5BQEA

Crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 -methylated form
Total Genus 8
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
101
structure length
101
Chain Sequence
DSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Signaling protein
molecule keywords Norrin
publication title Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
pubmed doi rcsb
source organism Homo sapiens
total genus 8
structure length 101
sequence length 101
ec nomenclature
pdb deposition date 2015-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00007 Cys_knot Cystine-knot domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 5bqeA00
2GOOA 1E9JA 1AGQA 3BK3A 2GYRA 1HCFA 3BMPA 4AY9A 1JPYA 5F3HI 2QJ9A 4UHZA 2IFGE 3MJGA 4X1JA 2XV7A 1BETA 1TZHV 1HD4A 2R52A 1CZ8V 3HH2A 5BQEA 2H62A 4UI0A 1NT3A 1BNDB 1ZKZA 3IJ2A 1TZIV 2R53A 2QJAA 1VPFA 3KFDA 3P9WA 4LXRJ 1KLCA 3QB4A 5HI5A 1NYSB 4MPLA 1MJVA 4KV5A 4GLSE 3B4VA 3V6BA 1HCNA 4ZFFC 2VPFA 1FL7B 1TGKA 5BQCA 5FV1V 1MKGA 5BQ8A 1BTGA 4GLNE 4HQUA 3BDYV 2ARPA 3EVSB 4EDXV 3MJKA 1LX5A 2FJHV 5E4GA 1REUA 1MKKA 4XPJA 2X1WA 1BMPA 1QFWA 4EFVA 4HSAA 2PJYA 1KTZA 1PDGA 4AY9B 5HHCA 4EC7A 5JZ7A 2X1XE 2QR0C 2P6AA 4EAXA 4QHUC 5BQEB 5HK5A 4BV4L 1XWDA 5F3BC 3V2AA 2V5EB 5FV2V 5HI3A 1WQ9A 1HRPA 2XACA 3E07A 4LXSJ 2GYZA 1SG1A 4YCGC 3SEKB 2B0UA 4MQWA 1BJ1V 4YCIC 1HCNB 4FAOA 1B98A 4N1DA 2ARVA 2FJGV 1M4UL 1FZVA 5BQ8B 1KATW 2C7WA 3RJRA 4UI1A 5HHDA 1WQ8A 2GNNA 2QCQA 4HQXA 4UHYA 1ES7A 1WWWV 3S1KV 1DZ7A 1B8MA 5BQBA 1QFWB 4QCIC 2QCWA 4ZBNA 2QJBA 3BUKA 3EO1C 3FUBB 1TGJA 4WPBA 3QTKA 1AOCA 1XWDB 2BHKA 1KLAA 1RV6V 1WQ9B 4UI2B 1HRPB 1M4UA 1BNDA 5HI4A 5HK5E 1REWA 4EDWV 5BPUA 5AEJA 3S1BV 2ASKA 2VXSA 4MQWB 2GH0C 5BQ8D 1B8KA 2KD3A 5HHVA 1TFGA 1NYUB 3JVFA 1FLTV 4KZNA 4QAFC 1LXIA 1FL7A 4KXZA 1SGFB 2TGIA 1WAQA 2VWEA 4HR9A 1QTYR 4MIDA 1VPPV 5HHXA 1B8MB 1S4YB 2H64A
chains in the Genus database with same CATH superfamily
2GOOA 1E9JA 1AGQA 3BK3A 2GYRA 1HCFA 3BMPA 4AY9A 1JPYA 5F3HI 2QJ9A 4UHZA 2IFGE 3MJGA 4X1JA 2XV7A 1BETA 1TZHV 1HD4A 2R52A 1CZ8V 3HH2A 5BQEA 2H62A 4UI0A 1NT3A 1BNDB 1ZKZA 3IJ2A 1TZIV 2R53A 2QJAA 1VPFA 3KFDA 3P9WA 4LXRJ 1KLCA 3QB4A 5HI5A 1NYSB 4MPLA 1MJVA 4KV5A 4GLSE 3B4VA 3V6BA 1HCNA 4ZFFC 2VPFA 1FL7B 1TGKA 5BQCA 5FV1V 1MKGA 5BQ8A 1BTGA 4GLNE 4HQUA 3BDYV 2ARPA 3EVSB 4EDXV 3MJKA 1LX5A 2FJHV 5E4GA 1REUA 1MKKA 4XPJA 2X1WA 1BMPA 1QFWA 4EFVA 4HSAA 2PJYA 1KTZA 1PDGA 4AY9B 5HHCA 4EC7A 5JZ7A 2X1XE 2QR0C 2P6AA 4EAXA 4QHUC 5BQEB 5HK5A 4BV4L 1XWDA 5F3BC 3V2AA 2V5EB 5FV2V 5HI3A 1WQ9A 1HRPA 2XACA 3E07A 4LXSJ 2GYZA 1SG1A 4YCGC 3SEKB 2B0UA 4MQWA 1BJ1V 4YCIC 1HCNB 4FAOA 1B98A 4N1DA 2ARVA 2FJGV 1M4UL 1FZVA 5BQ8B 1KATW 2C7WA 3RJRA 4UI1A 5HHDA 1WQ8A 2GNNA 2QCQA 4HQXA 4UHYA 1ES7A 1WWWV 3S1KV 1DZ7A 1B8MA 5BQBA 1QFWB 4QCIC 2QCWA 4ZBNA 2QJBA 3BUKA 3EO1C 3FUBB 1TGJA 4WPBA 3QTKA 1AOCA 1XWDB 2BHKA 1KLAA 1RV6V 1WQ9B 4UI2B 1HRPB 1M4UA 1BNDA 5HI4A 5HK5E 1REWA 4EDWV 5BPUA 5AEJA 3S1BV 2ASKA 2VXSA 4MQWB 2GH0C 5BQ8D 1B8KA 2KD3A 5HHVA 1TFGA 1NYUB 3JVFA 1FLTV 4KZNA 4QAFC 1LXIA 1FL7A 4KXZA 1SGFB 2TGIA 1WAQA 2VWEA 4HR9A 1QTYR 4MIDA 1VPPV 5HHXA 1B8MB 1S4YB 2H64A
chains in the Genus database with same CATH topology
2GOOA 1E9JA 1AGQA 3BK3A 2GYRA 1HCFA 3BMPA 4AY9A 1JPYA 5F3HI 2QJ9A 4UHZA 2IFGE 3MJGA 4X1JA 2XV7A 1BETA 1TZHV 1HD4A 2R52A 1CZ8V 3HH2A 5BQEA 2H62A 4UI0A 1NT3A 1BNDB 1ZKZA 3IJ2A 1TZIV 2R53A 2QJAA 1VPFA 3KFDA 3P9WA 4LXRJ 1KLCA 3QB4A 5HI5A 1NYSB 4MPLA 1MJVA 4KV5A 4GLSE 3B4VA 3V6BA 1HCNA 4ZFFC 2VPFA 1FL7B 1TGKA 5BQCA 5FV1V 1MKGA 5BQ8A 1BTGA 4GLNE 4HQUA 3BDYV 2ARPA 3EVSB 4EDXV 3MJKA 1LX5A 2FJHV 5E4GA 1REUA 1MKKA 4XPJA 2X1WA 1BMPA 1QFWA 4EFVA 4HSAA 2PJYA 1KTZA 1PDGA 4AY9B 5HHCA 4EC7A 5JZ7A 2X1XE 2QR0C 2P6AA 4EAXA 4QHUC 5BQEB 5HK5A 4BV4L 1XWDA 5F3BC 3V2AA 2V5EB 5FV2V 5HI3A 1WQ9A 1HRPA 2XACA 3E07A 4LXSJ 2GYZA 1SG1A 4YCGC 3SEKB 2B0UA 4MQWA 1BJ1V 4YCIC 1HCNB 4FAOA 1B98A 4N1DA 2ARVA 2FJGV 1M4UL 1FZVA 5BQ8B 1KATW 2C7WA 3RJRA 4UI1A 5HHDA 1WQ8A 2GNNA 2QCQA 4HQXA 4UHYA 1ES7A 1WWWV 3S1KV 1DZ7A 1B8MA 5BQBA 1QFWB 4QCIC 2QCWA 4ZBNA 2QJBA 3BUKA 3EO1C 3FUBB 1TGJA 4WPBA 3QTKA 1AOCA 1XWDB 2BHKA 1KLAA 1RV6V 1WQ9B 4UI2B 1HRPB 1M4UA 1BNDA 5HI4A 5HK5E 1REWA 4EDWV 5BPUA 5AEJA 3S1BV 2ASKA 2VXSA 4MQWB 2GH0C 5BQ8D 1B8KA 2KD3A 5HHVA 1TFGA 1NYUB 3JVFA 1FLTV 4KZNA 4QAFC 1LXIA 1FL7A 4KXZA 1SGFB 2TGIA 1WAQA 2VWEA 4HR9A 1QTYR 4MIDA 1VPPV 5HHXA 1B8MB 1S4YB 2H64A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GOO A;  1E9J A;  1AGQ A;  3BK3 A;  2GYR A;  1HCF A;  3BMP A;  4AY9 A;  1JPY A;  5F3H I;  2QJ9 A;  4UHZ A;  2IFG E;  3MJG A;  4X1J A;  2XV7 A;  1BET A;  1TZH V;  1HD4 A;  2R52 A;  1CZ8 V;  3HH2 A;  5BQE A;  2H62 A;  4UI0 A;  1NT3 A;  1BND B;  1ZKZ A;  3IJ2 A;  1TZI V;  2R53 A;  2QJA A;  1VPF A;  3KFD A;  3P9W A;  4LXR J;  1KLC A;  3QB4 A;  5HI5 A;  1NYS B;  4MPL A;  1MJV A;  4KV5 A;  4GLS E;  3B4V A;  3V6B A;  1HCN A;  4ZFF C;  2VPF A;  1FL7 B;  1TGK A;  5BQC A;  5FV1 V;  1MKG A;  5BQ8 A;  1BTG A;  4GLN E;  4HQU A;  3BDY V;  2ARP A;  3EVS B;  4EDX V;  3MJK A;  1LX5 A;  2FJH V;  5E4G A;  1REU A;  1MKK A;  4XPJ A;  2X1W A;  1BMP A;  1QFW A;  4EFV A;  4HSA A;  2PJY A;  1KTZ A;  1PDG A;  4AY9 B;  5HHC A;  4EC7 A;  5JZ7 A;  2X1X E;  2QR0 C;  2P6A A;  4EAX A;  4QHU C;  5BQE B;  5HK5 A;  4BV4 L;  1XWD A;  5F3B C;  3V2A A;  2V5E B;  5FV2 V;  5HI3 A;  1WQ9 A;  1HRP A;  2XAC A;  3E07 A;  4LXS J;  2GYZ A;  1SG1 A;  4YCG C;  3SEK B;  2B0U A;  4MQW A;  1BJ1 V;  4YCI C;  1HCN B;  4FAO A;  1B98 A;  4N1D A;  2ARV A;  2FJG V;  1M4U L;  1FZV A;  5BQ8 B;  1KAT W;  2C7W A;  3RJR A;  4UI1 A;  5HHD A;  1WQ8 A;  2GNN A;  2QCQ A;  4HQX A;  4UHY A;  1ES7 A;  1WWW V;  3S1K V;  1DZ7 A;  1B8M A;  5BQB A;  1QFW B;  4QCI C;  2QCW A;  4ZBN A;  2QJB A;  3BUK A;  3EO1 C;  3FUB B;  1TGJ A;  4WPB A;  3QTK A;  1AOC A;  1XWD B;  2BHK A;  1KLA A;  1RV6 V;  1WQ9 B;  4UI2 B;  1HRP B;  1M4U A;  1BND A;  5HI4 A;  5HK5 E;  1REW A;  4EDW V;  5BPU A;  5AEJ A;  3S1B V;  2ASK A;  2VXS A;  4MQW B;  2GH0 C;  5BQ8 D;  1B8K A;  2KD3 A;  5HHV A;  1TFG A;  1NYU B;  3JVF A;  1FLT V;  4KZN A;  4QAF C;  1LXI A;  1FL7 A;  4KXZ A;  1SGF B;  2TGI A;  1WAQ A;  2VWE A;  4HR9 A;  1QTY R;  4MID A;  1VPP V;  5HHX A;  1B8M B;  1S4Y B;  2H64 A; 
#chains in the Genus database with same CATH topology
 2GOO A;  1E9J A;  1AGQ A;  3BK3 A;  2GYR A;  1HCF A;  3BMP A;  4AY9 A;  1JPY A;  5F3H I;  2QJ9 A;  4UHZ A;  2IFG E;  3MJG A;  4X1J A;  2XV7 A;  1BET A;  1TZH V;  1HD4 A;  2R52 A;  1CZ8 V;  3HH2 A;  5BQE A;  2H62 A;  4UI0 A;  1NT3 A;  1BND B;  1ZKZ A;  3IJ2 A;  1TZI V;  2R53 A;  2QJA A;  1VPF A;  3KFD A;  3P9W A;  4LXR J;  1KLC A;  3QB4 A;  5HI5 A;  1NYS B;  4MPL A;  1MJV A;  4KV5 A;  4GLS E;  3B4V A;  3V6B A;  1HCN A;  4ZFF C;  2VPF A;  1FL7 B;  1TGK A;  5BQC A;  5FV1 V;  1MKG A;  5BQ8 A;  1BTG A;  4GLN E;  4HQU A;  3BDY V;  2ARP A;  3EVS B;  4EDX V;  3MJK A;  1LX5 A;  2FJH V;  5E4G A;  1REU A;  1MKK A;  4XPJ A;  2X1W A;  1BMP A;  1QFW A;  4EFV A;  4HSA A;  2PJY A;  1KTZ A;  1PDG A;  4AY9 B;  5HHC A;  4EC7 A;  5JZ7 A;  2X1X E;  2QR0 C;  2P6A A;  4EAX A;  4QHU C;  5BQE B;  5HK5 A;  4BV4 L;  1XWD A;  5F3B C;  3V2A A;  2V5E B;  5FV2 V;  5HI3 A;  1WQ9 A;  1HRP A;  2XAC A;  3E07 A;  4LXS J;  2GYZ A;  1SG1 A;  4YCG C;  3SEK B;  2B0U A;  4MQW A;  1BJ1 V;  4YCI C;  1HCN B;  4FAO A;  1B98 A;  4N1D A;  2ARV A;  2FJG V;  1M4U L;  1FZV A;  5BQ8 B;  1KAT W;  2C7W A;  3RJR A;  4UI1 A;  5HHD A;  1WQ8 A;  2GNN A;  2QCQ A;  4HQX A;  4UHY A;  1ES7 A;  1WWW V;  3S1K V;  1DZ7 A;  1B8M A;  5BQB A;  1QFW B;  4QCI C;  2QCW A;  4ZBN A;  2QJB A;  3BUK A;  3EO1 C;  3FUB B;  1TGJ A;  4WPB A;  3QTK A;  1AOC A;  1XWD B;  2BHK A;  1KLA A;  1RV6 V;  1WQ9 B;  4UI2 B;  1HRP B;  1M4U A;  1BND A;  5HI4 A;  5HK5 E;  1REW A;  4EDW V;  5BPU A;  5AEJ A;  3S1B V;  2ASK A;  2VXS A;  4MQW B;  2GH0 C;  5BQ8 D;  1B8K A;  2KD3 A;  5HHV A;  1TFG A;  1NYU B;  3JVF A;  1FLT V;  4KZN A;  4QAF C;  1LXI A;  1FL7 A;  4KXZ A;  1SGF B;  2TGI A;  1WAQ A;  2VWE A;  4HR9 A;  1QTY R;  4MID A;  1VPP V;  5HHX A;  1B8M B;  1S4Y B;  2H64 A; 
#chains in the Genus database with same CATH homology
 2GOO A;  1E9J A;  1AGQ A;  3BK3 A;  2GYR A;  1HCF A;  3BMP A;  4AY9 A;  1JPY A;  5F3H I;  2QJ9 A;  4UHZ A;  2IFG E;  3MJG A;  4X1J A;  2XV7 A;  1BET A;  1TZH V;  1HD4 A;  2R52 A;  1CZ8 V;  3HH2 A;  5BQE A;  2H62 A;  4UI0 A;  1NT3 A;  1BND B;  1ZKZ A;  3IJ2 A;  1TZI V;  2R53 A;  2QJA A;  1VPF A;  3KFD A;  3P9W A;  4LXR J;  1KLC A;  3QB4 A;  5HI5 A;  1NYS B;  4MPL A;  1MJV A;  4KV5 A;  4GLS E;  3B4V A;  3V6B A;  1HCN A;  4ZFF C;  2VPF A;  1FL7 B;  1TGK A;  5BQC A;  5FV1 V;  1MKG A;  5BQ8 A;  1BTG A;  4GLN E;  4HQU A;  3BDY V;  2ARP A;  3EVS B;  4EDX V;  3MJK A;  1LX5 A;  2FJH V;  5E4G A;  1REU A;  1MKK A;  4XPJ A;  2X1W A;  1BMP A;  1QFW A;  4EFV A;  4HSA A;  2PJY A;  1KTZ A;  1PDG A;  4AY9 B;  5HHC A;  4EC7 A;  5JZ7 A;  2X1X E;  2QR0 C;  2P6A A;  4EAX A;  4QHU C;  5BQE B;  5HK5 A;  4BV4 L;  1XWD A;  5F3B C;  3V2A A;  2V5E B;  5FV2 V;  5HI3 A;  1WQ9 A;  1HRP A;  2XAC A;  3E07 A;  4LXS J;  2GYZ A;  1SG1 A;  4YCG C;  3SEK B;  2B0U A;  4MQW A;  1BJ1 V;  4YCI C;  1HCN B;  4FAO A;  1B98 A;  4N1D A;  2ARV A;  2FJG V;  1M4U L;  1FZV A;  5BQ8 B;  1KAT W;  2C7W A;  3RJR A;  4UI1 A;  5HHD A;  1WQ8 A;  2GNN A;  2QCQ A;  4HQX A;  4UHY A;  1ES7 A;  1WWW V;  3S1K V;  1DZ7 A;  1B8M A;  5BQB A;  1QFW B;  4QCI C;  2QCW A;  4ZBN A;  2QJB A;  3BUK A;  3EO1 C;  3FUB B;  1TGJ A;  4WPB A;  3QTK A;  1AOC A;  1XWD B;  2BHK A;  1KLA A;  1RV6 V;  1WQ9 B;  4UI2 B;  1HRP B;  1M4U A;  1BND A;  5HI4 A;  5HK5 E;  1REW A;  4EDW V;  5BPU A;  5AEJ A;  3S1B V;  2ASK A;  2VXS A;  4MQW B;  2GH0 C;  5BQ8 D;  1B8K A;  2KD3 A;  5HHV A;  1TFG A;  1NYU B;  3JVF A;  1FLT V;  4KZN A;  4QAF C;  1LXI A;  1FL7 A;  4KXZ A;  1SGF B;  2TGI A;  1WAQ A;  2VWE A;  4HR9 A;  1QTY R;  4MID A;  1VPP V;  5HHX A;  1B8M B;  1S4Y B;  2H64 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...