5BQMB

Crystal structure of sxn101959, a clostridium botulinum neurotoxin type d derivative and targeted secretion inhibitor
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
403
structure length
387
Chain Sequence
GSALVLQCIKVKNNRLPYVADKDSISQEIFENKIITDETNVQVPINPEIVDPLLPNVNMEPLNLPGEEIVFYDDITKYVDYLNSYYYLESQKLSNNVENITLTTSVEEALGYSNKIYTFLPSLAEKVNKGVQAGLFLNWANEVVEDFTTNIMKKDTLDKISDVSVIIPYIGPALNIGNSALRGNFNQAFATAGVAFLLEGFPEFTIPALGVFTFYSSIQEREKIIKTIENCLEQRVKRWKDSYQWMVSNWLSRITTQFNHINYQMYDSLSYQADAIKAKIDLEYKKYSGSDKENIKSQVENLKNSLDVKISEAMNNINKFIRECSVTYLFKNMLPKVIDELNKFDLRTKTELINLIDSHNIILVGEVDRLKAKVNESFENTMPFNIF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Botulinum neurotoxin type D
publication title Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors.
pubmed doi rcsb
source organism Clostridium botulinum
total genus 100
structure length 387
sequence length 403
chains with identical sequence D
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2015-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00123 Hormone_2 Peptide hormone
B PF07952 Toxin_trans Clostridium neurotoxin, Translocation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1120.10 Mainly Alpha Up-down Bundle Clostridium botulinum neurotoxin B, "coiled-coil" domain Clostridium botulinum neurotoxin b, "coiled-coil" domain 5bqmB00
2NYYA 3V0AA 1S0CA 1S0GA 3BTAA 4ZKTB 2W2DB 1I1EA 1S0BA 2XHLB 3FFZA 3V0BB 3VUOA 1F31A 5BQNA 2NP0A 1S0FA 3V0BA 1G9DA 3ZURA 1G9AA 3ZUSA 5BQMB 1EPWA 2NZ9A 1S0EA 1S0DA 3ZUQA 1G9BA 3V0AB 1G9CA
chains in the Genus database with same CATH superfamily
2NYYA 3V0AA 1S0CA 1S0GA 3BTAA 4ZKTB 2W2DB 1I1EA 1S0BA 2XHLB 3FFZA 3V0BB 3VUOA 1F31A 5BQNA 2NP0A 1S0FA 3V0BA 1G9DA 3ZURA 1G9AA 3ZUSA 5BQMB 1EPWA 2NZ9A 1S0EA 1S0DA 3ZUQA 1G9BA 3V0AB 1G9CA
chains in the Genus database with same CATH topology
2NYYA 3V0AA 1S0CA 1S0GA 3BTAA 4ZKTB 2W2DB 1I1EA 1S0BA 2XHLB 3FFZA 3V0BB 3VUOA 1F31A 5BQNA 2NP0A 1S0FA 3V0BA 1G9DA 3ZURA 1G9AA 3ZUSA 5BQMB 1EPWA 2NZ9A 1S0EA 1S0DA 3ZUQA 1G9BA 3V0AB 1G9CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NYY A;  3V0A A;  1S0C A;  1S0G A;  3BTA A;  4ZKT B;  2W2D B;  1I1E A;  1S0B A;  2XHL B;  3FFZ A;  3V0B B;  3VUO A;  1F31 A;  5BQN A;  2NP0 A;  1S0F A;  3V0B A;  1G9D A;  3ZUR A;  1G9A A;  3ZUS A;  5BQM B;  1EPW A;  2NZ9 A;  1S0E A;  1S0D A;  3ZUQ A;  1G9B A;  3V0A B;  1G9C A; 
#chains in the Genus database with same CATH topology
 2NYY A;  3V0A A;  1S0C A;  1S0G A;  3BTA A;  4ZKT B;  2W2D B;  1I1E A;  1S0B A;  2XHL B;  3FFZ A;  3V0B B;  3VUO A;  1F31 A;  5BQN A;  2NP0 A;  1S0F A;  3V0B A;  1G9D A;  3ZUR A;  1G9A A;  3ZUS A;  5BQM B;  1EPW A;  2NZ9 A;  1S0E A;  1S0D A;  3ZUQ A;  1G9B A;  3V0A B;  1G9C A; 
#chains in the Genus database with same CATH homology
 2NYY A;  3V0A A;  1S0C A;  1S0G A;  3BTA A;  4ZKT B;  2W2D B;  1I1E A;  1S0B A;  2XHL B;  3FFZ A;  3V0B B;  3VUO A;  1F31 A;  5BQN A;  2NP0 A;  1S0F A;  3V0B A;  1G9D A;  3ZUR A;  1G9A A;  3ZUS A;  5BQM B;  1EPW A;  2NZ9 A;  1S0E A;  1S0D A;  3ZUQ A;  1G9B A;  3V0A B;  1G9C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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