5A7JA

Crystal structure of inpp5b in complex with benzene 1,2,4,5- tetrakisphosphate
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
309
structure length
309
Chain Sequence
MYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVAHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
total genus 85
structure length 309
sequence length 309
chains with identical sequence B
ec nomenclature ec 3.1.3.36: Phosphoinositide 5-phosphatase.
pdb deposition date 2015-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 5a7jA00
3G1KA 3NR8A 4L1ZA 5INMA 3L1WA 2JC5A 1DE9A 3G91A 5A7JA 4AWNA 2IMQX 4QH9A 5INQA 4B5GA 4GZ0A 2F2FB 2O3CA 4PUQA 3MTCA 1AKOA 4LNDA 3NGNA 2DDSA 3FZIA 2O3HA 2DDTA 3I5VA 5CFEA 5INOA 5INPA 4L20A 3G38A 4CMNA 1YJHA 2DNJA 4F1HA 1ZWXA 3W3DB 5INLA 5DFJA 5DFIA 5A7IA 2A40B 3G0AA 4C1RA 4IEMA 2V0SA 4F1RA 3N9VA 3G2DA 2V0RA 2D1KB 4K6LF 5DV4A 3G6SA 5J3SA 3G3YA 1VYBA 1Y21A 1E9NA 4F1IA 3W2XA 5J42A 3U8UA 4B5MA 2VOAA 1DEWA 5HT2A 4JG3A 5INNA 3G4TA 3MPRA 3WCXA 1DE8A 1ATND 3TEBA 5CFGA 4L21A 1I9ZA 1DNKA 3G3CA 3K55A 4FPVA 4B5IA 3NGOA 5J3ZA 1SI6X 3G0RA 3G00A 4F1HB 4B5FA 5EWTA 5J3PA 1SR4B 4A9CA 2J63A 5DFFA 4L1YA 4RUWA 3NGQA 1HD7A 3CJCD 1NTFA 5J8NA 4GYZA 3I41A 4CMLA 3DNIA 2A41B 2F1NA 3G2CA 2EI9A 2XSWA 2ISIA 5DG0A 3W2YA 2A3ZB 2UYRX 4GEWA 1WDUA 5DFHA 4B5HA 4GZ1A 4B5JA 2A42B 2JC4A 3I46A 3GA6A 4GZ2A 4QHDA 2DDRA 3G8VA 5DV2A 5INKA 3I48A 4QHEA 4FVAA 1I9YA 1BIXA
chains in the Genus database with same CATH superfamily
3G1KA 3NR8A 4L1ZA 5INMA 3L1WA 2JC5A 1DE9A 3G91A 5A7JA 4AWNA 2IMQX 4QH9A 5INQA 4B5GA 4GZ0A 2F2FB 2O3CA 4PUQA 3MTCA 1AKOA 4LNDA 3NGNA 2DDSA 3FZIA 2O3HA 2DDTA 3I5VA 5CFEA 5INOA 5INPA 4L20A 3G38A 4CMNA 1YJHA 2DNJA 4F1HA 1ZWXA 3W3DB 5INLA 5DFJA 5DFIA 5A7IA 2A40B 3G0AA 4C1RA 4IEMA 2V0SA 4F1RA 3N9VA 3G2DA 2V0RA 2D1KB 4K6LF 5DV4A 3G6SA 5J3SA 3G3YA 1VYBA 1Y21A 1E9NA 4F1IA 3W2XA 5J42A 3U8UA 4B5MA 2VOAA 1DEWA 5HT2A 4JG3A 5INNA 3G4TA 3MPRA 3WCXA 1DE8A 1ATND 3TEBA 5CFGA 4L21A 1I9ZA 1DNKA 3G3CA 3K55A 4FPVA 4B5IA 3NGOA 5J3ZA 1SI6X 3G0RA 3G00A 4F1HB 4B5FA 5EWTA 5J3PA 1SR4B 4A9CA 2J63A 5DFFA 4L1YA 4RUWA 3NGQA 1HD7A 3CJCD 1NTFA 5J8NA 4GYZA 3I41A 4CMLA 3DNIA 2A41B 2F1NA 3G2CA 2EI9A 2XSWA 2ISIA 5DG0A 3W2YA 2A3ZB 2UYRX 4GEWA 1WDUA 5DFHA 4B5HA 4GZ1A 4B5JA 2A42B 2JC4A 3I46A 3GA6A 4GZ2A 4QHDA 2DDRA 3G8VA 5DV2A 5INKA 3I48A 4QHEA 4FVAA 1I9YA 1BIXA
chains in the Genus database with same CATH topology
3G1KA 3NR8A 4L1ZA 5INMA 3L1WA 2JC5A 1DE9A 3G91A 5A7JA 4AWNA 2IMQX 4QH9A 5INQA 4B5GA 4GZ0A 2F2FB 2O3CA 4PUQA 3MTCA 1AKOA 4LNDA 3NGNA 2DDSA 3FZIA 2O3HA 2DDTA 3I5VA 5CFEA 5INOA 5INPA 4L20A 3G38A 4CMNA 1YJHA 2DNJA 4F1HA 1ZWXA 3W3DB 5INLA 5DFJA 5DFIA 5A7IA 2A40B 3G0AA 4C1RA 4IEMA 2V0SA 4F1RA 3N9VA 3G2DA 2V0RA 2D1KB 4K6LF 5DV4A 3G6SA 5J3SA 3G3YA 1VYBA 1Y21A 1E9NA 4F1IA 3W2XA 5J42A 3U8UA 4B5MA 2VOAA 1DEWA 5HT2A 4JG3A 5INNA 3G4TA 3MPRA 3WCXA 1DE8A 1ATND 3TEBA 5CFGA 4L21A 1I9ZA 1DNKA 3G3CA 3K55A 4FPVA 4B5IA 3NGOA 5J3ZA 1SI6X 3G0RA 3G00A 4F1HB 4B5FA 5EWTA 5J3PA 1SR4B 4A9CA 2J63A 5DFFA 4L1YA 4RUWA 3NGQA 1HD7A 3CJCD 1NTFA 5J8NA 4GYZA 3I41A 4CMLA 3DNIA 2A41B 2F1NA 3G2CA 2EI9A 2XSWA 2ISIA 5DG0A 3W2YA 2A3ZB 2UYRX 4GEWA 1WDUA 5DFHA 4B5HA 4GZ1A 4B5JA 2A42B 2JC4A 3I46A 3GA6A 4GZ2A 4QHDA 2DDRA 3G8VA 5DV2A 5INKA 3I48A 4QHEA 4FVAA 1I9YA 1BIXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3G1K A;  3NR8 A;  4L1Z A;  5INM A;  3L1W A;  2JC5 A;  1DE9 A;  3G91 A;  5A7J A;  4AWN A;  2IMQ X;  4QH9 A;  5INQ A;  4B5G A;  4GZ0 A;  2F2F B;  2O3C A;  4PUQ A;  3MTC A;  1AKO A;  4LND A;  3NGN A;  2DDS A;  3FZI A;  2O3H A;  2DDT A;  3I5V A;  5CFE A;  5INO A;  5INP A;  4L20 A;  3G38 A;  4CMN A;  1YJH A;  2DNJ A;  4F1H A;  1ZWX A;  3W3D B;  5INL A;  5DFJ A;  5DFI A;  5A7I A;  2A40 B;  3G0A A;  4C1R A;  4IEM A;  2V0S A;  4F1R A;  3N9V A;  3G2D A;  2V0R A;  2D1K B;  4K6L F;  5DV4 A;  3G6S A;  5J3S A;  3G3Y A;  1VYB A;  1Y21 A;  1E9N A;  4F1I A;  3W2X A;  5J42 A;  3U8U A;  4B5M A;  2VOA A;  1DEW A;  5HT2 A;  4JG3 A;  5INN A;  3G4T A;  3MPR A;  3WCX A;  1DE8 A;  1ATN D;  3TEB A;  5CFG A;  4L21 A;  1I9Z A;  1DNK A;  3G3C A;  3K55 A;  4FPV A;  4B5I A;  3NGO A;  5J3Z A;  1SI6 X;  3G0R A;  3G00 A;  4F1H B;  4B5F A;  5EWT A;  5J3P A;  1SR4 B;  4A9C A;  2J63 A;  5DFF A;  4L1Y A;  4RUW A;  3NGQ A;  1HD7 A;  3CJC D;  1NTF A;  5J8N A;  4GYZ A;  3I41 A;  4CML A;  3DNI A;  2A41 B;  2F1N A;  3G2C A;  2EI9 A;  2XSW A;  2ISI A;  5DG0 A;  3W2Y A;  2A3Z B;  2UYR X;  4GEW A;  1WDU A;  5DFH A;  4B5H A;  4GZ1 A;  4B5J A;  2A42 B;  2JC4 A;  3I46 A;  3GA6 A;  4GZ2 A;  4QHD A;  2DDR A;  3G8V A;  5DV2 A;  5INK A;  3I48 A;  4QHE A;  4FVA A;  1I9Y A;  1BIX A; 
#chains in the Genus database with same CATH topology
 3G1K A;  3NR8 A;  4L1Z A;  5INM A;  3L1W A;  2JC5 A;  1DE9 A;  3G91 A;  5A7J A;  4AWN A;  2IMQ X;  4QH9 A;  5INQ A;  4B5G A;  4GZ0 A;  2F2F B;  2O3C A;  4PUQ A;  3MTC A;  1AKO A;  4LND A;  3NGN A;  2DDS A;  3FZI A;  2O3H A;  2DDT A;  3I5V A;  5CFE A;  5INO A;  5INP A;  4L20 A;  3G38 A;  4CMN A;  1YJH A;  2DNJ A;  4F1H A;  1ZWX A;  3W3D B;  5INL A;  5DFJ A;  5DFI A;  5A7I A;  2A40 B;  3G0A A;  4C1R A;  4IEM A;  2V0S A;  4F1R A;  3N9V A;  3G2D A;  2V0R A;  2D1K B;  4K6L F;  5DV4 A;  3G6S A;  5J3S A;  3G3Y A;  1VYB A;  1Y21 A;  1E9N A;  4F1I A;  3W2X A;  5J42 A;  3U8U A;  4B5M A;  2VOA A;  1DEW A;  5HT2 A;  4JG3 A;  5INN A;  3G4T A;  3MPR A;  3WCX A;  1DE8 A;  1ATN D;  3TEB A;  5CFG A;  4L21 A;  1I9Z A;  1DNK A;  3G3C A;  3K55 A;  4FPV A;  4B5I A;  3NGO A;  5J3Z A;  1SI6 X;  3G0R A;  3G00 A;  4F1H B;  4B5F A;  5EWT A;  5J3P A;  1SR4 B;  4A9C A;  2J63 A;  5DFF A;  4L1Y A;  4RUW A;  3NGQ A;  1HD7 A;  3CJC D;  1NTF A;  5J8N A;  4GYZ A;  3I41 A;  4CML A;  3DNI A;  2A41 B;  2F1N A;  3G2C A;  2EI9 A;  2XSW A;  2ISI A;  5DG0 A;  3W2Y A;  2A3Z B;  2UYR X;  4GEW A;  1WDU A;  5DFH A;  4B5H A;  4GZ1 A;  4B5J A;  2A42 B;  2JC4 A;  3I46 A;  3GA6 A;  4GZ2 A;  4QHD A;  2DDR A;  3G8V A;  5DV2 A;  5INK A;  3I48 A;  4QHE A;  4FVA A;  1I9Y A;  1BIX A; 
#chains in the Genus database with same CATH homology
 3G1K A;  3NR8 A;  4L1Z A;  5INM A;  3L1W A;  2JC5 A;  1DE9 A;  3G91 A;  5A7J A;  4AWN A;  2IMQ X;  4QH9 A;  5INQ A;  4B5G A;  4GZ0 A;  2F2F B;  2O3C A;  4PUQ A;  3MTC A;  1AKO A;  4LND A;  3NGN A;  2DDS A;  3FZI A;  2O3H A;  2DDT A;  3I5V A;  5CFE A;  5INO A;  5INP A;  4L20 A;  3G38 A;  4CMN A;  1YJH A;  2DNJ A;  4F1H A;  1ZWX A;  3W3D B;  5INL A;  5DFJ A;  5DFI A;  5A7I A;  2A40 B;  3G0A A;  4C1R A;  4IEM A;  2V0S A;  4F1R A;  3N9V A;  3G2D A;  2V0R A;  2D1K B;  4K6L F;  5DV4 A;  3G6S A;  5J3S A;  3G3Y A;  1VYB A;  1Y21 A;  1E9N A;  4F1I A;  3W2X A;  5J42 A;  3U8U A;  4B5M A;  2VOA A;  1DEW A;  5HT2 A;  4JG3 A;  5INN A;  3G4T A;  3MPR A;  3WCX A;  1DE8 A;  1ATN D;  3TEB A;  5CFG A;  4L21 A;  1I9Z A;  1DNK A;  3G3C A;  3K55 A;  4FPV A;  4B5I A;  3NGO A;  5J3Z A;  1SI6 X;  3G0R A;  3G00 A;  4F1H B;  4B5F A;  5EWT A;  5J3P A;  1SR4 B;  4A9C A;  2J63 A;  5DFF A;  4L1Y A;  4RUW A;  3NGQ A;  1HD7 A;  3CJC D;  1NTF A;  5J8N A;  4GYZ A;  3I41 A;  4CML A;  3DNI A;  2A41 B;  2F1N A;  3G2C A;  2EI9 A;  2XSW A;  2ISI A;  5DG0 A;  3W2Y A;  2A3Z B;  2UYR X;  4GEW A;  1WDU A;  5DFH A;  4B5H A;  4GZ1 A;  4B5J A;  2A42 B;  2JC4 A;  3I46 A;  3GA6 A;  4GZ2 A;  4QHD A;  2DDR A;  3G8V A;  5DV2 A;  5INK A;  3I48 A;  4QHE A;  4FVA A;  1I9Y A;  1BIX A; 
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similar chains in the Genus database (?% sequence similarity)
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