  1UJO A;  1WJO A;  3REP B;  1SH6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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