5BQ8A

Crystal structure of norrin, a wnt signalling activator, crystal form ii
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
104
structure length
102
Chain Sequence
DPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLQPFRSSCHCCRPQTSKLALRLRCSGGMRLTATYRYILSCHCEECNSGTETS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Norrin
publication title Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
pubmed doi rcsb
source organism Homo sapiens
total genus 8
structure length 102
sequence length 104
chains with identical sequence C
ec nomenclature
pdb deposition date 2015-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00007 Cys_knot Cystine-knot domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 5bq8A00
2FJGV 2GYZA 2ASKA 3SEKB 2KD3A 2XV7A 3MJKA 4HSAA 1CZ8V 1LXIA 4MIDA 4UI2B 3S1KV 2TGIA 5BQBA 4HQUA 1FL7A 1VPFA 4YCIC 2B0UA 4QCIC 1M4UL 2VXSA 1BNDB 1HCNB 3BMPA 5BQ8A 1E9JA 1HRPB 1KLAA 4AY9A 1XWDA 5FV2V 1TZIV 1NYUB 2GH0C 1FZVA 1WQ9B 4HR9A 5BQCA 1MKGA 4MQWB 1TFGA 2XACA 1B8MB 2X1XE 3QB4A 1ZKZA 2R53A 2QCQA 1MKKA 1NYSB 1ES7A 3EVSB 5HK5A 1HD4A 2R52A 4FAOA 3B4VA 3BDYV 3V2AA 1QTYR 4ZBNA 1S4YB 5F3HI 4KXZA 1KLCA 4YCGC 2GOOA 1BMPA 1M4UA 3HH2A 5BQEA 3E07A 5FV1V 3EO1C 5HI3A 1QFWA 2X1WA 1WQ8A 2QJAA 4UI1A 5HHDA 1FL7B 2BHKA 3S1BV 3IJ2A 1SGFB 3MJGA 4LXRJ 4EC7A 4KV5A 1AOCA 4EAXA 1REUA 1B8KA 4X1JA 1FLTV 1AGQA 1REWA 3P9WA 1XWDB 2H64A 4AY9B 1WAQA 4BV4L 5HK5E 2GNNA 4GLSE 5HHCA 5BQ8D 1BETA 2VWEA 2FJHV 4EDXV 1KATW 1KTZA 1LX5A 4QHUC 1JPYA 2C7WA 4LXSJ 5F3BC 5AEJA 5HI4A 5HHXA 2GYRA 1TGJA 1TZHV 4XPJA 5HI5A 1BTGA 5E4GA 1TGKA 2QR0C 5BPUA 1WWWV 4GLNE 1DZ7A 3BUKA 1BNDA 1HCNA 2PJYA 1NT3A 2QJBA 2VPFA 2QCWA 5BQ8B 1VPPV 1HRPA 2QJ9A 5BQEB 2ARPA 4QAFC 5JZ7A 4KZNA 4UHZA 1QFWB 2V5EB 4UHYA 1MJVA 3JVFA 3V6BA 1SG1A 1HCFA 4ZFFC 1WQ9A 5HHVA 4EFVA 1B98A 4UI0A 4N1DA 3QTKA 4MQWA 3FUBB 1B8MA 1RV6V 4EDWV 1BJ1V 2ARVA 2IFGE 4HQXA 3BK3A 2P6AA 3KFDA 3RJRA 4MPLA 1PDGA 4WPBA 2H62A
chains in the Genus database with same CATH superfamily
2FJGV 2GYZA 2ASKA 3SEKB 2KD3A 2XV7A 3MJKA 4HSAA 1CZ8V 1LXIA 4MIDA 4UI2B 3S1KV 2TGIA 5BQBA 4HQUA 1FL7A 1VPFA 4YCIC 2B0UA 4QCIC 1M4UL 2VXSA 1BNDB 1HCNB 3BMPA 5BQ8A 1E9JA 1HRPB 1KLAA 4AY9A 1XWDA 5FV2V 1TZIV 1NYUB 2GH0C 1FZVA 1WQ9B 4HR9A 5BQCA 1MKGA 4MQWB 1TFGA 2XACA 1B8MB 2X1XE 3QB4A 1ZKZA 2R53A 2QCQA 1MKKA 1NYSB 1ES7A 3EVSB 5HK5A 1HD4A 2R52A 4FAOA 3B4VA 3BDYV 3V2AA 1QTYR 4ZBNA 1S4YB 5F3HI 4KXZA 1KLCA 4YCGC 2GOOA 1BMPA 1M4UA 3HH2A 5BQEA 3E07A 5FV1V 3EO1C 5HI3A 1QFWA 2X1WA 1WQ8A 2QJAA 4UI1A 5HHDA 1FL7B 2BHKA 3S1BV 3IJ2A 1SGFB 3MJGA 4LXRJ 4EC7A 4KV5A 1AOCA 4EAXA 1REUA 1B8KA 4X1JA 1FLTV 1AGQA 1REWA 3P9WA 1XWDB 2H64A 4AY9B 1WAQA 4BV4L 5HK5E 2GNNA 4GLSE 5HHCA 5BQ8D 1BETA 2VWEA 2FJHV 4EDXV 1KATW 1KTZA 1LX5A 4QHUC 1JPYA 2C7WA 4LXSJ 5F3BC 5AEJA 5HI4A 5HHXA 2GYRA 1TGJA 1TZHV 4XPJA 5HI5A 1BTGA 5E4GA 1TGKA 2QR0C 5BPUA 1WWWV 4GLNE 1DZ7A 3BUKA 1BNDA 1HCNA 2PJYA 1NT3A 2QJBA 2VPFA 2QCWA 5BQ8B 1VPPV 1HRPA 2QJ9A 5BQEB 2ARPA 4QAFC 5JZ7A 4KZNA 4UHZA 1QFWB 2V5EB 4UHYA 1MJVA 3JVFA 3V6BA 1SG1A 1HCFA 4ZFFC 1WQ9A 5HHVA 4EFVA 1B98A 4UI0A 4N1DA 3QTKA 4MQWA 3FUBB 1B8MA 1RV6V 4EDWV 1BJ1V 2ARVA 2IFGE 4HQXA 3BK3A 2P6AA 3KFDA 3RJRA 4MPLA 1PDGA 4WPBA 2H62A
chains in the Genus database with same CATH topology
2FJGV 2GYZA 2ASKA 3SEKB 2KD3A 2XV7A 3MJKA 4HSAA 1CZ8V 1LXIA 4MIDA 4UI2B 3S1KV 2TGIA 5BQBA 4HQUA 1FL7A 1VPFA 4YCIC 2B0UA 4QCIC 1M4UL 2VXSA 1BNDB 1HCNB 3BMPA 5BQ8A 1E9JA 1HRPB 1KLAA 4AY9A 1XWDA 5FV2V 1TZIV 1NYUB 2GH0C 1FZVA 1WQ9B 4HR9A 5BQCA 1MKGA 4MQWB 1TFGA 2XACA 1B8MB 2X1XE 3QB4A 1ZKZA 2R53A 2QCQA 1MKKA 1NYSB 1ES7A 3EVSB 5HK5A 1HD4A 2R52A 4FAOA 3B4VA 3BDYV 3V2AA 1QTYR 4ZBNA 1S4YB 5F3HI 4KXZA 1KLCA 4YCGC 2GOOA 1BMPA 1M4UA 3HH2A 5BQEA 3E07A 5FV1V 3EO1C 5HI3A 1QFWA 2X1WA 1WQ8A 2QJAA 4UI1A 5HHDA 1FL7B 2BHKA 3S1BV 3IJ2A 1SGFB 3MJGA 4LXRJ 4EC7A 4KV5A 1AOCA 4EAXA 1REUA 1B8KA 4X1JA 1FLTV 1AGQA 1REWA 3P9WA 1XWDB 2H64A 4AY9B 1WAQA 4BV4L 5HK5E 2GNNA 4GLSE 5HHCA 5BQ8D 1BETA 2VWEA 2FJHV 4EDXV 1KATW 1KTZA 1LX5A 4QHUC 1JPYA 2C7WA 4LXSJ 5F3BC 5AEJA 5HI4A 5HHXA 2GYRA 1TGJA 1TZHV 4XPJA 5HI5A 1BTGA 5E4GA 1TGKA 2QR0C 5BPUA 1WWWV 4GLNE 1DZ7A 3BUKA 1BNDA 1HCNA 2PJYA 1NT3A 2QJBA 2VPFA 2QCWA 5BQ8B 1VPPV 1HRPA 2QJ9A 5BQEB 2ARPA 4QAFC 5JZ7A 4KZNA 4UHZA 1QFWB 2V5EB 4UHYA 1MJVA 3JVFA 3V6BA 1SG1A 1HCFA 4ZFFC 1WQ9A 5HHVA 4EFVA 1B98A 4UI0A 4N1DA 3QTKA 4MQWA 3FUBB 1B8MA 1RV6V 4EDWV 1BJ1V 2ARVA 2IFGE 4HQXA 3BK3A 2P6AA 3KFDA 3RJRA 4MPLA 1PDGA 4WPBA 2H62A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FJG V;  2GYZ A;  2ASK A;  3SEK B;  2KD3 A;  2XV7 A;  3MJK A;  4HSA A;  1CZ8 V;  1LXI A;  4MID A;  4UI2 B;  3S1K V;  2TGI A;  5BQB A;  4HQU A;  1FL7 A;  1VPF A;  4YCI C;  2B0U A;  4QCI C;  1M4U L;  2VXS A;  1BND B;  1HCN B;  3BMP A;  5BQ8 A;  1E9J A;  1HRP B;  1KLA A;  4AY9 A;  1XWD A;  5FV2 V;  1TZI V;  1NYU B;  2GH0 C;  1FZV A;  1WQ9 B;  4HR9 A;  5BQC A;  1MKG A;  4MQW B;  1TFG A;  2XAC A;  1B8M B;  2X1X E;  3QB4 A;  1ZKZ A;  2R53 A;  2QCQ A;  1MKK A;  1NYS B;  1ES7 A;  3EVS B;  5HK5 A;  1HD4 A;  2R52 A;  4FAO A;  3B4V A;  3BDY V;  3V2A A;  1QTY R;  4ZBN A;  1S4Y B;  5F3H I;  4KXZ A;  1KLC A;  4YCG C;  2GOO A;  1BMP A;  1M4U A;  3HH2 A;  5BQE A;  3E07 A;  5FV1 V;  3EO1 C;  5HI3 A;  1QFW A;  2X1W A;  1WQ8 A;  2QJA A;  4UI1 A;  5HHD A;  1FL7 B;  2BHK A;  3S1B V;  3IJ2 A;  1SGF B;  3MJG A;  4LXR J;  4EC7 A;  4KV5 A;  1AOC A;  4EAX A;  1REU A;  1B8K A;  4X1J A;  1FLT V;  1AGQ A;  1REW A;  3P9W A;  1XWD B;  2H64 A;  4AY9 B;  1WAQ A;  4BV4 L;  5HK5 E;  2GNN A;  4GLS E;  5HHC A;  5BQ8 D;  1BET A;  2VWE A;  2FJH V;  4EDX V;  1KAT W;  1KTZ A;  1LX5 A;  4QHU C;  1JPY A;  2C7W A;  4LXS J;  5F3B C;  5AEJ A;  5HI4 A;  5HHX A;  2GYR A;  1TGJ A;  1TZH V;  4XPJ A;  5HI5 A;  1BTG A;  5E4G A;  1TGK A;  2QR0 C;  5BPU A;  1WWW V;  4GLN E;  1DZ7 A;  3BUK A;  1BND A;  1HCN A;  2PJY A;  1NT3 A;  2QJB A;  2VPF A;  2QCW A;  5BQ8 B;  1VPP V;  1HRP A;  2QJ9 A;  5BQE B;  2ARP A;  4QAF C;  5JZ7 A;  4KZN A;  4UHZ A;  1QFW B;  2V5E B;  4UHY A;  1MJV A;  3JVF A;  3V6B A;  1SG1 A;  1HCF A;  4ZFF C;  1WQ9 A;  5HHV A;  4EFV A;  1B98 A;  4UI0 A;  4N1D A;  3QTK A;  4MQW A;  3FUB B;  1B8M A;  1RV6 V;  4EDW V;  1BJ1 V;  2ARV A;  2IFG E;  4HQX A;  3BK3 A;  2P6A A;  3KFD A;  3RJR A;  4MPL A;  1PDG A;  4WPB A;  2H62 A; 
#chains in the Genus database with same CATH topology
 2FJG V;  2GYZ A;  2ASK A;  3SEK B;  2KD3 A;  2XV7 A;  3MJK A;  4HSA A;  1CZ8 V;  1LXI A;  4MID A;  4UI2 B;  3S1K V;  2TGI A;  5BQB A;  4HQU A;  1FL7 A;  1VPF A;  4YCI C;  2B0U A;  4QCI C;  1M4U L;  2VXS A;  1BND B;  1HCN B;  3BMP A;  5BQ8 A;  1E9J A;  1HRP B;  1KLA A;  4AY9 A;  1XWD A;  5FV2 V;  1TZI V;  1NYU B;  2GH0 C;  1FZV A;  1WQ9 B;  4HR9 A;  5BQC A;  1MKG A;  4MQW B;  1TFG A;  2XAC A;  1B8M B;  2X1X E;  3QB4 A;  1ZKZ A;  2R53 A;  2QCQ A;  1MKK A;  1NYS B;  1ES7 A;  3EVS B;  5HK5 A;  1HD4 A;  2R52 A;  4FAO A;  3B4V A;  3BDY V;  3V2A A;  1QTY R;  4ZBN A;  1S4Y B;  5F3H I;  4KXZ A;  1KLC A;  4YCG C;  2GOO A;  1BMP A;  1M4U A;  3HH2 A;  5BQE A;  3E07 A;  5FV1 V;  3EO1 C;  5HI3 A;  1QFW A;  2X1W A;  1WQ8 A;  2QJA A;  4UI1 A;  5HHD A;  1FL7 B;  2BHK A;  3S1B V;  3IJ2 A;  1SGF B;  3MJG A;  4LXR J;  4EC7 A;  4KV5 A;  1AOC A;  4EAX A;  1REU A;  1B8K A;  4X1J A;  1FLT V;  1AGQ A;  1REW A;  3P9W A;  1XWD B;  2H64 A;  4AY9 B;  1WAQ A;  4BV4 L;  5HK5 E;  2GNN A;  4GLS E;  5HHC A;  5BQ8 D;  1BET A;  2VWE A;  2FJH V;  4EDX V;  1KAT W;  1KTZ A;  1LX5 A;  4QHU C;  1JPY A;  2C7W A;  4LXS J;  5F3B C;  5AEJ A;  5HI4 A;  5HHX A;  2GYR A;  1TGJ A;  1TZH V;  4XPJ A;  5HI5 A;  1BTG A;  5E4G A;  1TGK A;  2QR0 C;  5BPU A;  1WWW V;  4GLN E;  1DZ7 A;  3BUK A;  1BND A;  1HCN A;  2PJY A;  1NT3 A;  2QJB A;  2VPF A;  2QCW A;  5BQ8 B;  1VPP V;  1HRP A;  2QJ9 A;  5BQE B;  2ARP A;  4QAF C;  5JZ7 A;  4KZN A;  4UHZ A;  1QFW B;  2V5E B;  4UHY A;  1MJV A;  3JVF A;  3V6B A;  1SG1 A;  1HCF A;  4ZFF C;  1WQ9 A;  5HHV A;  4EFV A;  1B98 A;  4UI0 A;  4N1D A;  3QTK A;  4MQW A;  3FUB B;  1B8M A;  1RV6 V;  4EDW V;  1BJ1 V;  2ARV A;  2IFG E;  4HQX A;  3BK3 A;  2P6A A;  3KFD A;  3RJR A;  4MPL A;  1PDG A;  4WPB A;  2H62 A; 
#chains in the Genus database with same CATH homology
 2FJG V;  2GYZ A;  2ASK A;  3SEK B;  2KD3 A;  2XV7 A;  3MJK A;  4HSA A;  1CZ8 V;  1LXI A;  4MID A;  4UI2 B;  3S1K V;  2TGI A;  5BQB A;  4HQU A;  1FL7 A;  1VPF A;  4YCI C;  2B0U A;  4QCI C;  1M4U L;  2VXS A;  1BND B;  1HCN B;  3BMP A;  5BQ8 A;  1E9J A;  1HRP B;  1KLA A;  4AY9 A;  1XWD A;  5FV2 V;  1TZI V;  1NYU B;  2GH0 C;  1FZV A;  1WQ9 B;  4HR9 A;  5BQC A;  1MKG A;  4MQW B;  1TFG A;  2XAC A;  1B8M B;  2X1X E;  3QB4 A;  1ZKZ A;  2R53 A;  2QCQ A;  1MKK A;  1NYS B;  1ES7 A;  3EVS B;  5HK5 A;  1HD4 A;  2R52 A;  4FAO A;  3B4V A;  3BDY V;  3V2A A;  1QTY R;  4ZBN A;  1S4Y B;  5F3H I;  4KXZ A;  1KLC A;  4YCG C;  2GOO A;  1BMP A;  1M4U A;  3HH2 A;  5BQE A;  3E07 A;  5FV1 V;  3EO1 C;  5HI3 A;  1QFW A;  2X1W A;  1WQ8 A;  2QJA A;  4UI1 A;  5HHD A;  1FL7 B;  2BHK A;  3S1B V;  3IJ2 A;  1SGF B;  3MJG A;  4LXR J;  4EC7 A;  4KV5 A;  1AOC A;  4EAX A;  1REU A;  1B8K A;  4X1J A;  1FLT V;  1AGQ A;  1REW A;  3P9W A;  1XWD B;  2H64 A;  4AY9 B;  1WAQ A;  4BV4 L;  5HK5 E;  2GNN A;  4GLS E;  5HHC A;  5BQ8 D;  1BET A;  2VWE A;  2FJH V;  4EDX V;  1KAT W;  1KTZ A;  1LX5 A;  4QHU C;  1JPY A;  2C7W A;  4LXS J;  5F3B C;  5AEJ A;  5HI4 A;  5HHX A;  2GYR A;  1TGJ A;  1TZH V;  4XPJ A;  5HI5 A;  1BTG A;  5E4G A;  1TGK A;  2QR0 C;  5BPU A;  1WWW V;  4GLN E;  1DZ7 A;  3BUK A;  1BND A;  1HCN A;  2PJY A;  1NT3 A;  2QJB A;  2VPF A;  2QCW A;  5BQ8 B;  1VPP V;  1HRP A;  2QJ9 A;  5BQE B;  2ARP A;  4QAF C;  5JZ7 A;  4KZN A;  4UHZ A;  1QFW B;  2V5E B;  4UHY A;  1MJV A;  3JVF A;  3V6B A;  1SG1 A;  1HCF A;  4ZFF C;  1WQ9 A;  5HHV A;  4EFV A;  1B98 A;  4UI0 A;  4N1D A;  3QTK A;  4MQW A;  3FUB B;  1B8M A;  1RV6 V;  4EDW V;  1BJ1 V;  2ARV A;  2IFG E;  4HQX A;  3BK3 A;  2P6A A;  3KFD A;  3RJR A;  4MPL A;  1PDG A;  4WPB A;  2H62 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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