5BPKA

Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
348
structure length
348
Chain Sequence
ASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELIEKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
rcsb
molecule keywords Gamma-glutamyltranspeptidase (Ggt)
molecule tags Hydrolase
source organism Helicobacter pylori 26695
total genus 107
structure length 348
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.130 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5bpkA02
2E0XA 4ZCGA 2Z8KA 2DG5A 2DBUA 2QMCA 2NQOA 3FNMA 5BPKA 4OTTA 3WHQA 4GDXA 4OTUA 2Z8IA 2DBWA 4ZBKA 4Z9OA 2E0YA 2DBXA 2V36A 3A75A 2QM6A 5B5TA 3WHSA 2Z8JA 3WHRA 4GG2A 4ZC6A
chains in the Genus database with same CATH superfamily
2E0XA 1E7BA 2EFEA 4FJCB 2BXNA 2EFHA 2Z8KA 4G03A 4F5VA 4L9QA 1HA2A 4GDLB 3V09A 3PLAA 2QMCA 3BPJA 5DBYA 4LUFA 1HK5A 2BXDA 2NQOA 3NVMA 4W4UB 2OZBB 2JUHA 4N0FD 2YDFA 2DBWA 2BXMA 1HK4A 3SIUB 2XVUA 1BM0A 2BX8A 2E0YA 1E78A 5IJ5A 3LU6A 2VUFA 1VFIA 4IW1A 1MA9A 2DBXA 1MUSA 1FOUA 2AGHB 2QM6A 4ZBQA 2XVVA 3LU8A 3JQZA 3WHSA 4F5TA 3NVIA 3B9LA 3VQIA 4ZBKA 4G04A 1KW2A 3H37A 3UIVA 1E7EA 3A73A 5D7GA 2BXPA 1H5WA 2LQHA 5HOZA 4ZCGA 2DG5A 3FWCC 4GDKB 4LB2A 5IIHA 2NNWA 2BXAA 5IFOA 3WHQA 1HK1A 2DYOA 3GQUA 4GDXA 5IJEA 4PO0A 1HK2A 4N3ZA 4DHXB 1LNSA 1E7CA 2OT3A 1KXPD 3B9MA 2XVWA 1JNBA 4LA0A 5GIPA 4G01A 5GIOA 3SQJA 4OT2A 2ROHA 1VZSA 2BXOA 2BXLA 3NMUA 3NVKA 4NAWB 1MIVA 4OR0A 2K0NA 4K71A 3V08A 3CX9A 1KDXA 1SB0A 1E7IA 4M70B 5ID7A 5IIXA 4C31B 2BXKA 4Z69A 1LOTA 1O9XA 3FNMA 4HGKA 2CKXA 3H3AA 1E7GA 5GHKA 4OTTA 5BPKA 1MM8A 2BXQA 1NT2B 2KWFA 2LXSA 3LU7A 2BXGA 3GA9L 1MIYA 4L8UA 2LOQA 4OTUA 3KIKA 3ECPA 1MUHA 3GQXA 3MHSB 3ICXA 4I9OA 4Z9OA 1IJGA 2BXCA 1N5UA 2LQIA 4L9KA 5DQFA 2QHBA 2KBZA 5FUOA 2BXIA 3G9KD 2VDBA 3V03A 4J2VA 2I2ZA 2V36A 3KJLA 4IW2A 3TDLA 4DM0A 1BJ5A 1AO6A 4WA6B 2BXHA 4JK4A 4TQ1A 1J78A 4FIPB 4MBEC 4ZBRA 5B5TA 5ID9A 1BKEA 4LUHA 2Z8JA 4F5SA 4GG2A 2AJEA 2EFCA 2BXFA 3FWBC 4D7XA 2XW0A 2XSIA 1GNJA 3W1SA 4HGMB 2BXEA 2DBUA 4S1YA 2XW1A 4BKEA 5IIUA 2LXTA 3M99C 2XMOA 4E99A 4K2CA 2Z8IA 1UORA 1E7FA 2EFDA 4FK5B 3JRYA 4ZUXV 2VUEA 4LB9A 5GINA 1GNIA 4EMXA 1MIWA 3A75A 4BY9C 1TXUA 1H9ZA 2XVQA 4F5UA 4TQ0A 1E7AA 1E7HA 1TF0A 2DYMA 2GUTA 3SIVB 2BXBA 1HK3A 3WHRA 5IJFA 1J7EA 3MHHB 4ZC6A 4N0UD 2I30A
chains in the Genus database with same CATH topology
2E0XA 1E7BA 2EFEA 4FJCB 2BXNA 2EFHA 2Z8KA 4G03A 4F5VA 4L9QA 1HA2A 4GDLB 3V09A 3PLAA 2QMCA 5DBYA 4LUFA 1HK5A 2BXDA 2NQOA 3NVMA 4W4UB 2OZBB 2JUHA 4N0FD 2YDFA 2DBWA 2BXMA 1HK4A 3SIUB 2XVUA 1BM0A 2BX8A 2E0YA 1E78A 5IJ5A 3LU6A 2VUFA 1VFIA 4IW1A 1MA9A 2DBXA 1FOUA 2QM6A 4ZBQA 2XVVA 3LU8A 3JQZA 3WHSA 4F5TA 3NVIA 3B9LA 3VQIA 4G04A 1KW2A 3H37A 3UIVA 1E7EA 3A73A 5D7GA 2BXPA 1H5WA 5HOZA 4ZCGA 2DG5A 3FWCC 4GDKB 4LB2A 5IIHA 2NNWA 2BXAA 5IFOA 3WHQA 1HK1A 2DYOA 3GQUA 4GDXA 5IJEA 4PO0A 1HK2A 4N3ZA 4DHXB 1LNSA 1E7CA 2OT3A 1KXPD 3B9MA 2XVWA 1JNBA 4LA0A 5GIPA 4G01A 5GIOA 3SQJA 4OT2A 2ROHA 1VZSA 2BXOA 2BXLA 3NMUA 3NVKA 4NAWB 1MIVA 4OR0A 4K71A 3V08A 3CX9A 1E7IA 4M70B 5ID7A 5IIXA 4C31B 2BXKA 4Z69A 1LOTA 1O9XA 3FNMA 4HGKA 2CKXA 3H3AA 1E7GA 5GHKA 4OTTA 5BPKA 2BXQA 1NT2B 3LU7A 2BXGA 3GA9L 1MIYA 4L8UA 2LOQA 4OTUA 3KIKA 3GQXA 3MHSB 3ICXA 4ZBKA 4Z9OA 1IJGA 2BXCA 1N5UA 4L9KA 5DQFA 2QHBA 2KBZA 5FUOA 2BXIA 3G9KD 2VDBA 3V03A 4J2VA 2I2ZA 2V36A 3KJLA 4IW2A 3TDLA 1BJ5A 1AO6A 4WA6B 2BXHA 4JK4A 4TQ1A 1J78A 4FIPB 4MBEC 4ZBRA 5B5TA 5ID9A 1BKEA 4LUHA 2Z8JA 4F5SA 4GG2A 2AJEA 2EFCA 2BXFA 3FWBC 2XW0A 2XSIA 1GNJA 3W1SA 4HGMB 2BXEA 2DBUA 4S1YA 2XW1A 4BKEA 5IIUA 3M99C 2XMOA 4E99A 4K2CA 2Z8IA 1UORA 1E7FA 2EFDA 4FK5B 3JRYA 4ZUXV 2VUEA 4LB9A 5GINA 1GNIA 4EMXA 1MIWA 3A75A 4BY9C 1TXUA 1H9ZA 2XVQA 4F5UA 4TQ0A 1E7AA 1E7HA 1TF0A 2DYMA 3SIVB 2BXBA 1HK3A 3WHRA 5IJFA 1J7EA 3MHHB 4ZC6A 4N0UD 2I30A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E0X A;  4ZCG A;  2Z8K A;  2DG5 A;  2DBU A;  2QMC A;  2NQO A;  3FNM A;  5BPK A;  4OTT A;  3WHQ A;  4GDX A;  4OTU A;  2Z8I A;  2DBW A;  4ZBK A;  4Z9O A;  2E0Y A;  2DBX A;  2V36 A;  3A75 A;  2QM6 A;  5B5T A;  3WHS A;  2Z8J A;  3WHR A;  4GG2 A;  4ZC6 A; 
#chains in the Genus database with same CATH topology
 2E0X A;  1E7B A;  2EFE A;  4FJC B;  2BXN A;  2EFH A;  2Z8K A;  4G03 A;  4F5V A;  4L9Q A;  1HA2 A;  4GDL B;  3V09 A;  3PLA A;  2QMC A;  3BPJ A;  5DBY A;  4LUF A;  1HK5 A;  2BXD A;  2NQO A;  3NVM A;  4W4U B;  2OZB B;  2JUH A;  4N0F D;  2YDF A;  2DBW A;  2BXM A;  1HK4 A;  3SIU B;  2XVU A;  1BM0 A;  2BX8 A;  2E0Y A;  1E78 A;  5IJ5 A;  3LU6 A;  2VUF A;  1VFI A;  4IW1 A;  1MA9 A;  2DBX A;  1MUS A;  1FOU A;  2AGH B;  2QM6 A;  4ZBQ A;  2XVV A;  3LU8 A;  3JQZ A;  3WHS A;  4F5T A;  3NVI A;  3B9L A;  3VQI A;  4ZBK A;  4G04 A;  1KW2 A;  3H37 A;  3UIV A;  1E7E A;  3A73 A;  5D7G A;  2BXP A;  1H5W A;  2LQH A;  5HOZ A;  4ZCG A;  2DG5 A;  3FWC C;  4GDK B;  4LB2 A;  5IIH A;  2NNW A;  2BXA A;  5IFO A;  3WHQ A;  1HK1 A;  2DYO A;  3GQU A;  4GDX A;  5IJE A;  4PO0 A;  1HK2 A;  4N3Z A;  4DHX B;  1LNS A;  1E7C A;  2OT3 A;  1KXP D;  3B9M A;  2XVW A;  1JNB A;  4LA0 A;  5GIP A;  4G01 A;  5GIO A;  3SQJ A;  4OT2 A;  2ROH A;  1VZS A;  2BXO A;  2BXL A;  3NMU A;  3NVK A;  4NAW B;  1MIV A;  4OR0 A;  2K0N A;  4K71 A;  3V08 A;  3CX9 A;  1KDX A;  1SB0 A;  1E7I A;  4M70 B;  5ID7 A;  5IIX A;  4C31 B;  2BXK A;  4Z69 A;  1LOT A;  1O9X A;  3FNM A;  4HGK A;  2CKX A;  3H3A A;  1E7G A;  5GHK A;  4OTT A;  5BPK A;  1MM8 A;  2BXQ A;  1NT2 B;  2KWF A;  2LXS A;  3LU7 A;  2BXG A;  3GA9 L;  1MIY A;  4L8U A;  2LOQ A;  4OTU A;  3KIK A;  3ECP A;  1MUH A;  3GQX A;  3MHS B;  3ICX A;  4I9O A;  4Z9O A;  1IJG A;  2BXC A;  1N5U A;  2LQI A;  4L9K A;  5DQF A;  2QHB A;  2KBZ A;  5FUO A;  2BXI A;  3G9K D;  2VDB A;  3V03 A;  4J2V A;  2I2Z A;  2V36 A;  3KJL A;  4IW2 A;  3TDL A;  4DM0 A;  1BJ5 A;  1AO6 A;  4WA6 B;  2BXH A;  4JK4 A;  4TQ1 A;  1J78 A;  4FIP B;  4MBE C;  4ZBR A;  5B5T A;  5ID9 A;  1BKE A;  4LUH A;  2Z8J A;  4F5S A;  4GG2 A;  2AJE A;  2EFC A;  2BXF A;  3FWB C;  4D7X A;  2XW0 A;  2XSI A;  1GNJ A;  3W1S A;  4HGM B;  2BXE A;  2DBU A;  4S1Y A;  2XW1 A;  4BKE A;  5IIU A;  2LXT A;  3M99 C;  2XMO A;  4E99 A;  4K2C A;  2Z8I A;  1UOR A;  1E7F A;  2EFD A;  4FK5 B;  3JRY A;  4ZUX V;  2VUE A;  4LB9 A;  5GIN A;  1GNI A;  4EMX A;  1MIW A;  3A75 A;  4BY9 C;  1TXU A;  1H9Z A;  2XVQ A;  4F5U A;  4TQ0 A;  1E7A A;  1E7H A;  1TF0 A;  2DYM A;  2GUT A;  3SIV B;  2BXB A;  1HK3 A;  3WHR A;  5IJF A;  1J7E A;  3MHH B;  4ZC6 A;  4N0U D;  2I30 A; 
#chains in the Genus database with same CATH homology
 2E0X A;  1E7B A;  2EFE A;  4FJC B;  2BXN A;  2EFH A;  2Z8K A;  4G03 A;  4F5V A;  4L9Q A;  1HA2 A;  4GDL B;  3V09 A;  3PLA A;  2QMC A;  5DBY A;  4LUF A;  1HK5 A;  2BXD A;  2NQO A;  3NVM A;  4W4U B;  2OZB B;  2JUH A;  4N0F D;  2YDF A;  2DBW A;  2BXM A;  1HK4 A;  3SIU B;  2XVU A;  1BM0 A;  2BX8 A;  2E0Y A;  1E78 A;  5IJ5 A;  3LU6 A;  2VUF A;  1VFI A;  4IW1 A;  1MA9 A;  2DBX A;  1FOU A;  2QM6 A;  4ZBQ A;  2XVV A;  3LU8 A;  3JQZ A;  3WHS A;  4F5T A;  3NVI A;  3B9L A;  3VQI A;  4G04 A;  1KW2 A;  3H37 A;  3UIV A;  1E7E A;  3A73 A;  5D7G A;  2BXP A;  1H5W A;  5HOZ A;  4ZCG A;  2DG5 A;  3FWC C;  4GDK B;  4LB2 A;  5IIH A;  2NNW A;  2BXA A;  5IFO A;  3WHQ A;  1HK1 A;  2DYO A;  3GQU A;  4GDX A;  5IJE A;  4PO0 A;  1HK2 A;  4N3Z A;  4DHX B;  1LNS A;  1E7C A;  2OT3 A;  1KXP D;  3B9M A;  2XVW A;  1JNB A;  4LA0 A;  5GIP A;  4G01 A;  5GIO A;  3SQJ A;  4OT2 A;  2ROH A;  1VZS A;  2BXO A;  2BXL A;  3NMU A;  3NVK A;  4NAW B;  1MIV A;  4OR0 A;  4K71 A;  3V08 A;  3CX9 A;  1E7I A;  4M70 B;  5ID7 A;  5IIX A;  4C31 B;  2BXK A;  4Z69 A;  1LOT A;  1O9X A;  3FNM A;  4HGK A;  2CKX A;  3H3A A;  1E7G A;  5GHK A;  4OTT A;  5BPK A;  2BXQ A;  1NT2 B;  3LU7 A;  2BXG A;  3GA9 L;  1MIY A;  4L8U A;  2LOQ A;  4OTU A;  3KIK A;  3GQX A;  3MHS B;  3ICX A;  4ZBK A;  4Z9O A;  1IJG A;  2BXC A;  1N5U A;  4L9K A;  5DQF A;  2QHB A;  2KBZ A;  5FUO A;  2BXI A;  3G9K D;  2VDB A;  3V03 A;  4J2V A;  2I2Z A;  2V36 A;  3KJL A;  4IW2 A;  3TDL A;  1BJ5 A;  1AO6 A;  4WA6 B;  2BXH A;  4JK4 A;  4TQ1 A;  1J78 A;  4FIP B;  4MBE C;  4ZBR A;  5B5T A;  5ID9 A;  1BKE A;  4LUH A;  2Z8J A;  4F5S A;  4GG2 A;  2AJE A;  2EFC A;  2BXF A;  3FWB C;  2XW0 A;  2XSI A;  1GNJ A;  3W1S A;  4HGM B;  2BXE A;  2DBU A;  4S1Y A;  2XW1 A;  4BKE A;  5IIU A;  3M99 C;  2XMO A;  4E99 A;  4K2C A;  2Z8I A;  1UOR A;  1E7F A;  2EFD A;  4FK5 B;  3JRY A;  4ZUX V;  2VUE A;  4LB9 A;  5GIN A;  1GNI A;  4EMX A;  1MIW A;  3A75 A;  4BY9 C;  1TXU A;  1H9Z A;  2XVQ A;  4F5U A;  4TQ0 A;  1E7A A;  1E7H A;  1TF0 A;  2DYM A;  3SIV B;  2BXB A;  1HK3 A;  3WHR A;  5IJF A;  1J7E A;  3MHH B;  4ZC6 A;  4N0U D;  2I30 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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