5ADQB

Crystal structure of human tankyrase 2 in complex with jw55
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
AHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords TANKYRASE-2
publication title Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 46
sequence length 46
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-08-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 5adqB00
4L0SC 4HLHC 4UI7C 4HKIC 4HKNC 5ADRB 4HLFC 4L2FC 5C5PC 4L0IC 4UI6C 4UI4C 4HL5C 4HKKB 4L2KC 4L32C 4HLGC 4L34C 4KZLC 4L31C 4UVPB 5C5RC 4HLKC 4L10C 4L2GC 4L0BC 4HMHC 4L33C 5ADSB 4KZUC 4L09C 4KZQC 5C5QC 4L0TC 4L0VC 5FPFC 5ADTB 5ADQB 4UI8C 4HLMC 4UI5C 4UI3C
chains in the Genus database with same CATH superfamily
4L0SC 2A6QA 4HLHC 4UI7C 2ODKA 4HKIC 4ZLXA 4HKNC 5ADRB 4HLFC 4L2FC 3HRYA 5C5PC 4L0IC 4UI6C 4UI4C 4HL5C 3KH2E 4HKKB 4L2KC 4L32C 3HS2A 4HLGC 4L34C 3K6QA 4KZLC 3HJ6A 4L31C 4UVPB 5C5RC 4HLKC 4L10C 2ZIXB 4L2GC 3OEIA 4L0BC 4UI5C 4HMHC 4L33C 3CTOA 5ADSB 4KZUC 4L09C 4KZQC 5C5QC 4L0TC 4L0VC 5FPFC 5ADTB 3D55A 3K33B 4UI8C 4ZM2A 5ADQB 3G5OA 4ZM0A 4HLMC 3OEIE 4UI3C
chains in the Genus database with same CATH topology
4L0SC 4HLHC 4UI7C 4HKIC 4HKNC 5ADRB 4HLFC 4L2FC 5C5PC 4L0IC 4UI6C 4UI4C 4HL5C 4HKKB 4L2KC 4L32C 4HLGC 4L34C 4KZLC 3HJ6A 4L31C 4UVPB 5C5RC 4HLKC 4L10C 2ZIXB 4L2GC 4L0BC 4HMHC 4L33C 5ADSB 4KZUC 4L09C 4KZQC 5C5QC 4L0TC 4L0VC 5FPFC 5ADTB 5ADQB 4UI8C 4HLMC 4UI5C 4UI3C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L0S C;  4HLH C;  4UI7 C;  4HKI C;  4HKN C;  5ADR B;  4HLF C;  4L2F C;  5C5P C;  4L0I C;  4UI6 C;  4UI4 C;  4HL5 C;  4HKK B;  4L2K C;  4L32 C;  4HLG C;  4L34 C;  4KZL C;  4L31 C;  4UVP B;  5C5R C;  4HLK C;  4L10 C;  4L2G C;  4L0B C;  4HMH C;  4L33 C;  5ADS B;  4KZU C;  4L09 C;  4KZQ C;  5C5Q C;  4L0T C;  4L0V C;  5FPF C;  5ADT B;  5ADQ B;  4UI8 C;  4HLM C;  4UI5 C;  4UI3 C; 
#chains in the Genus database with same CATH topology
 4L0S C;  2A6Q A;  4HLH C;  4UI7 C;  2ODK A;  4HKI C;  4ZLX A;  4HKN C;  5ADR B;  4HLF C;  4L2F C;  3HRY A;  5C5P C;  4L0I C;  4UI6 C;  4UI4 C;  4HL5 C;  3KH2 E;  4HKK B;  4L2K C;  4L32 C;  3HS2 A;  4HLG C;  4L34 C;  3K6Q A;  4KZL C;  3HJ6 A;  4L31 C;  4UVP B;  5C5R C;  4HLK C;  4L10 C;  2ZIX B;  4L2G C;  3OEI A;  4L0B C;  4UI5 C;  4HMH C;  4L33 C;  3CTO A;  5ADS B;  4KZU C;  4L09 C;  4KZQ C;  5C5Q C;  4L0T C;  4L0V C;  5FPF C;  5ADT B;  3D55 A;  3K33 B;  4UI8 C;  4ZM2 A;  5ADQ B;  3G5O A;  4ZM0 A;  4HLM C;  3OEI E;  4UI3 C; 
#chains in the Genus database with same CATH homology
 4L0S C;  4HLH C;  4UI7 C;  4HKI C;  4HKN C;  5ADR B;  4HLF C;  4L2F C;  5C5P C;  4L0I C;  4UI6 C;  4UI4 C;  4HL5 C;  4HKK B;  4L2K C;  4L32 C;  4HLG C;  4L34 C;  4KZL C;  3HJ6 A;  4L31 C;  4UVP B;  5C5R C;  4HLK C;  4L10 C;  2ZIX B;  4L2G C;  4L0B C;  4HMH C;  4L33 C;  5ADS B;  4KZU C;  4L09 C;  4KZQ C;  5C5Q C;  4L0T C;  4L0V C;  5FPF C;  5ADT B;  5ADQ B;  4UI8 C;  4HLM C;  4UI5 C;  4UI3 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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